1. Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing.
- Author
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Ping Zhang, Weeranoppanant, Nopphon, Thomas, Dale A., Kohei Tahara, Stelzer, Torsten, Russell, Mary Grace, O’Mahony, Marcus, Myerson, Allan S., Hongkun Lin, Kelly, Liam P., Jensen, Klavs F., Jamison, Timothy F., Chunhui Dai, Yuqing Cui, Briggs, Naomi, Beingessner, Rachel L., and Adamo, Andrea
- Subjects
CHLORIDES ,SULFATES ,CIPROFLOXACIN ,CHEMICAL engineering ,CHEMICAL synthesis - Abstract
As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy timescale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25% smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L) Χ 0.5 (D) Χ 1.3m (H)] stand-alone units for synthesis and purification/ formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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