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Your search keyword '"Dumonteil, Eric"' showing total 3 results
3 results on '"Dumonteil, Eric"'

1. Chagas Disease: "The New HIV/AIDS of the Americas".

Author

Hotez, Peter J., Dumonteil, Eric, Woc-Colburn, Laila, Serpa, Jose A., Bezek, Sarah, Edwards, Morven S., Hallmark, Camden J., Musselwhite, Laura W., Flink, Benjamin J., and Bottazzi, Maria Elena

Subjects
*CHAGAS' disease, *PUBLIC health, *HIV infections
Abstract

The article discusses issues related to emergence of Neglected tropical diseases (NTDs) in the U.S. According to an estimate all of the "bottom 100 million" in the nation suffer from at least one NTD including Chagas disease. It has been stated that there are many similarities between people living with Chagas disease and people living with HIV/AIDS that includes requirement for prolonged treatment courses in both diseases.

Published
2012
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2. Genetic diversity of Trypanosoma cruzi infecting raccoons (Procyon lotor) in 2 metropolitan areas of southern Louisiana: implications for parasite transmission networks.

Author

Majeau, Alicia, Cloherty, Erin, Anderson, A. Nikki, Straif-Bourgeois, Susanne C., Dumonteil, Eric, and Herrera, Claudia

Subjects
*METROPOLITAN areas, *GENETIC variation, *RACCOON, *TRYPANOSOMA cruzi, *PARASITES, *MIXED infections, *CHAGAS' disease, *NUCLEOTIDE sequencing
Abstract

Trypanosoma cruzi , the aetiological agent of Chagas disease, exists as an anthropozoonosis in Louisiana. Raccoons are an important reservoir, as they demonstrate high prevalence and maintain high parasitaemia longer than other mammals. Given the complex nature of parasite transmission networks and importance of raccoons as reservoirs that move between sylvatic and domestic environments, detailing the genetic diversity of T. cruzi in raccoons is crucial to assess risk to human health. Using a next-generation sequencing approach targeting the mini-exon, parasite diversity was assessed in 2 metropolitan areas of Louisiana. Sequences were analysed along with those previously identified in other mammals and vectors to determine if any association exists between ecoregion and parasite diversity. Parasites were identified from discrete typing units (DTUs) TcI, TcII, TcIV, TcV and TcVI. DTUs TcII, TcV and TcVI are previously unreported in raccoons in the United States (US). TcI was the most abundant DTU, comprising nearly 80% of all sequences. All but 1 raccoon harboured multiple haplotypes, some demonstrating mixed infections of different DTUs. Furthermore, there is significant association between DTU distribution and level III ecoregion in Louisiana. Finally, while certain sequences were distributed across multiple tissues, others appeared to have tissue-specific tropism. Taken together, these findings indicate that ongoing surveillance of T. cruzi in the US should be undertaken across ecoregions to fully assess risk to human health. Given potential connections between parasite diversity and clinical outcomes, deep sequencing technologies are crucial and interventions targeting raccoons may prove useful in mitigating human health risk. [ABSTRACT FROM AUTHOR]

Published
2023
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3. High prevalence of Trypanosoma cruzi infection in shelter dogs from southern Louisiana, USA.

Author

Elmayan, Ardem, Tu, Weihong, Duhon, Brandy, Marx, Preston, Wolfson, Wendy, Balsamo, Gary, Herrera, Claudia, and Dumonteil, Eric

Subjects
*CHAGAS' disease, *TRYPANOSOMA cruzi, *ZOONOSES, *DOGS, *DOG owners, *ANIMAL shelters, *INFECTION
Abstract

Background: Chagas disease is a zoonotic disease caused by the protozoan parasite Trypanosoma cruzi. The role of dogs as sentinels has been proposed in multiple regions, as they are a domestic reservoir for T. cruzi. Our objective was to determine the prevalence of T. cruzi infection in shelter dogs from southern Louisiana, and assess its magnitude and distribution. Results: A total of 540 dogs were enrolled, from 20 animal shelters, and tested for T. cruzi infection by serological tests (rapid test, ELISA and western blot) and PCR. We documented a high prevalence of T. cruzi infection with at least 6.9% (95% CI: 5.0–9.3%) seropositive and 15.7% (95% CI: 12.9–19.1%) PCR-positive dogs. Serological tests showed limited agreement, and concordance between serology and PCR was higher when considering reactivity to single serological tests. Trypanosoma cruzi infection was distributed evenly among shelters. Infection was significantly correlated with age (R2 = 0.99), indicating an incidence of new cases of 2.27 ± 0.25% per year. Conclusion: Trypanosoma cruzi infection is a significant and widespread veterinary problem in shelter dogs in the region, although it is mostly unnoticed by health professionals. This highlights the need for greater awareness of T. cruzi infection among the veterinary community and dog owners. [ABSTRACT FROM AUTHOR]

Published
2019
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