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Five auxiliary data sources (Landsat TM, IRS-IC, digitized aerial photographs, visual photo-interpretation and old forest compartment information) applying three study areas and three estimators, two-phase sampling with stratification, the k nearest neighbors and regression estimator, were examined. Auxiliary data were given for a high number of sample plots, which are here called first phase sample plots. The plots were distributed using a systematic grid over the study areas. Some of the plots were then measured in the field for the necessary ground truth. Each auxiliary data source in combination with field sample information was applied to produce a specific estimator for five forest stand characteristics: mean diameter, mean height, age, basal area, and volume of the growing stock. When five auxiliary data sources were used, each stand characteristic and each first phase sample plot were supplied with five alternative estimates with three alternative estimators. Mean square errors were then calculated for each alternative estimator using the cross validation method. The final estimates were produced by weighting alternative estimates inversely according to the mean square errors related to the corresponding estimator. The result was better than the final estimate of any of the single estimators. The improvement over the best single estimate, as measured in mean square error, was 16.9% on average for all five forest stand characteristics. The improvement was fairly equal for all five forest stand characteristics. Only minor differences among the accuracies of the three alternative estimators were recorded.

The increasing capacity of modern computers has created the opportunity to routinely process the very large data sets derived by digitizing aerial photographs. The very fine resolution of such data sets makes them better suited than satellite imagery for some applications; however, there may be problems in implementation resulting from variation in radial distortion and illumination across an aerial photograph. We investigated the feasibility of using local operators (e.g., non-overlapping moving window means and standard deviations) as auxiliary data for generating stand development classes via three steps: (i) derive 6 local operators intended to represent texture for a 16 by 16 m window corresponding to a forest inventory sampling unit, (ii) apply a calibration process (e.g., accounting for location relative to a photo's principal point and solar position) to these local operators, and (iii) apply the calibrated local operators to classify the forest for stand development. Results indicate that calibrated local operators significantly improve the classification compared to what is possible using uncalibrated local operators and satellite images.

The quality assurance system of postgraduate training is a powerful guarantee to ensure the quality of postgraduate training. By combing the literature research on the quality assurance system of postgraduate training in military academies, this paper finds three types and seven specific problems that affect the quality of training. In view of the current training characteristics, the prospect of quality improvement is put forward from three aspects : theoretical research, training status and system construction. The research results provide a theoretical basis for the construction of a quality assurance system for postgraduate training in military academies in the context of the new era.

Global navigation satellite system (GNSS) provides users with all-weather, continuous, high-precision positioning, navigation, and timing (PNT) services. In the operation and use of GNSS, the influence of the space environment is a factor that must be considered. For example, during geomagnetic storms, a series of changes in the Earth's magnetosphere, ionosphere, and upper atmosphere affect GNSS's positioning performance. To investigate the positioning performance of global satellite navigation systems during geomagnetic storms, this study selected three geomagnetic storm events that occurred from September to December 2023. Utilizing the global positioning system (GPS)/Beidou navigation satellite system (BDS) dual-system, kinematic precise point positioning (PPP) experiments were conducted, and the raw observational data from 100 stations worldwide was analyzed. The experimental results show that the positioning accuracy of some stations in high-latitude areas decreases significantly when using the conventional Geometry Free (GF) cycle-slip detection threshold during geomagnetic storms, which means that the GF is no longer applicable to high-precision positioning services. Meanwhile, there is no significant change in the satellite signal strengths received at the stations during the period of the decrease in positioning accuracy. Analyzing the cycle-slip rates for stations where abnormal accuracy occurred, it was observed that stations experiencing a significant decline in positioning accuracy exhibited serious cycle-slip misjudgments. To improve the kinematic PPP accuracy during magnetic storms, this paper proposes an adaptive threshold for cycle-slip detection and designs five experimental strategies. After using the GF adaptive threshold, the station positioning accuracy improved significantly. It achieved the accuracy level of the quiet period, while the cycle-slip incidence reached the average level. During magnetic storms, the ionosphere changes rapidly, and the use of the traditional GF constant threshold will cause serious cycle-slip misjudgments, which makes the dynamic accuracy in high latitude areas and some mid-latitude areas uncommon, while the use of the GF adaptive threshold can alleviate this phenomenon and improve the positioning accuracy in the high-latitude regions and some of the affected mid-latitude areas during the magnetic storms. [ABSTRACT FROM AUTHOR]

Differential code bias (DCB) of satellite is an error that cannot be ignored in precise positioning, timing, ionospheric modeling, satellite clock correction, and ambiguity resolution. The completion of the third generation of BeiDou Navigation Satellite System (BDS-3) has extended DCB to multichannel code bias observations and observable-specific signal bias (OSB). In this paper, the DCB and OSB products provided by the Chinese Academy of Sciences (CAS) are analyzed and compared. The DCB parameters for the BDS satellites are applied in both single- and dual-frequency single point positioning (SPP), and the results are intensively investigated. Based on the satellite DCB parameters of the BDS, the performance of precise point positioning (PPP) with different frequency combinations is also analyzed in terms of positioning accuracy and convergence time. The standard deviations (STDs) of DCBs at each signal pair fluctuate from 0.2 ns to 1.5 ns. The DCBs of BDS-2 are slightly more stable than those of BDS-3. The mean values and STDs of C2I and C7I OSBs for BDS-2 are at the same level and are numerically smaller than their counterparts for the C6I OSBs. The mean OSBs for each signal of the BDS-3, excluding C2I, fluctuate between 12.35 ns and 12.94 ns, and the STD fluctuates between 2.11 ns and 3.10 ns. The DCBs and OSBs of the BDS-3 of the IGSO satellites are more stable than those of the MEO satellites. The corrections for TGD and DCB are able to improve the accuracy of single-frequency SPP by 44.09% and 44.07%, respectively, and improve the accuracy of dual-frequency SPP by 6.44% and 12.85%, respectively. The most significant improvements from DCB correction are seen in single-frequency positioning with B1I and dual-frequency positioning with B2a+B3I. DCB correction can improve the horizontal and three-dimensional positioning accuracy of the dual-frequency PPP of different ionosphere-free combinations by 13.53% and 13.84% on average, respectively, although the convergence is slowed. [ABSTRACT FROM AUTHOR]

Summary: Background: Liver fibrosis is the strongest histological risk factor for liver‐related complications and mortality in metabolic dysfunction‐associated fatty liver disease (MAFLD). Second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) is a powerful tool for label‐free two‐dimensional and three‐dimensional tissue visualisation that shows promise in liver fibrosis assessment. Aim: To investigate combining multi‐photon microscopy (MPM) and deep learning techniques to develop and validate a new automated quantitative histological classification tool, named AutoFibroNet (Automated Liver Fibrosis Grading Network), for accurately staging liver fibrosis in MAFLD. Methods: AutoFibroNet was developed in a training cohort that consisted of 203 Chinese adults with biopsy‐confirmed MAFLD. Three deep learning models (VGG16, ResNet34, and MobileNet V3) were used to train pre‐processed images and test data sets. Multi‐layer perceptrons were used to fuse data (deep learning features, clinical features, and manual features) to build a joint model. This model was then validated in two further independent cohorts. Results: AutoFibroNet showed good discrimination in the training set. For F0, F1, F2 and F3‐4 fibrosis stages, the area under the receiver operating characteristic curves (AUROC) of AutoFibroNet were 1.00, 0.99, 0.98 and 0.98. The AUROCs of F0, F1, F2 and F3‐4 fibrosis stages for AutoFibroNet in the two validation cohorts were 0.99, 0.83, 0.80 and 0.90 and 1.00, 0.83, 0.80 and 0.94, respectively, showing a good discriminatory ability in different cohorts. Conclusion: AutoFibroNet is an automated quantitative tool that accurately identifies histological stages of liver fibrosis in Chinese individuals with MAFLD. [ABSTRACT FROM AUTHOR]

This study presents auxiliary support techniques for tree selection strategies based on the spatial structure indices and three competition indices in secondary forests, and discusses the importance of tree competition in forest management. The spatial structure parameter in the structured management is used as a quantitative index—the uniform angle index and three competition indices are used in the design of the algorithm for selective thinning for secondary forest. Based on the target tree-based management principles, simulation of selective thinning was carried out using GIS and C# programming languages. Data for this study were collected from experimental sample plots at Jilin Wangqing Forestry Bureau in China. The simulation results strongly support the use of auxiliary technology for scientifically selecting trees for thinning, avoiding the subjectivity of the traditional manual selection. Selection is largely based on the uniform angle index and competition index. Hegyi's competition index and its improved version used in the algorithm provided almost identical simulation results, i.e., thinning intensities suggested by these indices for the first sample plot are 21.8% and 21.5%, respectively, and for the second plot are 21.3% and 21.1%, respectively. Thus, one of these competition indices can be used to select trees for thinning. The comprehensive competition index (CCI, a combination of an improved version of Hegyi's competition index with tree species mingling) can avoid the selection of individual trees with high mingling and help maintain the tree species diversity. CCI suggests thinning intensities of 18.3% and 18.4% for the first and second sample plots, respectively. Presented methods and results may provide auxiliary supports for scientific thinning and help promote the application of information technology in forest management. [ABSTRACT FROM AUTHOR]

Tropospheric delay (TD) parameter estimation is a critical issue underlying high-precision data processing for global navigation satellite systems (GNSSs). The most widely used TD parameter estimation methods are the random walk (RW) and piece-wise constant (PWC). The RW method can effectively track rapid variations of tropospheric delay, but it may introduce excessive noise. In contrast, the PWC method introduces less noise, but it is less adaptable to cases of large variations of tropospheric delay. To address the problem of how to choose the optimal TD parameter estimation method, this paper investigates the variation patterns of international GNSS service zenith tropospheric delay (IGS ZTD) products and proposes a combined strategy model for TD parameter estimation. Firstly, this paper avoids the day-boundary jumps problem of IGS ZTD products by grouping based on single-day data. Secondly, this paper introduces discrete point areas (DPAs) to measure the magnitude of the ZTD values and uses comprehensive indicators to reflect the variation of ZTD. Next, based on the Köppen-Geiger climate classification, this study selected five different climate classifications with a total of 20 IGS stations as experimental data. The data assessed span from day of year (DOY) 001 to DOY 365 in 2022. This paper then applied 26 different parameter estimation strategies for static precise point positioning (PPP) data processing, and the parameter estimation strategies that were used include the RW and PWC (with the piece-wise constant ranging from twenty minutes to five hundred minutes at twenty-minute intervals). Finally, ZTD and positioning results were obtained using various parameter estimation methods, and a combined strategy model was established. We selected five different climate classifications of IGS stations as validation data and designed three sets of comparative experiments: RW, PWC120, and the combined strategy model, to verify the effectiveness of the combined strategy model. The experimental results revealed that: RW and the combined strategy model have a comparable ZTD accuracy and both are superior to PWC120. The combined strategy model improves the positioning accuracy in the U direction compared to RW and PWC120. In arid (B) and polar (E) regions with a small variation of TD, the PWC120 strategy displayed a better positioning accuracy than the RW strategy; in equatorial (A) and warm-temperate (C) regions, where there are large variations of TD, the RW strategy exhibited a better positioning accuracy than the PWC120 strategy. The combined strategy model can flexibly select the optimal parameter estimation method according to the comprehensive indicator while ensuring ZTD estimation accuracy; it enhances positioning accuracy. [ABSTRACT FROM AUTHOR]

Background: Rowell syndrome (RS) is an uncommon condition characterized by erythema multiforme (EM)‐like lesions and lupus erythematosus. It is more common in females, and EM may be the first manifestation of the disease with positive autoantibodies, such as antinuclear antibody (ANA), SSA, SSB and rheumatoid factor. The pathogenesis of RS is unknown and is likely caused by drug induction, ultraviolet exposure and infection. Method: We describe a case of RS from China which presented as characteristic targetoid‐like lesions and chilblain‐like erythema on hands and feet. This is a case of RS in a female patient from the inpatient department of dermatology. Results: A 41‐year‐old female with systemic lupus erythematosus exhibited chilblain‐like erythema and characteristic EM lesions on her extremities. She tested positive for serum ANA (1:320) and anti‐double‐stranded DNA, as well as other autoantibodies. Systemic glucocorticoids and hydroxychloroquine worked effectively for her. Conclusion: The present case met diagnostic criteria of RS. Notably, there was a co‑occurrence of facial butterfly erythema, chilblain‐like erythema and EM lesions distributed on the limbs in this case. [ABSTRACT FROM AUTHOR]

The meiotic entry of undifferentiated germ cells is sexually specific and strictly regulated by the testicular or ovarian environment. Germline stem cells with a set of abnormal sex chromosomes and associated autosomes undergo defective meiotic processes and are eventually eliminated by yet to be defined post‐transcriptional modifications. Herein, we report the role of gsdf, a member of BMP/TGFβ family uniquely found in teleost, in the regulation of meiotic entry in medaka (Oryzias latipes) via analyses of gametogenesis in gsdf‐deficient XX and XY gonads in comparison with their wild‐type siblings. Several differentially expressed genes, including the FKB506‐binding protein 7 (fkbp7), were significantly upregulated in pubertal gsdf‐deficient gonads. The increase in alternative pre‐mRNA isoforms of meiotic synaptonemal complex gene sycp3 was visualized using Integrative Genomics Viewer and confirmed by real‐time qPCR. Nevertheless, immunofluorescence analysis showed that Sycp3 protein products reduced significantly in gsdf‐deficient XY oocytes. Transmission electron microscope observations showed that normal synchronous cysts were replaced by asynchronous cysts in gsdf‐deficient testis. Breeding experiments showed that the sex ratio deviation of gsdf−/− XY gametes in a non‐Mendelian manner might be due to the non‐segregation of XY chromosomes. Taken together, our results suggest that gsdf plays a role in the proper execution of cytoplasmic and nuclear events through receptor Smad phosphorylation and Sycp3 dephosphorylation to coordinate medaka gametogenesis, including sex‐specific mitotic divisions and meiotic recombination. [ABSTRACT FROM AUTHOR]

The objects in remote sensing images are normally densely packed, arbitrarily oriented, and surrounded by complex backgrounds. Great efforts have been devoted to developing oriented object detection models to accommodate such data characteristics. We argue that an effective detection model hinges on three aspects: feature enhancement, feature decoupling for classification and localization, and an appropriate bounding box regression scheme. In this article, we instantiate the three aspects on top of the classical Faster R-CNN, with three novel components proposed. First, we propose a weighted fusion and refinement (WFR) module, which adaptively weighs multi-level features and leverages the attention mechanism to refine the fused features. Second, we decouple the RoI (region of interest) features for the subsequent classification and localization via a lightweight affine transformation-based feature decoupling (ATFD) module. Third, we propose a post-classification regression (PCR) module for generating the desired quadrilateral bounding boxes. Specifically, PCR predicts the precise vertex location on each side of a predicted horizontal box, by simply learning the following: (i) classify the discretized regression range of the vertex, and (ii) revise the vertex location with an offset. We conduct extensive experiments on the DOTA, DIOR-R, and HRSC2016 datasets to evaluate our method. [ABSTRACT FROM AUTHOR]

Precise point positioning (PPP) can measure ground motions with a centimetre-level accuracy using only one receiver. It has been widely used in earthquake monitoring and earthquake early warning (EEW) systems. However, traditional PPP highly depends on well-established and robust internet infrastructure for data communication. Along with the broadcast ephemeris, the orbit and clock corrections transmitted by the B2b signals of BeiDou Navigation Satellite System (BDS) can be used to recover the precise products of GPS and BDS. Since the B2b products, namely the satellite state parameter messages, are accessible even without internet infrastructure, PPP with B2b signals is more suitable for real-time applications. This study witnesses the application of PPP with B2b products in seismic monitoring for the first time. The shake table experiments demonstrate that PPP with B2b can reach a millimetre-level accuracy in horizontal in earthquake monitoring for GPS-only, BDS-only and GPS/BDS combination. The application to the 2021 M w 7.4 Maduo earthquake shows that the accuracies of seismic displacements derived from GPS-only PPP with B2b products are 1.7, 2.4 and 1.7 cm in east, north and vertical components, compared with those from GPS-only PPP with final precise products. We therefore conclude that PPP with B2b products has a promising prospect in seismogeodesy and related applications such as EEW and rapid hazard response. [ABSTRACT FROM AUTHOR]

Differential evolution (DE) is a very effective stochastic optimization algorithm based on population for solving various real-world problems. The quality of solutions to these problems is mainly determined by the combination of mutation strategies and their parameters in DE. However, in the process of solving these problems, the population diversity and local search ability will gradually deteriorate. Therefore, we propose a multi-population differential evolution (MUDE) algorithm with a uniform local search to balance exploitation and exploration. With MUDE, the population is divided into multiple subpopulations with different population sizes, which perform different mutation strategies according to the evolution ratio, i.e., DE/rand/1, DE/current-to-rand/1, and DE/current-to-pbest/1. To improve the diversity of the population, the information is migrated between subpopulations by the soft-island model. Furthermore, the local search ability is improved by way of the uniform local search. As a result, the proposed MUDE maintains exploitation and exploration capabilities throughout the process. MUDE is extensively evaluated on 25 functions of the CEC 2005 benchmark. The comparison results show that the MUDE algorithm is very competitive with other DE variants and optimization algorithms in generating efficient solutions. [ABSTRACT FROM AUTHOR]

Collagen in the tumor microenvironment is recognized as a potential biomarker for predicting treatment response. This study investigated whether the collagen features are associated with pathological complete response (pCR) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) and develop and validate a prediction model for individualized prediction of pCR. The prediction model was developed in a primary cohort (353 consecutive patients). In total, 142 collagen features were extracted from the multiphoton image of pretreatment biopsy, and the least absolute shrinkage and selection operator (Lasso) regression was applied for feature selection and collagen signature building. A nomogram was developed using multivariable analysis. The performance of the nomogram was assessed with respect to its discrimination, calibration, and clinical utility. An independent cohort (163 consecutive patients) was used to validate the model. The collagen signature comprised four collagen features significantly associated with pCR both in the primary and validation cohorts (p < 0.001). Predictors in the individualized prediction nomogram included the collagen signature and clinicopathological predictors. The nomogram showed good discrimination with area under the ROC curve (AUC) of 0.891 in the primary cohort and good calibration. Application of the nomogram in the validation cohort still gave good discrimination (AUC = 0.908) and good calibration. Decision curve analysis demonstrated that the nomogram was clinically useful. In conclusion, the collagen signature in the tumor microenvironment of pretreatment biopsy is significantly associated with pCR. The nomogram based on the collagen signature and clinicopathological predictors could be used for individualized prediction of pCR in LARC patients before nCRT. [ABSTRACT FROM AUTHOR]

Deep learning has substantially pushed forward remote sensing image change detection through extracting discriminative hierarchical features. However, as the increasingly high-resolution remote sensing images have abundant spatial details but limited spectral information, the use of conventional backbone networks would give rise to blurry boundaries between different semantics among hierarchical features. This explains why most false alarms in the final predictions distribute around change boundaries. To alleviate the problem, we pay attention to feature refinement and propose deep learning networks that deliver improved separability (ISNet). Our ISNet reaps the advantages from two strategies applied to refining bitemporal feature hierarchies: 1) margin maximization that clarifies the gap between changed and unchanged semantics and 2) targeted arrangement of attention mechanisms that direct the use of channel attention (CA) and spatial attention (SA) for highlighting semantic and positional information, respectively. Specifically, we insert CA modules into share-weighted backbone networks to facilitate semantic-specific feature extraction. The semantic boundaries in the extracted bitemporal hierarchical features are then clarified by margin maximization modules, followed by SA modules to enhance positional change responses. A top–down fusion pathway makes the final refined features cover multiscale representations and have strong separability for remote sensing image change detection. Extensive experimental evaluations demonstrate that our ISNet achieves state-of-the-art performance on the LEVIR-CD, SYSU-CD, and Season-Varying datasets in terms of overall accuracy (OA), Intersection-of-Union (IoU), and F1 score. Code is available at https://github.com/xingronaldo/ISNet. [ABSTRACT FROM AUTHOR]

When using remote sensing and geogrphaic information systems, accurately scaling-up spatial data of a variable and their uncertainties from a finer to a coarser spatial resolution is widely required in mapping and managing natural resources and ecological and environmental systems. In this study, four up-scaling methods were derived based on simple and ordinary cokriging estimators and a sequential Gaussian cosimulation algorithm for points and blocks. Taking spatial variability of variables into account in the up-scaling process made it possible to simultaneously and accurately obtain estimates and estimation variances of larger blocks from sample and image data of smaller supports. With the aid of Thematic Mapper imagery, these methods were compared in a case study where overall vegetation and tree covers were scaled up from a spatial resolution of 30 x 30 [m.sup.2] to 90 x 90 [m.sup.2] with a stratification method at 90 x 90 [m.sup.2]. The results showed that the methods Point simple coKriging_Point co-Simulation scaling UP (PsK_PSUP) and PsK_Block co-Simulation (PsK_BS) led to smaller errors and better reproduced spatial distribution and variability of the variables than the other methods. Choosing PsK_PSUP or PsK_BS depends on the users' emphasis on accuracy of estimates and variances, computational time, etc. The methods can be applied to multiple continuous variables that have any distribution. It is also expected that the general idea behind the methods can be expanded to scaling-up spatial data for categorical variables. Index Terms--Geostatistics, remotely sensed data, scaling-up, spatial variability, uncertainty, vegetation cover mapping.

Accurately mapping change in vegetation cover is difficult due to the need for permanent plots to collect field data of the change; errors from georeference, coregistration, and data analysis; a small coefficient of correlation between remote sensing and field data; and limitations of existing methods. In this study, four cosimulation procedures, two collocated cokriging procedures, and two regression procedures were compared. The results showed that with the same cosimulation or collocated cokriging methods, two postestimation procedures led to more accurate estimates than the corresponding two preestimation procedures. Among three postestimation procedures with the same image data, cosimulation resulted in the most accurate estimates and reliable variances, then regression modeling and collocated cokriging. Thus, cosimulation algorithms can be recommended for this purpose. Moreover, the accuracy by a joint cosimulation procedure of 1989 and 1992 vegetation cover was similar to that by a separate cosimulation procedure; however, the joint cosimulation overestimated the average change. In addition, adding more Thematic Mapper images increased the accuracy of mapping for the cosimulation procedures, and the increase was slight for the regression procedures. Index Terms--Geostatistics, Landsat Thematic Mapper (TM) imagery, mapping, vegetation cover change.

Background: Alopecia has become an exceedingly prevalent dermatological disorder. Etiologically, infection (bacterial and fungal infection), inflammation, and immune dysregulation are the main causes of immune-mediated hair loss. Treating hair loss has remained challenging as the available therapies are limited. Exosomes from adipose-derived stem cells (ADSC-Exos) have been used for treating neurodegenerative diseases and autoimmune diseases and in wound-healing treatments. However, the function and mechanism of ADSC-Exos in alopecia treatment remain unclear. This study is aimed at investigating the effects of ADSC-Exos on hair growth in vitro and in vivo for potentially treating immune-mediated alopecia and further exploring the underlying mechanism.Methods: Cell proliferation, migration, and apoptosis of dermal papilla cells (DPCs) that were treated with ADSC-Exos were detected using the cell counting kit-8 (CCK-8) assay, scratch wound-healing assay, and flow cytometry assay, respectively. A C57BL/6 hair-depilated mouse model was established in vivo; then, ADSC-Exos were subcutaneously injected alone or in combined with minoxidil. The effects of ADSC-Exos on hair growth, pathological changes, and the related mechanism were investigated by HE staining, quantitative real-time PCR (qRT-PCR), western blotting, and RNA sequencing (RNA-seq).Results: ADSC-Exos significantly promoted DPC proliferation and migration while also reducing apoptosis. In addition, compared with the control group, ADSC-Exos-treated mice had better hair growth, more hair follicles (HFs) and thicker dermis. RNA-seq revealed that the miR-22 and TNF-α signaling pathways were markedly downregulated in DPCs after ADSC-Exos treatment. In addition, according to qRT-PCR and western blotting results, the Wnt/β-catenin signaling pathway was activated in the skin of ADSC-Exos-treated mice.Conclusion: ADSC-Exos therapy positively affected the promotion of hair regrowth by regulating miR-22, the Wnt/β-catenin signaling pathway, and the TNF-α signaling pathway, implying that ADSC-Exos could be a promising cell-free therapeutic strategy for immune-mediated alopecia. [ABSTRACT FROM AUTHOR]

Objective: The primary aim was to assess associations between total steps per day and incident diabetes, whereas the secondary aim was to assess whether the intensity and/or cadence of steps is associated with incident diabetes.Research Design and Methods: Women without physician-diagnosed diabetes (n = 4,838; mean [SD] age 78.9 [6.7] years) were followed up to 6.9 years; 395 developed diabetes. Hip-worn ActiGraph GT3X+ accelerometers worn for 1 week enabled measures of total, light-intensity, and moderate- to vigorous-intensity (MV-intensity) steps per day. Using Cox proportional hazards analysis we modeled adjusted change in the hazard rate for incident diabetes associated with total, light-intensity, and MV-intensity steps per day. We further estimated the proportion of the steps-diabetes association mediated by BMI.Results: On average, participants took 3,729 (SD 2,114) steps/day, of which 1,875 (791) were light-intensity steps and 1,854 ± 1,762 were MV-intensity. More steps per day were associated with a lower hazard rate for incident diabetes. Confounder-adjusted models for a 2,000 steps/day increment yielded hazard ratio (HR) 0.88 (95% CI 0.78-1.00; P = 0.046). After further adjustment for BMI, HR was 0.90 (95% CI 0.80-1.02; P = 0.11). BMI did not significantly mediate the steps-diabetes association (proportion mediated = 17.7% [95% CI -55.0 to 142.0]; P = 0.09]). The relationship between MV-intensity steps per day (HR 0.86 [95% CI 0.74-1.00]; P = 0.04) and incident diabetes was stronger than for light-intensity steps per day (HR 0.97 [95% CI 0.73-1.29]; P = 0.84).Conclusions: These findings suggest that for older adults, more steps per day are associated with lower incident diabetes and MV-intensity steps are most strongly associated with a lower hazard of diabetes. This evidence supports that regular stepping is an important risk factor for type 2 diabetes prevention in older adults. [ABSTRACT FROM AUTHOR]

Tumor angiogenesis is a complex process that is unamenable to intravital whole‐process monitoring, especially on microscopic assessment of tumor microvessel and quantifying microvascular hemodynamics before and after the nanotherapeutics, which hinder the understanding of nanotheranostics outcomes in tumor treatment. Herein, a new photoacoustic (PA) imaging‐optical coherence tomography angiography (OCTA)‐laser speckle (LS) multimodal imaging strategy is first proposed, which is not only able to precisely macro guide the thermo‐chemotherapy of tumor by monitoring blood oxygen saturation (SaO2) and hemoglobin content (HbT), but also capable of long‐term microscopic investigating the microvessel morphology (microvascular density) and hemodynamics changes (relative blood flow) before and after the nanotherapeutics in vivo. Moreover, to realize the tumor thermo‐chemotherapy treatment based on this novel multimodal imaging strategy, a 2D 5‐fluorouracil silicon nanosheets (5‐Fu‐Si NSs) therapeutic agent is designed. Furthermore, 2D high‐resolution tumor microvascular images in different stage display that tendency of the thermo‐chemotherapy effect is closely associated with tumor angiogenesis. Taken together, the investigations establish the fundamental base in theory and technology for further tailoring the novel specific diagnosis and treatment strategy in tumor. More importantly, this technique will be beneficial to evaluate the tumor microvascular response to nanotherapeutics at microscale. [ABSTRACT FROM AUTHOR]

Forest canopy cover (CC) directly and indirectly influences various processes of forest ecosystems. Airborne light detection and ranging (LiDAR) can be used to characterize forest spatial structures and further obtain estimates of forest CC. However, nonreturn laser pulses from targets of interest impact the estimation accuracy of forest CC. The objective of this article was to develop a novel method of estimating the nonreturn laser pulses to improve the estimation accuracy of forest CC using LiDAR data. The improved models for estimating forest CC were developed by introducing the loss ratio of laser pulses and a CC coefficient into the original models. The forest CC reference data were collected and used to validate the forest CC estimates. The results show that the loss ratio for forested areas was much higher than that for open ground areas. The range between the sensor and a target was a crucial factor that caused the loss of returns. The relationship between the range and the loss ratio was nonlinear in both open ground and forested areas. Compared with the original models, the improved models combining the loss ratio and the CC coefficient statistically significantly increased the estimation accuracy of the forest CC. Moreover, the forest CC estimates from the canopy height model (CHM) were more accurate than those from the height normalized point cloud (NPC) data. In addition, the simplified models were more generalized than the other models. This article is novel and has great potential to improve mapping of forest CC. [ABSTRACT FROM AUTHOR]