16 results
Search Results
2. Papers Wanted.
- Author
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Foster, Andrea L.
- Subjects
ARCHIVES ,ONLINE information services ,RESEARCH ,COLLEGE teachers - Abstract
Describes the dilemma faced by the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts in running its online archive for research called DSpace as of June 25, 2004. Total number of items contained in the archive; Concerns of MIT professors about online archive; Strategy adopted by the university to build support for DSpace. INSET: Colleges Retain Their Part of the Broadcast Spectrum.
- Published
- 2004
3. Cutaneous Adverse Events to Type I BRAF Inhibitors: An Analysis of Effects Associated with Each Inhibitor and Therapeutic Time Interval to Onset.
- Author
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Filitis, Dan C. and Mahalingam, Meera
- Subjects
DRUG allergy ,HAIR ,MEDLINE ,MELANOMA ,NAILS (Anatomy) ,ONCOGENES ,ONLINE information services ,SYSTEMATIC reviews ,TREATMENT duration ,GENETICS - Abstract
The treatment of malignant melanoma with inhibitors targeting the BRAF V600E mutation has demonstrated dramatic clinical and radiographic response with improved progression-free and overall survival in the majority of patients receiving treatment. However, cutaneous adverse effects—from proliferative processes to more classic drug side effects—are increasingly being reported in patients on BRAF inhibitors. In this comprehensive literature review we provide (1) an all-inclusive list of cutaneous adverse effects associated with selective class I RAF inhibitors, (2) specific adverse effects associated with each inhibitor, and (3) the therapeutic time interval associated with the onset of all reported lesion types. Twenty-two studies reporting cutaneous adverse reactions with selective class I RAF inhibitor therapy were retrieved from PubMed and sourced from relevant articles referenced by other papers. We identified over 45 differently described lesion types, corresponding to close to 2,000 cases. The most commonly reported lesion types in order of decreasing frequency include inflammatory dermatoses, benign lesions, malignant lesions, and hair/nail-related abnormalities. For the most part, the terminologies used in the original studies were retained. Case totals and time-to-lesion onset are presented for every group, and where available, for individual lesion types, by associated BRAF inhibitor. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
4. EBSCO Publishing
- Author
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Carroll, Jennifer and Ginanni, Katy
- Subjects
ONLINE information services ,ABSTRACTING & indexing services - Abstract
EBSCO Publishing is an innovative company that has its roots in paper publishing. It now produces hundreds of online resources in a state-of-the-art facility located along the banks of the Ipswich River in Massachusetts. Considerable work occurs behind the scenes in Ipswich (and around the world) to produce the online databases in EBSCOhost that appear to the user at the click of a mouse. Jennifer Carroll toured the headquarters in Ipswich to learn about the processes that make these valuable resources available. Serials Review 2007; 33:145-148. © 2007 Elsevier Inc. All right reserved. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
5. Maternal Recall of Hypertensive Disorders in Pregnancy: A Systematic Review.
- Author
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Stuart, Jennifer J., Bairey Merz, C. Noel, Berga, Sarah L., Miller, Virginia M., Ouyang, Pamela, Shufelt, Chrisandra L., Steiner, Meir, Wenger, Nanette K., and Rich-Edwards, Janet W.
- Subjects
EXPERIENCE ,HYPERTENSION in pregnancy ,MEDICAL information storage & retrieval systems ,MEDLINE ,MEMORY ,ONLINE information services ,RESEARCH funding ,WOMEN'S health ,SYSTEMATIC reviews ,ATTITUDES of mothers - Abstract
Background: Hypertensive disorders in pregnancy are risk markers for future maternal coronary heart disease (CHD). Clinical assessment of a woman's history of pregnancy complications relies on self-report, but the predictive value of maternal recall is unclear. A systematic review was conducted to comprehensively review and critically assess the available literature on maternal recall of hypertensive disorders in pregnancy. Methods: The PubMed, EMBASE, and Web of Science databases were searched through August 2012. We included original research articles comparing maternal recall of hypertensive disorders in pregnancy with medical records. Results: Ten studies met eligibility criteria for qualitative analysis and were independently reviewed by two investigators. Recall periods ranged from 48 hours to 30 years. Length of recall did not appear to uniformly affect recall quality. Sensitivity was generally lower and less consistent for gestational hypertension than for preeclampsia. Specificity was >90% for all hypertensive disorders. Determinants of recall accuracy included maternal education and parity. Conclusions: Although maternal recall of hypertensive disorders of pregnancy is specific, low sensitivity and predictive values may limit the clinical utility of asking mothers to recall their history of hypertensive pregnancy complications. Future research on maternal recall of pregnancy complications should be designed to yield predictive values and test recall of disorder subtypes, recurrent complications, and changing recall over time in the same population. The utility of gestation length and offspring birth weight for clinical identification of women whose pregnancy history puts them at increased CHD risk should also be explored. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
6. Research Review: Psychosocial adjustment and mental health in former child soldiers - a systematic review of the literature and recommendations for future research.
- Author
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Betancourt, Theresa S, Borisova, Ivelina, Williams, Timothy P, Meyers‐Ohki, Sarah E, Rubin‐Smith, Julia E, Annan, Jeannie, and Kohrt, Brandon A
- Subjects
ADAPTABILITY (Personality) in children ,CHILD psychology ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,REHABILITATION of people with mental illness ,ONLINE information services ,RESEARCH funding ,PSYCHOLOGY of military personnel ,SOCIAL stigma ,SYSTEMATIC reviews ,FAMILY relations ,QUANTITATIVE research ,SOCIAL support ,INDEPENDENT living ,CHILDREN - Abstract
Aims and scope: This article reviews the available quantitative research on psychosocial adjustment and mental health among children (age <18 years) associated with armed forces and armed groups (CAAFAG) - commonly referred to as child soldiers. Methods: PRISMA standards for systematic reviews were used to search PubMed, PsycInfo, JSTOR, and Sociological Abstracts in February 2012 for all articles on former child soldiers and CAAFAG. Twenty-one quantitative studies from 10 countries were analyzed for author, year of publication, journal, objectives, design, selection population, setting, instruments, prevalence estimates, and associations with war experiences. Opinion pieces, editorials, and qualitative studies were deemed beyond the scope of this study. Quality of evidence was rated according to the Systematic Assessment of Quality in Observational Research (SAQOR). Findings: According to SAQOR criteria, among the available published studies, eight studies were of high quality, four were of moderate quality, and the remaining nine were of low quality. Common limitations were lack of validated mental health measures, unclear methodology including undefined sampling approaches, and failure to report missing data. Only five studies included a comparison group of youth not involved with armed forces/armed groups, and only five studies assessed mental health at more than one point in time. Across studies, a number of risk and protective factors were associated with postconflict psychosocial adjustment and social reintegration in CAAFAG. Abduction, age of conscription, exposure to violence, gender, and community stigma were associated with increased internalizing and externalizing mental health problems. Family acceptance, social support, and educational/economic opportunities were associated with improved psychosocial adjustment. Conclusions: Research on the social reintegration and psychosocial adjustment of former child soldiers is nascent. A number of gaps in the available literature warrant future study. Recommendations to bolster the evidence base on psychosocial adjustment in former child soldiers and other war-affected youth include more studies comprising longitudinal study designs, and validated cross-cultural instruments for assessing mental health, as well as more integrated community-based approaches to study design and research monitoring. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
7. Research Review: Gene-environment interaction research in youth depression - a systematic review with recommendations for future research.
- Author
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Dunn, Erin C., Uddin, Monica, Subramanian, S.V., Smoller, Jordan W., Galea, Sandro, and Koenen, Karestan C.
- Subjects
MENTAL depression genetics ,PREVENTION of mental depression ,MENTAL depression risk factors ,PSYCHOMETRICS ,CHILDREN'S health ,MENTAL depression ,ENVIRONMENTAL health ,GENES ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,ONLINE information services ,RESEARCH funding ,CAUSAL models ,FAMILY relations ,SOCIAL context ,CHILDREN - Abstract
Background: Depression is a major public health problem among youth, currently estimated to affect as many as 9% of US children and adolescents. The recognition that both genes (nature) and environments (nurture) are important for understanding the etiology of depression has led to a rapid growth in research exploring gene-environment interactions (GxE). However, there has been no systematic review of GxE in youth depression to date. Methods: The goal of this article was to systematically review evidence on the contribution of GxE to the risk of child and adolescent depression. Through a search of PubMed and PsycINFO databases to 1 April 2010, we identified 20 candidate gene-environment interaction studies focused on depression in youth (up to age 26) and compared each study in terms of the following characteristics: research design and sample studied; measure of depression and environment used; genes explored; and GxE findings in relation to these factors. Results: In total, 80% of studies ( n = 16) found at least one significant GxE association. However, there was wide variation in methods and analyses adopted across studies, especially with respect to environmental measures used and tests conducted to estimate GxE. This heterogeneity made it difficult to compare findings and evaluate the strength of the evidence for GxE. Conclusions: The existing body of GxE research on depression in youth contains studies that are conceptually and methodologically quite different, which contributes to mixed findings and makes it difficult to assess the current state of the evidence. To decrease this heterogeneity, we offer 20 recommendations that are focused on: (a) reporting GxE research; (b) testing and reporting GxE effects; (c) conceptualizing, measuring and analyzing depression; (d) conceptualizing, measuring and analyzing environment; (e) increasing power to test for GxE; and (f) improving the quality of genetic data used. Although targeted to GxE research on depression, these recommendations can be adopted by GxE researchers focusing on other mental health outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
8. Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis.
- Author
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Peter, I., Crosier, M. D., Yoshida, M., Booth, S. L., Cupples, L. A., Dawson-Hughes, B., Karasik, D., Kiel, D. P., Ordovas, J. M., and Trikalinos, T. A.
- Subjects
RISK factors of fractures ,ANALYSIS of variance ,APOLIPOPROTEINS ,BLOOD testing ,CHI-squared test ,CLINICAL trials ,COMPUTER software ,CONFIDENCE intervals ,DATABASES ,EPIDEMIOLOGY ,GENES ,GENETIC polymorphisms ,MEDLINE ,META-analysis ,MULTIVARIATE analysis ,ONLINE information services ,REGRESSION analysis ,VITAMIN K ,X-ray densitometry in medicine ,DATA analysis ,EQUIPMENT & supplies ,BONE density - Abstract
Summary: To determine the association of the Apolipoprotein E (APOE) E4 gene polymorphism with bone mineral density (BMD) and fractures we conducted a meta-analysis of 17 reports. Despite lower trochanteric and lumbar BMD in APOE4 carriers, there is insufficient evidence to support a consistent association of APOE with bone health. Introduction: APOE has been studied for its potential role in osteoporosis risk. It is hypothesized that genetic variation at APOE locus, known as E2, E3, and E4, may modulate BMD through its effects on lipoproteins and vitamin K transport. The purpose of this study was to determine the association of the APOE-E4 gene polymorphism with bone-related phenotypes. Methods: We conducted a meta-analysis that combined newly analyzed individual data from two community-based cohorts, the Framingham Offspring Study ( N = 1,495) and the vitamin K clinical trial ( N = 377), with 15 other eligible published reports. Bone phenotypes included BMD measurements of the hip (total hip and trochanteric and femoral neck sites) and lumbar spine (from the L2 to L4 vertebrae) and prevalence or incidence of vertebral, hip, and other fractures. Results: In sex-pooled analyses, APOE4 carriers had a 0.018 g/cm lower weighted mean trochanteric BMD than non carriers ( p = 0.0002) with no evidence for between-study heterogeneity. A significant association was also detected with lumbar spine BMD ( p = 0.006); however, inter-study heterogeneity was observed. Associations with lumbar spine and trochanteric BMD were observed predominantly in women and became less significant in meta-regression ( p = 0.055 and 0.01, respectively). There were no consistent associations of APOE4 genotype with BMD at other skeletal sites or with fracture risk. Conclusions: Based on these findings, there is insufficient evidence to support a strong and consistent association of the APOE genotype with BMD and fracture incidence. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
9. Online auctions helping agencies power up.
- Subjects
POWER resources ,AUCTIONS ,ENERGY industries ,ONLINE information services ,URBAN planning - Abstract
The article focuses on the World Energy Exchange, developed by the city of Springfield in Massachusetts. The World Energy Exchange is an online auction platform that helps the government secured the 60-month supply of electricity worth $47.5 million. This online auction will allow the energy consumers to buy electricity and other energy resources from the competing energy providers. It will also accommodate the brokering green power, natural gas and other energy-related products.
- Published
- 2008
10. Bibliodata Goes Electronic.
- Subjects
DIRECTORIES ,PERIODICALS ,ONLINE information services ,DATABASES - Abstract
The article states that "Fulltext Sources Online," a directory listing more than 3,600 journals, newsletters, newspapers and newswires that are available in fulltext format online, is now available as an electronic database from two suppliers: Data-Star (RadioSuisse) service, and SandPoint Corp. The directory provides coverage dates, degree of coverage and online hosts for each journal. Data-Star (RadioSuisse) is providing public online access for the BiblioData directory, which is known by the acronym FULL. The database will be updated quarterly, and is fully searchable from anywhere in the world. Cambridge, Massachusetts-based SandPoint Corp. delivers Fulltext Sources Online as an electronic publication to users of Lotus Notes, software that enables information access by multiple users over PC networks. Publications are organized alphabetically by geographic focus, by content focus, by source file, and by vendor for easy access by both information professionals and casual corporate users.
- Published
- 1992
11. OCLC grant helps support micro applications database.
- Subjects
LIBRARY schools ,ONLINE information services - Abstract
Reports that Online Computer Library Center Inc. has awarded money to the library school at Simmons College in Boston, Massachusetts for developing MicroUse, a microcomputer based database, that will help to provide information on microcomputer applications in libraries and information centers. Supervisors of the project; Documents that are to be submitted along with application forms.
- Published
- 1984
12. Museum of Science Database.
- Subjects
ONLINE information services ,ELECTRONIC directories ,ELECTRONIC information resource searching ,COMPUTER assisted instruction ,INTERNET in education ,SCIENCE museums - Abstract
Features the Educator Resource Center (ERC) online learning space developed by the Museum of Science in Boston, Massachusetts. Usability of the online service; Distinct features of the online collection; Levels of the online resources; Ways on searching the online resources.
- Published
- 2005
13. ONLINE.
- Subjects
DATING (Social customs) ,ONLINE information services ,UNIVERSITIES & colleges - Abstract
Presents information on the online matchmaking service developed by Massachusetts Institute of Technology alumnus Jonathan G. Monsarrat for those looking for a date. Purpose of developing the service; Details of the algorithm used in the service; Reason behind the reluctance of some people to try the service.
- Published
- 2003
14. Consumer Online Hype and Hoopla.
- Author
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Noble, Rick and Shafer, Keith
- Subjects
CONFERENCES & conventions ,ONLINE information services ,STRATEGIC alliances (Business) - Abstract
The article focuses on the happenings at the Interactive Service Association's 10th Annual Conference. The conference was held in mid-July 1995 in Boston, Massachusetts. Hundreds of other information industry types were in town attending the Interactive Service Association's 10th Annual Conference and Alliance Expo at the Marriott Copley Place. Russ Siegelman, general manager of the Microsoft Corp.'s was verbally assaulted by a tag team of senior executives from the "Big Three" consumer online services. Siegelman countered with innocent surprise at suggestions of unfair advantage and restraint of trade on the part of Microsoft. There are more people with telephones than operating systems in this country, suggested Siegelman, attempting to resuscitate old fears about the regional Bell operating companies. But Microsoft, with its huge penetration of the world's desktops has become "the dial tone of the digital age," warned Steve Case, president of America Online. The fact is, they all may be worried about the wrong playing field. Opinions of the speakers varied widely on the subject of what role the Internet will play in consumer online activities. Charles Brumback, chairman of the Tribune Co., felt that the opportunity will be all incremental and that online services will continue to prosper.
- Published
- 1995
15. Linking CPAs with Expertise.
- Subjects
ONLINE information services - Abstract
Reports the development of Allmerica Integrated Partners by Allmerica Financial in Worcester, Massachusetts. Objectives of Allmerica Integrated Partners; Discussion of company details at Allmerica web sites; Release of the online magazine by Wealth, Living, Giving.
- Published
- 2002
16. Linking CPAs with Expertise.
- Subjects
ONLINE information services - Abstract
Reports the establishment of Allmerica Integrated Partners by Allmerica Financial in Worcester, Massachusetts. Benefits of the Web sites; Access of certified public accountants to online resources of the organization; Inauguration of financial and investment management services.
- Published
- 2002
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