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No-tillage with limited supplementary irrigation is promising for improving crop growth and ensuring sustainable crop yield in semi-arid and semi-humid areas defined by their water scarcity and uneven seasonal precipitation distribution. Choosing effective irrigation methods and scheduling to improve irrigation water use efficiency (IWUE) and reduce the risk of soil nitrate leaching has become increasingly necessary for crop management. Field experiments were conducted on no-tillage summer maize over four consecutive years from 2014 to 2017 in a semi-humid and drought-prone region of Northwest China. Four irrigation strategies were used, i.e. rain-fed (RF, no irrigation), conventional flood irrigation (CK), full drip irrigation (FI) and deficit drip irrigation (DI, 75% FI). The results indicated that supplemental irrigation mitigated the drought stress resulting in improving maize growth and a stable, sustainable yield. Plant height, leaf area index and aboveground biomass of the DI treatment were lower than those of the CK and FI treatments, while the DI treatment produced insignificantly lower grain yield and increased grain nitrogen content. The DI treatment promoted the transfer of nutrients from vegetative organs to reproductive organs. The IWUE of the DI treatment was increased by 22.1%–27.3% and 28.4%–48.6% compared with the CK and FI treatments during the four growing seasons, respectively. Soil NO 3 −-N of the CK treatment was mainly distributed below 40 cm soil depth, while most soil NO 3 −-N remained above 40 cm in the FI and DI treatments, implying lower levels of nitrate leaching compared with the conventional flood irrigation. In conclusion, deficit drip supplementary irrigation is a sustainable agricultural production strategy that improves water use efficiency, maintains stable yield and alleviates the risk of soil nitrate pollution in the no-tillage agrisystem of arid and semi-arid regions. Image 1 • Deficit drip irrigation increased IWUE by 22.1–27.3% and 28.4–48.6% compared with flood and full drip irrigation. • Deficit drip irrigation promotes nutrients transfer to reproductive organs and increases grain N content. • Possibility of NO 3 −-N leaching under drip irrigation management was smaller than that of flood irrigation. • Deficit drip irrigation saved irrigation water and did not significantly reduce maize yield. [ABSTRACT FROM AUTHOR]