7 results on '"Onal, Sumru"'
Search Results
2. An Algorithm for the Diagnosis of Behçet Disease Uveitis in Adults.
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Tugal-Tutkun, Ilknur, Onal, Sumru, Stanford, Miles, Akman, Mehmet, Twisk, Jos W.R., Boers, Maarten, Oray, Merih, Özdal, P., Kadayifcilar, Sibel, Amer, Radgonde, Rathinam, Sivakumar R., Vedhanayaki, Rajesh, Khairallah, Moncef, Akova, Yonca, Yalcindag, F., Kardes, Esra, Basarir, Berna, Altan, Çigdem, Özyazgan, Yilmaz, and Gül, Ahmet
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IRIDOCYCLITIS , *BEHCET'S disease , *CART algorithms , *UVEITIS , *DIAGNOSIS , *ADULTS - Abstract
Purpose: To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings. Methods: Following an initial survey among uveitis experts, we collected multi-center retrospective data on 211 patients with BD uveitis and 207 patients with other uveitides, and identified ocular findings with a high diagnostic odds ratio (DOR). Subsequently, we collected multi-center prospective data on 127 patients with BD uveitis and 322 controls and developed a diagnostic algorithm using Classification and Regression Tree (CART) analysis and expert opinion. Results: We identified 10 items with DOR >5. The items that provided the highest accuracy in CART analysis included superficial retinal infiltrate, signs of occlusive retinal vasculitis, and diffuse retinal capillary leakage as well as the absence of granulomatous anterior uveitis or choroiditis in patients with vitritis. Conclusion: This study provides a diagnostic tree for BD uveitis that needs to be validated in future studies. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. Review for Diagnostics of the Year: Multimodal Imaging in Behçet Uveitis.
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Tugal-Tutkun, Ilknur, Ozdal, Pınar Cakar, Oray, Merih, and Onal, Sumru
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UVEAL diseases ,UVEITIS ,EYE inflammation ,VASCULITIS ,RETINAL diseases ,BEHCET'S disease ,ANGIOGRAPHY ,DIAGNOSTIC imaging ,PHOTOGRAPHY ,OPTICAL coherence tomography ,DIAGNOSIS - Abstract
Behçet disease is a chronic relapsing multisystem inflammatory disorder. Ocular involvement is characterized by a bilateral recurrent non-granulomatous panuveitis and retinal vasculitis. Posterior segment findings vary during the course of the disease, in parallel with the relapsing and remitting intraocular inflammation. Structural alterations occur with increased disease duration. Fluorescein angiography is the gold standard in revealing the extent and severity as well as the leaky and/or occlusive nature of retinal vasculitis. Multimodal imaging using color fundus photography, fluorescein angiography, and optical coherence tomography is essential in visualizing diagnostic features, detecting structural changes, and monitoring disease activity and response to treatment in patients with Behçet uveitis. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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4. Nonglaucomatous Localized Retinal Nerve Fiber Layer Defects in Behçet Uveitis.
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ORAY, MERIH, ONAL, SUMRU, BAYRAKTAR, SERIFE, IZGI, BELGIN, and TUGAL-TUTKUN, ILKNUR
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GLAUCOMA , *NERVE fibers , *BEHCET'S disease , *MULTIPLE sclerosis , *TOXOPLASMOSIS , *OPTICAL coherence tomography , *DISEASES , *PATIENTS - Abstract
PURPOSE: To describe nonglaucomatous retinal nerve fiber layer (RNFL) defects in patients with Behcet uveitis. DESIGN: Cross-sectional study and observational case series. METHODS: We reviewed the clinical photographs of patients with Behcet uveitis (n = 259), ocular toxoplasmosis (n = 120), and multiple sclerosis (MS)-associated uveitis (n = 40) for the presence of localized RNFL defects. Behcet patients with localized RNFL defects were invited to participate in a prospective evaluation including standard automated perimetry, spectraldomain optical coherence tomography (SD OCT), and RNFL thickness analysis. Main outcome measures were the prevalence of localized RNFL defects, perimetric and SD OCT findings, and RNFL thickness analysis. RESULTS: Sixty-two patients with Behcet uveitis (24%) had localized RNFL defect(s) without any visible scar. Twenty patients (17%) with ocular toxoplasmosis had a localized RNFL defect associated with a retinochoroidal scar in all. None of the MS patients had a localized RNFL defect. Of the 19 patients (24 eyes) with RNFL defect associated with Behcet uveitis who returned for follow-up, there was a corollary thinning on SD OCT B-scan in all and a corresponding visual field defect in 83%. RNFL thickness analysis was within normal limits in 54%, but revealed thinning in the thickness profile scale in 46% and in the pie chart in 21%. CONCLUSION: In Behcet uveitis, localized RNFL defects may be caused by microvascular ischemia at the optic nerve head and/or at the posterior pole and may serve as a helpful ocular diagnostic clue and an indicator of posterior pole involvement, a risk factor for poor visual prognosis. [ABSTRACT FROM AUTHOR]
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- 2015
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5. Validity and Agreement of Uveitis Experts in Interpretation of Ocular Photographs for Diagnosis of Behçet Uveitis*.
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Tugal-Tutkun, Ilknur, Onal, Sumru, Ozyazgan, Yilmaz, Soylu, Merih, and Akman, Mehmet
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BEHCET'S disease , *DISEASE prevalence , *DIAGNOSIS , *GENITAL diseases , *RETINAL diseases - Abstract
Purpose: To evaluate agreement and estimate sensitivity and specificity of uveitis specialists' interpretation of ocular photographs in diagnosing Behçet uveitis. Methods: Fourteen Turkish uveitis specialists, masked to demographic and clinical features of patients, independently labeled ocular photographs (29 Behçet/30 other diagnoses) as 'Behçet uveitis' or 'non-Behçet.' Level of agreement was evaluated using kappa statistics. Photographs were categorized based on ocular signs captured and performance of observers. Results: Exact agreement with the correct diagnosis was 56-81%. Seven reviewers correctly labeled more than 70% of photographs. Interobserver agreement among those 7 reviewers revealed moderate ( κ = 0.41-0.60) or substantial ( κ = 0.61-0.80) agreement in 76% of pairs. Smooth layered hypopyon, superficial retinal infiltrate with retinal hemorrhages, and branch retinal vein occlusion with vitreous haze were correctly recognized as Behçet uveitis by majority of reviewers. Conclusions: There are ocular signs of Behçet disease that can be considered diagnostic even in the absence of any other clinical information. [ABSTRACT FROM AUTHOR]
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- 2014
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6. Comparison of Presenting Features and Three-year Disease Course in Turkish Patients with Behçet Uveitis Who Presented in the Early 1990s and the Early 2000s.
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Cingu, Abdullah Kursat, Onal, Sumru, Urgancioglu, Meri, and Tugal-Tutkun, Ilknur
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BEHCET'S disease , *UVEITIS , *IMMUNOREGULATION , *INTERFERONS , *PROGNOSIS - Abstract
Purpose: To compare Behçet uveitis patients who presented in the 1990s and 2000s. Methods: Records of 170 patients seen in 1990-1994 and 258 patients seen in 2000-2004 were reviewed. Presenting features were analyzed in the whole cohort. Uveitis attacks, vision, complications, and immunomodulatory treatment (IMT) were compared in patients with 3-year follow-up. Results: Posterior segment involvement was less common, visual acuity was better, and more patients received IMT before referral in the 2000s. Follow-up revealed no significant difference in number of uveitis attacks in the first 3 years. Less eyes lost useful vision, no patient became legally blind, and fewer severe ocular complications occurred in the 2000s. IMT was started within 3 months in more patients and interferon alfa-2a was used only in the latter study period. Conclusions: The findings suggest a milder disease at referral, lower rate of severe complications, and a better 3-year visual outcome in patients who presented in the early 2000s. [ABSTRACT FROM AUTHOR]
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- 2012
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7. Clinical course of ocular Behçet's disease in siblings.
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Onal, Sumru, Tugal-Tutkun, Ilknur, Urgancioglu, Meri, Gul, Ahmet, Onal, S, Tugal-Tutkun, I, Urgancioglu, M, and Gul, A
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BEHCET'S disease , *FAMILIAL diseases , *EYE diseases - Abstract
Purpose: Familial occurrence has been reported in approximately 8% of Turkish patients with Behçet's disease. Our aim was to compare the clinical course of ocular Behçet's disease among siblings.Methods: We retrospectively studied five pairs of siblings with ocular involvement of Behçet's disease. No other family member of these siblings had any symptom of Behçet's disease.Results: The siblings comprised three sister-brother pairs, one sister-sister pair, and one brother-brother pair. There was a 5-10-year difference between the age at onset of ocular disease among siblings. Three of the five pairs (two sister-brother, one brother-brother) had a dissimilar course of disease activity. Female siblings had an earlier age at onset and tended to have a worse prognosis than their brothers.Conclusions: It is generally acknowledged that male sex is associated with a worse prognosis. In this study, however, we observed that, among siblings with a dissimilar course, female patients were more severely affected than male patients. Poor ocular prognosis in a patient does not indicate aggressive treatment in his/her sibling. We believe that each sibling should be managed on an individual basis. [ABSTRACT FROM AUTHOR]- Published
- 2001
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