1. Good syndrome and cytomegalovirus retinitis: A literature review.
- Author
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Cantu-Rosales C, Baquero-Ospina P, Peña-Ortiz S, Díaz-Castillo J, and Concha-Del-Rio LE
- Subjects
- Humans, Thymus Neoplasms complications, Thymus Neoplasms diagnosis, Cytomegalovirus Retinitis diagnosis, Cytomegalovirus Retinitis drug therapy, Thymoma complications, Thymoma diagnosis, Agammaglobulinemia diagnosis, Agammaglobulinemia complications
- Abstract
Good syndrome (GS) is a rare primary immunodeficiency in adults consisting of hypogammaglobulinemia and thymoma that affects both cellular and humoral immunity. It usually appears in patients between the 4th and 6th decade of life and affects both genders equally. Ophthalmological clinical presentation is highly variable; associations with herpetic keratitis, toxoplasmosis, and cytomegalovirus retinitis (CMVR) have been described. GS associated with CMVR is uncommon. Ophthalmologists may be the first to diagnose systemic disease and change the outcome. Only18 cases of CMVR have been described, most of them unilateral with poor visual outcomes. We discuss the clinical features of CMVR in patients with reported GS, pathogenesis, and outline a work-up for diagnosis. CMVR in an apparently healthy patient should encourage the clinician to search for human immunodeficiency virus (HIV) and non-HIV-associated immunosuppression., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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