1. Photoactivated Hydrogen Sulfide Donor with a Near-Infrared Fluorescence Report System for Accelerated Chronic Wound Healing.
- Author
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Yuan F, He X, Lu Y, Ning L, Zhao X, Zhang S, Guan F, Guo Y, and Zhang J
- Subjects
- Humans, Fluorescence, Reactive Oxygen Species, Wound Healing, Hydrogen Sulfide, Diabetes Complications
- Abstract
Delayed wound healing is one of the major diabetes complications that occur in 25% of diabetic patients. Specific wound management and combination treatment are required to repair the wound, which still remains a challenge with few effective therapies available currently. In this work, a new H
2 S donor PRO-F , which is characterized by the capability to promote wound healing in diabetes, was designed. PRO-F can be activated by light without consuming endogenous substances and the accompanying fluorescent signal makes the real-time tracking of released H2 S possible. PRO-F is able to deliver H2 S in an intracellular environment with moderate release efficiency (50%), which presents cytoprotective effects against excessive reactive oxygen species (ROS) induced damage. Furthermore, the potential of PRO-F to enhance chronic wound healing was validated by employing diabetic models. This work provides new insights into the therapeutic role of H2 S donors in complex wound conditions, which should advance the pathophysiological research associated with H2 S.- Published
- 2023
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