1. Laparoscopic versus open resection for stage II/III rectal cancer in obese patients: A multicenter propensity score‐based analysis of short‐ and long‐term outcomes.
- Author
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Akagi, Tomonori, Nakajima, Kentaro, Hirano, Yasumitsu, Abe, Tomoya, Inada, Ryo, Kono, Yohei, Shiroshita, Hidefumi, Ohyama, Tetsuji, Inomata, Masafumi, Yamamoto, Seiichiro, Naitoh, Takeshi, Sakai, Yoshiharu, and Watanabe, Masahiko
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RECTAL surgery ,RECTAL cancer ,LYMPHADENECTOMY ,CANCER patients ,LAPAROSCOPIC surgery ,PROPENSITY score matching - Abstract
Aim: Whether a laparoscopic procedure can contribute to the improvement of clinical outcomes in obese patients with stage II/III rectal cancer compared to an open procedure remains unclear. Objective: This study evaluated the technical and oncological safety of laparoscopic surgery versus open surgery in obese patients (body mass index [BMI] ≥25 kg/m2) with rectal cancer. Patients and Methods: Data were collected from patients with pathological stage II/III rectal cancer and analyzed. Operations were performed via laparoscopic or open surgery from 2009 to 2013. A comparative analysis was performed after applying propensity score matching to the two cohorts (laparoscopic group and open group). The primary endpoint was 3‐y relapse‐free survival (RFS). Results: Overall, 524 eligible cases were collected from 51 institutions. Equal numbers of propensity score‐matched patients were included in the laparoscopic (n = 193) group and open (n = 193) group. Although the rate of D3 lymph node dissection did not differ between the laparoscopic group (87.0%) and the open group (88.6%), the median number of harvested lymph nodes was significantly lower in the laparoscopic group versus open group (17.5 vs 21, P = 0.0047). The median postoperative hospital stay was also significantly shorter in the laparoscopic group (14 d) vs the open group (17 d) (P = 0.0014). Three‐y RFS was not significantly different between the two groups (hazard ratio 1.2454, 95% confidence interval 0.9201–1.6884, P = 0.4689). Conclusion: The short‐ and long‐term results of this large cohort study (UMIN ID: UMIN000033529) indicated that laparoscopic surgery in obese rectal cancer patients has advantageous short‐term outcomes and no disadvantageous long‐term outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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