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Background: To explore the short‐ and long‐term outcomes in patients with nasopharyngeal carcinoma (NPC) with magnetic resonance imaging (MRI)‐detected residual disease at 3 months post‐treatment who received intervention either promptly (0 month) or following observation (after an additional 3 months). Methods: A total of 272 patients with residual disease at 3 months post‐treatment (observation [observation for additional 3 months]: 122, intervention [prompt intervention]: 150) were analyzed. Univariate and multivariate analyses were performed to examine the survival. Adverse events were analyzed in all patients. Results: Patients in the observation group had a lower 3‐year overall survival (77.1% vs. 85.2%), progression‐free survival (10.2% vs. 18.1%), and locoregional relapse‐free survival (10.2% vs. 20.6%) (all p <.05), but not distant metastasis‐free survival (83.8% vs. 78.4%, p =.189), whereas patients in the intervention group achieved higher complete remission (CR) rates (43.3% vs. 21.2%, p =.003). Patients who achieved CR after prompt intervention had a better survival rate than those who achieved observation‐CR or non‐CR (p <.001). Multivariate analyses revealed that a wait‐and‐see policy was an independent prognostic factor for impaired survival (p <.001). No significant differences of acute or late toxicities were observed between the two groups. Conclusions: Patients with NPC with MRI‐detected residual disease 3 months post‐radiotherapy should be encouraged to undergo prompt intervention rather than adopting a passive wait‐and‐see policy. [ABSTRACT FROM AUTHOR]

An agricultural production function is estimated using a Chinese county-level dataset along with associated geographic information. County-specific output-input elasticities are computed using the geographically weighted regression (GWR) and mapped with the geographical information system (GIS). A comparison of the ordinary least squares and GWR estimates confirms that allowing spatial variation in the parameters improves model fit of the agricultural production function, and provides valuable insights into the relative importance of inputs in different regions. Moran's indices reveal the spatial dependence of output per unit of land, and four inputs across regions. Mappings of GWR estimates help to detect a few clusters of high output-input elasticities: for labour in the Northeast, North, Southwest and Northwest China, for land in the Central and Southwest, for mechanical power in the North, Northwest and coastal area of the East and South and for fertiliser in the East. The county-specific scale elasticities suggest constant return to scale is likely to hold in the Central, East, Southwest and South. [ABSTRACT FROM AUTHOR]