5 results on '"Islam, Arshad"'
Search Results
2. Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La2O3).
- Author
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Mohamed, Hamza Elsayed Ahmad, Khalil, Ali Talha, Hkiri, Khaoula, Ayaz, Muhammad, Usman, Asad, Sadiq, Abdul, Ullah, Farhat, Khan, Muhammad Arif, Islam, Arshad, Ovais, Muhammad, and Maaza, Malik
- Subjects
BIOSYNTHESIS ,LANTHANUM oxide ,CHORIOALLANTOIS ,RAMAN spectroscopy ,ARTEMIA - Abstract
Phytoextracts modulated synthesis of nano‐scaled spherical lanthanum oxide nanoparticles (La2O3 NPs) are reported using the aqueous extracts of Hyphaene thebaica as a bioreducing and chelating agent. X‐ray diffraction (XRD) pattern revealed sharp peaks and single‐phase purity. The Debye–Scherrer approximation indicated an average crystallite size of 37 nm, whereas W‐H plot revealed a crystallite size of 59 nm, complemented by the high‐resolution transmission electron microscopy (HR‐TEM). The infrared spectroscopy revealed characteristic La‐O band at 426 and 648 cm−1. K‐M function revealed the bandgap of 5.6 eV, whereas broad intense emission peaks between 345 and 750 nm. The Raman spectra revealed peaks at 182, 325, 384, and 491 cm−1. Elemental composition was confirmed using energy‐dispersive X‐ray spectroscopy (EDS) spectrum, and the spotty rings from selected area electron diffraction (SAED) indicated the crystalline nature of the HT‐La2O3 NPs. In addition, the HT‐La2O3 NPs were investigated for in vitro antioxidant, anticancer, antiangiogenic, and cytotoxic potentials. DPPH free radical scavenging activity was highest, that is, 49.54 ± 0.88% at 1000 μg/mL. MTT assay on MCF‐7 and 3T3 cell lines revealed a median lethal concentration of 114 and 43 μg/mL, respectively. The antiangiogenic effect examined by chick chorioallantoic membrane (CAM) assay indicated inhibition of 57.14 ± 0.96% at 1000‐μg/mL concentration with an IC50 of 551 μg/mL. IC50 for the brine shrimp lethality assay was 314.2 μg/mL. Our study indicates cytotoxicity of HT‐La2O3 NPs, and it further concluded that HT‐La2O3 NPs were more potent against 3T3 cells as compared with MCF‐7 cells. Further research on the biological synthesis and anticancer studies are recommended for the large‐scale applications of the La2O3 NPs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Impact of zinc oxide nanoflowers on growth dynamics and physio-biochemical response of Triticum aestivum.
- Author
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Haq, Ayesha Naveed Ul, Islam, Arshad, Younas, Farhan, Danish, Lubna, Ullah, Ikram, Nadhman, Akhtar, Shah, Hamidullah, and Khan, Imran
- Subjects
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PLANT defenses , *PHOTOSYNTHETIC pigments , *NANOPARTICLES , *PLANT shoots , *GERMINATION , *CAROTENOIDS - Abstract
Flower like zinc oxide nanoparticles have been synthesized and the effects of their aqueous suspensions at 200–1000 mg/L on seed germination and seedlings of Triticum aestivum have been investigated. When treated with suspensions of zinc oxide nanoparticles at concentrations of 200–1000 mg/L, germination was reduced to 45% and photosynthetic pigments (chlorophyll a, b, and carotenoids) were also depressed. Enzymatic and non-enzymatic plant defense mechanisms were adversely affected at the maximum concentration. Abnormalities in the concentrations of proline, malondialdehyde, phenols and flavonoids were observed in the roots and shoots of plant due to the zinc oxide nanoparticles at different concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La2O3).
- Author
-
Mohamed, Hamza Elsayed Ahmad, Khalil, Ali Talha, Hkiri, Khaoula, Ayaz, Muhammad, Usman, Asad, Sadiq, Abdul, Ullah, Farhat, Khan, Muhammad Arif, Islam, Arshad, Ovais, Muhammad, and Maaza, Malik
- Subjects
- *
BIOSYNTHESIS , *LANTHANUM oxide , *CHORIOALLANTOIS , *RAMAN spectroscopy , *ARTEMIA - Abstract
Phytoextracts modulated synthesis of nano‐scaled spherical lanthanum oxide nanoparticles (La2O3 NPs) are reported using the aqueous extracts of Hyphaene thebaica as a bioreducing and chelating agent. X‐ray diffraction (XRD) pattern revealed sharp peaks and single‐phase purity. The Debye–Scherrer approximation indicated an average crystallite size of 37 nm, whereas W‐H plot revealed a crystallite size of 59 nm, complemented by the high‐resolution transmission electron microscopy (HR‐TEM). The infrared spectroscopy revealed characteristic La‐O band at 426 and 648 cm−1. K‐M function revealed the bandgap of 5.6 eV, whereas broad intense emission peaks between 345 and 750 nm. The Raman spectra revealed peaks at 182, 325, 384, and 491 cm−1. Elemental composition was confirmed using energy‐dispersive X‐ray spectroscopy (EDS) spectrum, and the spotty rings from selected area electron diffraction (SAED) indicated the crystalline nature of the HT‐La2O3 NPs. In addition, the HT‐La2O3 NPs were investigated for in vitro antioxidant, anticancer, antiangiogenic, and cytotoxic potentials. DPPH free radical scavenging activity was highest, that is, 49.54 ± 0.88% at 1000 μg/mL. MTT assay on MCF‐7 and 3T3 cell lines revealed a median lethal concentration of 114 and 43 μg/mL, respectively. The antiangiogenic effect examined by chick chorioallantoic membrane (CAM) assay indicated inhibition of 57.14 ± 0.96% at 1000‐μg/mL concentration with an IC50 of 551 μg/mL. IC50 for the brine shrimp lethality assay was 314.2 μg/mL. Our study indicates cytotoxicity of HT‐La2O3 NPs, and it further concluded that HT‐La2O3 NPs were more potent against 3T3 cells as compared with MCF‐7 cells. Further research on the biological synthesis and anticancer studies are recommended for the large‐scale applications of the La2O3 NPs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Combination oral therapy against Leishmania amazonensis infection in BALB/c mice using nanoassemblies made from amphiphilic antimony(V) complex incorporating miltefosine
- Author
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Ricardo Toshio Fujiwara, Daniel Menezes Souza, Luis Rivas, Arshad Islam, Cynthia Demicheli, Frédéric Frézard, Juliane Sousa Lanza, Virgínia Mendes Carregal, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Fundação de Amparo à Pesquisa do Estado de São Paulo Minas Gerais, Redes Temáticas de Investigación Cooperativa en Salud (España), Carregal, Virginia, Islam, Arshad, Fujiwara, R. T., Rivas, Luis, Frézard, Frédéric, Carregal, Virginia [0000-0003-3505-9494], Islam, Arshad [0000-0002-9953-4816], Fujiwara, R. T. [0000-0002-4713-575X], Rivas, Luis, [0000-0002-2958-3233], and Frézard, Frédéric [0000-0003-3783-5717]
- Subjects
Drug ,Antimony ,Combination therapy ,media_common.quotation_subject ,Phosphorylcholine ,Leishmania mexicana ,Antiprotozoal Agents ,Oral route ,Administration, Oral ,Leishmaniasis, Cutaneous ,Drug resistance ,Pharmacology ,BALB/c ,Oral administration ,medicine ,Animals ,Drug combination ,Leishmaniasis ,media_common ,Miltefosine ,Mice, Inbred BALB C ,General Veterinary ,biology ,General Medicine ,biology.organism_classification ,Leishmania ,medicine.disease ,Disease Models, Animal ,Infectious Diseases ,Insect Science ,Nanoparticles ,Parasitology ,Female ,medicine.drug - Abstract
8p.-3 fig.-1 tab., Clinically available drugs for mucocutaneous and cutaneous leishmaniases (CL) include mainly pentavalent antimony (Sb(V)) complexes, liposomal amphotericin B, and miltefosine (HePC). However, they present at least one of the following limitations: long-term parenteral administration through repeated doses, severe side effects, drug resistance, and high cost. HePC is the only oral drug available, but the appearance of resistance has resulted in changes of its use from monotherapy to combination therapy. Amphiphilic Sb(V) complexes, such as SbL8 obtained from reaction of Sb(V) with N-octanoyl-N-methylglucamide, were recently found to be orally active against experimental CL. The property of SbL8 to self-assemble in aqueous solution, forming nanostructures, led us to investigate the incorporation of HePC into SbL8 nanoassemblies and the therapeutic efficacy of SbL8/HePC nanoformulation by oral route in a murine model of CL. HePC incorporation into the SbL8 nanosystem was evidenced by using a fluorescent analog of HePC. The antileishmanial activity of SbL8/HePC nanoassemblies was evaluated after daily oral administration for 30 days in Leishmania amazonensis-infected BALB/c mice, in comparison with monotherapies (SbL8 or HePC) and saline control. All the treatments resulted in significant reduction in the lesion size growth, when compared with control. Strikingly, only SbL8/HePC nanoassemblies promoted a significant decrease of the parasite burden in the lesion. This work establishes the therapeutic benefit of SbL8/HePC association by oral route in a CL model and constitutes an important step towards the development of new orally active drug combination., This work was supported by the Brazilian agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, grant number: 425332/2018–7), Coordenação de Aperfeicoamento de Pessoal de Nível Superior (CAPES, grant number: PNPD20131163), and Fundação de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG, grant number: APQ-03129-16) for financial support. F.F. was recipient of fellowship from CNPq (grant number: 305659/2017-0) and Chaire Jean d’Alembert, Université Paris-Saclay, France (ANR-11-IDEX-0003-02). L.R was supported by Program of Redes Temáticas de Investigación Cooperativa RETICS-FEDER (grant number: RD16/0027/0010).
- Published
- 2019
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