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Abstract The response surface methodology in the design of experiments (DOE) wizard and Gurson-Tvergaard-Needleman (GTN) model were employed to estimate the optimum GTN damage parameters and to validate their significant effects respectively on the ductile fracture behavior of ECAP deformed AZ61 magnesium alloy. Hollomon's flow stress was applied to identify uniform deformation and non-uniform deformation regions to investigate the void nucleation and coalescence processes separately. The significance of statistical results was evaluated with the analysis of variance (ANOVA) based on P-values and coefficients of determination (R 2). Correspondingly, the contributions of ECAP plastic deformation and the corresponding local plasticity (damage progresses) on the progress of GTN ductile fracture damage parameters were studied. Desirability function was used to show the significance of individual and interaction effects of optimum initial damage parameters on the respective response variables. By using response surface methodology, the optimum GTN damage parameters were determined at the corresponding positions of each critical response variables. Results also showed that varying both stress triaxiality and damage variables simultaneously can greatly affect the curve fitting process of experimental, simulation and GTN model curves. However, at constant stress triaxiality condition, the GTN model curve was observed perfectly fitting with the tensile test curve. [ABSTRACT FROM AUTHOR]