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Your search keyword '"Schlegel, Paul-Gerhard"' showing total 9 results
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9 results on '"Schlegel, Paul-Gerhard"'

1. Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia

Author

Stanulla, Martin, Schaeffeler, Elke, Möricke, Anja, Buchmann, Swantje, Zimmermann, Martin, Igel, Svitlana, Schmiegelow, Kjeld, Flotho, Christian, Hartmann, Hans, Illsinger, Sabine, Sauerbrey, Axel, Junk, Stefanie V., Schütte, Peter, Hinze, Laura, Lauten, Melchior, Modlich, Simon, Kolb, Reinhard, Rossig, Claudia, Schwabe, Georg, Gnekow, Astrid K., Fleischhack, Gudrun, Schlegel, Paul Gerhard, Schünemann, Holger J., Kratz, Christian P., Cario, Gunnar, Schrappe, Martin, and Schwab, Matthias

Published
2021
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2. Management of Patients Undergoing CAR-T Cell Therapy in Germany.

Author

Penack, Olaf, Dreger, Peter, Ajib, Salem, Ayuk, Francis, Baermann, Ben-Niklas, Bug, Gesine, Kriege, Oliver, Jentzsch, Madlen, Kobbe, Guido, Koenecke, Christian, Lutz, Mathias, Martin, Sonja, Schlegel, Paul-Gerhard, Schroers, Roland, von Tresckow, Bastian, Vucinic, Vladan, Subklewe, Marion, Bethge, Wolfgang, and Wolff, Daniel

Subjects
STEM cell transplantation, CELLULAR therapy, HEMATOPOIETIC stem cell transplantation, CELL transplantation, CYTOKINE release syndrome, NON-Hodgkin's lymphoma
Abstract

Introduction: Chimeric antigen receptor positive T cell (CAR-T cell) treatment became standard therapy for relapsed or refractory hematologic malignancies, such as non-Hodgkin's lymphoma and multiple myeloma. Owing to the rapidly progressing field of CAR-T cell therapy and the lack of generally accepted treatment guidelines, we hypothesized significant differences between centers in the prevention, diagnosis, and management of short- and long-term complications. Methods: To capture the current CAR-T cell management among German centers to determine the medical need and specific areas for future clinical research, the DAG-HSZT (Deutsche Arbeitsgemeinschaft für Hämatopoetische Stammzelltransplantation und Zelluläre Therapie; German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy) performed a survey among 26 German CAR-T cell centers. Results: We received answers from 17 centers (65%). The survey documents the relevance of evidence in the CAR-T cell field with a homogeneity of practice in areas with existing clinical evidence. In contrast, in areas with no – or low quality – clinical evidence, we identified significant variety in management in between the centers: management of cytokine release syndrome, immune effector cell-related neurotoxicity syndrome, IgG substitution, autologous stem cell backups, anti-infective prophylaxis, and vaccinations. Conclusion: The results indicate the urgent need for better harmonization of supportive care in CAR-T cell therapies including clinical research to improve clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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6. 92 - Incidence of Secondary Malignancies after Total Body Irradiation-Based Allogeneic HSCT in Children with ALL – Long-Term Follow-up from the Prospective ALL-SCT 2003 Trial

Author

Eichinger, Anna, Glogova, Evgenia, Poetschger, Ulrike, Bader, Peter, Basu, Oliver, Beier, Rita, Burkhardt, Birgit, Classen, Carl-Friedrich, Claviez, Alexander, Corbacioglu, Selim, Deubzer, Hedwig, Greil, Johann, Gruhn, Bernd, Gungor, Tayfun, Kafa, Kinan, Lang, Peter, Lange, Bjoern Soenke, Mueller, Ingo, Sauer, Martin G., Schlegel, Paul-Gerhard, Schulz, Ansgar, Stachel, Klaus Daniel, Strahm, Brigitte R., Wawer, Angela, Kühl, Jörn-Sven, Meisel, Roland, Peters, Christina, and Albert, Michael H.

Published
2022
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7. NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation

Author

Kreyenberg, Hermann, Jarisch, Andrea, Bayer, Christina, Schuster, Blanca, Willasch, Andre, Strahm, Brigitte, Kremens, Bernhard, Gruhn, Bernd, Schrauder, Andre, Burdach, Stefan, Führer, Monika, Rossig, Claudia, Kabisch, Hartmut, Schlegel, Paul-Gerhard, Stachel, Daniel, Beck, James F., Mauz-Koerholz, Christine, Chung, Tje Lin, Holler, Ernst, Klingebiel, Thomas, and Bader, Peter

Published
2011
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8. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.

Author

Niemeyer, Charlotte M., Kang, Michelle W., Shin, Danielle H., Furlan, Ingrid, Erlacher, Miriam, Bunin, Nancy J., Bunda, Severa, Finklestein, Jerry Z., Sakamoto, Kathleen M., Gorr, Thomas A., Mehta, Parinda, Schmid, Irene, Kropshofer, Gabriele, Corbacioglu, Selim, Lang, Peter J., Klein, Christoph, Schlegel, Paul-Gerhard, Heinzmann, Andrea, Schneider, Michaela, and Starý, Jan

Subjects
CBL proteins, UBIQUITIN, RNA, HEMATOPOIETIC growth factors, LEUKEMIA, GENETIC mutation
Abstract

CBL encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin ligase. We describe a dominant developmental disorder resulting from germline missense CBL mutations, which is characterized by impaired growth, developmental delay, cryptorchidism and a predisposition to juvenile myelomonocytic leukemia (JMML). Some individuals experienced spontaneous regression of their JMML but developed vasculitis later in life. Importantly, JMML specimens from affected children show loss of the normal CBL allele through acquired isodisomy. Consistent with these genetic data, the common p.371Y>H altered Cbl protein induces cytokine-independent growth and constitutive phosphorylation of ERK, AKT and S6 only in hematopoietic cells in which normal Cbl expression is reduced by RNA interference. We conclude that germline CBL mutations have developmental, tumorigenic and functional consequences that resemble disorders that are caused by hyperactive Ras/Raf/MEK/ERK signaling and include neurofibromatosis type 1, Noonan syndrome, Costello syndrome, cardiofaciocutaneous syndrome and Legius syndrome. [ABSTRACT FROM AUTHOR]

Published
2010
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9. To the editor: NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation.

Author

Kreyenberg, Hermann, Jarisch, Andrea, Bayer, Christina, Schuster, Blanca, Willasch, Andre, Strahm, Brigitte, Kremens, Bernhard, Gruhn, Bernd, Schrauder, Andre, Burdach, Stefan, Führer, Monika, Rossig, Claudia, Kabisch, Hartmut, Schlegel, Paul-Gerhard, Stachel, Daniel, Beck, James F., Mauz-Koerholz, Christine, Tje Lin Chung, Holler, Ernst, and Klingebiel, Thomas

Subjects
*LETTERS to the editor, *STEM cell transplantation, *GENETIC polymorphisms
Abstract

A letter to the editor is presented in response to an article on the impact of NOD2/CARD15 gene polymorphisms on pediatric allogeneic stem cell transplantation in the previous issue.

Published
2011
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