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Purpose: The rising incidence and mortality associated with cutaneous malignant tumours highlight the importance of early diagnosis of these tumors. In clinical practice, these tumors are often misdiagnosed as benign skin lesions such as melanocytic nevi (MN) and seborrheic keratosis (SK) because of their similar morphologic features. The incidence and clinicopathological subtypes of cutaneous malignancies in East Asia populations significantly differ from those in fair-skinned groups. However, studies on misdiagnoses in Eastern countries are lacking. Therefore, this study focused on the clinical and pathological features of cutaneous malignant tumors misdiagnosed as MN or SK in a Chinese population. Patients and Methods: A total of 4592 samples clinically diagnosed as MN (n = 3503) or SK (n = 1089) from July 2014 to June 2022 were collected and evaluated retrospectively. The clinical and pathological data were analyzed to identify associated factors. Results: Pathological assessments showed that 2.5% (86/3503) of the specimens clinically diagnosed as MN were malignancies, predominantly basal cell carcinoma (BCC, 84.9%, 73/86), followed by malignant melanoma (MM, 8.1%, 7/86) and squamous cell carcinoma (SCC, 7.0%, 6/86). Similarly, 5.7% (62/1089) of the specimens clinically diagnosed as SK were malignant tumors, of which BCC (50.0%, 31/62) was the most common, followed by SCC (41.9%, 26/62) and MM (8.1%, 5/62). In both types of specimens, advanced age and facial lesions were risk factors for malignancy misdiagnosis. The malignancy rate, mean age, and proportion of SCC in the specimens clinically diagnosed as SK were higher than those in the specimens clinically diagnosed as MN. Dermoscopy significantly reduced the rate of misdiagnosis of these tumors as MN or SK. Conclusion: In China, cutaneous malignant tumors misdiagnosed as MN or SK are not uncommon in clinical practice, and active introduction of noninvasive diagnostic techniques is essential to distinguish them. [ABSTRACT FROM AUTHOR]

This study examines whether there exist significant differences in tropical cyclone (TC) landfall between central Pacific (CP) El Niño, eastern Pacific (EP) El Niño, and La Niña during the peak TC season (June-October) and how and to what extent CP El Niño influences TC landfall over East Asia for the period 1961-2009. The peak TC season is subdivided into summer [June-August (JJA)] and autumn [September-October (SO)]. The results are summarized as follows: (i) during the summer of CP El Niño years, TCs are more likely to make landfall over East Asia because of a strong easterly steering flow anomaly induced by the westward shift of the subtropical high and northward-shifted TC genesis. In particular, TCs have a greater probability of making landfall over Japan and Korea during the summer of CP El Niño years. (ii) In the autumn of CP El Niño years, TC landfall in most areas of East Asia, especially Indochina, the Malay Peninsula, and the Philippines, is likely to be suppressed because the large-scale circulation resembles that of EP El Niño years. (iii) During the whole peak TC season [June-October (JJASO)] of CP El Niño years, TCs are more likely to make landfall over Japan and Korea. TC landfall in East Asia as a whole has an insignificant association with CP El Niño during the peak TC season. In addition, more (less) TCs are likely to make landfall in China, Indochina, the Malay Peninsula, and the Philippines during the peak TC season of La Niña (EP El Niño) years. [ABSTRACT FROM AUTHOR]