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Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry. The transient receptor potential mucolipin proteins (TRPMLs) have been shown to be strongly associated with virus infection and other physiological processes in humans, but their tissue distribution and responses to PRRSV in pigs remain unknown.

C4H10N2O2, monoclinic, Cc (no. 9), a = 9.5726(8) Å, b = 9.2271(9) Å, c = 7.4577(7) Å, β = 115.295(3)°, V = 595.56(9) Å3, Z = 4, Rgt (F) = 0.0520, wRref (F 2) = 0.1436, T = 298 K .

Background: Anlotinib is a novel oral small-molecule receptor tyrosine kinase inhibitor. However, the efficacy and safety of its combined use with chemotherapy remain unclear in patients with advanced ovarian cancer. Objectives: To assess the efficacy and safety of the combined use of Anlotinib with chemotherapy in patients with advanced ovarian cancer. Design: A multi-center retrospective real-world analysis and a meta-analysis. Data sources and methods: We enrolled patients with advanced ovarian cancer who received a combination therapy of Anlotinib and chemotherapy from 15 medical centers. We also searched electronic databases for studies assessing the efficacy and safety of the combined use of Anlotinib with chemotherapy in patients with ovarian cancer. The outcomes of interest included objective response rate (ORR), disease control rate (DCR), and median progression-free survival (mPFS). Results: A total of 71 patients, who were predominantly recurrent cases, were included in the real-world study. The ORR and DCR of the included patients were 40.8% and 76.1%, respectively; and their mPFS was 4.6 months. The log-rank test showed that previous antiangiogenic therapy was related to a longer mPFS (p < 0.05). Five studies in total were eligible for meta-analysis. The random-effects meta-analysis model showed that the ORR, DCR, and mPFS were 33.8% [95% confidence interval (CI) 22.7–44.8% from four studies], 90.6% (95% CI 73.6–99.9% from five studies), and 6.6 months (95% CI 4.9–8.4 months from five studies). The most common adverse events were hand-foot syndrome and hypertension. Conclusion: The combined use of Anlotinib with chemotherapy showed potential in treating patients with advanced ovarian cancer, with a tolerable safety profile. [ABSTRACT FROM AUTHOR]

C4H10N2O2, monoclinic, Cc (no. 9), a = 9.5726(8) Å, b = 9.2271(9) Å, c = 7.4577(7) Å, β = 115.295(3)°, V = 595.56(9) Å3, Z = 4, Rgt(F) = 0.0520, wRref(F2) = 0.1436, T = 298 K. [ABSTRACT FROM AUTHOR]

In order to verify effect of the industrial policies on solving the problem of market failure, we collect the data from China A-share listed companies among 2008-2019, and analyze the effect of government subsidies on the entity over-financialization. The results show that government subsidies significantly inhibit the entity over-financialization. Because the government subsidies could increase the performance of enterprise's main business and level of the enterprise's profitability. Subsequently, the enterprise's arbitrage from cross-industries and the managers' composition could be decreased. Consequently, government subsidies could reduce the entity over-financialization by the reduce of enterprise's arbitrage from multi-industries and increase of the managers' composition which is related to the enterprise's performance. The results also indicate that the entity financialization is mainly motivated by enterprise arbitrage rather than 'preventive reserve' in China. Moreover, the inhibitory effect of government subsidies on the entity over-financialization is only significant in the enterprises with non-state-owned, high-tech, and higher level of demand of innovation. Thus, the government should accurately implement subsidy policies for the enterprises and increase the supports for enterprises with high-tech and higher level of demand of innovation, which could promote economy high-quality development. [ABSTRACT FROM AUTHOR]

Consumption trends demand healthier meat products and require research into reformulation strategies. Ambiguities in consumer preferences for two processed meat reformulation strategies (i.e., ingredient "reduction" and nutrient "addition") were investigated. Using physical prototypes of omega-3-enriched pork sausages and sensory evaluation to reduce hypothetical bias, followed by a choice-based conjoint experiment, results suggested that consumers valued both "addition" and "reduction" reformulation strategies, and consumers' willingness-to-pay (WTP) premiums were the highest for omega-3 addition, followed by fat reduction, and were lowest for salt reduction. Moreover, WTP was influenced by sensory preferences and was positively correlated with sensory liking levels. Providing health-related information improved consumers' sensory perceptions of omega-3-enriched sausages. Findings imply that reformulated healthier meat products are acceptable to consumers. Moreover, to enhance consumers' valuation on new launches of healthier processed meat products, meat manufacturers should inform consumers of health-related reformulation information, provide consumers with opportunities to taste newly developed healthier processed meat products, and continuously optimize consumers' sensory experience. [ABSTRACT FROM AUTHOR]

As marketing tools, nutrition claims (NCs) and health claims (HCs) can be used to convey the nutritional properties and health benefits of food to consumers, but their respective effects on consumers' perceptions of healthier meat products are inconsistent in the literature. Using a physical prototype of omega-3-enriched sausages as a research interest, this paper explores how HCs and NCs differently influence consumers' sensory preferences and willingness to pay (WTP). Sensory tests were carried out among 330 participants, followed by a choice-based conjoint (CBC) experiment to measure consumers' WTP. Results indicate that, in comparison with the uninformed condition, labeling an omega-3 nutrition claim increased consumers' sensory liking for omega-3-enriched sausages in the attributes of appearance and texture. Moreover, consumers were willing to pay more for healthier sausages, but labeling HCs did not significantly improve participants' WTP for omega-3-enriched sausages more than NCs. Hence, HCs did not significantly outperform NCs, when it comes to positively influencing consumers' sensory liking and paying intentions for omega-3-enriched sausages. The findings of this study have implications for the meat industry in developing healthier sausage formulations with greater likelihood of success in the market. [ABSTRACT FROM AUTHOR]

Mechanical behaviors at fatigue crack tips of cracked specimens under negative loading ratios are studied in detail by the finite element method in this paper. Three factors induced by specimen type and loading type on fatigue crack field are discussed, including constraint, compressive loading effect (CL effect) and crack contact closure. For mode I crack under negative loading ratios, the effects of the CL effect and crack contact closure on plastic strain accumulations are dominant, with the constraint effect being minor. The constraint effect has effects on the monotonous plastic zone, while the CL effect and contact closure both have effects on the reversed plastic zone (RPZ) and residual tensile plastic zone (RTPZ). That is, the higher the constraint, the smaller the size of the monotonous plastic zone; the greater the CL effect, or the smaller the contact degree, the larger the size of RPZ and RTPZ. For mode II crack, there is only CL effect on the crack tip field without the effect of constraint and contact closure, so plastic strain accumulation at the mode II crack tip is much greater than that at the mode I crack tip when they are under the same loading level. [ABSTRACT FROM AUTHOR]

In the context of the One Country–Two Systems policy, Shenzhen and Hong Kong have rapidly grown into a dual-core international metropolis. However, a huge barrier is the commuting cost incurred by the tariff policy, which blocks the road to the high-quality development of the Guangdong–Hong Kong–Macao Greater Bay Area (GBA). Based on traffic accessibility and kernel density analysis of the subway network and points of interest (POIs) of urban functional areas with ArcGIS, this study analyzed the commute time and convenience level of the functional areas in the two separate tariff zones. The traffic (commute) time in 75 min was taken as the turning point of the efficiency of the Shenzhen–Hong Kong connection, and it was found that both the customs clearance time and the accessible areas show the shape of a parabolic function with an upward opening. It was also found that, in Shenzhen and Hong Kong, the commute time in most of the business, commercial, residential, and industrial areas is 60–75 min. In particular, the comfortable range within 45 min was not achieved. It is necessary to further promote the effectiveness of the Shenzhen–Hong Kong customs clearance system and continuously reduce the customs clearance cost so as to promote the integration of Shenzhen and Hong Kong in order to implement the national strategy of "dual circulation" and innovation-driven development and efficiently drive the coordinated construction of the GBA. [ABSTRACT FROM AUTHOR]

C4H10N2O2, monoclinic, Cc (no. 9), a = 9.5726(8) Å, b = 9.2271(9) Å, c = 7.4577(7) Å, β = 115.295(3)°, V = 595.56(9) Å3, Z = 4, Rgt(F) = 0.0520, wRref(F2) = 0.1436, T = 298 K. [ABSTRACT FROM AUTHOR]

• The gene expression of three TRPMLs is abundant in mouse spleen, lung, and kidney tissues. • Three TRPMLs show different responses to pathogen stimuli in lung tissue and A549 cells. • The responses of three TRPMLs to pathogen stimuli that occur similarly in other tissues. • LPS exhibits a significant effect on three overexpressed TRPMLs in A549 cells. • Both TRPML1- and TRPML3-specific activators show dose-dependent upregulation of inflammatory factors. The transient receptor potential mucolipin (TRPML) subfamily in mammalian has three members, namely TRPML1, TRPML2, and TRPML3, who play key roles in regulating intracellular Ca2+ homeostasis, endosomal pH, membrane trafficking and autophagy. Previous studies had shown that three TRPMLs are closely related to the occurrence of pathogen invasion and immune regulation in some immune tissues or cells, but the relationship between TRPMLs expression and pathogen invasion in lung tissue or cell remains elusive. Here, we investigated the expression distribution of three TRPML channels in mouse different tissues by qRT-PCR, and then found that all three TRPMLs were highly expressed in the mouse lung tissue, as well as mouse spleen and kidney tissues. The expression of TRPML1 or TRPML3 in all three mouse tissues had a significant down-regulation after the treatment of Salmonella or LPS, but TRPML2 expression showed a remarkable increase. Consistently, TRPML1 or TRPML3 but not TRPML2 in A549 cells also displayed a decreased expression induced by LPS stimulation, which shared a similar regulation pattern in the mouse lung tissue. Furthermore, the treatment of the TRPML1 or TRPML3 specific activator induced a dose-dependent up-regulation of inflammatory factors IL-1β, IL-6 and TNFα, suggesting that TRPML1 and TRPML3 are likely to play an important role in immune and inflammatory regulation. Together, our study identified the gene expression of TRPMLs induced by pathogen stimulation in vivo and in vitro , which may provide novel targets for innate immunity or pathogen regulation. [ABSTRACT FROM AUTHOR]