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Your search keyword '"Lindner, Axel"' showing total 2 results
Start Over Author "Lindner, Axel" Topic functional magnetic resonance imaging Topic prefrontal cortex Language english
2 results on '"Lindner, Axel"'

1. Human posterior parietal and dorsal premotor cortex encode the visual properties of an upcoming action

Author

Pilacinski, Artur, Wallscheid, Melanie, and Lindner, Axel

Subjects
Male, genetic structures, Eye Movements, Vision, Physiology, Visual System, Sensory Physiology, lcsh:Medicine, Social Sciences, Diagnostic Radiology, Mathematical and Statistical Techniques, Functional Magnetic Resonance Imaging, Parietal Lobe, Medicine and Health Sciences, Psychology, lcsh:Science, Musculoskeletal System, Cerebral Cortex, Brain Mapping, Radiology and Imaging, Statistics, Motor Cortex, Brain, Magnetic Resonance Imaging, Sensory Systems, Physical Sciences, Visual Perception, Sensory Perception, Female, Anatomy, psychological phenomena and processes, Research Article, Imaging Techniques, Cognitive Neuroscience, Movement, Prefrontal Cortex, Neuroimaging, Research and Analysis Methods, behavioral disciplines and activities, Diagnostic Medicine, Reaction Time, Humans, Statistical Methods, Vision, Ocular, Analysis of Variance, lcsh:R, Biology and Life Sciences, Cognitive Science, lcsh:Q, Mathematics, Photic Stimulation, Psychomotor Performance, Neuroscience
Abstract

Behavioral studies show that motor actions are planned by adapting motor programs to produce desired visual consequences. Does this mean that the brain plans these visual consequences independent of the motor actions required to obtain them? Here we addressed this question by investigating planning-related fMRI activity in human posterior parietal (PPC) and dorsal premotor (PMd) cortex. By manipulating visual movement of a virtual end-effector controlled via button presses we could dissociate motor actions from their sensory outcome. A clear representation of the visual consequences was visible in both PPC and PMd activity during early planning stages. Our findings suggest that in both PPC and PMd action plans are initially represented on the basis of the desired sensory outcomes while later activity shifts towards representing motor programs.

Published
2018

2. Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age.

Author

Höller-Wallscheid, Melanie S., Thier, Peter, Pomper, Jörn K., and Lindner, Axel

Subjects
CEREBRAL dominance, PREFRONTAL cortex, SHORT-term memory, FUNCTIONAL magnetic resonance imaging, OLDER patients
Abstract

Elderly adults may master challenging cognitive demands by additionally recruiting the cross-hemispheric counterparts of otherwise unilaterally engaged brain regions, a strategy that seems to be at odds with the notion of lateralized functions in cerebral cortex. We wondered whether bilateral activation might be a general coping strategy that is independent of age, task content and brain region. While using functional magnetic resonance imaging (fMRI), we pushed young and old subjects to their working memory (WM) capacity limits in verbal, spatial, and object domains. Then, we compared the fMRI signal reflecting WM maintenance between hemispheric counterparts of various task-relevant cerebral regions that are known to exhibit lateralization. Whereas language-related areas kept their lateralized activation pattern independent of age in difficult tasks, we observed bilaterality in dorsolateral and anterior prefrontal cortex across WM domains and age groups. In summary, the additional recruitment of cross-hemispheric counterparts seems to be an age-independent domain-general strategy to master cognitive challenges. This phenomenon is largely confined to prefrontal cortex, which is arguably less specialized and more flexible than other parts of the brain. [ABSTRACT FROM AUTHOR]

Published
2017
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