Search

I DDX41 i mutations were detected in 0.6% (2/329) adult ALL patients of our cohorts comparable with a recent report.[10] Previous studies showed that I DDX41 i -mutated patients of MNs presented as male predominance and old age. Germline DDX41 mutations define a significant entity within adult MDS/AML patients. We found three variants in I DDX41 i (p.R525H, p.G530D and p.Y259C) and confirmed the germline origin of p.Y259C of I DDX41 i by Sanger sequencing. [Extracted from the article]

To reduce the short‐term load forecasting (STLF) error of off‐line forecasting model, a VMD‐IWOA‐LSTM (VIL) method for STLF is proposed. Firstly, variational mode decomposition (VMD) is used to decompose the historical power load signals. Then, the decomposed signals are reconstructed according to the similarity of Pearson correlation coefficient (PCC), and meteorological data are chosen for each reconstructed component based on the set PCC threshold. The long short‐term memory (LSTM) models are used to predict the corresponding components, and improved whale optimization algorithm (IWOA) is used to optimize the parameters in LSTM. Finally, the forecast results of each component are added together to get the final forecast result. The experimental results of power load data in a certain area show that the proposed method has the advantages of strong anti‐interference performance and high prediction accuracy compared with other methods, and has strong practicability. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Overall survival (OS) (A) and OS censored at the time of transplantation (B) of 24 relapsed pediatric B-ALL patients with mean VAF >=20% versus patients with mean VAF < 20% at relapse. Moreover, in 18 patients with remission-relapse pairs, VAF was significantly increased in relapsed patients, indicating delta VAF can be used to evaluate patients for recurrence ( I p i < 0.001) (Figure 2B). (C) Comparison of VAFs at three different relapse stages in 24 relapsed patients, including very early, early and late relapse stage. [Extracted from the article]

The polycomb group BMI1 is proved to be crucial in malignant myeloid progression. However, the underlying mechanism of the action of BMI1 in myeloid malignant progression was not well characterized. In this study, we found that the patients of both myelodysplastic syndromes and chronic myeloid leukaemia with BMI1 overexpression had a higher risk in malignant myeloid progression. In vitro gene transfection studies showed that BMI1 inhibited cell myeloid and erythroid differentiation induced by 12-O-tetradecanoyl phorbol-13-acetate ( TPA) and histone deacetylase inhibitor sodium butyrate respectively. BMI1 also resisted apoptosis induced by arsenic trioxide. Moreover, the transcript levels of Runx1 and Pten were down-regulated in Bmi1-transfected cells in company with histone deacetylation modification. By using chromatin immunoprecipitation (Ch IP) collaborated with secondary generation sequencing and verified by Ch IP- PCR, we found that BMI1 directly bound to the promoter region of Zmym3, which encodes a component of histone deacetylase-containing complexes. In addition, as one of the downstream target genes of this complex, c-fos was activated with increasing histone acetylation when ZMYM3 was suppressed in the Bmi1-transfected cells. These results suggested that BMI1 may reprogramme the histone acetylation profile in multiple genes through either indirect or direct binding effects which probably contributes to the malignant progression of myeloid progenitor cells. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented which discusses a study showing that DNA methyltransferases (DNM)T3A has nothing to do with leukemogenesis of chronic myeloid leukemia (CML) and the progression from CML to chronic phase (CP) and from CML to blast crisis (BC).