6,408 results
Search Results
2. A disposable gold foil paper–based aptasensor for detection of enteropathogenic Escherichia coli with SERS analysis and magnetic separation technology
- Author
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Zhu, Xiaoying, Zhao, Yuwen, Zhang, Zeshuai, Wang, Haixia, Liu, Boshi, Li, Zheng, and Wang, Mengfan
- Published
- 2021
- Full Text
- View/download PDF
3. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay
- Author
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Zhang, Liding, Du, Xuewei, Su, Ying, Niu, Shiqi, Li, Yanqing, Liang, Xiaohan, and Luo, Haiming
- Published
- 2021
- Full Text
- View/download PDF
4. Comment on the Paper “Magnetic Field Effect on the Magnetic Nanoparticles Trajectories in Pulsating Blood Flow: a Computational Model, BioNanoScience (2022) 12:571–581”
- Author
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Pantokratoras, Asterios
- Published
- 2023
- Full Text
- View/download PDF
5. Optimization of Magnetic and Paper-Based Molecularly Imprinted Polymers for Selective Extraction of Charantin in Momordica charantia
- Author
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Nantana Nuchtavorn, Jiraporn Leanpolchareanchai, Satsawat Visansirikul, and Somnuk Bunsupa
- Subjects
charantin ,magnetic nanoparticles ,M. charantia ,molecularly imprinted polymers ,paper-based devices ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Charantin is a mixture of β-sitosterol and stigmastadienol glucosides, which effectively lowers high blood glucose. Novel molecularly imprinted polymers coated magnetic nanoparticles (Fe3O4@MIPs) and filter paper (paper@MIPs) were synthesized by sol-gel polymerization to selectively extract charantin. β-sitosterol glucoside was selected as a template for imprinting a specific recognition owing to its larger molecular surface area than that of 5,25-stigmastadienol glucoside. Factorial designs were used to examine the effects of the types of porogenic solvents and cross-linkers on the extraction efficiency and imprinting factor before investigating other factors (for example, amounts of template and coated MIPs, and types of substrates for MIP immobilization). Compared to traditional liquid–liquid extraction, the optimal Fe3O4@MIP-based dispersive micro-solid phase extraction and paper@MIP extraction provided excellent extraction efficiency (87.5 ± 2.1% and 85.0 ± 2.9%, respectively) and selectivity. Charantin was well separated, and a new unidentified sterol glucoside was observed using the developed high-performance liquid chromatography with diode-array detection (Rs ≥ 2.0, n > 16,400). The developed methods were successfully utilized to extract and quantify charantin from M. charantia fruit powder and herbal products. Moreover, these methods are rapid (
- Published
- 2023
- Full Text
- View/download PDF
6. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay
- Author
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Liding Zhang, Xuewei Du, Ying Su, Shiqi Niu, Yanqing Li, Xiaohan Liang, and Haiming Luo
- Subjects
Alzheimer’s disease ,Blood ,Aβ42 monomer ,Aβ42 oligomer ,Magnetic nanoparticles ,Gold nanoparticle ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Aβ42 is one of the most extensively studied blood and Cerebrospinal fluid (CSF) biomarkers for the diagnosis of symptomatic and prodromal Alzheimer’s disease (AD). Because of the heterogeneity and transient nature of Aβ42 oligomers (Aβ42Os), the development of technologies for dynamically detecting changes in the blood or CSF levels of Aβ42 monomers (Aβ42Ms) and Aβ42Os is essential for the accurate diagnosis of AD. The currently commonly used Aβ42 ELISA test kits usually mis-detected the elevated Aβ42Os, leading to incomplete analysis and underestimation of soluble Aβ42, resulting in a comprised performance in AD diagnosis. Herein, we developed a dual-target lateral flow immunoassay (dLFI) using anti-Aβ42 monoclonal antibodies 1F12 and 2C6 for the rapid and point-of-care detection of Aβ42Ms and Aβ42Os in blood samples within 30 min for AD diagnosis. By naked eye observation, the visual detection limit of Aβ42Ms or/and Aβ42Os in dLFI was 154 pg/mL. The test results for dLFI were similar to those observed in the enzyme-linked immunosorbent assay (ELISA). Therefore, this paper-based dLFI provides a practical and rapid method for the on-site detection of two biomarkers in blood or CSF samples without the need for additional expertise or equipment. Graphical Abstract
- Published
- 2021
- Full Text
- View/download PDF
7. Optimization of Magnetic and Paper-Based Molecularly Imprinted Polymers for Selective Extraction of Charantin in Momordica charantia.
- Author
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Nuchtavorn, Nantana, Leanpolchareanchai, Jiraporn, Visansirikul, Satsawat, and Bunsupa, Somnuk
- Subjects
- *
IMPRINTED polymers , *MOMORDICA charantia , *HIGH performance liquid chromatography , *MAGNETIC nanoparticles , *LIQUID-liquid extraction , *FACTORIAL experiment designs , *SOLVENT extraction , *POLYMER colloids - Abstract
Charantin is a mixture of β-sitosterol and stigmastadienol glucosides, which effectively lowers high blood glucose. Novel molecularly imprinted polymers coated magnetic nanoparticles (Fe3O4@MIPs) and filter paper (paper@MIPs) were synthesized by sol-gel polymerization to selectively extract charantin. β-sitosterol glucoside was selected as a template for imprinting a specific recognition owing to its larger molecular surface area than that of 5,25-stigmastadienol glucoside. Factorial designs were used to examine the effects of the types of porogenic solvents and cross-linkers on the extraction efficiency and imprinting factor before investigating other factors (for example, amounts of template and coated MIPs, and types of substrates for MIP immobilization). Compared to traditional liquid–liquid extraction, the optimal Fe3O4@MIP-based dispersive micro-solid phase extraction and paper@MIP extraction provided excellent extraction efficiency (87.5 ± 2.1% and 85.0 ± 2.9%, respectively) and selectivity. Charantin was well separated, and a new unidentified sterol glucoside was observed using the developed high-performance liquid chromatography with diode-array detection (Rs ≥ 2.0, n > 16,400). The developed methods were successfully utilized to extract and quantify charantin from M. charantia fruit powder and herbal products. Moreover, these methods are rapid (<10 min), inexpensive, simple, reproducible, and environmentally friendly. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Immobilization and Characterization of a Processive Endoglucanase EG5C-1 from Bacillus subtilis on Melamine–Glutaraldehyde Dendrimer-Functionalized Magnetic Nanoparticles.
- Author
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Li, Xiaozhou, Chen, Jie, Wu, Bin, Gao, Zhen, and He, Bingfang
- Subjects
MAGNETIC nanoparticles ,BACILLUS subtilis ,DENDRIMERS ,FILTER paper ,GRAFT copolymers ,CARBOXYL group ,CELLULASE - Abstract
Exploring an appropriate immobilization approach to enhance catalytic activity and reusability of cellulase is of great importance to reduce the price of enzymes and promote the industrialization of cellulose-derived biochemicals. In this study, Fe
3 O4 magnetic nanoparticles (MNPs) were functionalized with meso-2,3-dimercaptosuccinic acid to introduce carboxyl groups on the surface (DMNPs). Then, melamine–glutaraldehyde dendrimer-like polymers were grafted on DMNPs to increase protein binding sites for the immobilization of processive endoglucanase EG5C-1. Moreover, this dendrimer-like structure was beneficial to protect the conformation of EG5C-1 and facilitate the interaction between substrate and active center. The loading capacity of the functionalized copolymers (MG-DMNPs) for EG5C-1 was about 195 mg/g, where more than 90% of the activity was recovered. Immobilized EG5C-1 exhibited improved thermal stability and increased tolerability over a broad pH range compared with the free one. Additionally, MG-DMNP/EG5C-1 biocomposite maintained approximately 80% of its initial hydrolysis productivity after five cycles of usage using filter paper as the substrate. Our results provided a promising approach for the functionalization of MNPs, enabling the immobilization of cellulases with a high loading capacity and excellent activity recovery. [ABSTRACT FROM AUTHOR]- Published
- 2024
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9. Magnetic-gold nanoparticle-mediated paper-based biosensor for highly sensitive colorimetric detection of food adulteration.
- Author
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Wang, Anyu, Chen, Zihan, Feng, Xiao, He, Guangyun, Zhong, Tian, Xiao, Ying, and Yu, Xi
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- *
FOOD adulteration , *COLLOIDAL gold , *SMART devices , *MAGNETIC nanoparticles , *BIOSENSORS , *RAMAN scattering - Abstract
Food adulteration presents a significant challenge due to the evasion of legal oversight and the difficulty of identification. Addressing this issue, there is an urgent need for on-site, rapid, visually based small-scale equipment, along with large-scale screening technology, to enable prompt results without providing opportunities for dishonest traders to react. Colorimetric reactions offer advantages in terms of speed, visualization, and miniaturization. However, there is a scarcity of suitable colorimetric reactions for food adulteration detection, and interference from colored food impurities and easily comparable color results affects accuracy. To overcome limitations, this study introduces a novel approach utilizing polydopamine magnetic nanoparticles to enrich DNA in food samples, effectively eliminating interfering components. By employing gold nanoparticles to generate magnetic-gold nanoparticles, a single magnetic bead achieves simultaneous enrichment, impurity removal, and detection. The use of paper-based biosensors and visualization equipment allows for the visualization and digital analysis of results, achieving a low detection limit of 4.59 nmol mL−1. The method also exhibits high accuracy and repeatability, with a RSD ranging from 1.6 % to 4.0 %. This innovative colorimetric method addresses the need for rapid, miniaturized, and large-scale detection, thus providing a solution for food adulteration challenges. [Display omitted] • Magnetic enrichment and colloid gold colorimetric detection were collaboratively designed. • Aptamer was combined with the magnetic-gold-nanocomposite to recognize food adulteration. • Paper-based biosensors and smart devices were jointly applied to develop real-time detection methods. • The proposed method is rapid, sensitive, accurate and specific. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
10. Portable paper-based colorimetric nanoprobe for the detection of Stachybotrys chartarum using peptide labeled magnetic nanoparticles
- Author
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Suaifan, Ghadeer A. R. Y. and Zourob, Mohammed
- Published
- 2019
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11. Paper based colorimetric sensor using novel green magnetized nanocomposite of pinus for hydrogen peroxide detection in water and milk.
- Author
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Buzdar, Mehrosh, Yaqub, Asim, Hayat, Akhtar, Ul Haq, Muhammad Zia, Khan, Aizaz, and Ajab, Huma
- Subjects
HYDROGEN peroxide ,FOURIER transform infrared spectroscopy ,PINE ,MAGNETIC nanoparticles ,SCANNING electron microscopes ,NANOCOMPOSITE materials ,DRINKING water - Abstract
The present work was focused on the Hydrogen peroxide (H 2 O 2) detection by designing a portable and sustainable filter paper based sensor based on novel use of green enzyme mimic magnetic nanoparticles of Pinus needles (MNP). The nanozymes were synthesized via an easy ecofriendly and cheap route besides characterized by UV–Vis spectroscopy, Scanning Electron Microscope, Fourier transform infrared spectroscopy, Zeta potential, X-ray diffraction and Vibrating Sample Magnetometer etc. The characterization study supported the suitability and optical properties of MNP for sensor fabrication like presence of various functional groups, availability of binding sites, moderate stability, super paramagnetic properties and amorphous structure etc. The coactive effect of Pinus needles and magnetic nanoparticles components on sensing platform demonstrated an inherent peroxidase-like activity with enhanced optical response for catalyzing the oxidation of substrate 3,3′,5,5′-tetramethylbenzidine with perceived naked eye reaction. The optimization was carried out with respect to different parameters such as incubation time (15 min), Gel concentration (0.2 mg/mL) and concentration of MNP (2 mg/mL) etc. A good sensitivity was achieved by using color analyzing model at a lower limit of detection (LOD) 0.007 μ M in a relative wide-ranging of 0.01 μ M–0.09 μ M. The application in biological and samples environmental (tap water and milk) indicated that the proposed paper-based sensor delivers reasonable platforms for simple, sustainable, and quick detection of H 2 O 2 with high selectivity. [Display omitted] • Nanozyme based on magnetic nanoparticles of Pinus needles for Hydrogen peroxide detection. • Better sensitivity and selectivity through an affordable and ecofriendly approach. • Portable filter paper based assay for direct onsite monitoring of food quality. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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12. Paper-based microfluidics and magnetic nanoparticles for point-of-care devices. Potential solutions for toxic cyanobacteria detection
- Author
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Stanojev, Jovana, Podunavac, Ivana, Omerović, Nejra, Davidović, Petar, and Đisalov, Mila
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magnetic nanoparticles ,paper-based microfluidics ,point-of-care device ,cyanobacteria - Abstract
It is of great importance to involve Young Researchers in the project implementation. We are very pleased that our ESRs showed much interest in being included in all IPANEMA activities, particularly in Online Journal Clubs. On June 3, 2020, they organized the 3rd OJC related to the IPANEMA SOL3 topic: Molecular diagnostics based on DNA amplification and magnetic sensor arrays. This time, Young Scientists from BioSense Institute were talking about the latest innovations and future perspectives in the field of point-of-care devices development and cyanobacteria detection., IPANEMA - 872662 - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications
- Published
- 2020
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13. Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels.
- Author
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Walgama, Charuksha, Nguyen, Michael P., Boatner, Lisa M., Richards, Ian, and Crooks, Richard M.
- Subjects
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MICROFLUIDIC devices , *FLUIDIC devices , *CELLULOSE fibers , *DETECTION limit , *LABELS , *MAGNETIC nanoparticles , *MICROBUBBLES - Abstract
In the present article we report a new hybrid microfluidic device (hyFlow) comprising a disposable paper electrode and a three-dimensional (3D) printed plastic chip for the electrochemical detection of a magnetic bead–silver nanoparticle (MB–AgNP) bioconjugate. This hybrid device evolved due to the difficulty of incorporating micron-scale MBs into paper-only fluidic devices. Specifically, paper fluidic devices can entrap MB-containing conjugates within their cellulose or nitrocellulose fiber matrix. The hyFlow system was designed to minimize such issues and transport MB conjugates more efficiently to the electrochemical detection zone of the device. The hyFlow system retains the benefit of fluid transport by pressure-driven flow, however, no pump is required for its operation. The hyFlow device is capable of detecting either pre-formed MB–AgNP conjugates or conjugates formed in situ. The detection limit of AgNPs using this device is 12 pM, which represents just 22 AgNPs per MB. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
14. Paper based DNA biosensor for detection of chikungunya virus using gold shells coated magnetic nanocubes.
- Author
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Singhal, Chaitali, Dubey, Amidha, Mathur, Ashish, Pundir, C.S., and Narang, Jagriti
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NUCLEOTIDE sequencing , *BIOSENSORS , *CHIKUNGUNYA virus , *MAGNETIC nanoparticles , *ELECTROCHEMICAL analysis - Abstract
Graphical abstract Highlights • Electrochemical paper analytical devices (ePADs) were used in the present sensor. • These ePADs are cost effective, disposable and easy to use. • eDADs have potential for commercialization and can be used as point-of-care devices. • This is the first report on electrochemical sensing of chikungunya virus DNA. • Fe 3 O 4 @Au nanocubes amplifies the electrochemical response. Abstract Electrochemical DNA (E-DNA) sensors have attracted large attention, as they play an important role in early diagnosis of infectious diseases. Herein, we have rationally utilized the ultra-high charge-transfer efficiency of gold nanoparticles (Au) and biocompatibility associated with magnetic nanoparticles (Fe 3 O 4) to develop detection platform for chikungunya virus DNA (CHIKV). The use of electrochemical paper analytical device (ePADs) further adds on to the attractive attributes of the sensor, because paper being an inexpensive substrate could help in mass production of the platform easily. Therefore, a simple, sensitive and inexpensive platform has been developed for the detection of target DNA of CHIKV. The detection limit of the present sensor was 0.1 nM with a linear range from 0.1 nM to 100 μM. The use of paper makes it too economic for mass production and has the capability to convert for commercial use. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
15. Magnetic paper from sugarcane bagasse fibers modified with cobalt ferrite nanoparticles.
- Author
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Piñeres, Oscar H., Salcedo, Emma C., Herrera, Adriana P., Sánchez, Jorge H., and Quintana, Germán C.
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BAGASSE ,FIBERS ,MAGNETIC nanoparticles ,FERRITES ,SUGARCANE ,RAW materials ,COBALT ,ZINC ferrites - Abstract
Magnetic paper sheets were prepared from bleached sugarcane bagasse fibers and cobalt ferrite nanoparticles by lumen loading method. Sugarcane bagasse is an important fibrous raw material widely used worldwide for papermaking, whereas cobalt ferrite nanoparticles is an appropriate material for fibers modification given their magnetic properties. Cobalt ferrite nanoparticles were synthetized by coprecipitation method and coated with silica by hydrolysis and condensation of tetraethyl orthosilicate (TEOS) molecules. Then, silica coated magnetic nanoparticles were functionalized with polyethylenimine (PEI), as retention aid, by electrostatic bonding. It was observed that the loading degree of magnetic fibers depends on nanoparticles concentration and PEI dosage, which was determined by thermogravimetric analysis (TGA). Scanning electron microscope (SEM) shows the deposition of coated nanoparticles on the surface and into macropores of fibers. All samples exhibited ferromagnetic behavior. The coercivity values of magnetic fibers are higher than 0.2 kOe. This indicates that these fibers could be used to produce paper for magnetic recording purposes. Magnetic papers with 10 and 20% of modified fibers were manufactured. Brightness and tensile index of papers were decreased with the rise of loading degree. CIEL*a*b analysis shows the color differences between unmodified and modified papers. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
16. Microfluidic paper-based multiplex colorimetric immunodevice based on the catalytic effect of Pd/Fe3O4@C peroxidase mimetics on multiple chromogenic reactions.
- Author
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Liang, Linlin, Ge, Shenguang, Li, Li, Liu, Fang, and Yu, Jinghua
- Subjects
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MICROFLUIDIC devices , *COLORIMETRIC analysis , *PALLADIUM catalysts , *IRON oxide nanoparticles , *PEROXIDASE , *CHROMOGENIC compounds , *MAGNETIC nanoparticles , *CATALYTIC activity - Abstract
In this report, a non-toxic method was proposed for the simple synthesis of palladium nanoparticles (Pd)/Fe 3 O 4 @C peroxidase mimetics by virtue of in situ growth of Pd nanoparticles on Fe 3 O 4 @C magnetic nanoparticles. And a microfluidic paper-based multiplex colorimetric immunodevice (named α-sheet) was developed by site-selectively immobilizing multiple antigens owing to its intrinsic high-efficiency catalytic activity of peroxidase mimetics to multiple chromogenic reactions. The immunosensor platform was prepared by growing a layer of flower-like gold nanoparticles which could entrap the primary antibodies onto paper sensing zones, and the as-prepared Pd/Fe 3 O 4 @C peroxidase mimetics was used to label secondary antibodies. In the presence of 3,3′,5,5′-tetramethylbenzidine and o -phenylenediamine chromogenic substrates, Pd/Fe 3 O 4 @C peroxidase mimetics catalyzed chromogenic reactions and showed different colors with respective intensity. To precisely identify the intensity, a piece of black wax printed chromatographic paper with three observing windows (named β-sheet) was flatted on α-sheet. Under the optimal condition, the proposed multiplex colorimetric immunodevice displayed wide linear ranges from 0.005 to 30 ng mL −1 with low detection limits of 1.7 pg mL −1 for carcinoembryonic antigen (CEA) and α-fetoprotein (α-AFP). Meanwhile, the proposed method provided provided a non-toxic, low-cost and promising tool for point-of-care diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
17. Long-chain ionic liquid based mixed hemimicelles and magnetic dispersed solid-phase extraction for the extraction of fluorescent whitening agents in paper materials.
- Author
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Wang, Qing, Qiu, Bin, Chen, Xianbo, Wang, Bin, Zhang, Hui, and Zhang, Xiaoyuan
- Subjects
- *
OPTICAL brighteners , *IONIC liquids , *MICELLES , *SOLID phase extraction , *PAPER textiles - Abstract
A novel mixed hemimicelles and magnetic dispersive solid-phase extraction method based on long-chain ionic liquids for the extraction of five fluorescent whitening agents was established. The factors influenced on extraction efficiency were investigated. Under the optimal conditions, namely, the pH of sample solution at 8.0, the concentration of long chain ionic liquid at 0.5 mmol/L, the amount of Fe3O4 nanoparticle at 12 mg, extraction time at 10 min, pH 6.0 of methanol as eluent, and the desorption time at 1 min, satisfactory results were obtained. Wide linear ranges (0.02-10 ng/mL) and good linearity were attained (0.9997-0.9999). The intraday and interday RSDs were 2.1-8.3%. Limits of detection were 0.004-0.01 ng/mL, which were decreased by almost an order of magnitude compared to direct detection without extraction. The present method was applied to extract the fluorescent whitening agents in two kinds of paper samples, obtaining satisfactory results. All showed results illustrated that the detection sensitivity was improved and the proposed method was a good choice for the enriching and monitoring of trace fluorescent whitening agents. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
18. NZVI modified magnetic filter paper with high redox and catalytic activities for advanced water treatment technologies.
- Author
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Datta, K. K. R., Datta, K. J., Perman, J. A., Tucek, J., Otyepka, M., Zoppellaro, G., Zboril, R., Petala, E., and Bartak, P.
- Subjects
MAGNETIC properties of nanocomposite materials ,NANOCOMPOSITE materials ,MAGNETIC separators ,DRINKING water purification ,CHROMIUM removal (Water purification) ,FILTER paper ,MAGNETIC nanoparticles - Abstract
The in situ synthesis of air-stable zero-valent iron nanoparticles (NZVI) embedded in cellulose fibers leads to the assembly of highly reactive magnetic filter papers. These engineered materials display a wide range of applications in the treatment of wastewater and drinking water, including chromium removal, phenol degradation, environmental bioremediation, and catalysis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
19. Linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles: application to controlled drug delivery
- Author
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Tiam Kapen, Pascalin, Njingang Ketchate, Cédric Gervais, Fokwa, Didier, and Tchuen, Ghislain
- Published
- 2022
- Full Text
- View/download PDF
20. Comment on the paper "Fractional order model of thermo-solutal and magnetic nanoparticles transport for drug delivery applications, Subrata Maiti, Sachin Shaw, G.C. Shit, [Colloids Surf. B Biointerfaces, 203(2021) 111754]″.
- Author
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Pantokratoras, Asterios
- Subjects
- *
BIOLOGICAL interfaces , *MAGNETIC nanoparticles , *COLLOIDS , *DRUGS - Abstract
Some errors exist in the above paper. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
21. Dynamical Detection of Magnetic Nanoparticles in Paper Microfluidics With Spin Valve Sensors for Point-of-Care Applications.
- Author
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Chicharo, Alexandre, Cardoso, Filipe, Cardoso, Susana, and Freitas, Paulo P.
- Subjects
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MAGNETIC nanoparticles , *MICROFLUIDICS , *SPIN valves , *POINT-of-care testing , *SENSITIVITY analysis , *BIOMOLECULES - Abstract
In the pursuit of point-of-care systems that present high sensitivity and fast turnaround time, lateral flow is considered a remarkable promising class of in vitro diagnostics, and popularized by the pregnancy tests. A variety of lateral flow tests have emerged able to provide cardiac panels in emergency conditions, infectious disease screening, drug abuse, among others. However, most commercial tests only provide qualitative results, limiting their applicability for quantification thresholds of most biomarkers. In this paper, we propose a novel detection architecture for quantification of biomolecules labeled with magnetic nanoparticles employing two spin valve sensors. The main goal of this paper is to demonstrate that this architecture can detect and monitor MNPs flowing in a LFT strip for detection and quantification of different solutions varying in MNP concentration. In addition, we present preliminary analytical results that support our strategy for achieving biomolecular quantification using the proposed solution. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
22. Paper-based magnetic nanoparticle-peptide probe for rapid and quantitative colorimetric detection of Escherichia coli O157:H7.
- Author
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Suaifan, Ghadeer A.R.Y., Alhogail, Sahar, and Zourob, Mohammed
- Subjects
- *
MAGNETIC nanoparticles , *COLORIMETRIC analysis , *ESCHERICHIA coli , *FOOD microbiology , *FOODBORNE diseases - Abstract
There is a critical and urgent demand for a simple, rapid and specific qualitative and quantitative colorimetric biosensor for the detection of the food contaminant Escherichia coli O157:H7 ( E. coli O157:H7) in complex food products due to the recent outbreaks of food-borne diseases. Traditional detection techniques are time-consuming, require expensive instrumentation and are labour-intensive. To overcome these limitations, a novel, ultra-rapid visual biosensor was developed based on the ability of E. coli O157:H7 proteases to change the optical response of a surface-modified, magnetic nanoparticle-specific (MNP-specific) peptide probe. Upon proteolysis, a gradual increase in the golden color of the sensor surface was visually observed. The intensification of color was correlated with the E. coli O157:H7 concentration. The color change resulting from the dissociation of the self-assembled monolayer (SAM) was detected by the naked eye and analysed using an image analysis software (ImageJ) for the purpose of quantitative detection. This biosensor demonstrated high sensitivity and applicability, with lower limits of detection of 12 CFU mL −1 in broth samples and 30–300 CFU mL −1 in spiked complex food matrices. In conclusion, this approach permits the use of a disposable biosensor chip that can be mass-produced at low cost and can be used not only by food manufacturers but also by regulatory agencies for better control of potential health risks associated with the consumption of contaminated foods. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
23. A Simple and Scalable Approach for Fabricating High-Performance Superparamagnetic Natural Cellulose Fibers and Papers.
- Author
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Mashkour, Mahdi and Mashkour, Mozhdeh
- Subjects
- *
NATURAL fibers , *CHEMICAL processes , *PULPING , *SUPERPARAMAGNETIC materials , *CELLULOSE fibers , *SULFATE pulping process , *MAGNETIC nanoparticles - Abstract
• A new combined method is proposed for fabricating high-performance SPNCFs. • The SPNCFs were prepared by kraft pulping of pre-prepared magnetic wood. • The outer surface of SPNCFs was free from the magnetic nanoparticles. • Papers made of the SPNCFs showed good appearance, printability and tensile properties. This study introduces a new combined method of wood impregnation and chemical pulping processes leading to the production of superparamagnetic cellulose fibers with a magnetic nanoparticle-free outer surface. First, magnetic wood chips (MWCs) were prepared by in situ synthesizing of magnetite (Fe 3 O 4) nanoparticles during the wood impregnation process. The MWCs were then converted into magnetic fibers by kraft pulping. The results showed that the resulting magnetic fibers had an outer surface comparable to that of non-magnetic fibers while showing superparamagnetic behavior. The XRD results confirmed that the in situ synthesized magnetic nanoparticles were magnetite. Papers made from the new type of magnetic cellulose fibers had much more desirable tensile properties, appearance, and printability than papers made from conventional magnetic cellulose fibers, comparable to those made from non-magnetic fibers. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
24. Mathematical modeling of the production of magnetic nanoparticles through counter-flow non-premixed combustion for biomedical applications
- Author
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Akbari, Shahin, Hasanvand, Nima, Sadeghi, Sadegh, Bidabadi, Mehdi, and Xiong, Qingang
- Published
- 2021
- Full Text
- View/download PDF
25. Optimization of Multicore-Shell Fe3O4-SiO2 Magnetic Nanocomposites Synthesis and Retention in Cellulose Pulp.
- Author
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Buteica, Dan, Borbath, Istvan, Nicolae, Ionel Valentin, Turcu, Rodica, Marinica, Oana, and Socoliuc, Vlad
- Subjects
NANOPARTICLES ,MAGNETIC nanoparticles ,MAGNETIC materials ,COMPOSITE materials ,CELLULOSE nanocrystals - Abstract
The use of magnetite nanoparticles to produce magnetic paper has a severe effect on the color of the paper, which is worth searching means to alleviate. Multicore-shell Fe3O4-SiO2 magnetic nanocomposites were synthesized. The nanocomposite powder was dispersed in cellulose pulp and paper was produced by dehydration on a Rapid Kothen machine. The nanocomposite retention efficiency was investigated in correlation with nanocomposite shell thickness, the resinous vs. deciduous fiber content of the cellulose pulp, the long and short fibers' grinding degree, the cationic starch and polymeric retention agent content of the pulp. The whiteness and magnetization was measured for all paper samples. It was proved that the use of multi-core shell magnetic nanocomposites leads to weaker paper coloring. This effect is enhanced by increasing the polymeric retention agent content of the pulp, in spite of higher composite content. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
26. Enhanced Performance of Immobilized Xylanase/Filter Paper-ase on a Magnetic Chitosan Support.
- Author
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Amaro-Reyes, Aldo, Díaz-Hernández, Azariel, Gracida, Jorge, García-Almendárez, Blanca E., Escamilla-García, Monserrat, Arredondo-Ochoa, Teresita, and Regalado, Carlos
- Subjects
- *
MAGNETIC separators , *IMMOBILIZED enzymes , *XYLANASES , *CHITOSAN , *MAGNETIC nanoparticles , *HYDROLASES - Abstract
Enzyme immobilization on different supports has emerged as an efficient and cost-effective tool to improve their stability and reuse capacity. This work aimed to produce a stable immobilized multienzymatic system of xylanase and filter paper-ase (FPase) onto magnetic chitosan using genipin as a cross-linking agent and to evaluate its biochemical properties and reuse capacity. A mixture of chitosan magnetic nanoparticles, xylanase, and FPase was covalently bonded using genipin. Immobilization yield and efficiency were quantified. The activity of free and immobilized enzymes was quantified at different values of pH, temperature, substrate concentration (Km and Vmax), and reuse cycles. The immobilization yield, immobilization efficiency, and activity recovery were 145.3% ± 3.06%, 14.8% ± 0.81%, and 21.5% ± 0.72%, respectively, measured as the total hydrolytic activity. Immobilization confers resistance to acidic/basic conditions and thermal stability compared to the free form. Immobilization improved 3.5-fold and 78-fold the catalytic efficiency (Kcat/Km) of the xylanase and filter paper-ase activities, while immobilized xylanase and FPase could be reused for 34 min and 43 min, respectively. Cross-linking significantly improved the biochemical properties of immobilized enzymes, combined with their simplicity of reuse due to the paramagnetic property of the support. Multienzyme immobilization technology is an important issue for industrial applications. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
27. Synthesizing a nanoparticle distribution in magnetic fluid hyperthermia
- Author
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Di Barba, P., Dughiero, F., Sieni, E., Prof.. Dughiero, Fabrizio, Prof. Dr.. Baake, Egbert, and Professor. Forzan, Michele
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- 2011
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28. Numerical Simulation of Thermal Therapy for Melanoma in Mice.
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Zhang, Yunfei and Lu, Mai
- Subjects
MAGNETIC flux density ,ELECTROMAGNETIC induction ,ELECTROMAGNETS ,ELECTROMAGNETIC fields ,MAGNETIC nanoparticles - Abstract
In recent years, the progressively escalating incidence and exceptionally high fatality rate of cutaneous melanoma have drawn the attention of numerous scholars. Magnetic induction hyperthermia, as an efficacious tumor treatment modality, has been promoted and applied in the therapy of some tumors. In this paper, the melanoma atop the mice's heads was chosen as the research subject, and a magnetic induction hyperthermia approach based on Helmholtz coils as the magnetic field excitation was investigated and designed. The influence of the electromagnetic field and thermal field on organisms was addressed through modeling by COMSOL simulation software. The results showed that the maximum values of induced electric field and magnetic induction strength in mouse tumor tissues were 63.1 V/m and 8.5621 mT, respectively, which reached the threshold value of magnetic field strength required for magnetic induction hyperthermia. The maxima of the induced electric field and magnetic induction intensity in brain tissues are, respectively, 35.828 V/m and 8.57 mT. Approximately 93% of the tumor tissue can reach 42 °C, and the maximum temperature is 44.2 °C. Within this temperature range, a large quantity of tumor cells can be successfully induced to undergo apoptosis without harming normal cells, and the therapeutic effect is favorable. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
29. Potential Use of DMSA‐Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID‐19 Disease
- Author
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Carlos E. de Castro, Elisama S. Martins, Paula S. Haddad, Camila Chagas, Tatiane N. Britos, Ariane Espindola, Fernando Luiz Affonso Fonseca, and Emerson Barbosa
- Subjects
iron oxide ,Materials science ,Full Paper ,Iron oxide ,Nanoparticle ,COVID-19 ,General Chemistry ,Full Papers ,chemistry.chemical_compound ,biocompatibility ,chemistry ,Dynamic light scattering ,Transmission electron microscopy ,drug delivery ,Magnetic nanoparticles ,nanoparticles ,Materials Science inc. Nanomaterials & Polymers ,Iron oxide nanoparticles ,Magnetite ,Superparamagnetism ,Nuclear chemistry - Abstract
Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID‐19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co‐precipitation of iron salts and coated with meso‐2,3‐dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X‐ray diffraction (XRD), Fourier transformed infrared (FT‐IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid‐state and are superparamagnetic at room temperature. There is no toxicity of SPIONS‐DMSA under the cells of patients with COVID‐19. Taken together the results show that DMSA‐ Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells., Superparamagnetic iron oxide magnetic nanoparticles (SPIONs) have been proposed for an increasing number of biomedical applications, such as drug delivery. Thiol groups on the surface of DMSA‐coated nanoparticles can be promising candidates to combat the disease COVID‐19 treatment.
- Published
- 2021
30. Advances in Supported Nanoparticle Catalysts.
- Author
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Carabineiro, Sónia Alexandra Correia
- Subjects
NANOPARTICLES ,CATALYSTS ,CHEMICAL amplification ,METAL nanoparticles ,NANOPARTICLE synthesis ,MAGNETIC nanoparticles ,MESOPOROUS silica - Abstract
This document is an editorial from the journal Processes, titled "Advances in Supported Nanoparticle Catalysts." It highlights a collection of research papers that showcase the forefront of innovation in developing and utilizing supported nanoparticle catalysts. The research papers cover various topics such as the efficient removal of anionic dyes from water, the synthesis of metal nanoparticles for environmentally benign processes, the fabrication of superhydrophobic carbon nanomaterials, and the enhancement of polymer nanoparticles for immunoanalysis applications. The document emphasizes the importance of understanding supported nanoparticle systems for optimizing photocatalytic processes and tailoring catalysts for diverse catalytic reactions. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
31. Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)
- Author
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Reza Didarian and Ibrahim Vargel
- Subjects
Hyperthermia ,Chemistry ,Coprecipitation ,Nanoparticle ,Self-assembled monolayer ,Hyperthermia, Induced ,medicine.disease ,Electronic, Optical and Magnetic Materials ,Original Research Paper ,chemistry.chemical_compound ,Neoplasms ,Monolayer ,medicine ,Biophysics ,Surface modification ,Magnetic nanoparticles ,Humans ,Gold ,Electrical and Electronic Engineering ,Magnetite Nanoparticles ,Original Research Papers ,TP248.13-248.65 ,Biotechnology ,Carbodiimide - Abstract
Intelligent inorganic nanoparticles were designed and produced for use in imaging and annihilating tumour cells by radio‐frequency (RF) hyperthermia. Nanoparticles synthesised to provide RF hyperthermia must have magnetite properties. For this purpose, magnetite nanoparticles were first synthesised by the coprecipitation method (10–15 NM). These superparamagnetic nanoparticles were then covered with gold ions without losing their magnetic properties. In this step, gold ions are reduced around the magnetite nanoparticles. Surface modification of the gold‐coated magnetic nanoparticles was performed in the next step. A self‐assembled monolayer was created using cysteamine (2‐aminoethanethiol) molecules, which have two different end groups (SH and NH2). These molecules react with the gold surface by SH groups. The NH2 groups give a positive charge to the nanoparticles. After that, a monoclonal antibody (Monoclonal Anti‐N‐CAM Clone NCAM‐OB11) was immobilised by the 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide/N‐hydroxysuccinimide method. Then, the antenna RF system (144.00015 MHz) was created for RF hyperthermia. The antibody‐nanoparticle binding rate and cytotoxicity tests were followed by in vitro and in vivo experiments. As the main result, antibody‐bound gold‐coated magnetic nanoparticles were successfully connected to tumour cells. After RF hyperthermia, the tumour size decreased owing to apoptosis and necrosis of tumour cells.
- Published
- 2021
32. Magnetic core‐shell Fe3O4@TiO2 nanocomposites for broad spectrum antibacterial applications
- Author
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Nisha Rani and Brijnandan S. Dehiya
- Subjects
Titanium ,Materials science ,Nanocomposite ,Nanostructure ,Magnetic Phenomena ,Nanoparticle ,Electronic, Optical and Magnetic Materials ,Anti-Bacterial Agents ,Nanocomposites ,Original Research Paper ,chemistry.chemical_compound ,chemistry ,Titanium dioxide ,Spectroscopy, Fourier Transform Infrared ,Photocatalysis ,Escherichia coli ,Magnetic nanoparticles ,Electrical and Electronic Engineering ,Antibacterial activity ,Original Research Papers ,TP248.13-248.65 ,Nuclear chemistry ,Magnetite ,Biotechnology - Abstract
The authors have synthesised a core‐shell Fe3O4@TiO2 nanocomposite consisting of Fe3O4 as a magnetic core, and TiO2 as its external shell. The TiO2 shell is primarily intended for use as a biocompatible and antimicrobial carrier for drug delivery and possible other applications such as wastewater remediation purposes because of its known antibacterial and photocatalytic properties. The magnetic core enables quick and easy concentration and separation of nanoparticles. The magnetite nanoparticles were synthesized by a hydrothermal route using ferric chloride as a single‐source precursor. The magnetite nanoparticles were then coated with titanium dioxide using titanium butoxide as a precursor. The core‐shell Fe3O4@TiO2 nanostructure particles were characterized by XRD, UV spectroscopy, and FT‐IR, TEM, and VSM techniques. The saturation magnetization of Fe3O4 nanoparticles was significantly reduced from 74.2 to 13.7 emu/g after the TiO2 coating. The antibacterial studies of magnetic nanoparticles and the titania‐coated magnetic nanocomposite were carried out against gram+ve, and gram–ve bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Shigella flexneri , Escherichia coli, and Salmonella typhi) using well diffusion technique. The inhibition zone for E. coli (17 mm after 24 h) was higher than the other bacterial strains; nevertheless, both the uncoated and TiO2‐coated magnetite nanocomposites showed admirable antibacterial activity against each of the above bacterial strains.
- Published
- 2021
33. Heating ability of elongated magnetic nanoparticles
- Author
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Vladimir A. Oleinikov, N. A. Usov, and Elizaveta M. Gubanova
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Technology ,Materials science ,Science ,QC1-999 ,General Physics and Astronomy ,Nanoparticle ,TP1-1185 ,Molecular physics ,Full Research Paper ,elongated magnetic nanoparticles ,Cluster (physics) ,Nanotechnology ,General Materials Science ,magnetic hyperthermia ,Electrical and Electronic Engineering ,Chemical technology ,Physics ,Magnetic field ,Nanoscience ,Hysteresis ,Magnetic hyperthermia ,specific absorption rate ,numerical simulation ,Volume fraction ,Magnetic nanoparticles ,Particle - Abstract
Low-frequency hysteresis loops and specific absorption rate (SAR) of various assemblies of elongated spheroidal magnetite nanoparticles have been calculated for a range of particle semiaxis ratios a/b = 1.0–3.0. The SAR of a dilute randomly oriented assembly of magnetite nanoparticles in an alternating magnetic field of moderate frequency, f = 300 kHz, and amplitude H0 = 100–200 Oe is shown to decrease significantly with an increase in the aspect ratio of nanoparticles. In addition, there is a narrowing and shift of the intervals of optimal particle diameters towards smaller particle sizes. However, the orientation of a dilute assembly of elongated nanoparticles in a magnetic field leads to an almost twofold increase in SAR at the same frequency and amplitude of the alternating magnetic field, the range of optimal particle diameters remaining unchanged. The effect of the magneto-dipole interaction on the SAR of a dilute assembly of oriented clusters of elongated magnetite nanoparticles has also been investigated depending on the volume fraction of nanoparticles in a cluster. It has been found that the SAR of the assembly of oriented clusters decreases by approximately an order of magnitude with an increase in the volume fraction of nanoparticles in a cluster in the range of 0.04–0.2.
- Published
- 2021
34. Synthesis and Antimicrobial Activity of (E)-1-Aryl-2-(1H-tetrazol-5-yl)acrylonitrile Derivatives via [3+2] Cycloaddition Reaction Using Reusable Heterogeneous Nanocatalyst under Microwave Irradiation.
- Author
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Nanda, Ayashkanta, Kaur, Navneet, Kaur, Manvinder, Husain, Fohad Mabood, Han, Haesook, Bhowmik, Pradip K., and Sohal, Harvinder Singh
- Subjects
MAGNETIC nanoparticles ,CATALYSTS recycling ,RING formation (Chemistry) ,NANOPARTICLES ,HETEROGENEOUS catalysts ,TETRAZOLES - Abstract
The magnetically recoverable heterogeneous Fe
2 O3 @cellulose@Mn nanocomposite was synthesized by a stepwise fabrication of Mn nanoparticles on cellulose-modified magnetic Fe2 O3 nanocomposites, and the morphology of the nanocomposite was characterized through advanced spectroscopic techniques. This nanocomposite was investigated as a heterogeneous catalyst for the synthesis of medicinally important tetrazole derivatives through Knoevenagel condensation between aromatic/heteroaromatic aldehyde and malononitrile followed by [3+2] cycloaddition reaction with sodium azide. Thirteen potent (E)-1-aryl-2-(1H-tetrazol-5-yl)acrylonitrile derivatives are reported in this paper with very high yields (up to 98%) and with excellent purity (as crystals) in a very short period (3 min @ 120 W) using microwave irradiation. The present procedure offers several advantages over recent protocols, including minimal catalyst loading, quick reaction time, and the utilization of an eco-friendly solvent. Furthermore, the synthesized (E)-1-aryl-2-(1H-tetrazol-5-yl)acrylonitrile derivatives (4b, 4c, and 4m) are shown to have excellent resistance against various fungal strains over bacterial strains as compared to the standard drugs Cefixime (4 μg/mL) and Fluconazole (2 μg/mL). [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
35. Magnetic Hyperthermia in Glioblastoma Multiforme Treatment.
- Author
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Manescu, Veronica, Antoniac, Iulian, Paltanea, Gheorghe, Nemoianu, Iosif Vasile, Mohan, Aurel George, Antoniac, Aurora, Rau, Julietta V., Laptoiu, Stefan Alexandru, Mihai, Petruta, Gavrila, Horia, Al-Moushaly, Abdel Rahim, and Bodog, Alin Danut
- Subjects
ANEMIA treatment ,IRON oxide nanoparticles ,GLIOBLASTOMA multiforme ,MAGNETIC nanoparticles ,NEUROLOGICAL disorders - Abstract
Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At a worldwide level, new therapeutic methods are continuously being researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as a solution used as a single therapy or combined with others for glioma tumor assessment in preclinical and clinical studies. It is based on magnetic nanoparticles (MNPs) that are injected into the tumor, and, under the effect of an external alternating magnetic field, they produce heat with temperatures higher than 42 °C, which determines cancer cell death. It is well known that iron oxide nanoparticles have received FDA approval for anemia treatment and to be used as contrast substances in the medical imagining domain. Today, energetic, efficient MNPs are developed that are especially dedicated to MHT treatments. In this review, the subject's importance will be emphasized by specifying the number of patients with cancer worldwide, presenting the main features of GBM, and detailing the physical theory accompanying the MHT treatment. Then, synthesis routes for thermally efficient MNP manufacturing, strategies adopted in practice for increasing MHT heat performance, and significant in vitro and in vivo studies are presented. This review paper also includes combined cancer therapies, the main reasons for using these approaches with MHT, and important clinical studies on human subjects found in the literature. This review ends by describing the most critical challenges associated with MHT and future perspectives. It is concluded that MHT can be successfully and regularly applied as a treatment for GBM if specific improvements are made. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. In Vitro Superparamagnetic Hyperthermia Employing Magnetite Gamma-Cyclodextrin Nanobioconjugates for Human Squamous Skin Carcinoma Therapy.
- Author
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Caizer-Gaitan, Isabela-Simona, Watz, Claudia-Geanina, Caizer, Costica, Dehelean, Cristina-Adriana, Bratu, Tiberiu, Crainiceanu, Zorin, Coroaba, Adina, Pinteala, Mariana, and Soica, Codruta-Marinela
- Subjects
MAGNETIC nanoparticles ,SQUAMOUS cell carcinoma ,MAGNETIC suspension ,POLYACRYLIC acid ,CELL survival - Abstract
In vitro alternative therapy of human epidermoid squamous carcinoma (A431) by superparamagnetic hyperthermia (SPMHT) using Fe
3 O4 (magnetite) superparamagnetic nanoparticles (SPIONs) with an average diameter of 15.8 nm, bioconjugated with hydroxypropyl gamma-cyclodextrins (HP-γ-CDs) by means of polyacrylic acid (PAA) biopolymer, is presented in this paper. The therapy was carried out at a temperature of 43 °C for 30 min using the concentrations of Fe3 O4 ferrimagnetic nanoparticles from nanobioconjugates of 1, 5, and 10 mg/mL nanoparticles in cell suspension, which were previously found by us to be non-toxic for healthy cells (cell viabilities close to 100%), according to ISO standards (cell viability must be greater than 70%). The temperature for the in vitro therapy was obtained by the safe application (without exceeding the biological limit and cellular damage) of an alternating magnetic field with a frequency of 312.4 kHz and amplitudes of 168, 208, and 370 G, depending on the concentration of the magnetic nanoparticles. The optimal concentration of magnetic nanoparticles in suspension was found experimentally. The results obtained after the treatment show its high effectiveness in destroying the A431 tumor cells, up to 83%, with the possibility of increasing even more, which demonstrates the viability of the SPMHT method with Fe3 O4 -PAA–(HP-γ-CDs) nanobioconjugates for human squamous cancer therapy. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
37. The Potential of Helianthin Loaded Into Magnetic Nanoparticles to Induce Cytotoxicity in Glioblastoma Cells
- Author
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Alexandra, Costachi, Cătălina Elena, Cioc, Sandra Alice, Buteică, Daniela Elise, Tache, Ştefan-Alexandru, Artene, Ani-Simona, Sevastre, Oana, Alexandru, Ligia Gabriela, Tătăranu, Ştefana Oana, Popescu, and Anica, Dricu
- Subjects
helianthin ,Original Paper ,magnetic nanoparticles ,Glioblastoma - Abstract
The central nervous system tumors are the most common solid tumors in adults.. Unlike other types of cancers, brain cancer is much difficult to treat because of the blood-brain barrier (BBB) that prevents drug substances from crossing it and accessing the brain. Different types of methods to overcome BBB have been used in vivo and in vitro, of which the use of nanoparticle-mediated delivery of therapeutic drugs is particularly promising. In the present study, we used iron oxide magnetic nanoparticles (NPs) as carrier system for helianthin (He/NPs) to treat cancer cells derived from glioblastoma. An early passage cell cultures (GB1B), established in our laboratory from tissue obtained from a patient diagnosed with glioblastoma, was used. The cells were treated with different concentrations of NPs or HeNPs and then cell proliferation was measured at 24, 48 and 72 hours. Our results showed that the treatment with NPs was well tolerated by glioblastoma cells, the viability of the cells increased very slightly after the treatment. Furthermore, we demonstrated that helianthin loaded Fe3O4 magnetic nanoparticles induced cytotoxicity in human glioblastoma cells. The treatment with HeNPs induced dose and time dependent.
- Published
- 2021
38. Evaluation of column studies using Cynodon dactylon plant‐mediated amino‐grouped silica‐layered magnetic nanoadsorbent to remove noxious hexavalent chromium metal ions
- Author
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Balaji Dhandapani and Dhanya Vishnu
- Subjects
Chromium ,Ions ,Chemistry ,Magnetic Phenomena ,Metal ions in aqueous solution ,Silicon Dioxide ,Article ,Water Purification ,Electronic, Optical and Magnetic Materials ,Volumetric flow rate ,Original Research Paper ,chemistry.chemical_compound ,Adsorption ,Cynodon ,Chemical engineering ,Magnetic nanoparticles ,Electrical and Electronic Engineering ,Hexavalent chromium ,Effluent ,Water Pollutants, Chemical ,TP248.13-248.65 ,Magnetite ,Superparamagnetism ,Biotechnology - Abstract
Magnetic nanoparticles are desirable adsorbents because of their unique superparamagnetic nature with the enhanced binding specificity and surface material interaction. The above unique features attract researchers to use it for wider applications. Herein, the study focuses on the amino‐induced silica‐layered magnetic nanoparticles amalgamated with plant‐extracted products of Cynodon dactylon in order to turn them into a potent adsorbing material in a continuous column set up for the elimination of noxiously distributed Cr(VI) ionsin the effluents. The selected plant‐mediated magnetite nanoadsorbent, which was used in the fixed column studies, is optimised with the attributes of inlet concentration, adsorbent bed depth, and flow rate. Thomas, Yoon‐Nelson and bed depth model showed the best experimental fit. Breakthrough adsorption time was reported for the various inlet concentrations of 100, 200 and 300 mg/L, adsorbent bed depths 2, 3 and 4 cm and volumetric flow rates of 4, 5 and 6 mL/min. The breakthrough point evaluated for the optimised attribute of inlet concentration of 100 mg/L, packed adsorbent depth 4 cm and flow rate 4 mL/min was 1400 min and the maximum removal efficiency was 60.6%. A better insight of the adsorption of metal ions for large‐scale industrial effluents is provided.
- Published
- 2021
39. Retraction Note to: Amine functionalized magnetic nanoparticles for removal of oil droplets from produced water and accelerated magnetic separation.
- Author
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Ko, Saebom, Kim, Eun Song, Park, Siman, Daigle, Hugh, Milner, Thomas E., Huh, Chun, Bennetzen, Martin V., and Geremia, Giuliano A.
- Subjects
MAGNETIC separation ,OIL field brines ,MAGNETIC nanoparticles ,PETROLEUM ,AMINES ,CONFERENCE papers - Published
- 2021
- Full Text
- View/download PDF
40. Novel Magnetic Polymeric Filters with Laccase-Based Nanoparticles for Improving Congo Red Decolorization in Bioreactors.
- Author
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Sotelo, Diana C., Ornelas-Soto, Nancy, and Osma, Johann F.
- Subjects
CONGO red (Staining dye) ,MAGNETIC separators ,LACCASE ,NANOPARTICLES ,BIOREACTORS ,PERMANENT magnets ,MAGNETITE ,MAGNETIC nanoparticles - Abstract
In this work, five different magnetic biofilters, containing magnetic nanoparticles (142 nm), immobilized laccase on nanoparticles (190 nm) and permanent magnetic elements, such as neodymium magnets and metallic meshes, were designed, manufactured and tested. The five types of filters were compared by measuring the decolorization of Congo Red dye inside bioreactors, the half-life of the filters and the amount of magnetic nanoparticle and enzyme lost during multiple cycles of operation. Filters containing laccase immobilized on magnetite (Laccase-magnetite), permanent magnets and metallic mesh presented the highest Congo Red decolorization (27%) and the largest half-life among all types of filters (seven cycles). The overall dye decolorization efficiencies were 5%, 13%, 17%, 23%, and 27% for the paper filter, paper filter with magnetite, paper filter with Laccase-magnetite, paper filter with Laccase-magnetite with magnets and paper filter with Laccase-magnetite with magnets and metallic mesh, respectively. Although the highest losses of magnetite occurred when using the filters containing magnets (57 mg), the use of permanent magnetic elements in the filters increased the half-life of the filter three-fold compared to the filters without enzymatic properties and two-fold compared to the filters with Laccase-magnetite. Results indicate that the novel use of permanent magnetic elements improved the nanoparticle retention in the filters and promoted the mass transfer between the dye and the biocatalyst to enhance wastewater treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
41. Magnetic-field-assisted synthesis of anisotropic iron oxide particles: Effect of pH
- Author
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Darya E Kessel, Anton S. Orekhov, Petr V. Shvets, Roman Kamyshinsky, Sergey S. Abramchuk, Alexei R. Khokhlov, Olga E. Philippova, and A.V. Shibaev
- Subjects
magnetic nanoparticles ,Nanostructure ,Materials science ,magnetite ,General Physics and Astronomy ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,lcsh:Chemical technology ,01 natural sciences ,lcsh:Technology ,Full Research Paper ,symbols.namesake ,chemistry.chemical_compound ,transmission electron microscopy ,Nanotechnology ,General Materials Science ,lcsh:TP1-1185 ,Electrical and Electronic Engineering ,lcsh:Science ,Magnetite ,lcsh:T ,021001 nanoscience & nanotechnology ,lcsh:QC1-999 ,0104 chemical sciences ,Nanoscience ,anisotropic nanoparticles ,Chemical engineering ,Electron diffraction ,chemistry ,Transmission electron microscopy ,symbols ,Magnetic nanoparticles ,Nanorod ,lcsh:Q ,0210 nano-technology ,Raman spectroscopy ,nanorods ,lcsh:Physics - Abstract
The synthesis of magnetite (Fe3O4) nanorods using reverse co-precipitation of Fe3+ and Fe2+ ions in the presence of a static magnetic field is reported in this work. The phase composition and crystal structure of the synthesized material were investigated using electron diffraction, Raman spectroscopy, and transmission electron microscopy. It was shown that the morphology of the reaction product strongly depends on the amount of OH− ions in the reaction mixture, varying from Fe3O4 nanorods to spherical Fe3O4 nanoparticles. Fe3O4 nanorods were examined using high-resolution transmission electron microscopy proving that they are single-crystalline and do not have any preferred crystallographic orientation along the axis of the rods. According to the data obtained a growth mechanism was proposed for the rods that consists of the dipole–dipole interaction between their building blocks (small hexagonal faceted magnetite nanocrystals), which are formed during the first step of the reaction. The study suggests a facile, green and controllable method for synthesizing anisotropic magnetic nanoparticles in the absence of stabilizers, which is important for further modification of their surfaces and/or incorporation of the nanoparticles into different media.
- Published
- 2020
42. Wet-spinning of magneto-responsive helical chitosan microfibers
- Author
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Michael Maas, Matheus Grande de Aguiar, Dorothea Brüggemann, Johanna Michel, and Naiana Suter
- Subjects
business.product_category ,Fabrication ,Materials science ,Ferromagnetic material properties ,biocompatible actuators ,Composite number ,General Physics and Astronomy ,02 engineering and technology ,mechanical properties ,lcsh:Chemical technology ,lcsh:Technology ,Full Research Paper ,03 medical and health sciences ,Microfiber ,Nanotechnology ,General Materials Science ,lcsh:TP1-1185 ,Fiber ,Electrical and Electronic Engineering ,Composite material ,lcsh:Science ,Spinning ,030304 developmental biology ,0303 health sciences ,Quantitative Biology::Biomolecules ,lcsh:T ,helical fibers ,021001 nanoscience & nanotechnology ,lcsh:QC1-999 ,Nanoscience ,magnetic tissue engineering ,Magnet ,Magnetic nanoparticles ,wet-spinning ,lcsh:Q ,0210 nano-technology ,business ,lcsh:Physics ,chitosan fibers - Abstract
Helical structures can be found in nature at various length scales ranging from the molecular level to the macroscale. Due to their ability to store mechanical energy and to optimize the accessible surface area, helical shapes contribute particularly to motion-driven processes and structural reinforcement. Due to these special features, helical fibers have become highly attractive for biotechnological and tissue engineering applications. However, there are only a few methods available for the production of biocompatible helical microfibers. Given that, we present here a simple technique for the fabrication of helical chitosan microfibers with embedded magnetic nanoparticles. Composite fibers were prepared by wet-spinning and coagulation in an ethanol bath. Thereby, no toxic components were introduced into the wet-spun chitosan fibers. After drying, the helical fibers had a diameter of approximately 130 µm. Scanning electron microscopy analysis of wet-spun helices revealed that the magnetic nanoparticles agglomerated into clusters inside the fiber matrix. The helical constructs exhibited a diameter of approximately 500 µm with one to two windings per millimeter. Due to their ferromagnetic properties they are easily attracted to a permanent magnet. The results from the tensile testing show that the helical chitosan microfibers exhibited an average Young’s modulus of 14 MPa. By taking advantage of the magnetic properties of the feedstock solution, the production of the helical fibers could be automated. The fabrication of the helical fibers was achieved by utilizing the magnetic properties of the feedstock solution and winding the emerging fiber around a rotating magnetic collector needle upon coagulation. In summary, our helical chitosan microfibers are very attractive for future use in magnetic tissue engineering or for the development of biocompatible actuator systems.
- Published
- 2020
43. Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers
- Author
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Jer Tsong Hsieh, Nikhil Pandey, Jian Yang, Jyothi U. Menon, Kytai T. Nguyen, Aniket S. Wadajkar, and Masaya Takahashi
- Subjects
Male ,magnetic nanoparticles ,Biomedical Engineering ,Medicine (miscellaneous) ,Nanoparticle ,Antineoplastic Agents ,Mice, SCID ,Multimodal Imaging ,Theranostic Nanomedicine ,Cell Line ,Mice ,In vivo ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Doxorubicin ,theranostic systems ,Cytotoxicity ,Magnetite Nanoparticles ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Fluorescent Dyes ,Chemistry ,Temperature ,Neoplasms, Experimental ,solid tumors ,Xenograft Model Antitumor Assays ,photoluminescent polymers ,Drug delivery ,Biophysics ,Magnetic nanoparticles ,thermo-responsive polymers ,Preclinical imaging ,Biotechnology ,Superparamagnetism ,medicine.drug ,Research Paper - Abstract
Theranostic systems capable of delivering imaging and therapeutic agents at a specific target are the focus of intense research efforts in drug delivery. To overcome non-degradability and toxicity concerns of conventional theranostic systems, we formulated a novel thermo-responsive fluorescent polymer (TFP) and conjugated it on the surface of iron oxide magnetic nanoparticles (MNPs) for imaging and therapeutic applications in solid tumors. Methods: TFP-MNPs were synthesized by copolymerizing poly(N-isopropylacrylamide), allylamine and a biodegradable photoluminescent polymer, and conjugating it on MNPs via a free radical polymerization reaction. Physicochemical properties of the nanoparticles were characterized using Fourier transform infrared spectroscopy, dynamic light scattering, and vibrational sample magnetometry. Nanoparticle cytocompatibility, cellular uptake and cytotoxicity were evaluated using in vitro cell assays. Finally, in vivo imaging and therapeutic efficacy studies were performed in subcutaneous tumor xenograft mouse models. Results: TFP-MNPs of ~135 nm diameter and -31 mV ζ potential maintained colloidal stability and superparamagnetic properties. The TFP shell was thermo-responsive, fluorescent, degradable, and released doxorubicin in response to temperature changes. In vitro cell studies showed that TFP-MNPs were compatible to human dermal fibroblasts and prostate epithelial cells. These nanoparticles were also taken up by prostate and skin cancer cells in a dose-dependent manner and exhibited enhanced killing of tumor cells at 41°C. Preliminary in vivo studies showed theranostic capabilities of the nanoparticles with bright fluorescence, MRI signal, and therapeutic efficacy under magnetic targeting after systemic administration in tumor bearing mice. Conclusion: These results indicate the potential of TFP-MNPs as multifunctional theranostic nanoparticles for various biological applications, including solid cancer management.
- Published
- 2020
44. Stir bar sorptive-dispersive microextraction by a poly(methacrylic acid-co-ethylene glycol dimethacrylate)-based magnetic sorbent for the determination of tricyclic antidepressants and their main active metabolites in human urine
- Author
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Víctor Vállez-Gomis, Sara Exojo-Trujillo, Juan L. Benedé, Alberto Chisvert, and Amparo Salvador
- Subjects
Original Paper ,Stir bar sorptive-dispersive microextraction ,Magnetic Phenomena ,Cobalt ,Antidepressive Agents, Tricyclic ,Silicon Dioxide ,Ferric Compounds ,Active metabolites ,Analytical Chemistry ,Tricyclic antidepressants ,Polymethacrylic Acids ,Tandem Mass Spectrometry ,Magnetic nanoparticles ,Humans ,Polymeric sorbent ,Human urine ,Solid Phase Microextraction ,Chromatography, Liquid - Abstract
Abstract A poly(methacrylic acid-co-ethylene glycol dimethacrylate)-based magnetic sorbent was used for the rapid and sensitive determination of tricyclic antidepressants and their main active metabolites in human urine. This material was characterized by magnetism measurements, zeta potential, scanning electron microscopy, nitrogen adsorption–desorption isotherms, and thermogravimetric analysis. The proposed analytical method is based on stir bar sorptive-dispersive microextraction (SBSDME) followed by liquid chromatography–tandem mass spectrometry. The main parameters involved in the extraction step were optimized by using the response surface methodology as a multivariate optimization method, whereas a univariate approach was employed to study the desorption parameters. Under the optimized conditions, the proposed method was properly validated showing good linearity (at least up to 50 ng mL−1) and enrichment factors (13–22), limits of detection and quantification in the low ng L−1 range (1.4–7.0 ng L−1), and good intra- and inter-day repeatability (relative standard deviations below 15%). Matrix effects were observed for the direct analysis of urine samples, but they were negligible when a 1:1 v/v dilution with deionized water was performed. Finally, the method was successfully applied to human urine samples from three volunteers, one of them consuming a prescribed drug for depression that tested positive for clomipramine and its main active metabolite. Quantitative relative recoveries (80–113%) were obtained by external calibration. The present work expands the applicability of the SBSDME to new analytes and new types of magnetic sorbents. Graphical abstract
- Published
- 2022
45. Impact of Segmented Magnetization on the Flagellar Propulsion of Sperm-Templated Microrobots
- Author
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Marilena Vendittelli, Sumit Mohanty, Anke Klingner, Sarthak Misra, Juliane Simmchen, Veronika Magdanz, Jacopo Vivaldi, Islam S. M. Khalil, Man, Biomaterials and Microbes (MBM), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Robotics and image-guided minimally-invasive surgery (ROBOTICS), TechMed Centre, and Biomechanical Engineering
- Subjects
Medical robotics ,Microrobots ,Flagellar propulsion ,Materials science ,Science ,General Chemical Engineering ,biohybrid microrobots ,Flow (psychology) ,General Physics and Astronomy ,Medicine (miscellaneous) ,Thrust ,02 engineering and technology ,Propulsion ,010402 general chemistry ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,flagellar propulsion ,magnetic actuation ,Quantitative Biology::Cell Behavior ,Protein filament ,Computer Science::Robotics ,Magnetization ,General Materials Science ,Physics::Biological Physics ,Full Paper ,Deformation (mechanics) ,General Engineering ,Mechanics ,Full Papers ,021001 nanoscience & nanotechnology ,equipment and supplies ,0104 chemical sciences ,Magnetic field ,sperm cells ,Magnetic nanoparticles ,nanoparticles ,0210 nano-technology ,human activities - Abstract
Technical design features for improving the way a passive elastic filament produces propulsive thrust can be understood by analyzing the deformation of sperm‐templated microrobots with segmented magnetization. Magnetic nanoparticles are electrostatically self‐assembled on bovine sperm cells with nonuniform surface charge, producing different categories of sperm‐templated microrobots. Depending on the amount and location of the nanoparticles on each cellular segment, magnetoelastic and viscous forces determine the wave pattern of each category during flagellar motion. Passively propagating waves are induced along the length of these microrobots using external rotating magnetic fields and the resultant wave patterns are measured. The response of the microrobots to the external field reveals distinct flow fields, propulsive thrust, and frequency responses during flagellar propulsion. This work allows predictions for optimizing the design and propulsion of flexible magnetic microrobots with segmented magnetization., Sperm‐templated flexible magnetic microrobots are categorized based on the location and combination of their magnetic segments. The different magnetization profiles lead to distinct wave patterns once exposed to rotating 3D magnetic fields. This results in a variety of frequency responses, flow fields surrounding the microrobots and propulsive thrust force. The article gives indications for the design of flexible magnetic microrobots.
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- 2021
46. A Robust, Safe, and Scalable Magnetic Nanoparticle Workflow for RNA Extraction of Pathogens from Clinical and Wastewater Samples
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Digambar Balaji Shinde, Sharif Hala, Arnab Pain, Mo Li, Afrah Alsomali, Samir M. Hamdan, Rahul Salunke, Jinna Xu, Anwar M. Hashem, Fadwa S. Alofi, Naif A.M. Almontashiri, Asim Khogeer, Sara Mfarrej, Pei-Ying Hong, Gerardo Ramos-Mandujano, and Andri Taruna Rachmadi
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magnetic nanoparticles ,nucleic acid purification ,Technology ,Full Paper ,Isolation (health care) ,Computer science ,Nucleic acid methods ,Full Papers ,Biocontainment ,SARS‐CoV‐2 ,Environmental sciences ,Workflow ,wastewater surveillance ,Wastewater ,Trizol ,BioHazard ,GE1-350 ,RNA extraction ,Biochemical engineering ,influenza - Abstract
Molecular diagnosis and surveillance of pathogens such as SARS‐CoV‐2 depend on nucleic acid isolation. Pandemics at the scale of COVID‐19 can cause a global shortage of proprietary commercial reagents and BSL‐2 laboratories to safely perform testing. Therefore, alternative solutions are urgently needed to address these challenges. An open‐source method, magnetic‐nanoparticle‐aided viral RNA isolation from contagious samples (MAVRICS), built upon readily available reagents, and easily assembled in any basically equipped laboratory, is thus developed. The performance of MAVRICS is evaluated using validated pathogen detection assays and real‐world and contrived samples. Unlike conventional methods, MAVRICS works directly in samples inactivated in phenol‐chloroform (e.g., TRIzol), thus allowing infectious samples to be handled safely without biocontainment facilities. MAVRICS allows wastewater biomass immobilized on membranes to be directly inactivated and lysed in TRIzol followed by RNA extraction by magnetic nanoparticles, thereby greatly reducing biohazard risk and simplifying processing procedures. Using 39 COVID‐19 patient samples and two wastewater samples, it is shown that MAVRICS rivals commercial kits in detection of SARS‐CoV‐2, influenza viruses, and respiratory syncytial virus. Therefore, MAVRICS is safe, fast, and scalable. It is field‐deployable with minimal equipment requirements and could become an enabling technology for widespread testing and wastewater monitoring of diverse pathogens., One important bottleneck in the diagnosis and surveillance of COVID‐19 is the shortage of kits for RNA extraction. Magnetic‐nanoparticle‐aided viral RNA isolation from contagious samples (MAVRICS) is an open‐source, safe, fast, and scalable method for RNA extraction. MAVRICS rivals commercial kits but requires minimal materials, and thus could become an enabling technology for widespread community testing of diverse pathogens.
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- 2021
47. Implementation of magnetic bentonite in food industry wastewater treatment for reuse in agricultural irrigation
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Wilfredo Marimon-Bolivar, Angélica Mateus, Laura Pulgarín, and Julieth Torres
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Food industry ,0208 environmental biotechnology ,Geography, Planning and Development ,02 engineering and technology ,Wastewater treatment ,010501 environmental sciences ,Wastewater reuse ,01 natural sciences ,symbols.namesake ,Adsorption ,Desorption ,Management. Industrial management ,0105 earth and related environmental sciences ,Water Science and Technology ,Chemistry ,business.industry ,Langmuir adsorption model ,Irrigation water ,Pulp and paper industry ,HD28-70 ,020801 environmental engineering ,Wastewater ,Bentonite ,Magnetic nanoparticles ,symbols ,Clay ,Sewage treatment ,Water treatment ,business - Abstract
Combining natural materials and pretreatment processes with nanomaterials is an alternative to be evaluated for the increase in efficiency and cost reduction of water treatment processes. This work aimed to study the combination of pretreatment processes and primary treatments with bentonite impregnated with magnetic nanoparticles (Bentonite@MNPs) to reuse wastewater from the food indust|ry. Bentonite@MNPs were obtained by green synthesis using glucose as a reducing/stabilizing agent, and the nanocomposite was characterized by SEM, EDS, FTIR, VSM, and XRD analysis. The synthesized nanocomposite was used to remove nitrates and COD from wastewater from the production of guava bars that had been pretreated with coagulation-flocculation-sedimentation processes. Batch adsorption experiments were conducted, where the influence of several parameters such as contact time, adsorbent amount, and the temperature was studied. According to the results, the wastewater treated with the coagulation-flocculation-sedimentation processes was still outside the standards for agricultural reuse. After applying the treatment with Bentonite@MNPs, a reduction of COD, nitrates, chlorides, and sulfates of 82%, 75.4%, 98.18%, and 70%, respectively, was achieved. The adsorption isotherm data were best explained by the Langmuir model for COD, and Frendluich model for Nitrates and the adsorption capacity of Bentonite@MNPs for COD and Nitrates was 34.84 and 28.11 mg/g when adsorption temperature was 318 K. The results of thermodynamic studies (ΔG°, ΔH°, and ΔS°) showed the spontaneous, endothermic and randomness in the adsorption process. Desorption studies showed excellent regenerative efficiency (up to the 10th cycle) of nanocomposites using 0.01 M NaOH, so this wastewater treatment system for the food industry is promising to implement for the sake of using wastewater as a circular economy component.
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- 2021
48. Historical Perspective of the Addition of Magnetic Nanoparticles Into Anaerobic Digesters (2014-2021)
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Eudald Casals, Antoni Sánchez, Xavier Font, Víctor F. Puntes, Raquel Barrena, and Edgar Gonzalez
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chemistry.chemical_classification ,Technology ,magnetite ,Chemical technology ,iron nanoparticles ,TP1-1185 ,Pulp and paper industry ,Methane ,Anaerobic digestion ,chemistry.chemical_compound ,chemistry ,Biogas ,enhancement mechanisms ,biogas ,Magnetic nanoparticles ,anerobic digestion ,Organic matter ,Anaerobic exercise - Abstract
The addition of magnetic nanoparticles to batch anaerobic digestion was first reported in 2014. Afterwards, the number of works dealing with this subject has been increasing year by year. The discovery of the enhancement of anaerobic digestion by adding iron-based nanoparticles has created a multidisciplinary emerging research field. As a consequence, in the last years, great efforts have been made to understand the enhancement mechanisms by which magnetic nanoparticles (NPs) addition enhances the anaerobic digestion process of numerous organic wastes. Some hypotheses point to the dissolution of iron as essential iron for anaerobic digestion development, and the state of oxidation of iron NPs that can reduce organic matter to methane. The evolution and trends of this novel topic are discussed in this manuscript. Perspectives on the needed works on this topic are also presented.
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- 2021
49. Technology and research on the influence of liquid crystal cladding doped with magnetic Fe3O4 nanoparticles on light propagation in an optical taper sensor.
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Niewczas, Michał, Stasiewicz, Karol A., Przybysz, Natalia, Pakuła, Anna, Paczesny, Jan, Zbonikowski, Rafał, Dziaduszek, Jerzy, Kula, Przemysław, and Jaroszewicz, Leszek R.
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MAGNETIC nanoparticles ,LIGHT propagation ,OPTICAL sensors ,MAGNETIC field effects ,OPTICAL spectra ,SINGLE-mode optical fibers ,LIQUID crystals ,OPTICAL fibers - Abstract
The results obtained for new dual-cladding optical fiber tapers surrounded by liquid crystal (LC) doped with Fe
3 O4 nanoparticles in a specially developed glass cell are presented. The created structures are sensitive to changes in refractive index values in the surrounding medium caused by modifying external environment parameters. In this investigation, cells are filled with nematic LCs 6CHBT and with the same mixture doped with 0.1 wt% and 0.5 wt% of magnetic nanoparticles (Fe3 O4 NPs). The taper is made on a standard single-mode telecommunication fiber, stretched out to a length of 20.0 ± 0.5 mm, and the diameter of the tapers is approximately 15.0 ± 0.3 µm, with a loss lower than 0.5 dB @ 1,550 nm. Measurements are carried out in a wide range covering the visible and infrared ranges in two setups: 1) without a magnetic field, with steering only by voltage and 2) with an applied magnetic field. The presented spectrum results are divided into two ranges according to the parameters of optical spectrum analyzers: 350-1,200 nm and 1,200-2,400 nm. For all investigations, a steering voltage is chosen from the range of 0 to 200 V, which allows for establishing the influence of dopants on transmitted power and time response at different arrangements. Due to the sensitivity of LCs to temperature changes, this paper focuses on measuring at room temperature the effect of the magnetic field on propagation in a fiber optic taper. The proposed solution demonstrates the technology for creating advanced components as a combination of fiber optic technology, LCs, and nanoparticles. The presented results show the possibility of creating new sensors of various external factors such as magnetic or electric fields in miniaturized dimensions. [ABSTRACT FROM AUTHOR]- Published
- 2024
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50. Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective.
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Milewska, Sylwia, Sadowska, Anna, Stefaniuk, Natalia, Misztalewska-Turkowicz, Iwona, Wilczewska, Agnieszka Z., Car, Halina, and Niemirowicz-Laskowska, Katarzyna
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MAGNETIC nanoparticles ,PEPTIDES ,CAUSES of death ,CANCER treatment ,SUPPLY & demand - Abstract
According to data from the World Health Organization (WHO), cancer is considered to be one of the leading causes of death worldwide, and new therapeutic approaches, especially improved novel cancer treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend to have poor pharmacokinetic profiles, including rapid clearance and limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead to remarkable improvements. This is confirmed by an increasing number of papers in this field, showing that the on-target peptide functionalization of magnetic nanoparticles improves their penetration properties and ensures tumor-specific binding, which results in an increased clinical response. This review aims to highlight the potential applications of THPs in combination with magnetic carriers across various fields, including a pharmacoeconomic perspective. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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