1. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications.
- Author
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Mitsiades, Constantine S., Mitsiades, Nicholas S., McMullan, Ciaran J., Poulaki, Vassiliki, Shringarpure, Reshma, Hideshima, Teru, Akiyama, Masaharu, Chauhan, Dharminder, Munshi, Nikhil, Xuesong Gu, Bailey, Charles, Joseph, Marie, Libermann, Towia A., Richon, Victoria M., Marks, Paul A., and Anderson, Kenneth C.
- Subjects
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HISTONE deacetylase , *GROWTH factors , *APOPTOSIS , *ACETYLATION , *CELL death , *MULTIPLE myeloma , *TUMORS - Abstract
The cell growth is affected by histone deacetylases at the transcriptional level by regulating the acetylation status of nucleosomal histones. HDAC inhibition induces differentiation and apoptosis in transformed cells. Researchers recently showed that HDAC inhibitors, such as suberoylanilide hydroxamic acid, potently induce apoptosis of human multiple myeloma (MM) cells. In this study, researchers focused on MM as a model to study the transcriptional profile of HDAC inhibitor treatment on tumor cells and to address their pathophysiological implications with confirmatory mechanistic and functional assays.
- Published
- 2004
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