1. Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics
- Author
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Bin Li, Chunjian Zhao, Jiating Xu, Zhiguo Liu, Jin Ye, Yu-Jie Fu, Jiao Jiao, and Jun Wang
- Subjects
coordination ,Theranostic Nanomedicine ,bindind ligands ,General Chemical Engineering ,Science ,Supramolecular chemistry ,General Physics and Astronomy ,Medicine (miscellaneous) ,Reviews ,Nanotechnology ,02 engineering and technology ,Review ,010402 general chemistry ,Ligands ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Mice ,Neoplasms ,Tumor Microenvironment ,Animals ,General Materials Science ,Molecular Structure ,Chemistry ,General Engineering ,metal ions ,supramolecular self‐assembly ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Disease Models, Animal ,Metals ,cancer theranostics ,0210 nano-technology - Abstract
Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome., This review summarizes the recent progress made on metal‐coordinated supramolecular nanomedicines for cancer theranostic by classifying the coordination metal ions in the order of periodic table. Especially, the superiority of the tumor‐responsive nanomedicines for in vivo coordinated self‐assembling cancer theranostic is discussed, with an emphasis on how to realize high nanomedicine accumulation on tumor and therefore ideal theranostic outcome.
- Published
- 2021