1. Earlier detection of gestational diabetes impacts on medication requirements, neonatal and maternal outcomes.
- Author
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Tirado‐Aguilar, Omar Alberto, Martinez‐Cruz, Nayeli, Arce‐Sanchez, Lidia, Borboa‐Olivares, Hector, Reyes‐Muñoz, Enrique, Espino‐y‐Sosa, Salvador, Villafan‐Bernal, Jose Rafael, Martinez‐Portilla, Raigam Jafet, Estrada‐Gutierrez, Guadalupe, Uribe‐Torres, Regina, Tirado Aguilar, Ricardo Daniel, Lopez‐Torres, Maria Fernanda, Ramos‐Mendoza, Cecilia, Camacho‐Martinez, Zaira Alexi, Aguilar‐Jaimes, Nelson Yesid, and Torres‐Torres, Johnatan
- Subjects
GESTATIONAL diabetes ,GLUCOSE tolerance tests ,GLYCEMIC control ,DRUGS ,RESPIRATORY distress syndrome ,NUTRITIONAL requirements - Abstract
Aim: Gestational diabetes (GD) is a global health concern with significant implications for maternal and neonatal outcomes. This study investigates the association between early GD (eGD) diagnosis (<24 weeks), pharmacotherapy requirements and adverse neonatal outcomes. Materials and Methods: A cohort of 369 pregnant women underwent a 75‐g oral glucose tolerance test. Maternal variables, pharmacotherapy prescriptions and neonatal outcomes were analysed employing t‐tests, χ2 tests, and logistic regression. A p <.05 was considered significant. Results: Early GD increased the odds of neonatal hypoglycaemia [odds ratio (OR): 18.57, p =.013] and respiratory distress syndrome (OR: 4.75, p =.034). Nutritional therapy prescription by an accredited nutritionist was the most common treatment in women diagnosed after 24 weeks, but those with eGD required more frequently specialized nutritional consulting + metformin to achieve glycaemic control (p =.027). eGD was associated with a higher requirement of nutritional therapy prescription + metformin (OR: 2.26, 95% confidence interval: 1.25‐4.09, p =.007) and with maternal hyperglycaemia during the post‐partum period at 2 h of the oral glucose tolerance test (OR: 1.03, 95% confidence interval: 1.02‐1.13, p =.024). Conclusion: Timely diagnosis and personalized treatment of GD are desirable because an earlier presentation is related to a higher risk of adverse neonatal and maternal outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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