1. Assessing Neuronal Metabolism In Vivo by Modeling Imaging Measures.
- Author
-
Ciccarelli, Olga, Toosy, Ahmed T., de Stefano, Nicola, Wheeler-Kingshott, Claudia A. M., Miller, David H., and Thompson, Alan J.
- Subjects
- *
NEUROPLASTICITY , *MICRODIALYSIS , *MITOCHONDRIAL pathology , *MULTIPLE sclerosis , *ACAMPROSATE , *AXONAL transport - Abstract
Mitochondrial dysfunction contributes to the pathogenesis of many neurological diseases, including multiple sclerosis (MS), but is not directly measurable in vivo. We modeled N-acetyl-aspartate (NAA), which reflects axonal structural integrity and mitochondrial metabolism, with imaging measures of axonal structural integrity (axial diffusivity and cord cross-sectional area) to extract its mitochondrial metabolic contribution. Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF