127 results on '"Gu, Xiaoying"'
Search Results
2. A coupled thermo-mechanical model for investigating cracking and failure of composite interbedded rock
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Yang, Zheng, Tao, Ming, Fei, Wenbin, Yin, Tubing, Gu, Xiaoying, and Narsilio, Guillermo A.
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- 2024
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3. Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors
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Wang, Yeming, Guo, Li, Fan, Guohui, Han, Yang, Zhang, Qiao, Ren, Lili, Zhang, Hui, Wang, Geng, Zhang, Xueyang, Huang, Tingxuan, Wang, Weiyang, Chen, Lan, Huang, Lixue, Gu, Xiaoying, Wang, Xinming, Zhong, Jingchuan, Wang, Ying, Li, Hui, Yu, Jiapei, Liu, Zhibo, Huang, Chaolin, Cao, Bin, and Wang, Jianwei
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- 2024
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4. Exploration and Research on Chinese Culture in University English Translation Teaching in the Background of Internet+
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Gu Xiaoying
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bm word alignment model ,tf-idf similarity ,skeleton knowledge ,probability estimation ,english translation teaching ,68t05 ,Mathematics ,QA1-939 - Abstract
Under the background of Internet+, for the problems of high comprehension difficulty and inaccurate translation in university English translation teaching, this paper proposes the skeleton knowledge translation model to assist university English translation teaching that integrates Chinese culture. Starting from the objectives of university English translation teaching, Chinese culture is explored in university English translation materials to complete the design of university English translation teaching that integrates Chinese culture. Propose the application of Internet technology in the above teaching design, utilize the IBM word alignment model and TF-IDF similarity to preprocess the university English translation textbooks, and on the basis of preprocessing, estimate the probability and decode the generated phrase pairs, and then complete the construction of the English translation model based on skeleton knowledge. The English translation model’s performance analysis is carried out using skeleton knowledge after determining the data set and evaluation criteria. The results show that for the whole 400 000 batch training, the training time of the English translation model based on skeleton knowledge is about one-fifth less than that of the unsupervised neural machine translation model, indicating that with the increase of the number of rounds, the performance of the English translation model based on skeleton knowledge is also better. This study serves as a guide for exploring and researching Chinese culture in university English translation teaching and promotes the development of university English translation teaching in colleges and universities.
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- 2024
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5. Durability and cross-reactive immune memory to SARS-CoV-2 in individuals 2 years after recovery from COVID-19: a longitudinal cohort study
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Guo, Li, Zhang, Qiao, Gu, Xiaoying, Ren, Lili, Huang, Tingxuan, Li, Yanan, Zhang, Hui, Liu, Ying, Zhong, Jingchuan, Wang, Xinming, Chen, Lan, Zhang, Yin, Li, Danyang, Fang, Meiyu, Xu, Liuhui, Li, Haibo, Wang, Zai, Li, Hui, Bai, Tao, Liu, Wen, Peng, Yanchun, Dong, Tao, Cao, Bin, and Wang, Jianwei
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- 2024
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6. The mortality and years of life lost for community-acquired pneumonia before and during COVID-19 pandemic in China
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Fan, Guohui, Zhou, Yuchang, Zhou, Fei, Yu, Zhongguang, Gu, Xiaoying, Zhang, Xueyang, Liu, Zhengping, Zhou, Maigeng, and Cao, Bin
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- 2024
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7. Mechanisms of long COVID: An updated review
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Liu, Yan, Gu, Xiaoying, Li, Haibo, Zhang, Hui, and Xu, Jiuyang
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- 2023
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8. Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors
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Gu, Xiaoying, Wang, Siyuan, Zhang, Wanying, Li, Caihong, Guo, Li, Wang, Zai, Li, Haibo, Zhang, Hui, Zhou, Yuhan, Liang, Weijian, Li, Hui, Liu, Yan, Wang, Yeming, Huang, Lixue, Dong, Tao, Zhang, Dingyu, Wong, Catherine C.L., and Cao, Bin
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- 2023
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9. Time series online forecasting based on sequence decomposition learning networks
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Ma, Yunpeng, Xu, Chenheng, Wang, Hua, Liu, Shengkai, and Gu, Xiaoying
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- 2023
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10. Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review
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Zhang, Yiyuan, Shang, Ke, Li, Jialin, Sun, Mengyao, and Gu, Xiaoying
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- 2024
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11. Drug-related adverse events potentially predict the efficacy of apatinib on advanced hepatocellular carcinoma
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Gu, Xiaoying, Zhang, Su, Yang, Xuejiao, Guan, Tao, Hou, Zhenyu, Cao, Manqing, Li, Huikai, and Zhang, Ti
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- 2022
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12. Gold triangular nanoplates with edge effect for reaction monitoring under dark-field microscopy
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Zou, Hongyan, Gu, Xiaoying, Xia, Chang, Cheng, Ru, Huang, Chengzhi, Li, Yuanfang, and Gao, Pengfei
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- 2022
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13. Associations of residential greenness with lung function and chronic obstructive pulmonary disease in China
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Xiao, Yalan, Gu, Xiaoying, Niu, Hongtao, Meng, Xia, Zhang, Lina, Xu, Jianying, Yang, Lan, Zhao, Jianping, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Chen, Yahong, Sun, Tieying, Shan, Guangliang, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, Wang, Ruiying, Shi, Zhihong, Xu, Yongjian, Ye, Xianwei, Song, Yuanlin, Wang, Qiuyue, Zhou, Yumin, Ding, Liren, Li, Diandian, Yao, Wanzhen, Guo, Yanfei, Xiao, Fei, Lu, Yong, Peng, Xiaoxia, Zhang, Biao, Xiao, Dan, Wang, Zuomin, Zhang, Hong, Bu, Xiaoning, Zhang, Xiaolei, An, Li, Zhang, Shu, Cao, Zhixin, Zhan, Qingyuan, Yang, Yuanhua, Liang, Lirong, Cao, Bin, Dai, Huaping, Wu, Tangchun, He, Jiang, Kan, Haidong, Chen, Renjie, Yang, Ting, and Wang, Chen
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- 2022
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14. Self-assembly of structured CeCO3OH and its decomposition in H2 for a novel tactic to obtain CeO2-x with excellent photocatalytic property
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Mao, Xisong, Xia, Xuewen, Li, Junqi, Chen, Chaoyi, Gu, Xiaoying, Li, Song, and Lan, Yuan-Pei
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- 2021
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15. Low-to-moderate dose corticosteroids treatment in hospitalized adults with COVID-19
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Liu, Zhibo, Li, Xia, Fan, Guohui, Zhou, Fei, Wang, Yeming, Huang, Lixue, Yu, Jiapei, Yang, Luning, Shang, Lianhan, Xie, Ke, Xu, Jiuyang, Huang, Zhisheng, Gu, Xiaoying, Li, Hui, Zhang, Yi, Wang, Yimin, Huang, Zhenghui, and Cao, Bin
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- 2021
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16. Association of Monocyte Count With Lung Function and Exercise Capacity Among Hospitalized COVID‐19 Survivors: A 2‐Year Cohort Study.
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Gu, Xiaoying, Huang, Lixue, Li, Xia, Zhou, Yuting, Zhang, Hui, Wang, Yeming, Cui, Dan, Yu, Ting, Wang, Yimin, and Cao, Bin
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Background: Abnormal changes of monocytes have been observed in acute COVID‐19, whereas associations of monocyte count with long COVID were not sufficiently elucidated. Methods: A cohort study was conducted among COVID‐19 survivors discharged from hospital. The primary outcomes were core symptoms of long COVID, distance walked in 6 min, and lung function, and the secondary outcomes were health‐related quality of life and healthcare use after discharge. Latent variable mixture modeling was used to classify individuals into groups with similar trajectory of monocyte count from discharge to 2‐year after symptom onset. Multivariable adjusted generalized linear regression models and logistic regression models were used to estimate the associations of monocyte count trajectories and monocyte count at discharge with outcomes. Results: In total, 1389 study participants were included in this study. Two monocyte count trajectories including high to normal high and normal trajectory were identified. After multivariable adjustment, participants in high to normal high trajectory group had an odds ratio (OR) of 2.52 (95% CI, 1.44–4.42) for smell disorder, 2.27 (1.27–4.04) for 6‐min walking distance less than lower limit of normal range, 2.45 (1.08–5.57) for total lung capacity (TLC) < 80% of predicted, 3.37 (1.16–9.76) for personal care problem, and 1.70 (1.12–2.58) for rehospitalization after discharge at 2‐year follow‐up compared with those in normal trajectory group. Monocyte count at discharge showed similar results, which was associated with smell disorder, TLC < 80% of predicted, diffusion impairment, and rehospitalization. Conclusions: Monocyte count may serve as an easily accessible marker for long‐term management of people recovering from COVID‐19. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Clinical characteristics of patients with bronchiectasis with nontuberculous mycobacterial disease in Mainland China: a single center cross-sectional study
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Yin, Hongjun, Gu, Xiaoying, Wang, Yimin, Fan, Guohui, Lu, Binghuai, Liu, Min, Wang, Chunlei, Cao, Bin, and Wang, Chen
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- 2021
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18. C-reactive protein or procalcitonin combined with rhinorrhea for discrimination of viral from bacterial infections in hospitalized adults in non-intensive care units with lower respiratory tract infections
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Duan, Shengchen, Gu, Xiaoying, Fan, Guohui, Zhou, Fei, Zhu, Guangfa, and Cao, Bin
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- 2021
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19. Authors’ reply to Letter regarding “Probing Long COVID through a Proteomic Lens: a Comprehensive Two-Year Longitudinal Cohort Study of Hospitalised Survivor”
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Gu, Xiaoying, Wong, Catherine C.L., and Cao, Bin
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- 2024
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20. Tunable superluminal propagation at spectral hole-burning regions in magneto-optical atomic medium
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Khan, Aizaz, Gu, Xiaoying, Gao, Lei, Hou, Lianping, Akbar, Jehan, and Gao, Dongliang
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- 2024
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21. Association of Lipids With Ischemic and Hemorrhagic Stroke: A Prospective Cohort Study Among 267 500 Chinese
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Gu, Xiaoying, Li, Yunzhi, Chen, Shuohua, Yang, Xueli, Liu, Fangchao, Li, Ying, Li, Jianxin, Cao, Jie, Liu, Xiaoqing, Chen, Jichun, Shen, Chong, Yu, Ling, Huang, Jianfeng, Lam, Tai-Hing, Fang, Xianghua, He, Yao, Zhang, Xinhua, Lu, Xiangfeng, Wu, Shouling, and Gu, Dongfeng
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- 2019
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22. Airway-invasion-associated pulmonary computed tomography presentations characteristic of invasive pulmonary Aspergillosis in non-immunocompromised adults: a National Multicenter Retrospective Survey in China
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Liu, Zhibo, Li, Yuping, Tian, Xinlun, Liu, Qinghua, Li, Erran, Gu, Xiaoying, Liu, Min, Xu, Jiuyang, He, Zhiyi, Huang, Yi, Xu, Shuyun, Lai, Guoxiang, Chen, Yusheng, Zhang, Xiangyan, Zhang, Tiantuo, Xu, Jinfu, Zhu, Lanyan, Qu, Jieming, and Cao, Bin
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- 2020
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23. Text Sentiment Analysis Based on a New Hybrid Network Model.
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Zhou, Yancong, Zhang, Qian, Wang, Dongdong, and Gu, Xiaoying
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DEEP learning ,SENTIMENT analysis ,FEATURE extraction ,USER-generated content ,TEXT messages - Abstract
The research of text sentiment analysis based on deep learning is increasingly rich, but the current models still have different degrees of deviation in understanding of semantic information. In order to reduce the loss of semantic information and improve the prediction accuracy as much as possible, the paper creatively combines the doc2vec model with the deep learning model and attention mechanism and proposes a new hybrid sentiment analysis model based on the doc2vec + CNN + BiLSTM + Attention. The new hybrid model effectively exploits the structural features of each part. In the model, the understanding of the overall semantic information of the sentence is enhanced through the paragraph vector pretrained by the doc2vec structure which can effectively reduce the loss of semantic information. The local features of the text are extracted through the CNN structure. The context information interaction is completed through the bidirectional cycle structure of the BiLSTM. The performance is improved by allocating weight and resources to the text information of different importance through the attention mechanism. The new model was built based on Keras framework, and performance comparison experiments and analysis were performed on the IMDB dataset and the DailyDialog dataset. The results have shown that the accuracy of the new model on the two datasets is 91.3% and 93.3%, respectively, and the loss rate is 22.1% and 19.9%, respectively. The accuracy on the IMDB datasets is 1.0% and 0.5% higher than that of the CNN-BiLSTM-Attention model and ATT-MCNN-BGRUM model in the references. Comprehensive comparison has shown the overall performance is improved, and the new model is effective. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Model NOx, SO 2 Emissions Concentration and Thermal Efficiency of CFBB Based on a Hyper-Parameter Self-Optimized Broad Learning System.
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Ma, Yunpeng, Xu, Chenheng, Wang, Hua, Wang, Ran, Liu, Shilin, and Gu, Xiaoying
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THERMAL efficiency ,FLUIDIZED-bed combustion ,INSTRUCTIONAL systems ,COAL combustion ,SEARCH algorithms ,REAL-time control ,POLLUTION - Abstract
At present, establishing a multidimensional characteristic model of a boiler combustion system plays an important role in realizing its dynamic optimization and real-time control, so as to achieve the purpose of reducing environmental pollution and saving coal resources. However, the complexity of the boiler combustion process makes it difficult to model it using traditional mathematical methods. In this paper, a kind of hyper-parameter self-optimized broad learning system by a sparrow search algorithm is proposed to model the NOx, SO
2 emissions concentration and thermal efficiency of a circulation fluidized bed boiler (CFBB). A broad learning system (BLS) is a novel neural network algorithm, which shows good performance in multidimensional feature learning. However, the BLS has several hyper-parameters to be set in a wide range, so that the optimal combination between hyper-parameters is difficult to determine. This paper uses a sparrow search algorithm (SSA) to select the optimal hyper-parameters combination of the broad learning system, namely as SSA-BLS. To verify the effectiveness of SSA-BLS, ten benchmark regression datasets are applied. Experimental results show that SSA-BLS obtains good regression accuracy and model stability. Additionally, the proposed SSA-BLS is applied to model the combustion process parameters of a 330 MW circulating fluidized bed boiler. Experimental results reveal that SSA-BLS can establish the accurate prediction models for thermal efficiency, NOx emission concentration and SO2 emission concentration, separately. Altogether, SSA-BLS is an effective modelling method. [ABSTRACT FROM AUTHOR]- Published
- 2022
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25. Risk Factors of Viral RNAaemia and Its Association With Clinical Prognosis Among Patients With Severe Coronavirus Disease 2019
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Li, Hui, Gu, Xiaoying, Xu, Jiuyang, Wang, Yeming, Li, Haibo, Cao, Bin, Li, Huadong, Gong, Fengyun, Ruan, Shunan, and Yang, Qingyu
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Research Letter - Published
- 2021
26. Rheumatic Symptoms Following Coronavirus Disease 2019 (COVID-19): A Chronic Post–COVID-19 Condition.
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Cui, Dan, Wang, Yeming, Huang, Lixue, Gu, Xiaoying, Huang, Zhisheng, Mu, Shengrui, Wang, Chen, and Cao, Bin
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COVID-19 ,KNEE joint ,JOINT pain ,CHRONIC diseases ,JOINT diseases ,CORONAVIRUS diseases - Abstract
Background Detailed characteristics of rheumatic symptoms of coronavirus disease 2019 (COVID-19) were still unknown. We aim to investigate the proportions, characteristics, and risk factors of this condition. Methods In this prospective, longitudinal cohort study, discharged patients with COVID-19 were interviewed face-to-face at 12 months after symptom onset. Rheumatic symptoms following COVID-19 included newly occurring joint pain and/or joint swelling. The risk factors of developing rheumatic symptoms were identified by multivariable logistic regression analysis. Results In total, 1296 of 2469 discharged patients with COVID-19 were enrolled in this study. Among them, 160 (12.3% [95% confidence interval {CI}, 10.6%–14.3%]) suffered from rheumatic symptoms following COVID-19 at 12-month follow-up. The most frequently involved joints were the knee joints (38%), followed by hand (25%) and shoulder (19%). Rheumatic symptoms were independent of the severity of illness and corticosteroid treatment during the acute phase, while elderly age (odds ratio [OR], 1.22 [95% CI, 1.06–1.40]) and female sex (OR, 1.58 [95% CI, 1.12–2.23]) were identified as the risk factors for this condition. Conclusions Our investigation showed a considerable proportion of rheumatic symptoms following COVID-19 in discharged patients, which highlights the need for continuing attention. Notably, rheumatic symptoms following COVID-19 were independent of the severity of illness and corticosteroid treatment during the acute phase. [ABSTRACT FROM AUTHOR]
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- 2022
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27. PRDX2 Knockdown Inhibits Extracellular Matrix Synthesis of Chondrocytes by Inhibiting Wnt5a/YAP1/CTGF and Activating IL-6/JAK2/STAT3 Pathways in Deer Antler.
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Sun, Xuyang, Gu, Xiaoying, Peng, Jingna, Yang, Liguo, Zhang, Xinxin, Ran, Zaohong, and Xiong, Jiajun
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CARTILAGE cells , *EXTRACELLULAR matrix , *CONNECTIVE tissue growth factor , *CHONDROGENESIS , *ANTLERS , *DEER - Abstract
Although peroxiredoxin 2 (PRDX2) plays a vital role in relieving oxidative stress, its physiological function in cartilage development remains almost unknown. In this study, we found that the expression of PRDX2 significantly increased in the chondrocytes compared with pre-chondrocytes. PRDX2 knockdown significantly decreased the expression of extracellular matrix (ECM) protein (Col2a and Aggrecan), which led to blocked cartilage formation. Moreover, PRDX2 knockdown also inhibited the expression of connective tissue growth factor (CTGF). CTGF is an important growth factor that regulates synthesis of ECM proteins. We explored the possible regulatory mechanism by which PRDX2 regulated the expression of CTGF. Our results demonstrated that PRDX2 knockdown downregulated the expression of CTGF by inhibiting Wnt5a/Yes-associated protein 1 (YAP1) pathway. In addition, PRDX2 knockdown promoted the expression of interleukin 6 (IL-6), indicating PRDX2 expression had an anti-inflammatory function during antler growth. Mechanistically, PRDX2 knockdown promoted cartilage matrix degradation by activating the IL-6-mediated Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling pathway. These results reveal that PRDX2 is a potential regulator that promotes cartilage extracellular matrix synthesis. [ABSTRACT FROM AUTHOR]
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- 2022
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28. Antibody Responses and Clinical Outcomes in Adults Hospitalized with Severe COVID-19: A Post hoc Analysis of LOTUS China Trial
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Ren, Lili, Fan, Guohui, Wu, Wenjuan, Guo, Li, Wang, Yeming, Li, Xia, Wang, Conghui, Gu, Xiaoying, Li, Caihong, Wang, Ying, Wang, Geng, Zhou, Fei, Liu, Zhibo, Ge, Qing, Zhang, Yi, Li, Hui, Zhang, Lulu, Xu, Jiuyang, Wang, Chen, Wang, Jianwei, and Cao, Bin
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Adult ,China ,LOTUS China ,dynamic changes ,SARS-CoV-2 ,neutralizing antibody ,severe COVID-19 ,COVID-19 ,Antibodies, Viral ,clinical outcomes ,AcademicSubjects/MED00290 ,Immunoglobulin M ,Antibody Formation ,Major Article ,Humans ,humoral response - Abstract
The characteristics of neutralizing antibodies (NAbs) and antibody against major antigen proteins related to clinical outcomes in severe coronavirus disease 2019 (COVID-19) patients were still less known.NAbs and antibodies targeting nucleocapsid (N), spike protein (S), and the receptor-binding domain (RBD) in longitudinal plasma samples from the LOTUS China trial were measured by microneutralization assay and enzyme-linked immunosorbent assay (ELISA). Viral load was determined by real-time reverse transcription polymerase chain reaction (RT-PCR). A total of 576 plasma and 576 throat swabs were collected from 191 COVID-19 patients. Antibody titers related to adverse outcome and clinical improvement were analyzed. Multivariable adjusted generalized linear mixed model for random effects were developed.After day 28 post symptoms onset, the rate of antibody positivity reached 100% for RBD-immunoglobulin M (IgM), 97.8% for S-IgM, 100% for N-immunoglobulin G (IgG), 100% for RBD-IgG, 91.1% for N-IgM, and 91.1% for NAbs. The NAbs titers increased over time in both survivors and nonsurvivors and correlated to IgG antibodies against N, S, and RBD, whereas its presence showed no statistical correlation with death. N-IgG (slope -2.11, 95% confidence interval [CI] -3.04 to -1.18, P.0001), S-IgG (slope -2.44, 95% CI -3.35 to -1.54, P.0001), and RBD-IgG (slope -1.43, 95% CI -1.98 to -.88, P.0001) were negatively correlated with viral load. S-IgG titers were lower in nonsurvivors than survivors (P = .020) at week 4 after symptoms onset.IgM and IgG against N, S, and RBD and NAbs developed in most severe COVID-19 patients and do not correlate clearly with clinical outcomes. The levels of IgG antibodies against N, S, and RBD were related to viral clearance.
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- 2020
29. Exogenous Melatonin Activating Nuclear Factor E2-Related Factor 2 (Nrf2) Pathway via Melatonin Receptor to Reduce Oxidative Stress and Apoptosis in Antler Mesenchymal Stem Cells.
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Jing, Huansong, Sun, Xuyang, Li, Mengqi, Peng, Jingna, Gu, Xiaoying, and Xiong, Jiajun
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MESENCHYMAL stem cells ,OXIDATIVE stress ,MESENCHYMAL stem cell differentiation ,ANTLERS ,NUCLEAR factor E2 related factor ,FLOW cytometry - Abstract
Antler growth depends on the proliferation and differentiation of mesenchymal stem cells (MSCs), and this process may be adversely affected by oxidative stress. Melatonin (MLT) has antioxidant functions, but its role in Cervidae remains largely unknown. In this article, flow cytometry, reactive oxygen species (ROS) identification, qPCR, and other methods were used to investigate the protective mechanism of MLT in H
2 O2 -induced oxidative stress of antler MSCs. The results showed that MLT significantly increases cell viability by relieving the oxidative stress of antler MSCs. MLT inhibits cell apoptosis by protecting mitochondrial function. We blocked the melatonin receptor with luzindole (Luz) and found that the receptor blockade significantly increases H2 O2 -induced hyperoxide levels and causes significant inhibition of mitochondrial function. MLT treatment activates the nuclear factor E2-related factor 2 (Nrf2) antioxidant signaling pathway, up-regulates the expression of NAD(P)H quinone oxidoreductase 1 (NQO1) and other genes and it could inhibit apoptosis. In contrast, the melatonin receptor blockade down-regulates the expression of Nrf2 pathway-related genes, but significantly up-regulates the expression of apoptotic genes. It was indicated that MLT activates the Nrf2 pathway through the melatonin receptor and alleviates H2 O2 -induced oxidative stress and apoptosis in antler MSCs. This study provides a theoretical basis for further studying the oxidative stress and antioxidant process of antler MSCs and, thereby, increasing antler yields. [ABSTRACT FROM AUTHOR]- Published
- 2022
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30. Drug-Related Hypertension Associated with the Efficacy of Apatinib on Hepatocellular Carcinoma [Corrigendum]
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Yang,XueJiao, Hou,ZhenYu, Zhu,KeYun, Zhang,Su, Gu,XiaoYing, Wang,ZhiWei, Mu,Han, Zhou,HongYuan, Chen,Ping, Zhu,XiaoLin, Cui,YunLong, Li,Qiang, Li,HuiKai, and Zhang,Ti
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Cancer Management and Research - Abstract
Yang X, Hou Z, Zhu K, et al. Cancer Manag Res. 2020;12:3163– 3173. The authors have advised there is an error with Figure 2 onpage 3170. The figure parts C-H do not match the descriptionin the figure caption or figure citations throughout thetext. The authors apologizefor this error. Read the original article
- Published
- 2020
31. The Heterogeneity of Inflammatory Response and Emphysema in Chronic Obstructive Pulmonary Disease.
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Xu, Xia, Huang, Ke, Dong, Fen, Qumu, Shiwei, Zhao, Qichao, Niu, Hongtao, Ren, Xiaoxia, Gu, Xiaoying, Yu, Tao, Pan, Lin, Yang, Ting, and Wang, Chen
- Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by chronic inflammation, emphysema, airway remodeling, and altered lung function. Despite the canonical classification of COPD as a neutrophilic disease, blood and airway eosinophilia are found in COPD patients. Identifying the tools to assess eosinophilic airway inflammation in COPD models during stable disease and exacerbations will enable the development of novel anti-eosinophilic treatments. We developed different animal models to mimic the pathological features of COPD. Our results show that eosinophils accumulated in the lungs of pancreatic porcine elastase-treated mice, with emphysema arising from the alveolar septa. A lipopolysaccharide challenge significantly increased IL-17 levels and induced a swift change from a type-2 response to an IL-17-driven inflammatory response. However, lipopolysaccharides can exacerbate cigarette smoking-induced airway inflammation dominated by neutrophil infiltration and airway remodeling in COPD models. Our results suggest that eosinophils may be associated with emphysema arising from the alveolar septa, which may be different from the small airway disease-associated emphysema that is dominated by neutrophilic inflammation in cigarette smoke-induced models. The characterization of heterogeneity seen in the COPD-associated inflammatory signature could pave the way for personalized medicine to identify new and effective therapeutic approaches for COPD. [ABSTRACT FROM AUTHOR]
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- 2021
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32. Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study.
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Guo, Li, Wang, Yeming, Kang, Liang, Hu, Yongfeng, Wang, Linghang, Zhong, Jingchuan, Chen, Hong, Ren, Lili, Gu, Xiaoying, Wang, Geng, Wang, Conghui, Dong, Xiaojing, Wu, Chao, Han, Lianlian, Wang, Ying, Fan, Guohui, Zou, Xiaohui, Li, Haibo, Xu, Jiuyang, and Jin, Qi
- Published
- 2021
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33. Micro Expression Recognition via Dual-Stream Spatiotemporal Attention Network.
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Wang, Yan, Huang, Yikun, Liu, Can, Gu, Xiaoying, Yang, Dandan, Wang, Shuopeng, and Zhang, Bo
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PROBLEM solving ,OPTICAL flow ,MACHINE learning - Abstract
Microexpression can manifest the real mood of humans, which has been widely concerned in clinical diagnosis and depression analysis. To solve the problem of missing discriminative spatiotemporal features in a small data set caused by the short duration and subtle movement changes of microexpression, we present a dual-stream spatiotemporal attention network (DSTAN) that integrates dual-stream spatiotemporal network and attention mechanism to capture the deformation features and spatiotemporal features of microexpression in the case of small samples. The Spatiotemporal networks in DSTAN are based on two lightweight networks, namely, the spatiotemporal appearance network (STAN) learning the appearance features from the microexpression sequences and the spatiotemporal motion network (STMN) learning the motion features from optical flow sequences. To focus on the discriminative motion areas of microexpression, we construct a novel attention mechanism for the spatial model of STAN and STMN, including a multiscale kernel spatial attention mechanism and global dual-pool channel attention mechanism. To obtain the importance of each frame in the microexpression sequence, we design a temporal attention mechanism for the temporal model of STAN and STMN to form spatiotemporal appearance network-attention (STAN-A) and spatiotemporal motion network-attention (STMN-A), which can adaptively perform dynamic feature refinement. Finally, the feature concatenate-SVM method is used to integrate STAN-A and STMN-A to a novel network, DSTAN. The extensive experiments on three small spontaneous microexpression data sets of SMIC, CASME, and CASME II demonstrate the proposed DSTAN can effectively cope with the recognition of microexpressions. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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34. The efficacy and safety of therapeutic lung lavage for exogenous lipoid pneumonia: A systematic review.
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Shang, Lianhan, Gu, Xiaoying, Du, Sisi, Wang, Yimin, Cao, Bin, and Wang, Chen
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BRONCHOALVEOLAR lavage , *DRUG efficacy , *PULMONARY alveolar proteinosis , *TREATMENT effectiveness , *PULMONARY edema , *PNEUMONIA - Abstract
Introduction and objectives: Exogenous lipoid pneumonia (ELP) is a lung inflammatory disease with low prevalence and has the feature of external lipid substances presented in the alveoli. Therapeutic lung lavage (segmental bronchoalveolar lavage and whole lung lavage) has been gradually recognized as an important therapy for the disease. There was no comprehensive summary on its efficacy and safety. Methods: We searched PubMed, Embase, Cochrane Library, CNKI, Wanfang Database, clinicaltrials.gov, and the references of included studies. After study selection, data extraction and quality assessment, we performed a qualitative description of current data. Results: We included 90 ELP patients from 25 case reports and 8 case series studies. Eighty‐four (93.3%) patients received segmental bronchoalveolar lavage and six (6.7%) patients received whole lung lavage. Eighty‐seven (96.7%) patients got clinical improvement after lavages, while three (3.3%) patients had no improvement and eventually died. The follow‐up status was reported in 29 patients, of whom 24 patients remained well without any use of drugs and 4 patients remained well with some periods of corticosteroids. One patient endured recurrence. The radiological change was reported in 72 patients, of whom 41 (56.9%) patients had full resolution until the last follow‐up. Two studies reported acute pulmonary edema and transient hypoxemia during lavages. Conclusions: Therapeutic lung lavage might be an effective and safe therapy with long‐term benefits for ELP. Current studies were all case reports and case series with relatively high risk of bias. Prospective controlled studies are needed to explore the actual efficacy, safety, individualized indications, and optimized treatment procedures of therapeutic lung lavage for ELP. [ABSTRACT FROM AUTHOR]
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- 2021
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35. High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients.
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Li, Haibo, Ren, Lili, Zhang, Lulu, Wang, Yeming, Guo, Li, Wang, Conghui, Xiao, Yan, Wang, Ying, Rao, Jian, Wang, Xinming, Liu, Ying, Huang, Chaolin, Gu, Xiaoying, Fan, Guohui, Li, Hui, Lu, Binghuai, Cao, Bin, and Wang, Jianwei
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- 2020
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36. Enjoying Breathing Program: A National Prospective Study Protocol to Improve Chronic Obstructive Pulmonary Disease Management in Chinese Primary Health Care.
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Jia, Cunbo, Zhang, Chunyu, Fang, Fang, Huang, Ke, Dong, Fen, Gu, Xiaoying, Niu, Hongtao, Li, Shan, Wang, Chen, and Yang, Ting
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- 2020
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37. Faunistische Diversität und Nahrungsnetzrestauration auf großen Vertebratenkadavern
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Gu, Xiaoying
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Bodenökologie ,Lieberoser Heide ,ddc:595 ,ddc:577 ,Kadaver - Abstract
Carcasses of large vertebrate animals are integral elements in the natural environment. The aim of the present study is to clarify the relation between large carcasses and local ecosystems. It has been investigated which and how many animals are directly or indirectly involved into the carcass decomposition process, and whether there is a succession of community pattern during different carcass decomposition stages. A special focus was on the question how the temporal and the spatial distribution of arthropods are influenced by the carcass and its properties. A new classification of decomposition stages is proposed based on a new openness index for a carcass. Three carcass food web models for the research area were composed dependent on different seasons in the course of the year: Carcass exposed in spring, summer, and winter, respectively. Subsequently, the feasibility of using carcasses as a tool for food web restoration on a regional scale has been discussed. From 2009 to 2011, in total, nine different carcasses from Meles meles, Capreolus capreolus, Cervus elaphus, and Sus scrofa were exposed in the research area, a former military training area situated in Eastern Germany. Pitfall traps were used to collect arthropods visiting the carcasses. Bird’s and Mammal’s attendance have been detected by automatic cameras and direct observation. In total, more than 112,000 arthropods from 25 taxa were identified. For Coleoptera Silphidae, Geotrupidae, Trogidae, Staphylinidae (partly) and Heteroptera the investigation could be carried out on species level. The existence of carcasses in the research area significantly increased arthropod diversity and abundance. Long term exposed carcasses significantly influenced vertebrates occurrence, vegetation and the surrounding soil as to diversity and various environmental conditions, respectively. The main consumers of carcasses in summer were various arthropods, Corvus corax and Haliaeetus albicilla. Besides the already well-known carrion arthropods, Orthoptera, Lepidoptera, and Apocrita were observed using carcasses directly. In winter, the main consumers of carcasses were Sus scrofa, Vulpes vulpes, Canis lupus, Corvus corax, and Haliaeetus albicilla. By multivariate analysis it could be shown that the main factors influencing the occurrences of arthropods are the weight and the degree of openness of the carcass, and the main factor for the carcasses decomposition process is the openness index of the carcass. Carcass exposition is a cheap and efficient method to use large wild games which did not die from disease for the food web restoration in the research area. Kadaver größerer Wirbeltiere sind integraler Bestandteile einer naturnahen Landschaft. Das Ziel der vorliegenden Arbeit ist es, die Bedeutung größerer Kadaver für das lokale Ökosystem weitergehend zu klären. Dazu wurde untersucht, welche und wie viele Tiere direkt oder indirekt am Dekompositionsprozess beteiligt sind und ob es eine bestimmte Abfolge bestimmter Lebensgemeinschaften im Verlauf verschiedener Abbaustadien gibt. Insbesondere wurde die Frage nach der zeitlichen und räumlichen Verteilung verschiedener Tiergruppen am Aas untersucht. Eine neue Klassifikation verschiedener Dekompositionsstadien auf Grundlage eines neu eingeführten „openness index“ für Kadaver wird vorgeschlagen. Drei verschiedene Modelle für die Sukzession der Lebensgemeinschaften am Kadaver werden entwickelt, je nachdem, ob das Aas im Frühling, Sommer oder Winter exponiert ist. Des Weiteren wird die Möglichkeit diskutiert, Kadaver als Mittel zur Wiederherstellung natürlicher Nahrungsnetze auf regionaler Ebene einzusetzen. Zwischen 2009 und 2011 wurden insgesamt neun Kadaver der Säugetierarten Meles meles, Capreolus capreolus, Cervus elaphus und Sus scrofa im Untersuchungsgebiet Lieberoser Heide, einem ehemaligen Truppenübungsplatz in Ostdeutschland, exponiert. Die Erfassung der Arthropoden am Aas erfolgte mit Bodenfallen. Die Präsenz von Vögeln und Säugetieren am Aas wurde mit automatischen Kameras und direkter Beobachtung ermittelt. Insgesamt wurden ca. 112.000 Arthropoden aus 25 Taxa identifiziert. Für die Coleoptera Silphidae, Geotrupidae, Trogidae, Staphylinidae (zum Teil) und Heteroptera konnten die Untersuchungen auf Artebene erfolgen. Die Präsenz von Kadavern führte zur deutlichen Erhöhung der lokalen Biodiversität und Abundanz der Arthropoden. Über eine längere Zeitdauer exponierte Kadaver führten zu vermehrtem Auftreten von Wirbeltieren und beeinflussten Vegetation und Bodenparameter der unmittelbaren Umgebung deutlich. Die wichtigsten Konsumenten am Aas im Sommer waren diverse Arthropoden, Corvus corax und Haliaeetus albicilla. Neben den bereits bekannten aasfressenden Arthropoden wurden auch Orthopteren, Lepidopteren und Apocrita als direkte Nutzer am Aas beobachtet. Im Winter waren die wichtigsten Konsumenten Sus scrofa, Vulpes vulpes, Canis lupus, Corvus corax, und Haliaeetus albicilla. Durch die Anwendung multivariater Statistik konnte gezeigt werden, dass die wichtigsten Faktoren, die das Auftreten von Arthropoden beeinflussen, das Gewicht und der Öffnungsgrad (openness index) des Kadavers sind, der wichtigste Faktor für den konkreten Ablauf der Dekomposition wiederum der Öffnungsgrad. Die Exposition von Kadavern größerer, nicht krankheitsbedingt verendeter Wildtiere ist eine günstige und effektive Methode zur Etablierung natürlicher Nahrungsnetze.
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- 2014
38. Melatonin Promotes Antler Growth by Accelerating MT1-Mediated Mesenchymal Cell Differentiation and Inhibiting VEGF-Induced Degeneration of Chondrocytes.
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Sun, Xuyang, Gu, Xiaoying, Li, Keke, Li, Mengqi, Peng, Jingna, Zhang, Xinxin, Yang, Liguo, and Xiong, Jiajun
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SOX transcription factors , *CELL differentiation , *VASCULAR endothelial growth factors , *CHONDROGENESIS , *ANIMAL breeding - Abstract
The sika deer is one type of seasonal breeding animal, and the growth of its antler is affected by light signals. Melatonin (MLT) is a neuroendocrine hormone synthesized by the pineal gland and plays an important role in controlling the circadian rhythm. Although the MLT/MT1 (melatonin 1A receptor) signal has been identified during antler development, its physiological function remains almost unknown. The role of MLT on antler growth in vivo and in vitro is discussed in this paper. In vivo, MLT implantation was found to significantly increase the weight of antlers. The relative growth rate of antlers showed a remarkable increased trend as well. In vitro, the experiment showed MLT accelerated antler mesenchymal cell differentiation. Further, results revealed that MLT regulated the expression of Collage type II (Col2a) through the MT1 binding mediated transcription of Yes-associated protein 1 (YAP1) in antler mesenchymal cells. In addition, treatment with vascular endothelial growth factor (VEGF) promoted chondrocytes degeneration by downregulating the expression of Col2a and Sox9 (SRY-Box Transcription Factor 9). MLT effectively inhibited VEGF-induced degeneration of antler chondrocytes by inhibiting the Signal transducers and activators of transcription 5/Interleukin-6 (STAT5/IL-6) pathway and activating the AKT/CREB (Cyclin AMP response-element binding protein) pathway dependent on Sox9 expression. Together, our results indicate that MLT plays a vital role in the development of antler cartilage. [ABSTRACT FROM AUTHOR]
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- 2022
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39. Ginsenoside Rb1 Mitigates Escherichia coli Lipopolysaccharide-Induced Endometritis through TLR4-Mediated NF-κB Pathway.
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Shaukat, Aftab, Shaukat, Irfan, Rajput, Shahid Ali, Shukat, Rizwan, Hanif, Sana, Shaukat, Imran, Zhang, Xinxin, Chen, Chao, Sun, Xuyang, Ye, Tingzhu, Niu, Kaifeng, Yao, Zhiqiu, Shaukat, Shadab, Safdar, Muhammad, Abdelrahman, Mohamed, Riaz, Umair, Zhao, Junwei, Gu, Xiaoying, and Yang, Liguo
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ENDOMETRITIS ,ESCHERICHIA coli ,CELLULAR signal transduction ,LABORATORY mice ,GINSENG ,ENDOMETRIUM - Abstract
Endometritis is the inflammatory response of the endometrial lining of the uterus and is associated with low conception rates, early embryonic mortality, and prolonged inter-calving intervals, and thus poses huge economic losses to the dairy industry worldwide. Ginsenoside Rb1 (GnRb1) is a natural compound obtained from the roots of Panax ginseng, having several pharmacological and biological properties. However, the anti-inflammatory properties of GnRb1 in lipopolysaccharide (LPS)-challenged endometritis through the TLR4-mediated NF-κB signaling pathway has not yet been researched. This study was planned to evaluate the mechanisms of how GnRb1 rescues LPS-induced endometritis. In the present research, histopathological findings revealed that GnRb1 ameliorated LPS-triggered uterine injury. The ELISA and RT-qPCR assay findings indicated that GnRb1 suppressed the expression level of pro-inflammatory molecules (TNF-α, IL-1β and IL-6) and boosted the level of anti-inflammatory (IL-10) cytokine. Furthermore, the molecular study suggested that GnRb1 attenuated TLR4-mediated NF-κB signaling. The results demonstrated the therapeutic efficacy of GnRb1 in the mouse model of LPS-triggered endometritis via the inhibition of the TLR4-associated NF-κB pathway. Taken together, this study provides a baseline for the protective effect of GnRb1 to treat endometritis in both humans and animals. [ABSTRACT FROM AUTHOR]
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- 2021
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40. Abnormal Crosstalk between Endothelial Cells and Podocytes Mediates Tyrosine Kinase Inhibitor (TKI)-Induced Nephrotoxicity.
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Gu, Xiaoying, Zhang, Su, Zhang, Ti, Kalyuzhny, Alexander E., and Fan, Guo-Chang
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PROTEIN-tyrosine kinase inhibitors , *ENDOTHELIAL cells , *VASCULAR endothelial growth factors , *NEPHROTOXICOLOGY - Abstract
Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway. The proteinuric kidney damage induced by VEGFR2 tyrosine kinase inhibitors (TKIs) is characterized by podocyte foot process effacement. TKI therapy promotes the formation of abnormal endothelial‒podocyte crosstalk, which plays a key role in TKI-induced podocyte injury and proteinuric nephropathy. This review article summarizes the underlying mechanism by which the abnormal endothelial‒podocyte crosstalk mediates podocyte injury and discusses the possible molecules and signal pathways involved in abnormal endothelial‒podocyte crosstalk. What is more, we highlight the molecules involved in podocyte injury and determine the essential roles of Rac1 and Cdc42; this provides evidence for exploring the abnormal endothelial‒podocyte crosstalk in TKI-induced nephrotoxicity. [ABSTRACT FROM AUTHOR]
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- 2021
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41. Radiation Induced Surface Modification of Nanoparticles and Their Dispersion in the Polymer Matrix.
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Fu, Zhiang, Gu, Xiaoying, Hu, Lingmin, Li, Yongjin, and Li, Jingye
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GRAFT copolymers , *DOUBLE bonds , *NANOPARTICLES , *RADIATION , *GAMMA rays - Abstract
Polymer grafted inorganic nanoparticles attract significant attention, but pose challenges because of the complexity. In this work, a facile strategy to the graft polymer onto the surface of nanoparticles have been introduced. The vinyl functionalized SiO2 nanoparticles (NPs) were first prepared by the surface modification of the unmodified SiO2 using γ-methacryloxy propyl-trimethoxylsilane. The NPs were then mixed with polyvinylidene fluoride (PVDF), which was followed by the Co-60 Gamma radiation at room temperature. PVDF molecular chains were chemically grafted onto the surface of SiO2 nanoparticles by the linking of the double bond on the NPs. The graft ratio of PVDF on SiO2 NPs surface can be precisely controlled by adjusting the absorbed dose and reactant feed ratio (maximum graft ratio was 31.3 wt%). The strategy is simple and it should be applied to the surface modification of many other nanoparticles. The prepared PVDF-grafted SiO2 NPs were then dispersed in the PVDF matrix to make the nanocomposites. It was found that the modified NPs can be precisely dispersed into the PVDF matrix, as compared with pristine silica. The filling content of modifications SiO2 NPs on the PVDF nanocomposites is almost doubled than the pristine SiO2 counterpart. Accordingly, the mechanical property of the nanocomposites is significantly improved. [ABSTRACT FROM AUTHOR]
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- 2020
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42. Improvement of PLLA Ductility by Blending with PVDF: Localization of Compatibilizers at Interface and Its Glycidyl Methacrylate Content Dependency.
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Zhang, Yan, Gu, Xiaoying, Ni, Chunjun, Li, Fei, Li, Yongjin, and You, Jichun
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GLYCIDYL methacrylate , *COMPATIBILIZERS , *DUCTILITY , *POLYVINYLIDENE fluoride , *GRAFT copolymers - Abstract
In this work, the localization of reactive compatibilizer (RC, containing poly(methyl methacrylate) (PMMA) backbone with randomly distributed glycidyl methacrylate (GMA) on it) at the polyvinylidene fluoride/poly(l-lactic acid) (PVDF/PLLA) interface has been manipulated by means of GMA contents. At the very beginning of mixing, RC tends to stay in the PVDF phase due to the miscibility between PVDF and PMMA. Upon further shearing, more and more PLLA chains have been grafted on PMMA backbone, producing PLLA–g–PMMA copolymer. The balanced stress on two sides accounts for the localization of compatibilizers at the PVDF/PLLA interface. Finally, the stress of the PLLA side has been enhanced remarkably due to the higher graft density of PLLA, resulting in the enrichment of the copolymer in the PLLA matrix. The migration of RC from the PVDF phase to the immiscible interface and PLLA matrix can be accelerated by employing RC with higher GMA content. Furthermore, the compatibilizer localization produces a significant influence on the morphology and ductility of the PVDF/PLLA blend. Only when the compatibilizers precisely localize at the interface, the blend exhibits the smallest domain and highest elongation at break. Our results are of great significance for not only the fabrication of PLLA with high ductility, but also the precise localization of compatibilizers at the interface of the immiscible blend. [ABSTRACT FROM AUTHOR]
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- 2020
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43. Fabrication of PLLA with High Ductility and Transparence by Blending with Tiny Amount of PVDF and Compatibilizers.
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Zhang, Yan, Li, Fei, Yu, Qunli, Ni, Chunjun, Gu, Xiaoying, Li, Yongjin, and You, Jichun
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COMPATIBILIZERS ,DUCTILITY ,POLYVINYLIDENE fluoride - Abstract
B Inside Front Cover b : In article number 1900316, Jichun You and co-workers provide an efficient strategy to prepare poly(L-lactic acid) (PLLA) with high ductility and transparency, in which tiny amount of polyvinylidene fluoride (PVDF) and compatibilizers are added to the PLLA matrix. The left part is the PVDF/PLLA blend without compatibilizers while the right part is the PVDF/PLLA blend with compatibilizers. [Extracted from the article]
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- 2019
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44. Association of fine particulate matter air pollution and its constituents with lung function: The China Pulmonary Health study.
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Yang, Ting, Chen, Renjie, Gu, Xiaoying, Xu, Jianying, Yang, Lan, Zhao, Jianping, Zhang, Xiangyan, Bai, Chunxue, Kang, Jian, Ran, Pixin, Shen, Huahao, Wen, Fuqiang, Huang, Kewu, Chen, Yahong, Sun, Tieying, Shan, Guangliang, Lin, Yingxiang, Wu, Sinan, Zhu, Jianguo, and Wang, Ruiying
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LUNGS , *PARTICULATE matter , *AIR pollution , *FORCED expiratory volume , *VITAL capacity (Respiration) , *EXPIRATORY flow - Abstract
• Long-term exposure to PM 2.5 are associated with large- and small- airway function. • Organic matter and nitrate show stronger associations with lung function than PM 2.5. • Exposure to PM 2.5 constituents might be more important in impairing lung function. The associations of long-term exposure to various constituents of fine particulate matter (≤2.5 μm in aerodynamic diameter, PM 2.5) air pollution with lung function were not clearly elucidated in developing countries. The aim was to evaluate the associations of long-term exposure to main constituents of PM 2.5 with lung function in China. This is a nationwide, cross-sectional analysis among 50,991 study participants from the China Pulmonary Health study. Multivariable linear regression models were used to obtain differences of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC), FEV 1 /FVC, peak expiratory flow (PEF), and forced expiratory flow at 25–75% of exhaled FVC (FEF 25-75%) associated with an interquartile range (IQR) change of PM 2.5 or its constituents. Residential annual PM 2.5 levels varied from 26 μg/m3 to 92 μg/m3 (average: 53 μg/m3). An IQR increase of PM 2.5 concentrations was associated with lower FEV 1 (19.82 mL, 95% CI: 11.30–28.33), FVC (17.45 mL, 95% CI: 7.16–27.74), PEF (86.64 mL/s, 95% CI: 59.77–113.52), and FEF 25-75% (31.93 mL/s, 95% CI: 16.64–47.22). Black carbon, organic matter, ammonium, sulfate, and nitrate were negatively associated with most lung function indicators, with organic matter and nitrate showing consistently larger magnitude of associations than PM 2.5 mass. This large-scale study provides first-hand epidemiological evidence that long-term exposure to ambient PM 2.5 and some constituents, especially organic matter and nitrate, were associated with lower large- and small- airway function. [ABSTRACT FROM AUTHOR]
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- 2021
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45. Interfacially located nanoparticles: Barren nanorods versus polymer grafted nanorods.
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Li, Xuan, Fu, Zhiang, Gu, Xiaoying, Liu, Huanhuan, Wang, Hengti, and Li, Yongjin
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POLYBUTENES , *GRAFT copolymers , *NANORODS , *NANOPARTICLES , *POLYMERIC nanocomposites , *POLYMER blends - Abstract
Polymer blend nanocomposites with the nanoparticles exclusively located at the interface have attracted significant attention while the compatibilization functions of such nanoparticles in the blends are still controversial. Herein, the pristine boehmite nanorods (p-BNRs) and epoxide group modified boehmite nanorods (m-BNRs) have been synthesized and incorporated in the immiscible Poly(l -lactide)/Poly(1,4-butylene succinate) (PLLA/PBSU) blends. It is found that both p-BNRs and m-BNRs are thermodynamically located at the interface and the phase morphologies of the two nanocomposites are very similar at the same nanofiller loadings. However, the two nanocomposites exhibit different mechanical properties. The PLLA/PBSU blend nanocomposites with m-BNRs show increased elongation at break, enhanced notched impact strength and improved yield strength, as compared with the binary PLLA/PBSU blends. In contrast, p-BNRs lead to drastically deteriorating mechanical properties of the PLLA/PBSU blends even with all p-BNRs located at the interface. The investigation indicates that p-BNRs at the interface have barren surface and are lack of specific interactions with the polymers in the neighboring phases. In contrast, the epoxide groups on m-BNRs reacted with the end carboxylic acid groups of both PLLA and PBSU and the polymer chains were chemically bonded onto the surface of nanorods. The chemically bonded polymer chains on the nanorods at the interface can entangle with the molecular chains of the two polymers to enhance the interfacial adhesion. This paper demonstrates the significance of molecular chain entanglements of the compatibilizing nanoparticles and paves a new possibility to fabricate new materials with simultaneously enhanced strength and toughness. Image 1 • Ternary Poly(l -lactide)/Poly(1,4-butylene succinate)/boehmite nanorods nanocomposites were prepared. • Both pristine boehmite nanorods and epoxide groups modified boehmite nanorods are thermodynamically located at the interface of PLLA/PBSU. • Barren nanorods deteriorate the mechanical properties of PLLA/PBSU blends, but surface grafted nanorods enhance the mechanical properties drastically. • Molecular entanglements of the grafted nanorods are the prerequisite for the compatibilization of immiscible polymer blends. [ABSTRACT FROM AUTHOR]
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- 2020
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46. The mortality and years of life lost for community-acquired pneumonia before and during COVID-19 pandemic in China.
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Fan G, Zhou Y, Zhou F, Yu Z, Gu X, Zhang X, Liu Z, Zhou M, and Cao B
- Abstract
Background: Community-acquired pneumonia (CAP) is a leading cause of mortality worldwide, but disease burden of CAP is not clear so far. We aim to explore the spatial and temporal trends of mortality and years of life lost (YLL) due to CAP during 2013-2021 in mainland China, especially the mortality changes before and during COVID-19 pandemic due to COVID-19 related non-pharmaceutical interventions (NPIs)., Methods: We used data from the National Mortality Surveillance System to estimate the age-standardized rates of death and YLL of CAP at national and provincial level in China during 2013-2021. Monthly and provincial NPIs data were obtained from Oxford COVID-19 Government Response Tracker. The Average annual percentage change (AAPC) and mortality reduction were estimated by log-linear regression and interrupted time series, respectively., Findings: In China, most CAP that caused deaths had no clear etiology, and bacterial pneumonia and viral pneumonia were the leading 2 causes among CAP deaths with determined etiology before and during COVID-19 pandemic. The age-standardized CAP mortality rate decreased from 11.18 per 100,000 in 2013 to 8.76 per 100,000 in 2019, and to 5.74 per 100,000 in 2021 (AAPC -4.51% vs -7.89%). Trends were similar in age-standardized rate of YLL. Both rates declined more for viral pneumonia, compared with bacterial pneumonia. After adjusting for NPIs at provincial level after 2020, the NPIs for COVID-19 was associated with significant reductions in CAP mortality (-0.34 per 100,000, -0.41 to -0.27; p < 0.0001), and provinces that economically developed and conducted strict regular NPIs against COVID-19 contributed the most reduction., Interpretation: We observed a decreasing trend of age-standardized CAP mortality from 2013 to 2019, and a dramatical reduction during COVID-19 pandemic, especially for viral pneumonia. Our study provided the evidence for the effectiveness of regular NPIs on the significant reductions in CAP mortality., Funding: This work has been supported by Beijing Municipal Science and Technology Project Z191100006619101, Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1-048), CAMS Institute of Respiratory Medicine Grant for Young Scholars (2023-ZF-8) and the New Cornerstone Science Foundation., Competing Interests: All authors declared no conflicts of interest., (© 2023 The Author(s).)
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- 2023
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47. LDP alleviates TKI-induced proteinuria through reversing the expression of RelA in renal tissues.
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Fu Z, Zhang S, Gu X, Guan T, Wang C, Zhang J, Wang Y, Guo H, Wang L, and Zhang T
- Abstract
Tyrosine kinase inhibitors (TKIs), as an important tumor therapy, can induce severe proteinuria that significantly affects anti-tumor therapy. Existing therapies against proteinuria induced by other etiologies are currently ineffective for TKI-induced proteinuria. It has been shown that various types of proteinuria are related to podocyte damage caused by changes in the RelA signaling pathway. Our experiments confirmed that TKIs activate the renal RelA signaling pathway, and induce death of podocytes and destruction of the glomerular filtration barrier. Here we found that Liuwei Dihuang Pill (LDP) attenuated the inflammatory injury of podocytes through inhibiting activation of RelA, and subsequently relieved TKI-related proteinuria and prevented the progression of TMA and FSGS. Our finding indicated that LDP may be effective for the treatment of TKI-induced proteinuria, which is clinically significant., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Fu, Zhang, Gu, Guan, Wang, Zhang, Wang, Guo, Wang and Zhang.)
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- 2023
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48. Prevalence and burden of chronic cough in China: a national cross-sectional study.
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Huang K, Gu X, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Wu S, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Xiao D, Bu X, Zhang H, Zhang X, An L, Zhang S, Cao Z, Zhan Q, Yang Y, Liang L, Dai H, Cao B, He J, Chung KF, and Wang C
- Abstract
Background: Chronic cough is a common complaint, but there are no population-based data on its burden in China. We determined the prevalence of chronic cough and its impact on health status in adults stratified by sex, age and the diagnosis of COPD or the presence of small airway dysfunction (SAD)., Methods: A representative sample of 57 779 Chinese adults aged 20 years or older was recruited and pulmonary function test was measured. Chronic cough was defined as cough lasting for >3 months in each year. Quality of life was assessed by the 12-item Short Form Health Survey (SF-12), and self-reported history of hospital visits was recorded., Results: Chronic cough was found in 3.6% (95% CI 3.1-4.1) of Chinese adults, 2.4% (95% CI 1.9-3.1) of those aged 20-49 years and 6.0% (95% CI 5.3-6.8) of those aged 50 years or older. Individuals with chronic cough had an impaired physical component summary (PCS) score of the SF-12 (p<0.0001) and more emergency visits (p=0.0042) and hospital admissions (p=0.0002). Furthermore, the impact of chronic cough on PCS score was more significant in those aged 50 years or older, or with COPD (p = 0.0018 or 0.0002, respectively), with the impact on hospital admission being more significant in those with COPD or with SAD (p=0.0026 or 0.0065, respectively)., Conclusions: Chronic cough is prevalent in China and is associated with a poorer health status, especially in individuals aged 50 years or older and those with the diagnosis of COPD or SAD., Competing Interests: Conflict of interest: None declared., (Copyright ©The authors 2022.)
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- 2022
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49. Polymyxin B/Tigecycline Combination vs. Polymyxin B or Tigecycline Alone for the Treatment of Hospital-Acquired Pneumonia Caused by Carbapenem-Resistant Enterobacteriaceae or Carbapenem-Resistant Acinetobacter baumannii .
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Chang K, Wang H, Zhao J, Yang X, Wu B, Sun W, Huang M, Cheng Z, Chen H, Song Y, Chen P, Chen X, Gan X, Ma W, Xing L, Wang Y, Gu X, Zou X, and Cao B
- Abstract
Introduction: It is not clear whether polymyxin B/tigecycline (PMB/TGC) combination is better than PMB or TGC alone in the treatment of hospital-acquired pneumonia (HAP) caused by carbapenem-resistant organisms (CROs)., Methods: We conducted a multicenter, retrospective cohort study in patients with HAP caused by CROs. The primary outcome was 28-day mortality, and the secondary outcomes included clinical success and the incidence of acute kidney injury (AKI). Multivariate Cox regression analysis was performed to examine the relationship between antimicrobial treatments and 28-day mortality by adjusting other potential confounding factors., Results: A total of 364 eligible patients were included in the final analysis, i.e., 99 in the PMB group, 173 in the TGC group, and 92 in the PMB/TGC combination group. The 28-day mortality rate was 28.3% (28/99) in the PMB group, 39.3% (68/173) in the TGC group, and 48.9% (45/92) in the PMB/TGC combination group ( p = 0.014). The multivariate Cox regression model showed that there was a statistically significant lower risk of 28-day mortality among participants in the PMB group when compared with the PMB/TGC combination group [hazard ratio (HR) 0.50, 95% confidence interval (CI) 0.31-0.81, p = 0.004] and that participants in the TGC group had a lower risk of 28-day mortality than in the PMB/TGC combination group but without statistical significance. The incidence of AKI in the PMB group (52.5%) and the PMB/TGC combination group (53.3%) was significantly higher than that in the TGC group (33.5%, p = 0.001)., Conclusion: The appropriate PMB/TGC combination was not superior to appropriate PMB therapy in the treatment of HAP caused by carbapenem-resistant Enterobacteriaceae /carbapenem-resistant Acinetobacter baumannii (CRE/CRAB) in terms of 28-day mortality., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Chang, Wang, Zhao, Yang, Wu, Sun, Huang, Cheng, Chen, Song, Chen, Chen, Gan, Ma, Xing, Wang, Gu, Zou and Cao.)
- Published
- 2022
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50. Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China.
- Author
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Huang K, Chung KF, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Xu G, Wu S, Wang Y, Gu X, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Xiao D, Bu X, Zhang H, Zhang X, An L, Zhang S, Cao Z, Zhan Q, Yang Y, Liang L, Wang W, Dai H, Cao B, He J, and Wang C
- Abstract
Background: Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) are seen commonly in the clinic but less is known in the general population. We investigated the prevalence and the heterogeneity of COPD with concomitant features of asthma in Chinese adult population., Methods: COPD was defined as post-bronchodilator ratio of forced expiratory volume in 1s (FEV
1 ) to forced vital capacity of less than the lower limits of normal. COPD with concomitant features of asthma was defined as either COPD with asthma diagnosed by self-reported physician-diagnosis or by presence of current wheeze, or as COPD with high bronchodilator response (HBR) defined as an increase in FEV1 >15% and >400 ml after bronchodilator., Results: COPD with concomitant features of asthma was found in 1.62% (95% CI 1.31-2.00) of adults (≥20 years) or in 15.2% (95% CI 13.0-17.7) of COPD patients. Compared with COPD with HBR, COPD with asthma diagnosis or wheeze were older (61.8 ± 1.1 years vs. 47.4 ± 2.8 years, P < 0.001), and with a lower post-bronchodilator FEV1 %pred (68.2 ± 2.3 vs. 96.6 ± 3.4, P < 0.001). Age, smoking status, biomass use and allergic rhinitis were associated with increasing prevalence of COPD with asthma diagnosis or wheeze, and had greater impaired health status, more comorbidities and more acute exacerbations in the preceding 12 months., Conclusions: COPD with concomitant features of asthma is common in people with COPD and those with COPD with asthma diagnosis or wheeze experience worse clinical severity than COPD with HBR. These findings will help toward the definition of the asthma-COPD overlap condition., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Huang, Chung, Yang, Xu, Yang, Zhao, Zhang, Bai, Kang, Ran, Shen, Wen, Chen, Sun, Shan, Lin, Xu, Wu, Wang, Gu, Wang, Shi, Xu, Ye, Song, Wang, Zhou, Li, Ding, Wan, Yao, Guo, Xiao, Lu, Peng, Xiao, Bu, Zhang, Zhang, An, Zhang, Cao, Zhan, Yang, Liang, Wang, Dai, Cao, He and Wang.)- Published
- 2022
- Full Text
- View/download PDF
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