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Your search keyword '"Chen, Gairong"' showing total 1 results
Start Over Author "Chen, Gairong" Language english Publisher taylor & francis ltd
1 results on '"Chen, Gairong"'

1. A New Synthesis of 2-chloro-2'-deoxyadenosine (Cladribine), CdA).

Author

Xu, Shaohong, Yao, Peng, Chen, Gairong, and Wang, Hui

Subjects
ORGANIC synthesis, HYDROXYLAMINE, NUCLEOSIDES, PYRIDINE, SODIUM acetate, CHLORIDES, HYDROXYL group
Abstract

A new efficient route for the synthesis of 2-chloro-2';-deoxyadenosine (Cladribine), CdA) has been developed. The key step of this method was selective deprotection of the acetyl group at the 2' position; the 3', 5' acetyl groups were not affected. This can be accomplished efficiently with hydroxylamine hydrochloride and sodium acetate in pyridine. The 2' hydroxyl group was removed by the Barton-McCombie reaction. Using this strategy, CdA was prepared in five steps and 31.0% yields. [ABSTRACT FROM AUTHOR]

Published
2011
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