1. Severe myelosuppression involving HPV‐B19 infection and NUDT15 polymorphisms during therapy for LCH.
- Author
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Hosokawa, Hiroki, Kitazawa, Hironobu, Akita, Nobuhiro, Yoshida, Nao, and Hama, Asahito
- Subjects
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CRANIAL radiography , *GENETIC mutation , *LANGERHANS-cell histiocytosis , *GENETIC polymorphisms , *NEUTROPHILS , *PAPILLOMAVIRUS diseases , *BONE marrow diseases , *HEADACHE , *COMPUTED tomography , *POLYMERASE chain reaction , *GENETIC techniques , *IMMUNOSUPPRESSIVE agents , *RARE diseases , *DISEASE complications - Abstract
The article presents a case study of a seven-year-old boy with Langerhans cell histiocytosis (LCH) who experienced severe myelosuppression during chemotherapy with oral 6-mercaptopurine (6-MP). Topics discussed include the association of NUDT15 polymorphisms with fatal myelosuppression, the risk of human parvovirus B19 (HPV-B19) infection during myelosuppression, and the recommendation for genotyping NUDT15 before initiating thiopurine-containing therapy to avoid excess toxicity.
- Published
- 2023
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