Search

Your search keyword '"Chen, Yu-Ming"' showing total 719 results
Start Over Author "Chen, Yu-Ming" Search Limiters Peer Reviewed Language english
719 results on '"Chen, Yu-Ming"'

3. Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

Author

Xu, Fengzhe, Yu, Evan Yi-Wen, Cai, Xue, Yue, Liang, Jing, Li-peng, Liang, Xinxiu, Fu, Yuanqing, Miao, Zelei, Yang, Min, Shuai, Menglei, Gou, Wanglong, Xiao, Congmei, Xue, Zhangzhi, Xie, Yuting, Li, Sainan, Lu, Sha, Shi, Meiqi, Wang, Xuhong, Hu, Wensheng, Langenberg, Claudia, Yang, Jian, Chen, Yu-ming, Guo, Tiannan, and Zheng, Ju-Sheng

Published
2023
Full Text
View/download PDF

20. Associations of dietary diversity with the gut microbiome, fecal metabolites, and host metabolism: results from 2 prospective Chinese cohorts

Author

Xiao, Congmei, Wang, Jia-ting, Su, Chang, Miao, Zelei, Tang, Jun, Ouyang, Yifei, Yan, Yan, Jiang, Zengliang, Fu, Yuanqing, Shuai, Menglei, Gou, Wanglong, Xu, Fengzhe, Yu, Evan Y-W, Liang, Yuhui, Liang, Xinxiu, Tian, Yunyi, Wang, Jiali, Huang, Feifei, Zhang, Bing, Wang, Huijun, Chen, Yu-ming, and Zheng, Ju-Sheng

Published
2022
Full Text
View/download PDF

26. Relationship between Circulating 25-Hydroxyvitamin D and Metabolic Syndrome in Chinese Adults: A Large Nationwide Longitudinal Study.

Author

Shu, Mi, Xi, Yue, Wu, Jie, Zhuo, Lai-Bao, Yan, Yan, Yang, Yi-Duo, Feng, Yue-Yue, Tan, Hua-Qiao, Yang, Hui-Fang, and Chen, Yu-Ming

Abstract

Objective: This study investigated the association of circulating levels of 25-hydroxyvitamin D (25[OH]D) with the risk of metabolic syndrome (MetS) and its components in adults. Methods: This nationwide cohort involved 23,810 Chinese adults attending annual health evaluations. Serum 25(OH)D levels, MetS status, and covariates were determined at each examination. Among them, 8146, 3310, and 1971 completed two, three, and more than three evaluations, respectively. A hybrid mixed-effects and Cox regression model was employed to determine the cross-sectional and longitudinal relationships. Results: The odds ratios (ORs) and 95% confidence intervals (CIs) of MetS were significantly lower in individuals within quartile 4 (vs. 1) of serum 25(OH)D for both between-individual (0.43 [0.35, 0.52]) and within-individual comparisons (0.60 [0.50, 0.73]), respectively (all p-trends < 0.001). Among the MetS components, the corresponding ORs (95% CI) in between- and within-individual comparisons were 0.40 (0.29, 0.54) and 0.26 (0.19, 0.36) for abdominal obesity, 0.49 (0.41, 0.58) and 0.78 (0.66, 0.93) for high triglycerides, 0.70 (0.59, 0.82) and 0.75 (0.64, 0.87) for hypertriglyceridemia, 0.48 (0.39, 0.59) and 0.87 (0.71, 1.07) for low HDL cholesterol, and 0.92 (0.76, 1.12) and 0.49 (0.41, 0.59) for hypertension, respectively. Decreased hazard ratios (95% CIs) in quartile 4 (vs. 1) of 25(OH)D were found for MetS (0.80 [0.65, 1.00]), high triglycerides (0.76 [0.62, 0.92]), abdominal obesity (0.77 [0.63, 0.96]), and low HDL cholesterol (0.64 [0.50, 0.81]). Conclusions: Decreased concentrations of serum 25(OH)D correlate significantly to a heightened MetS risk and specific components. Our findings underscore the potential preventive function of circulating vitamin D concerning metabolic disorders. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Proteome‐wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8‐year prospective study.

Author

Xu, Jinjian, Cai, Xue, Miao, Zelei, Yan, Yan, Chen, Danyu, Yang, Zhen‐xiao, Yue, Liang, Hu, Wei, Zhuo, Laibao, Wang, Jia‐ting, Xue, Zhangzhi, Fu, Yuanqing, Xu, Ying, Zheng, Ju‐Sheng, Guo, Tiannan, and Chen, Yu‐ming

Subjects
LIQUID chromatography-mass spectrometry, DUAL-energy X-ray absorptiometry, BONE density, OSTEOPOROSIS, BLOOD proteins, LONGITUDINAL method, FEMUR neck
Abstract

The role of circulatory proteomics in osteoporosis is unclear. Proteome‐wide profiling holds the potential to offer mechanistic insights into osteoporosis. Serum proteome with 413 proteins was profiled by liquid chromatography–tandem mass spectrometry (LC–MS/MS) at baseline, and the 2nd, and 3rd follow‐ups (7704 person‐tests) in the prospective Chinese cohorts with 9.8 follow‐up years: discovery cohort (n = 1785) and internal validation cohort (n = 1630). Bone mineral density (BMD) was measured using dual‐energy X‐ray absorptiometry (DXA) at follow‐ups 1 through 3 at lumbar spine (LS) and femoral neck (FN). We used the Light Gradient Boosting Machine (LightGBM) to identify the osteoporosis (OP)‐related proteomic features. The relationships between serum proteins and BMD in the two cohorts were estimated by linear mixed‐effects model (LMM). Meta‐analysis was then performed to explore the combined associations. We identified 53 proteins associated with osteoporosis using LightGBM, and a meta‐analysis showed that 22 of these proteins illuminated a significant correlation with BMD (p < 0.05). The most common proteins among them were PHLD, SAMP, PEDF, HPTR, APOA1, SHBG, CO6, A2MG, CBPN, RAIN APOD, and THBG. The identified proteins were used to generate the biological age (BA) of bone. Each 1 SD‐year increase in KDM‐Proage was associated with higher risk of LS‐OP (hazard ratio [HR], 1.25; 95% CI, 1.14–1.36, p = 4.96 × 10−06), and FN‐OP (HR, 1.13; 95% CI, 1.02–1.23, p = 9.71 × 10−03). The findings uncovered that the apolipoproteins, zymoproteins, complements, and binding proteins presented new mechanistic insights into osteoporosis. Serum proteomics could be a crucial indicator for evaluating bone aging. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results