1. An updated synthesis of [11C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor.
- Author
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Blecha, Joseph E., Henderson, Bradford D., Hockley, Brian G., VanBrocklin, Henry F., Zubieta, Jon ‐ Kar, DaSilva, Alexandre F., Kilbourn, Michael R., Koeppe, Robert A., Scott, Peter J.H., and Shao, Xia
- Subjects
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RADIOACTIVE tracers , *POSITRON emission tomography , *OPIOID receptors , *METHYLATION , *SOLID phase extraction - Abstract
[11C]Carfentanil ([11C]CFN) is a selective radiotracer for in vivo positron emission tomography imaging studies of the μ-opioid system that, in our laboratories, is synthesized by methylation of the corresponding carboxylate precursor with [11C]MeOTf, and purified using a C2 solid-phase extraction cartridge. Changes in the commercial availability of common C2 cartridges have necessitated future proofing the synthesis of [11C]CFN to maintain reliable delivery of the radiotracer for clinical imaging studies. An updated synthesis of [11C]CFN is reported that replaces a now obsolete purification cartridge with a new commercially available version and also substitutes the organic solvents used in traditional production methods with ethanol. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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