1. Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease.
- Author
-
Shahrani, Shahreedhan, Gill, Sandeep Singh, Sooi, Choong Yeong, Skantha, Ruben, Kumar, C Vikneshwaran Chandra, Limun, Mohd Fairul, Affendi, Nik Arsyad Nik Muhamad, Chuah, Kee Huat, Khoo, Stanley, Rajaram, Ruveena Bhavani, Chan, Wah Kheong, and Mahadeva, Sanjiv
- Subjects
- *
LIVER diseases , *FATTY liver , *NON-alcoholic fatty liver disease , *CHRONIC hepatitis B , *FATTY degeneration , *CHRONIC diseases - Abstract
Background: With changes in the epidemiology and treatment of chronic liver disease (CLD), the impact of various etiologies of liver disease on steatosis and advanced fibrosis are uncertain. Methods: A retrospective study was conducted among liver disease patients of various etiologies undergoing transient elastography (TE) over a 9‐year duration. Results: Data for 2886 patients were analyzed and had the following demographics: The median age was 60 (IQR: 45–69) years, 51% were males, and ethnicity was predominantly Chinese (52.5%), followed by Malays (34%) and Indians (12.3%). The median CAP score was 272 (IQR: 219–319) dB/m and the median liver stiffness measurement (LSM) score was 6.5 (IQR: 4.9–9.7) kPa. Hepatic steatosis occurred across the spectrum of etiologies of CLD. Among patients with steatosis, the most common etiologies were nonalcoholic fatty liver disease (NAFLD) at 62% and chronic hepatitis B (CHB) at 26.3%. TE findings suggestive of cACLD (10.1–15 kPa) and highly suggestive of cACLD (>15 kPa) were observed in 11.3% and 12.4% of patients, respectively. NAFLD was found to be the most common etiology for cases with suggestive of cACLD (47.2%) and highly suggestive of cACLD (41.5%). Conclusion: Hepatic steatosis is common in CLD, regardless of etiology. Compared with other etiologies, NAFLD is now the leading cause of cACLD. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF