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The evaluation of the scientific and technological (S&T) innovation efficiency of universities is important for the 'double first-class' construction in China. However, related research often only considers desirable outputs while ignoring undesirable ones, which tends to produce biased evaluation results. For this reason, this study takes the ratio of unemployed graduates as undesirable output, and uses the global Malmquist – Luenberger index method to evaluate the S&T innovation efficiency of 31 relevant universities in China during 2013–2017, then develops a panel Tobit model to analyse its influencing factors. The results reveal that: first, during the sample period, the S&T innovation efficiency of those universities improved overall, and technical progress was the main driver. Second, excluding undesirable output will result in an overestimate of the S&T innovation efficiency of universities. Third, the S&T innovation efficiency of universities features regional distribution, with high efficiency in the west and low efficiency in the east. Moreover, different regions have different drivers for the improvement of S&T innovation efficiency of universities, with technical progress for the east and technical efficiency changes for the central and west. Finally, the 'double first-class' construction proposal in China has significantly promoted the improvement of S&T innovation efficiency in universities. [ABSTRACT FROM AUTHOR]

Based on the data of 31 provinces in China during 2004–2015 and the models of panel threshold regression and panel quantile regression, this paper investigates the impact of China's higher education on regional carbon emissions. The results indicate that there exists threshold effect of both China's higher education scale and quality on regional carbon emissions per capita. Specifically, in terms of higher education scale, its further progress may facilitate the positive effect on carbon emissions per capita when technology is above threshold. As for higher education quality, its further growth may moderate the positive effect on carbon emissions per capita when income exceeds threshold; it also can promote its constrained effect on carbon emissions per capita when exceeding the technology threshold; and the continuous improvement of higher education quality may help to reduce carbon emissions per capita. Besides, the positive impact of higher education scale on carbon emissions per capita appears smaller in regions with more carbon emissions per capita; meanwhile, only in the regions with larger carbon emissions per capita, may higher education quality promote carbon emissions per capita, while the curbing impact of technology level is relatively constant among different regions with various carbon emissions. [ABSTRACT FROM AUTHOR]

A new Sr(II)-based metal organic framework (MOF) formulated as [Sr(HTATB)(H2O)2(DMF)4 (1) has been prepared by reaction of Sr(NO3)2 with the rigid tricarboxylic acid linker 4,4′,4″-s-triazine-2, 4, 6-triyltribenzoic acid (H3TATB) in a mixed solvent of N,N-dimethylformamide (DMF) and water. Complex 1 has been characterized by powder X-ray diffraction (PXRD), elemental analysis (EA) and single crystal X-ray diffraction (SCXRD). In light of its large inner spaces as well as widely distributed open metal sites, the guest-free 1 (1a) has been used as a crystalline vessel for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu), which exhibits an outstanding loading capacity around 36.48 wt%. Furthermore, the cumulative release value of 5-Fu at 48 h was about 96.5% in phosphate buffer saline (PBS). In addition, the 3-(4,5-dimethyl-2-thiazolyl)−2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was employed to evaluate the in vitro cytotoxicity of the carrier 5-Fu loaded 1a against the human melanoma cell lines. [ABSTRACT FROM AUTHOR]

PhD enrolment quota allocation proves the key concern for China’s universities to promote institutional reform and improve research level, and it is often characterized by the zero sum game among schools within a university. Therefore, this article develops a new indicator system for PhD enrolment quota allocation and efficiency evaluation in China, and then it reallocates the quotas considering the preferences of decision-makers and the efficiency based on the historical data during 2011-2015 in a research-oriented university in China. The results indicate that, first, the preferences of decision-makers in the university for article publications and research funds may significantly affect the allocation of PhD enrolment quotas among schools. Second, when the linear combination weighting method is used, the overall efficiency for PhD enrolment allocation proves the highest, among various weighting methods concerned. Finally, to improve the overall efficiency of the 19 schools, five social science schools and four engineering schools have to cut their PhD enrolment quotas; among them, three engineering schools should reduce the largest redundant quotas sharply. The methods and results in this article are conducive to the allocation of education resources which have the zero sum feature and are often accompanied with undesirable outputs. [ABSTRACT FROM AUTHOR]

Abstract Objective: This study aimed to investigate the functions of lncRNA H19 on glomerular endothelial structural damage of diabetic nephropathy (DN). Materials and Methods: Rats were fed a high sugar and fat high feed die, and intraperitoneally administrated with streptozotocin (30 mg/kg) to induce DN model. Meanwile, rat glomerular endothelial cells (rGEnCs) were treated with high a level of glucose （HG, 30 mM glucose）to induce structural damage. Results: Our results showed that H19 level was drastically increased in diabetic glomeruli and high-glucose (HG)-stimulated rat glomerular endothelial cells (rGEnCs). Deficiency of H19 ameliorated microalbumin, creatinine, BUN, and histopathological alterations in diabetic rats. In addition, H19 deficiency significantly attenuated the damage of endothelial structure by upregulating the expression of junction proteins ZO-1 and Occludin, glycolcalyx protein Syndecan-1, and endothelial activation marker sVCAM-1 and sICAM-1 in diabetic rats. The in vitro results also showed that H19-siRNA alleviated glycocalyx shedding, tight junctions damage, and endothelial activation in HG-stimulated rGEnCs. Moreover, H19 deficiency significantly enhanced the expression of p-Akt and p-eNOS and NO concentration in vitro and in vivo. Pre-treatment with Akt inhibitor LY294002 abrogated these favourable effects mediated by H19 deficiency. Discussion and Conclusion: These results indicate that H19 deficiency could mitigate the structural damage of glomerular endothelium in DN via activating Akt/eNOS pathway. [ABSTRACT FROM AUTHOR]