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This study aimed to investigate the impact of as-received biomass fly ashes (BFA) and green liquor dregs obtained from a pulp and paper plant in Brazil as substitutes for metakaolin in geopolymeric formulations. The properties of this type of waste material vary widely between different industrial plants. This study refrains from subjecting the waste materials to any form of pretreatment, taking into account their organic matter and particle size heterogeneity, requiring extensive characterization to evaluate their influence on the compressive strength, apparent open porosity, and water absorption of the geopolymeric samples. The objective was to assess their potential for upcycling purposes as an alternative to energy-intensive materials, such as ordinary Portland cement (OPC) and advanced ceramics. This potential arises from the ability of alkali-activated materials (AAM) to undergo curing at ambient temperatures, coupled with the possibility of compositions primarily derived from waste materials. To improve the sustainability of the products, the amorphous content of the raw material, which is more reactive than crystalline phases, was quantified and used as the base for mixture ratios. This approach aimed to reduce the requirement for alkaline activators, which have significant environmental impacts, while also increasing the waste content in the formulation. The incorporation of waste materials into the geopolymer matrix generally led to a reduction in the compressive strength compared to the benchmark metakaolin sample (19.4 MPa) but did not present a trend. The dregs led to values of 4.1 MPa at 25 wt% and 7.1 MPa at 50 wt%, a behavior that is somewhat counterintuitive, and BFA at 10 wt% presented 5.7 MPa. Nevertheless, the apparent open porosity remained at high levels for all the samples, close to 50%, and the compressive strength of most of them was over the values obtained for the metakaolin-only samples with mixture ratios calculated from the total composition instead of the amorphous composition. The decrease in strength and the increase in porosity were attributed to the specific characteristics of the waste materials, such as their high crystallinity, presence of organic matter, heterogeneous particle composition, and size. Overall, this study provides insight into the variations in geopolymerization based on the bulk and amorphous content of the aluminosilicate sources and how the characteristics of the waste materials influence the geopolymer matrix. It also highlights how calculating mixture ratios based on the amorphous composition improves the possibility of waste valorization through alkali activation. Additionally, it suggests that BFA and dregs might be effectively utilized in applications other than OPC substitution, such as adsorption, filtration, and catalysis. [ABSTRACT FROM AUTHOR]

Background: The concept introduced by protocols of enhanced recovery after surgery modifies perioperative traditional care in digestive surgery. The integration of these modern recommendations components during the perioperative period is of great importance to ensure fewer postoperative complications, reduced length of hospital stay, and decreased surgical costs., Aims: To emphasize the most important points of a multimodal perioperative care protocol., Methods: Careful analysis of each recommendation of both ERAS and ACERTO protocols, justifying their inclusion in the multimodal care recommended for digestive surgery patients., Results: Enhanced recovery programs (ERPs) such as ERAS and ACERTO protocols are a cornerstone in modern perioperative care. Nutritional therapy is fundamental in digestive surgery, and thus, both preoperative and postoperative nutrition care are key to ensuring fewer postoperative complications and reducing the length of hospital stay. The concept of prehabilitation is another key element in ERPs. The handling of crystalloid fluids in a perfect balance is vital. Fluid overload can delay the recovery of patients and increase postoperative complications. Abbreviation of preoperative fasting for two hours before anesthesia is now accepted by various guidelines of both surgical and anesthesiology societies. Combined with early postoperative refeeding, these prescriptions are not only safe but can also enhance the recovery of patients undergoing digestive procedures., Conclusions: This position paper from the Brazilian College of Digestive Surgery strongly emphasizes that the implementation of ERPs in digestive surgery represents a paradigm shift in perioperative care, transcending traditional practices and embracing an intelligent approach to patient well-being.

Drugs of abuse are psychoactive substances illicitly distributed and used worldwide. In Rio de Janeiro, Brazil, they represent a public health issue and are directly related to several social problems. The recent increase in appearances of new psychoactive substances (NPS), derived from structural modifications of existing psychoactive substances, poses a threat to public health and forensic laboratories worldwide, as little is known about these substances. This study aimed to chemically and geographically map drugs of abuse from blotter papers seized by the Civil Police of Rio de Janeiro State (PCERJ) between 2006 and 2019. High-performance analytical techniques, such as gas chromatography-mass spectrometry (GC-MS) and Orbitrap mass spectrometry (Orbitrap-MS), combined with statistical analyses, were employed to characterize the seized samples. The most common chemical compounds in NPS found in this study were synthetic phenethylamines, i.e., molecules from the 25I-NBOH (2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol) and 25I-NBOMe (2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine) families. Prior to 2014, the majority of seized blotter papers contained lysergic acid diethylamide (LSD) and were concentrated in the Metropolitan region. An upsurge in blotter paper seizures was observed from 2014 to 2017; the most common substances during this time were from the NBOMe family. NBOH compounds emerged in 2016 in coastal regions with high tourism, reaching over 1300 items only in 2017. Only one synthetic cannabinoid was found among the blotter papers seized in Rio de Janeiro between 2006 and 2019. The assembled chemical data and statistical analyses allowed the mapping and monitoring of the chemical profiles of the seized blotter papers, providing a strong foundation for the understanding of the origins and movement of these drugs around the RJ State., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Pulp and paper mill wastewater (PPMWW) contains high concentrations of recalcitrant compounds that cause toxicity to organisms. Advanced oxidation processes (AOPs) have the ability to degrade these compounds and reduce overall toxicity. Physicochemical characterization and Lactuca sativa toxicity test were conducted to compare the effectiveness of two post-treatments: UV/H 2 O 2 and photo-Fenton. A comparison of four phytotoxicity indexes was carried out. PPMWW from a Brazilian treatment plant was characterized by high values of phenols, color, integrated spectral area (ISA), and chemical oxygen demand (COD), and caused significant inhibition to seedling development. The use of both post-treatments allowed the removal of over 75% of phenols, color, ISA, and COD. Although UV/H 2 O 2 was more effective in removing phenols and ISA, photo-Fenton better reduced phytotoxicity. The most sensitive phytotoxicity indexes were RGIC 0.8 and GIC 80% , whereas SGC 0 , REC -0.25 and REC -0.50 better showed the effectiveness of the post-treatments. We suggest the combined use of two phytotoxicity indexes: one that evaluates the effects on seed germination and, another, on root elongation, e.g., SGC 0 and RGIC 0.8 . Additionally, we recommend the use of ISA for monitoring programs of wastewater treatments because it is a cost-effective approach that allows narrowing down the search and identification of compounds present in complex mixtures., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Pulp and paper industries are very important for developing the Brazilian economy. During production processes, many effluents are generated with high polluting potential. The objective of this study is to conduct an extensive literature review on the characteristics of effluents and treatment forms adopted by Brazilian mills in this industrial sector. Most consulted studies address raw (without treatment) and secondary (after biological treatment) effluents, considering their main characteristics like pH, chemical and biochemical oxygen demands (COD and BOD, respectively), color, solids, organochlorines, toxicity, estrogenic activity, and phenols. Raw effluents differ considerably in composition, depending on the type of paper produced, the pulping process employed, and other steps, like pulp bleaching. Raw effluent characteristics indicate that this effluent cannot be directly disposed of into water bodies, because it does not comply with federal and state disposal standards. Secondary effluents normally comply with Brazilian legislations, although some studies have reported COD and total phenol concentrations higher than disposal standards, suggesting that additional treatments are necessary. Treated effluent reuse was verified in some Brazilian mills, while its disposal in eucalyptus plantations has been considered a promising alternative for irrigation purposes., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Bisphenol A (BPA) is a high-production-volume chemical with endocrine disrupting properties commonly used as color developer in thermal paper. Concerns about the potential hazards of human BPA exposure have led to the increasing utilization of alternatives such as bisphenol S (BPS) and bisphenol F (BPF). This study was designed to assess: (i) BPA, BPS, and BPF concentrations in 112 thermal paper receipts from Brazil, France, and Spain by liquid chromatography coupled to mass spectrometry (LC-MS); and (ii) hormone-like activities of these receipts using two receptor-specific bioassays, the E-Screen for (anti-)estrogenicity and PALM luciferase assay for (anti-)androgenicity. BPA was present in 95.3% of receipts from Spain, 90.9% of those from Brazil, and 51.1% of those from France at concentrations up to 20.27 mg/g of paper. Only two samples from Brazil, two from Spain, and ten from France had a BPS concentration ranging from 6.46 to 13.29 mg/g; no BPA or BPS was detected in 27.7% of French samples. No BPF was detected in any receipt. Estrogenic activity was observed in all samples from Brazil and Spain and in 74.5% of those from France. Anti-androgenic activity was observed in > 90% of samples from Brazil and Spain and in 53.2% of those from France. Only 25.5% of French samples were negative for both estrogenic and anti-androgenic activity. Estrogenic and anti-androgenic activities per gram of paper were up to 1.411 µM estradiol (E 2 ) equivalent units (E 2 eq) and up to 359.5 mM procymidone equivalent units (Proceq), respectively. BPA but not BPS concentrations were positively correlated with both estrogenic and anti-androgenic activities. BPA still dominates the thermal paper market in Brazil and Spain, and BPS appears to be one of the main alternatives in France. There is an urgent need to evaluate the safety of alternatives proposed to replace BPA as developer in thermal printing. The large proportion of samples with hormonal activity calls for the adoption of preventive measures., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Acute cholecystitis (AC) is an acute inflammatory process of the gallbladder that may be associated with potentially severe complications, such as empyema, gangrene, perforation of the gallbladder, and sepsis. The gold standard treatment for AC is laparoscopic cholecystectomy. However, for a small group of AC patients, the risk of laparoscopic cholecystectomy can be very high, mainly in the elderly with associated severe diseases. In these critically ill patients, percutaneous cholecystostomy or endoscopic ultrasound gallbladder drainage may be a temporary therapeutic option, a bridge to cholecystectomy. The objective of this Brazilian College of Digestive Surgery Position Paper is to present new advances in AC treatment in high-risk surgical patients to help surgeons, endoscopists, and physicians select the best treatment for their patients. The effectiveness, safety, advantages, disadvantages, and outcomes of each procedure are discussed. The main conclusions are: a) AC patients with elevated surgical risk must be preferably treated in tertiary hospitals where surgical, radiological, and endoscopic expertise and resources are available; b) The optimal treatment modality for high-surgical-risk patients should be individualized based on clinical conditions and available expertise; c) Laparoscopic cholecystectomy remains an excellent option of treatment, mainly in hospitals in which percutaneous or endoscopic gallbladder drainage is not available; d) Percutaneous cholecystostomy and endoscopic gallbladder drainage should be performed only in well-equipped hospitals with experienced interventional radiologist and/or endoscopist; e) Cholecystostomy catheter should be removed after resolution of AC. However, in patients who have no clinical condition to undergo cholecystectomy, the catheter may be maintained for a prolonged period or even definitively; f) If the cholecystostomy catheter is maintained for a long period of time several complications may occur, such as bleeding, bile leakage, obstruction, pain at the insertion site, accidental removal of the catheter, and recurrent AC; g) The ideal waiting time between cholecystostomy and cholecystectomy has not yet been established and ranges from immediately after clinical improvement to months. h) Long waiting periods between cholecystostomy and cholecystectomy may be associated with new episodes of acute cholecystitis, multiple hospital readmissions, and increased costs. Finally, when selecting the best treatment option other aspects should also be considered, such as costs, procedures available at the medical center, and the patient's desire. The patient and his family should be fully informed about all treatment options, so they can help making the final decision.

Background: Surgical antibiotic prophylaxis is an essential component of perioperative care. The use of prophylactic regimens of antibiotics is a well-established practice that is encouraged to be implemented in preoperative/perioperative protocols in order to prevent surgical site infections., Aims: The aim of this study was to emphasize the crucial aspects of antibiotic prophylaxis in abdominal surgery., Results: Antibiotic prophylaxis is defined as the administration of antibiotics before contamination occurs, given with the intention of preventing infection by achieving tissue levels of antibiotics above the minimum inhibitory concentration at the time of surgical incision. It is indicated for clean operations with prosthetic materials or in cases where severe consequences may arise in the event of an infection. It is also suitable for all clean-contaminated and contaminated operations. The spectrum of action is determined by the pathogens present at the surgical site. Ideally, a single intravenous bolus dose should be administered within 60 min before the surgical incision. An additional dose should be given in case of hemorrhage or prolonged surgery, according to the half-life of the drug. Factors such as the patient's weight, history of allergies, and the likelihood of colonization by resistant bacteria should be considered. Compliance with institutional protocols enhances the effectiveness of antibiotic use., Conclusion: Surgical antibiotic prophylaxis is associated with reduced rates of surgical site infection, hospital stay, and morbimortality.

Silicon (Si) is a chemical element that is not yet considered essential for plants. However, over the past few decades, an increasing number of scientifi c studies have focused on the role of Si in soil-plant interactions. At the same time, many countries are leading the development and use of silicon-based fertilizers. Si can be taken up by plants predominantly in a mobile form (H4SiO4) in the soil through both passive and active uptake mechanisms. Therefore, Scopus data from 2012 to 2022 were used to understand the implementation and current status of research on the benefi cial effects of silicon fertilizers on soil and plants and the role of soil forms of silicon in improving soil quality. A bibliometric study of articles published in the database on the role of Si in soil and silicon fertilizers was carried out. Various tools, such as Microsoft Offi ce Excel 2021, VOS Viewer and Mapchart.net were used in this study. The fi nal literature includes 440 articles, 82% of which are scientifi c. Over the past decade, the number of published articles has increased signifi cantly. For example, in the years 2021–2022, a total of 91 articles were published, which is six times higher than the number of articles published in 2012–2013 (15 articles). This signifi cant increase in publications highlights the growing interest in the role Si and Si fertilizer research. It was found around 32.04% of China, 13.2% of the USA and 9.8% of Brazil the reviewed publications focused on the role of Si and Si fertilizers studies. Among the authors who published the most articles on this topic during the selected period are Wang X. (with 12 articles), Liang Yu., Rizwan M. and Ali S. (each with 8 articles). [ABSTRACT FROM AUTHOR]

This article describes how The Language Center at the Espirito Santo Federal University changed from using traditional pencil-andpaper tests to performance testing, based on authentic tasks. The change was prompted because people thought that their testing did not reflect a communicative approach to language teaching. The Assessment Project lasted for two years; the author discusses its participants, goals, stages (including pilot testing), and results. Content and construct validity improved, leading to positive washback. Learning objectives and criteria for passing were clarified.

Recycled paper has the potential to be used as a mulch for vegetable production and can be adopted for the cultivation of Italian zucchini. However, there have been no studies about the water savings or crop coefficient values used in irrigation management in this system; therefore, there is a need for more research. In view of the above, this study aimed to evaluate the effects of recycled paper mulch on evaporation and evapotranspiration in Italian zucchini and to determine the crop coefficients in its developmental stages. The study was carried out in two cultivation cycles conducted at the Lysimetric Station in Viçosa, MG, Brazil. The experiments were installed in a randomized block design with four replicates. Four lysimeter cultivation treatments were applied: without mulch (C); with recycled paper as mulch (CP); with only recycled paper (P); and with Bahia grass (G). Irrigation and drainage measurements were performed daily to calculate the crop and reference evapotranspiration, and thus the crop coefficient (Kc) values. The following characteristics were evaluated: fruit yield, NDVI and water productivity. For the cultivation of Italian zucchini using paper as mulch, Kc values of 0.54, 0.77 and 0.44 and Kcb values of 0.15, 0.45 and 0.18 are recommended for the initial, intermediate and final stages, respectively. NDVI can be used to estimate the Kc values for Italian zucchini. The use of recycled paper as mulch reduces the water consumption of Italian zucchini. [ABSTRACT FROM AUTHOR]

Taking as an example the very interesting and motivating paper by Sousa Ribeiro et al. (2021) an attempt is made of providing a couple of insights into the decision making process from the point of view of the potentially helpful aspects of data analysis and OR-related modelling. These are just hints and suggestions, meant primarily to emphasise the multifaceted character of the decision making situations and processes, especially when concerning more complex issues. While the course of the procedure proposed and exemplified in Sousa Ribeiro et al. (2021) is treated as fully correctly and successfully carried out to the end, we wish to show the potential use of information, constituting in a sense a "by-product" of such a procedure, or, actually, of any similar procedure, aimed at supporting decision making. [ABSTRACT FROM AUTHOR]

This study analyzes the characteristics of the top 100 most-cited papers related to tooth bleaching. A literature search was performed on the Web of Science up to March 2022. The number of citations was cross-matched with the citation count on Scopus and Google Scholar. The following data were collected: number and density of citations; authorship; year and journal of publication; study design and thematic; keywords; institution and country of origin. Spearman's correlation and Poisson regression were used to determine associations between the number of citations and study characteristics. The VOSviewer software was used to generate collaborative network maps for the authors and keywords. The number of citations ranged from 66 to 450. Papers were published between 1981 and 2020. The most frequent study design and topic were laboratory-based studies and 'interaction of the bleaching agent with dental tissues', respectively. Cochran M, Loguercio AD, Matis B, Reis A, and Suliman M were the authors with the highest number of papers. The countries with the most papers were the United States of America (USA) (28%) and Brazil (20%). Indiana University and State University of Ponta Grossa were the institutions with the most papers (6% each). There was a very strong correlation among the number of citations of the three databases. The 100 most-cited papers related to tooth bleaching were mainly published by the USA and Brazil, with laboratory-based studies addressing topics related to the effects of bleaching agents on tooth structure being the most prevalent.

In July 2015, China's national legislature brought in prosecutor-led civil environmental public interest litigation ("EPIL") for thirteen selected provincial areas of the country. After a two-year legal experiment, this prosecutor-led civil EPIL system was then established nationwide in July 2017. Yet, can it be said that prosecutorial regulators in China are in fact a paper tiger? Drawing upon content analysis of the 655 prosecutor-led civil EPILs and in-depth interviews with twelve frontline prosecutors and judges, this article examines the dynamics of regulatory practice and the motivation of the Chinese prosecutorial organs to engage in environmental regulation through litigation. Based upon the above two legislative landmarks in the law reform of this area, the regulatory practice of prosecutorial organs can be viewed as having occurred in three stages, with each stage featuring a distinct regulatory model: ad hoc regulation through local innovation before July 2015, forced regulation during the legal experiment from July 2015 to July 2017, and perfunctory regulation after the nationwide establishment of the prosecutor-led civil EPIL system in July 2017. The data shows that the Chinese prosecutorial organs have engaged in a larger number of such lawsuits since the second stage, but they have shown a strong preference for cases with less complicated facts, weak and small defendants, and minor environmental violations. Three factors that influence regulatory motivation are employed to analyse the change in regulatory models: the ambiguity of the law, the top-down political pressure for regulation, and the cost of regulation. This study highlights the very limited effectiveness of vertical political pressure in boosting prosecutorial regulation and the strong impacts of the cost of regulation and the ambiguity of the law. In particular, the high cost of regulation that takes weak regulatory capacity, lack of regulatory autonomy, and the winning rate-oriented performance appraisal system into account have significantly weakened the motivation of prosecutorial organs to pursue civil EPIL. The findings of this study echo the conditions present in the successful prosecutorial regulations in Brazil and contribute to the scholarship about prosecutorial regulations in the field of environmental protection in the Global South. [ABSTRACT FROM AUTHOR]

The subsector of pulp and paper presented in 2013 an electric power consumption of 9.3% of electricity consumption in the industrial sector in Brazil. It experienced a significant growth of production in the last 20 years, exceeding 160%, and their consumption of electricity increased by 130%, reaching the level of 19,594GWh. Due to its characteristics, with a known structure and production processes, and its importance in the country's industrial sector, this subsector was selected for study in this paper, to evaluate the behavior of its long-term annual electricity demand, at the horizon of 20 years ahead, in energy efficiency scenarios through bottom-up approach. This approach is data intensive and requires data with good quality; it consists of a hierarchical structure that enables to check how specific actions can affect the results at each level and its effect on higher levels. [ABSTRACT FROM AUTHOR]

Visceral leishmaniasis remains a serious public health issue, and Brazil was among the seven countries with the highest prevalence of this disease worldwide. The measures to control this disease are not easily developed, and the improvement of its diagnosis, surveillance, and control is still needed. This study aimed to carry out the polymerase chain reaction (PCR) diagnosis of Leishmania infantum in vector samples in some municipalities of the State of São Paulo, which included two municipalities with human disease transmission and two with dog transmission only. Vectors were collected in traps with luminous bait. Next, they were killed at −4 °C and kept in 70% alcohol. Groups of ten female insects (pools) were mashed on cation exchange paper (fine cellulose phosphate with 18 µEq/cm² ionic exchange capacity) for DNA extraction. The PCR was carried out to identify the natural infection of the Leishmania genus in female Lutzomyia longipalpis (Lu. Longipalpis). Out of the 3,880 Lu. longipalpis phlebotomines, 1060 were female and 2820 were male (3:1). The method used to extract the DNA in pools of ten phlebotomines and the PCR resulted in sensitivity, specificity, practicality, and faster analyses when compared to the individual analysis method. The procedure described can be used on a large scale in the leishmaniasis epidemiological surveillance, enabling a higher number of analyses and the optimization of human resources because the traditional diagnostic method is carried out via desiccation of the insect digestive system and microscopic examination, which is time-demanding and there is the need of manual skills. [ABSTRACT FROM AUTHOR]

The Museu de Zoologia da Universidade de São Paulo (MZUSP), São Paulo, Brazil houses the largest and most representative Brazilian collection of Diptera. In the present study, following a recommendation of the International Code of Zoological Nomenclature, it is presented a catalogue of the type specimens of Diadocidiidae and Ditomyiidae (Diptera: Bibionomorpha) held in the collection of the MZUSP. Label data and the condition of preservation of 27 type specimens (nine holotypes, two paralectotypes, and 16 paratypes) of 14 Neotropical species are provided. [ABSTRACT FROM AUTHOR]

Calls from policymakers to assimilate immigrants through English literacy have grown urgent. Yet the 2007 U.S. Census has reported that one in five U.S. residents speaks a language other than English at home. What's more, new immigrants often settle in long-standing immigrant communities in which these non-English languages are the lingua franca. These demographic trends call for a reconceptualization of the problematic relationship of literacy to immigrant assimilation. To whom, precisely, are immigrants assimilating, especially in multi-ethnic communities? And how exactly does literacy, especially biliteracy, shape this process? Through an ethnographic investigation of how two different immigrant groups form biliterate partnerships in the quest for legal immigration papers, this essay examines how literacy and assimilation function in light of the changing writing demands of contemporary immigrant life. (Contains 8 notes.)

The purpose of this review was to identify and analyze the main characteristics of the 100 most-cited papers in the field of endodontic therapy in primary teeth. A search for the most-cited articles was conducted in the Clarivate Analytics Web of Science 'Core-Collection' (WoS-CC) database up to December 2020. Papers were ranked in descending order, by number of citations, and each paper was matched with the citation count on Scopus and Google Scholar. Two independent reviewers selected the most-cited papers and analyzed it according to the number and density of citations, year and journal of publication, authors, countries and contributing institutions, study design, topic of the paper, and keywords. Spearman's correlation and Poisson regression were used to determine associations between the number of citations and study characteristics. The citation count varied from 15 to 135 (WoS-CC), 8 to 141 (Scopus), and 14 to 317 (Google Scholar). Of the 306 contributing authors, most paper contributions were from Sakai VT, Oliveira TM, and Machado MAAM (5 each). Most of the papers originated from the USA (n=21) and Brazil (n=18). Randomized trials were the most common study design (n=32), and "pulpotomy" was the most frequently used keyword (n=35). Poisson regression showed that the number of citations decreased by 1.5% each year, and increased by 9.7% for each unit of impact factor. This bibliometric analysis highlighted papers, authors, and institutions that have contributed to endodontic therapy in primary teeth. Common terms of interest in this research area was also identified, representing the first bibliometric analysis on this subject.

This paper describes a cradle-to-gate life cycle assessment of offset paper production in Brazil. The production system is classified into two subsystems: a forest production subsystem, which involves seedling production, soil preparation, seedling planting, forest maintenance, and wood harvesting and transport processes; and an industrial production subsystem, involving wood pulp extraction and bleaching, chemical recovery, and offset paper manufacturing processes. The environmental analysis includes the primary energy demand, environmental impact assessment, and land use indicators. The primary energy demand indicated that the largest amount of both renewable and non-renewable primary energy is consumed by the industrial production subsystem, accounting for 91.0% of the total energy demand. The potential environmental impact assessment included eight impact categories: acidification, ecotoxicity, global warming, human toxicity – cancer effects, human toxicity – non-cancer effects, nutrient enrichment, ozone depletion, and photochemical oxidation. Most of the potential impacts are attributed to the processes of pulp extraction and bleaching, and offset paper manufacturing, mainly due to the production of electricity and thermal energy. As for impacts on land use during the forest activities, a recent developed approach was applied for the regionalized assessment of impacts. Land occupation impacts on erosion resistance, physicochemical filtration, and mechanical filtration showed a reduction in the soil ecological functions, whereas groundwater recharge indicated a credit for the performance of the soil function. With a view to reducing the main life cycle impacts of the industrial production subsystem, an evaluation is made of alternative production scenarios. The best scenario was the substitution of biomass and diesel in the energy generation unit by biomass gasification and optimization of the recovery boiler. [ABSTRACT FROM AUTHOR]

Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.

Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

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The paper recycling process generates a sludge characterized by a high content of cellulose fiber. To understand the behavior of this fibrous material, this article presents an interpretation of the geotechnical behavior of a waste sludge from a paper recycling plant situated in southern Brazil using data from laboratory tests. Engineering properties of compacted paper mill sludges are similar to those of most fibrous organic soils: low hydraulic conductivity upon compression and high compressibility. The waste studied has a water content of approximately 250%, organic content of 48%, mineral charges, and water. The one-dimensional compressibility parameters are indicative of high compressibility. For the determination of the strength parameters of the material, undrained triaxial tests were carried out. An incredibly high effective friction angle ([lowercase_phi_synonym]′=53°) was found, probably because of the fibrous nature of the paper sludge. In addition, hydraulic conductivity tests were performed on a flexible wall permeameter. The hydraulic conductivity of the fibrous paper sludge reached values near10-9 m/s. The results showed that the paper mill sludge is a ductile material with reduced hydraulic conductivity and elevated shear strength that could have multiple applications, such as in the construction of bottom liners, cover liners, and steep side-slope liners for solid-waste landfills. [ABSTRACT FROM AUTHOR]