Search

Your search keyword '"Rai, Shivam"' showing total 16 results
Start Over Author "Rai, Shivam" Search Limiters Full Text Language english
16 results on '"Rai, Shivam"'

5. Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms

Author

Stetka, Jan, Usart, Marc, Kubovcakova, Lucia, Rai, Shivam, Rao, Tata Nageswara, Sutter, Joshua, Hao-Shen, Hui, Dirnhofer, Stefan, Geier, Florian, Bader, Michael S., Passweg, Jakob R., Manolova, Vania, Dürrenberger, Franz, Ahmed, Nouraiz, Schroeder, Timm, Ganz, Tomas, Nemeth, Elizabeta, Silvestri, Laura, Nai, Antonella, Camaschella, Clara, and Skoda, Radek C.

Published
2023
Full Text
View/download PDF

8. JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms

Author

Rao, Tata Nageswara, Hansen, Nils, Hilfiker, Julian, Rai, Shivam, Majewska, Julia-Magdalena, Leković, Danijela, Gezer, Deniz, Andina, Nicola, Galli, Serena, Cassel, Teresa, Geier, Florian, Delezie, Julien, Nienhold, Ronny, Hao-Shen, Hui, Beisel, Christian, Di Palma, Serena, Dimeloe, Sarah, Trebicka, Jonel, Wolf, Dominik, Gassmann, Max, Fan, Teresa W.-M., Lane, Andrew N., Handschin, Christoph, Dirnhofer, Stefan, Kröger, Nicolaus, Hess, Christoph, Radimerski, Thomas, Koschmieder, Steffen, Čokić, Vladan P., and Skoda, Radek C.

Published
2019
Full Text
View/download PDF

12. The Second Generation Type II JAK2 Inhibitor, AJ1-10502, Demonstrates Enhanced Selectivity, Improved Therapeutic Efficacy and Reduced Mutant Cell Fraction Compared to Type I JAK2 Inhibitors in Models of Myeloproliferative Neoplasms (MPNs)

Author

Rai, Shivam, Stetka, Jan, Usart, MARC, Hao-Shen, Hui, Park, Young, Houston, Remie, Martinez Benitez, Anthony R., Wereski, Matthew, Guzzardi, Emily, Persaud, Sonali, Ramzan, Hailey, Futran, Alan, Xu, Charley, Greenwood, Jeremy, Mondal, Sayan, Masse, Craig, Levine, Ross L., Skoda, Radek C., and Dunbar, Andrew

Published
2022
Full Text
View/download PDF

16. Evaluation of DNA damage in Type 2 diabetes mellitus patients with and without peripheral neuropathy: A study in South Indian population.

Author

Prasad, Mukul, Charles Bronson, Stephen, Warrier, Tushar, Badarinath, Agnihotram, Rai, Shivam, Baid, Kaushal, Sitaraman, Sneha, George, Alex, Moses, Anand, Saraswathy, Radha, Vasuki, Ranganathan, and Shanmugam, Alagianambi

Subjects
DNA damage, DIABETES, PERIPHERAL neuropathy, OXIDATIVE stress, CYTOKINESIS, LYMPHOCYTES
Abstract

Background: The increasing incidence of Type 2 diabetes mellitus globally has collaterally increased the incidence of diabetes-associated complications such as neuropathy. Oxidative stress induced DNA damage is one of the mechanisms implicated in the pathogenesis of diabetic complications. Here we aimed to evaluate the extent of DNA damage in diabetes patients with and without clinical neuropathy using the Cytokinesis Block Micronucleus Cytome assay, in a group of South Indian population. Materials and Methods: The Cytokinesis Block Micronucleus Cytome assay was performed in lymphocyte cultures of 42 type 2 diabetes patients (22 with neuropathy and 20 without neuropathy) and 42 age and sex matched controls. Nuclear aberrations like Nuclear Buds, Nucleoplasmic Bridges and Micronuclei were analyzed. Results: The frequency of nuclear aberrations in diabetes patients with neuropathy was higher than compared to diabetes patients without neuropathy. The mean frequencies of nuclear aberrations per cell in diabetes patients with neuropathy and without neuropathy were 0.02 ± 0.02 and 0.01 ± 0.01, respectively. This was significantly higher than in the controls (0.002 ± 0.002) (P < 0.0001). An increasing trend of nuclear aberrations in correlation with the duration of diabetes was observed. Conclusion: This study highlights the use of the Cytokinesis Block Micronucleus Cytome assay as a potent tool for the identification of DNA damage, which may prove to be useful biomarker to assess the severity diabetes-associated complications such as neuropathy. Implementation of this technique at the clinical level would potentially enhance the quality of management of patients with diabetes and its complications like neuropathy. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results