19 results on '"Zhou, Te"'
Search Results
2. Insulator fouling assessment model based on RBF neural network
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Liu, Bingcai, Pei, Huikun, Fu, Jiaqing, Wang, Zhenhua, Fang, Zhiwen, and Zhou, Te
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- 2022
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3. Research on flexible smart home appliance load participating in demand side response based on power direct control technology
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Zhang, Linghao, Tang, Yong, Zhou, Te, Tang, Chao, Liang, Huihui, and Zhang, Jie
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- 2022
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4. Capacity Configuration and Coordinated Operation of a Hybrid Wind Farm With FSIG-Based and PMSG-Based Wind Farms During Grid Faults.
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Yao, Jun, Guo, Lisha, Zhou, Te, Xu, Depeng, and Liu, Ruikuo
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WIND power plants ,INDUCTION generators ,ELECTRIC power system faults - Abstract
This paper mainly proposes a capacity configuration strategy for a hybrid wind farm with fixed-speed induction generator (FSIG)-based and permanent magnet synchronous generator (PMSG)-based wind farms during grid faults. In this paper, FSIG-based wind farm realizes low voltage ride through (LVRT) with the associated control of nearby PMSG systems as StatComs to provide the required reactive power. By establishing the mathematical model of hybrid wind farm containing network parameters, the operation characteristics of the FSIG-based wind farm during grid faults are analyzed in detail. Based on the characteristics and the critical clearing time of FSIG-based wind farm, a novel capacity configuration method for the hybrid wind farm is proposed to calculate the required reactive power of FSIG-based wind farm for a LVRT operation. Based on the capacity configuration result, the minimum installed capacity of PMSG-based wind farm could be determined. Taking into account the impact of reactive power compensation capacity and grid transmission line parameters, the coordinated LVRT capability of the hybrid wind farm is then analyzed. Finally, simulation and experimental results demonstrate the effectiveness of the proposed capacity configuration method and the coordinated operation performance of the hybrid wind farm respectively. [ABSTRACT FROM PUBLISHER]
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- 2017
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5. Editorial: Regulation of inflammation and metabolism in retinal neurodegenerative disorders.
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Leinonen H, Zhou TE, Ballios BG, Kauppinen A, and Fu Z
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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- 2022
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6. Overview of the Canadian Clinician Investigator Trainees' research presented at the 2019 CSCI-CITAC Joint Meeting.
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Castanov V, Zhou TE, Balestrini CS, Lefebvre C, Cook EK, Whittaker HT, Macklin J, Briard JN, Lazarte J, Trinder M, Ware MA, Hu S, Pietrobon A, Marvasti TB, and Sivakami
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- Alberta, Canada, Child, Humans, Societies, Medical, Universities, Biomedical Research, Research Personnel
- Abstract
The 2019 Annual General Meeting and Young Investigators' Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherche Clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada / Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was held in Banff, Alberta on November 8-10th, 2019. The theme was "Positioning Early Career Investigators for Success: Strategy and Resilience". Lectures and workshops provided knowledge and tools to facilitate the attendees' development as clinician investigators. Dr. Jason Berman (President of CSCI/SCRC), Elina Cook (President of CITAC/ACCFC) and Drs. Doreen Rabi and Zelma Kiss (University of Calgary Organizing Co-Chairs) gave opening presentations. The keynote speakers were Dr. William Foulkes (McGill University) (Distinguished Scientist Award winner) and Dr. Andrés Finzi (Université de Montréal) (Joe Doupe Young Investigator Award winner). Dr. Robert Bortolussi (Dalhousie University) received the Distinguished Service Award for his work as the Editor-in-Chief of Clinical and Investigative Medicine and for being instrumental in the development of the Canadian Child Health Clinician Scientist Program. This meeting was the first to host a panel discussion with Drs. Stephen Robbins and Marcello Tonelli from the Canadian Institutes of Health Research. Workshops on communication, career planning and work-life balance were hosted by André Picard and Drs. Todd Anderson, Karen Tang, William Ghali, May Lynn Quan, Alicia Polachek and Shannon Ruzycki. The AGM showcased 90 presentations from clinician investigator trainees from across Canada. Most of the abstracts are summarized in this review. Eight outstanding abstracts were selected for oral presentation at the President's Forum.
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- 2020
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7. Novel Anti-Interleukin-1β Therapy Preserves Retinal Integrity: A Longitudinal Investigation Using OCT Imaging and Automated Retinal Segmentation in Small Rodents.
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Sayah DN, Zhou TE, Omri S, Mazzaferri J, Quiniou C, Wirth M, Côté F, Dabouz R, Desjarlais M, Costantino S, and Chemtob S
- Abstract
Retinopathy of prematurity (ROP) is the leading cause of blindness in neonates. Inflammation, in particular interleukin-1β (IL-1β), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxygen-induced retinopathy (OIR) model of ROP. A small peptide antagonist of IL-1 receptor, composed of the amino acid sequence, rytvela, has been shown to exert beneficial anti-inflammatory effects without compromising immunovigilance-related NF-κB in reproductive tissues. We conducted a longitudinal study to determine the efficacy of "rytvela" in preserving the integrity of the retina in OIR model, using optical coherence tomography (OCT) which provides high-resolution cross-sectional imaging of ocular structures in vivo . Sprague-Dawley rats subjected to OIR and treated or not with "rytvela" were compared to IL-1 receptor antagonist (Kineret). OCT imaging and custom automated segmentation algorithm used to measure retinal thickness (RT) were obtained at P14 and P30; gold-standard immunohistochemistry (IHC) was used to confirm retinal anatomical changes. OCT revealed significant retinal thinning in untreated animals by P30, confirmed by IHC; these changes were coherently associated with increased apoptosis. Both rytvela and Kineret subsided apoptosis and preserved RT. As anticipated, Kineret diminished both SAPK/JNK and NF-κB axes, whereas rytvela selectively abated the former which resulted in preserved monocyte phagocytic function. Altogether, OCT imaging with automated segmentation is a reliable non-invasive approach to study longitudinally retinal pathology in small animal models of retinopathy., (Copyright © 2020 Sayah, Zhou, Omri, Mazzaferri, Quiniou, Wirth, Côté, Dabouz, Desjarlais, Costantino and Chemtob.)
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- 2020
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8. The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.
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Zhou TE, Zhu T, Rivera JC, Omri S, Tahiri H, Lahaie I, Rouget R, Wirth M, Nattel S, Lodygensky G, Ferbeyre G, Nezhady M, Desjarlais M, Hamel P, and Chemtob S
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- Animals, Animals, Newborn, Cells, Cultured, Choroid metabolism, Choroid pathology, Disease Models, Animal, Down-Regulation drug effects, Down-Regulation genetics, HEK293 Cells, Humans, Neovascularization, Physiologic genetics, Oxygen pharmacology, Rats, Rats, Long-Evans, Retinal Pigment Epithelium metabolism, Retinal Pigment Epithelium pathology, Retinopathy of Prematurity physiopathology, Signal Transduction drug effects, Signal Transduction genetics, Choroid blood supply, Choroid drug effects, MicroRNAs physiology, Neovascularization, Physiologic drug effects, Oxygen adverse effects, Retinopathy of Prematurity genetics, Retinopathy of Prematurity pathology, Tumor Suppressor Protein p53 physiology
- Abstract
Retinopathy of prematurity (ROP) is characterized by an initial retinal avascularization, followed by pathologic neovascularization. Recently, choroidal thinning has also been detected in children formerly diagnosed with ROP; a similar sustained choroidal thinning is observed in ROP models. But the mechanism underlying the lack of choroidal revascularization remains unclear and was investigated in an oxygen-induced retinopathy (OIR) model. In OIR, evidence of senescence was detected, preceded by oxidative stress in the choroid and the retinal pigment epithelium. This was associated with a global reduction of proangiogenic factors, including insulin-like growth factor 1 receptor (Igf1R). Coincidentally, tumor suppressor p53 was highly expressed in the OIR retinae. Curtailing p53 activity resulted in reversal of senescence, normalization of Igf1r expression, and preservation of choroidal integrity. OIR-induced down-regulation of Igf1r was mediated at least partly by miR-let-7b as i) let-7b expression was augmented throughout and beyond the period of oxygen exposure, ii) let-7b directly targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, and elicited choroidal revascularization. Finally, restoration of Igf1r expression rescued choroid thickness. Altogether, this study uncovers a significant mechanism for defective choroidal revascularization in OIR, revealing a new role for p53/let-7b/IGF-1R axis in the retina. Future investigations on this (and connected) pathway could further our understanding of other degenerative choroidopathies, such as geographic atrophy., (Copyright © 2019 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
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- 2019
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9. Newsletter Spring 2018: Clinician Investigator Trainee Association of Canada (CITAC).
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Zhou TE, Zaslavsky K, Barton K, Abraham KJ, and Bortolussi R
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- Canada, Humans, Biomedical Research education, Education, Professional, Societies, Medical, Societies, Scientific
- Abstract
A decade of CITAC Annual General Meetings: 2007-2017 In 2007, the Clinician Investigator Trainee Association of Canada (CITAC) launched its inaugural Annual General Meeting (AGM). The AGM has since become a major annual event, jointly organized by CITAC and leaders from the Canadian Society for Clinical Investigation (CSCI), and continues to provide a forum for clinician investigator (CI) trainees to exchange ideas, advance career prospects and engage with the broader community. Indeed, since its inception, all Canadian institutions with medical doctor and clinician investigator (MD+CI) training programs have participated in the AGM, while more than 1,000 trainees have registered as CITAC members. The 10th CITAC-CSCI AGM was recently held in Toronto (November 20-22, 2017). There were nearly 200 attendees, including CI trainees, faculty member and physician leaders from across Canada (Figure 1A, 1B). Trainees spanning diverse career stages had opportunities to participate in interactive poster sessions, workshops and lectures by leading physician-scientists. These exercises were designed to encourage and enhance networking, career development and mentorship for prospective physician-scientists.
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- 2018
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10. Scientific Overview on CSCI-CITAC Annual General Meeting and 2016 Young Investigators' Forum.
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Zhou TE, Barton KI, Cook E, Benesch MGK, Jette N, Moderie C, Ondrusova K, Lees C, Steadman PE, Marvasti TB, Mirali S, Liu PJ, Babadagli EM, Abraham KJ, and Zaslavsky KJ
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- Canada, Humans, Biomedical Research, Congresses as Topic, Societies, Medical, Societies, Scientific
- Abstract
The 2016 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national conference held in Toronto November 21-23, 2016, in conjunction with The University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "Mapping Your Career as a Clinician-Scientist"; emphasizing essential skills for developing a fruitful career as clinician-scientist. The meeting featured an opening presentation by Dr. Alan Underhill, Dr. Nicola Jones and Alexandra Kuzyk. The keynote speakers were Dr. Nada Jabado (McGill University), who discussed the association between cancer and histones, Dr. Norman Rosenblum (University of Toronto), who addressed the career path and the "calling" of the Clinician Scientist, Dr. Martin Schmeing (McGill University), who was the 2016 Joe Doupe Award recipient, and Dr. Linda Rabeneck (Cancer Care Ontario and University of Toronto), who received the Friends of CIHR lectureship. The workshops, focusing on career development for clinician scientists, were hosted by Drs. Alan Underhill, Nicola Jones, Lynn Raymond, Michael Schlossmacher and Norman Rosenblum, as well as University of Toronto communication specialists, Caitlin Johannesson and Suzanne Gold. In addition, the Young Investigators' Forum included presentations from clinician investigator trainees from across the country. The research topics were diverse and comprehensive: from basic sciences to clinical practice; from epidemiology to medical engineering. All scientific abstracts are summarized in this review. Over 70 abstracts were showcased at this year's meeting during two poster sessions, with six outstanding abstracts selected for oral presentations during the President's Forum.
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- 2017
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11. Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies.
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Rivera JC, Holm M, Austeng D, Morken TS, Zhou TE, Beaudry-Richard A, Sierra EM, Dammann O, and Chemtob S
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- Animals, Choroid Diseases pathology, Choroid Diseases therapy, Humans, Laser Therapy trends, Nerve Degeneration pathology, Nerve Degeneration therapy, Retinal Pigment Epithelium metabolism, Retinal Pigment Epithelium pathology, Retinopathy of Prematurity pathology, Retinopathy of Prematurity therapy, Visual Acuity physiology, Choroid Diseases metabolism, Inflammation Mediators metabolism, Nerve Degeneration metabolism, Retinopathy of Prematurity metabolism
- Abstract
Retinopathy of prematurity (ROP) is an important cause of childhood blindness globally, and the incidence is rising. The disease is characterized by initial arrested retinal vascularization followed by neovascularization and ensuing retinal detachment causing permanent visual loss. Although neovascularization can be effectively treated via retinal laser ablation, it is unknown which children are at risk of entering this vision-threatening phase of the disease. Laser ablation may itself induce visual field deficits, and there is therefore a need to identify targets for novel and less destructive treatments of ROP. Inflammation is considered a key contributor to the pathogenesis of ROP. A large proportion of preterm infants with ROP will have residual visual loss linked to loss of photoreceptor (PR) and the integrity of the retinal pigment epithelium (RPE) in the macular region. Recent studies using animal models of ROP suggest that choroidal degeneration may be associated with a loss of integrity of the outer retina, a phenomenon so far largely undescribed in ROP pathogenesis. In this review, we highlight inflammatory and neuron-derived factors related to ROP progression, as well, potential targets for new treatment strategies. We also introduce choroidal degeneration as a significant cause of residual visual loss following ROP. We propose that ROP should no longer be considered an inner retinal vasculopathy only, but also a disease of choroidal degeneration affecting both retinal pigment epithelium and photoreceptor integrity.
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- 2017
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12. Training the next generation of Canadian Clinician-Scientists: charting a path to success.
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Yin C, Steadman PE, Apramian T, Zhou TE, Ishaque A, Wang X, Kuzyk A, and Warsi N
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- Biomedical Research economics, Canada, Education, Medical economics, Education, Medical organization & administration, Humans, Mentors statistics & numerical data, Training Support economics, Biomedical Research organization & administration, Training Support organization & administration
- Abstract
Clinician-scientists are physicians with training in both clinical medicine and research that enables them to occupy a unique niche as specialists in basic and translational biomedical research. While there is widespread acknowledgement of the importance of clinician-scientists in today's landscape of evidence-based medical practice, training of clinician-scientists in Canada has been on the decline, with fewer opportunities to obtain funding. With the increasing length of training and lower financial compensation, fewer medical graduates are choosing to pursue such a career. MD-PhD programs, in which trainees receive both medical and research training, have the potential to be an important tool in training the next generation of clinician-scientists; however, MD-PhD trainees in Canada face barriers that include an increase in medical school tuition and a decrease in the amount of financial support. We examined the available data on MD-PhD training in Canada and identified a lack of oversight, a lack of funding and poor mentorship as barriers experienced by MD-PhD trainees. Specific recommendations are provided to begin the process of addressing these challenges, starting with the establishment of an overseeing national body that would track long-term outcome data for MD-PhD trainees. This national body could then function to implement best practices from individual programs across the country and to provide further mentorship and support for early-career physician-scientists. MD-PhD programs have the potential to address Canada's growing shortage of clinician-scientists, and strengthening MD-PhD programs will help to effect positive change.
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- 2017
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13. Preventing Corneal Calcification Associated With Xylazine for Longitudinal Optical Coherence Tomography in Young Rodents.
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Zhou TE, Sayah DN, Noueihed B, Mazzaferri J, Costantino S, Brunette I, and Chemtob S
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- Adrenergic alpha-2 Receptor Agonists administration & dosage, Adrenergic alpha-2 Receptor Agonists toxicity, Animals, Calcinosis pathology, Calcium metabolism, Cornea metabolism, Cornea pathology, Corneal Diseases chemically induced, Corneal Diseases pathology, Disease Models, Animal, Dose-Response Relationship, Drug, Immunohistochemistry, Mice, Microscopy, Confocal, Rats, Rats, Long-Evans, Rats, Sprague-Dawley, Xylazine administration & dosage, Calcinosis prevention & control, Cornea drug effects, Corneal Diseases prevention & control, Tomography, Optical Coherence methods, Xylazine toxicity
- Abstract
Purpose: Spectral-domain optical coherence tomography (SD-OCT) is widely used in clinical ophthalmology and recently gained popularity in laboratory research involving small rodents. Its noninvasive nature allows repeated measurements, thereby decreasing the number of animals required. However, when used at a conventional dosage, xylazine (an α2-adrenoceptor) can cause irreversible corneal calcification, especially among young rodents. In the present study, we test whether corneal calcification associated with xylazine is mediated by the α2-adrenoceptor., Methods: Our study tested Sprague-Dawley rats, Long-Evans rats, and CD-1 mice (postnatal day [P]14). Retinal images were captured by SD-OCT. Quantitative PCR (qPCR) was used to study gene expression, whereas receptor localization was examined by immunofluorescent staining followed by confocal microscopy. Calcium deposits were detected via von Kossa staining., Results: When used at dosages appropriate for adult animals, ketamine-xylazine anesthetics led to a high rate of respiratory failure, increased apoptotic activity in the corneal epithelium, and irreversible corneal calcification in P14 rat pups. Meanwhile, OCT image quality decreased drastically as a result of corneal calcification among animals recovering from anesthesia. α2-Adrenoceptor subtypes were highly expressed on P14, in line with rodents' age-specific sensitivity to xylazine. Clonidine, a potent α2-adrenoceptor agonist, dose-dependently induced corneal calcification, which could be prevented by an α2-adrenoceptor antagonist., Conclusions: These data suggest that α2-adrenoceptors contribute to corneal calcification in young rodents. Therefore, we developed a suitable OCT imaging protocol for this cohort, including a carefully tailored ketamine-xylazine dosage (60 mg/kg and 2.5 kg/mg, respectively).
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- 2017
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14. Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1β.
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Zhou TE, Rivera JC, Bhosle VK, Lahaie I, Shao Z, Tahiri H, Zhu T, Polosa A, Dorfman A, Beaudry-Richard A, Costantino S, Lodygensky GA, Lachapelle P, and Chemtob S
- Subjects
- Animals, Animals, Newborn, Choroid metabolism, Choroid physiopathology, Choroid Diseases etiology, Choroid Diseases metabolism, Disease Models, Animal, Disease Progression, Electroretinography, Endothelium metabolism, Humans, Infant, Newborn, Oxygen adverse effects, Photoreceptor Cells metabolism, Rats, Rats, Sprague-Dawley, Retina metabolism, Retina physiopathology, Retinal Pigment Epithelium metabolism, Retinal Pigment Epithelium physiopathology, Retinopathy of Prematurity chemically induced, Retinopathy of Prematurity etiology, Retinopathy of Prematurity metabolism, Choroid Diseases physiopathology, Interleukin-1beta metabolism, Retinopathy of Prematurity physiopathology
- Abstract
Retinopathy of prematurity (ROP), the most common cause of blindness in premature infants, has long been associated with inner retinal alterations. However, recent studies reveal outer retinal dysfunctions in patients formerly afflicted with ROP. We have recently demonstrated that choroidal involution occurs early in retinopathy. Herein, we investigated the mechanisms underlying the choroidal involution and its long-term impact on retinal function. An oxygen-induced retinopathy (OIR) model was used. In vitro and ex vivo assays were applied to evaluate cytotoxic effects of IL-1β on choroidal endothelium. Electroretinogram was used to evaluate visual function. We found that proinflammatory IL-1β was markedly increased in retinal pigment epithelium (RPE)/choroid and positively correlated with choroidal degeneration in the early stages of retinopathy. IL-1β was found to be cytotoxic to choroid in vitro, ex vivo, and in vivo. Long-term effects on choroidal involution included a hypoxic outer neuroretina, associated with a progressive loss of RPE and photoreceptors, and visual deterioration. Early inhibition of IL-1β receptor preserved choroid, decreased subretinal hypoxia, and prevented RPE/photoreceptor death, resulting in life-long improved visual function in IL-1 receptor antagonist-treated OIR animals. Together, these findings suggest a critical role for IL-1β-induced choroidal degeneration in outer retinal dysfunction. Neonatal therapy using IL-1 receptor antagonist preserves choroid and prevents protracted outer neuroretinal anomalies in OIR, suggesting IL-1β as a potential therapeutic target in ROP., (Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
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- 2016
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15. Scientific Overview: CSCI-CITAC Annual General Meeting and Young Investigators' Forum 2015.
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Zhao EY, Zhou TE, Benesch MG, Dey A, Liu P, Steadman PE, Zaslavsky K, Schneider R, and Kuzyk A
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- Canada, Cardiology methods, Education, Medical, Humans, Internal Medicine methods, Medical Oncology methods, Ontario, Translational Research, Biomedical, Universities, Biomedical Research methods, Research Personnel
- Abstract
The 2015 Annual General Meeting of The Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was held in Toronto November 23-25, 2015, in conjunction with The University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "It takes a village" and the focus was the various support systems necessary to train a successful clinician scientist. The meeting featured an opening presentation by Dr. Vincent Dumez and workshops by Dr. Peter Nickerson, Dr. Jane Aubin, Dr. Kelly Warmington and Dr. Norman Rosenblum, and MD/PhD trainees Nardin Samuel, Kevin Wang and Kirill Zaslavsky. The keynote speakers were Dr. David Malkin (Hospital for Sick Children) who received the CSCI-RCPSC Henry Friesen Award, Dr. Brent Richards (McGill University) who received the Joe Doupe Award and Ernesto Shiffrin (Lady Davis Institute) who received the Distinguished Scientist Award. As always, the conference showcased outstanding scientific presentations from clinician investigator trainees from across the country at the Young Investigators' Forum. The research topics, which ranged from basic sciences to clinical medicine and translational work, are summarized in this review. Over 90 abstracts were presented at this year's meeting during two poster sessions, with several of the outstanding abstracts selected for oral presentations.
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- 2016
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16. Erratum: Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.
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Bhosle VK, Rivera JC, Zhou TE, Omri S, Sanchez M, Hamel D, Zhu T, Rouget R, Rabea AA, Hou X, Lahaie I, Ribeiro-da-Silva A, and Chemtob S
- Abstract
[This corrects the article DOI: 10.1038/celldisc.2016.17.].
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- 2016
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17. Nuclear localization of platelet-activating factor receptor controls retinal neovascularization.
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Bhosle VK, Rivera JC, Zhou TE, Omri S, Sanchez M, Hamel D, Zhu T, Rouget R, Rabea AA, Hou X, Lahaie I, Ribeiro-da-Silva A, and Chemtob S
- Abstract
Platelet-activating factor (PAF) is a pleiotropic phospholipid with proinflammatory, procoagulant and angiogenic actions on the vasculature. We and others have reported the presence of PAF receptor (Ptafr) at intracellular sites such as the nucleus. However, mechanisms of localization and physiologic functions of intracellular Ptafr remain poorly understood. We hereby identify the importance of C-terminal motif of the receptor and uncover novel roles of Rab11a GTPase and importin-5 in nuclear translocation of Ptafr in primary human retinal microvascular endothelial cells. Nuclear localization of Ptafr is independent of exogenous PAF stimulation as well as intracellular PAF biosynthesis. Moreover, nuclear Ptafr is responsible for the upregulation of unique set of growth factors, including vascular endothelial growth factor, in vitro and ex vivo. We further corroborate the intracrine PAF signaling, resulting in angiogenesis in vivo, using Ptafr antagonists with distinct plasma membrane permeability. Collectively, our findings show that nuclear Ptafr translocates in an agonist-independent manner, and distinctive functions of Ptafr based on its cellular localization point to another dimension needed for pharmacologic selectivity of drugs.
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- 2016
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18. Tailoring Myopic CNV Treatment Based on Preexisting Ophthalmic Condition.
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Zhou TE, Bhosle VK, and Chemtob S
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- Female, Humans, Male, Angiogenesis Inhibitors therapeutic use, Bevacizumab therapeutic use, Choroid pathology, Choroidal Neovascularization drug therapy, Myopia, Degenerative drug therapy, Ranibizumab therapeutic use, Vascular Endothelial Growth Factor A antagonists & inhibitors
- Published
- 2015
- Full Text
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19. Changes of the immunological barrier of intestinal mucosa in rats with sepsis.
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Jiang LY, Zhang M, Zhou TE, Yang ZF, Wen LQ, and Chang JX
- Abstract
Background: Sepsis has become the greatest threat to in-patients, with a mortality of over 25%. The dysfunction of gut barrier, especially the immunological barrier, plays an important role in the development of sepsis. This dysfunction occurs after surgery, but the magnitude of change does not differentiate patients with sepsis from those without sepsis. Increased intestinal permeability before surgery is of no value in predicating sepsis. The present study aimed to observe the changes of intestinal mucosal immunologic barrier in rat models of sepsis induced by cecal ligation and puncture., Methods: Sixty Sprague-Dawley rats were randomly divided into a sepsis group (n=45) and a control group (n=15). The rats in the sepsis group were subjected to cecal ligation and puncture (CLP), whereas the rats in the control group underwent a sham operation. The ileac mucosa and segments were harvested 3, 6 and 12 hours after CLP, and blood samples were collected. Pathological changes, protein levels of defensin-5 (RD-5) and trefoil factor-3 (TFF3) mRNA, and lymphocytes apoptosis in the intestinal mucosa were determined. In an additional experiment, the gut-origin bacterial DNA in blood was detected., Results: The intestinal mucosa showed marked injury with loss of ileal villi, desquamation of epithelium, detachment of lamina propria, hemorrhage and ulceration in the sepsis group. The expression of TFF3 mRNA and level of RD-5 protein were decreased and the apoptosis of mucosal lymphocyte increased (P<0.05) in the sepsis group compared with the control group. Significant differences were observed in RD-5 and TFF3 mRNA 3 hours after CLP and they were progressively increased 6 and 12 hours after CLP in the sepsis group compared with the control group (P<0.05, RD-5 F=11.76, TFF3 F=16.86 and apoptosis F=122.52). In addition, the gut-origin bacterial DNA detected in plasma was positive in the sepsis group., Conclusion: The immunological function of the intestinal mucosa was impaired in septic rats and further deteriorated in the course of sepsis.
- Published
- 2010
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