1. Prognostic role of tissue and circulating microRNA-200c in malignant tumors: a systematic review and meta-analysis.
- Author
-
Shao Y, Geng Y, Gu W, Huang J, Pei H, and Jiang J
- Subjects
- Biomarkers, Tumor genetics, Humans, MicroRNAs genetics, Neoplasm Staging, Neoplasms pathology, Neoplastic Cells, Circulating, Survival Analysis, Biomarkers, Tumor biosynthesis, MicroRNAs biosynthesis, Neoplasms genetics, Prognosis
- Abstract
Background: Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may serve as prognostic biomarkers. We performed a systematic review and meta-analysis to evaluate the prognostic role of miR-200c expression in different cancers., Methods: Studies were recruited by searching PubMed, Embase and the Cochrane Library (last search update was May 2014) and assessed by further quality evaluation., Results: A total of 25 studies dealing with various carcinomas were identified for systematic review. Among them, 18 studies were ultimately included in the meta-analysis. Our results indicated that the expression of tissue miR-200c was not associated with OS and PFS in various carcinomas; however, downregulation of tissue miR-200c did predict poor OS of patients with stage I disease (HR=0.41, 95% CI 0.25-0.68, P=0.001). Furthermore, overexpression of blood miR-200c was significantly related to poor OS and PFS (HR=3.07 95% CI 1.58-5.96 P=0.001, HR=2.26 95% CI 1.66-3.08 P<0.001, respectively), especially in patients with advanced disease., Conclusion: This systematic review and meta-analysis clarified that low expression of miR-200c in primary tissue was significantly associated with poor survival in cancer patients at early stage, whereas a high level of blood miR-200c predicted poor prognosis in patients with advanced tumors., (© 2015 S. Karger AG, Basel)
- Published
- 2015
- Full Text
- View/download PDF