1. Engineering Ag-Decorated Graphene Oxide Nano-Photothermal Platforms with Enhanced Antibacterial Properties for Promoting Infectious Wound Healing.
- Author
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Sun Z, Chen X, Miao F, Meng N, Hu K, Xiong S, Peng X, Ma L, Zhou C, and Yang Y
- Subjects
- Animals, Humans, Mice, Photothermal Therapy methods, Nanoparticles chemistry, Wound Infection drug therapy, Wound Infection microbiology, Escherichia coli drug effects, Staphylococcus aureus drug effects, Cell Movement drug effects, Graphite chemistry, Graphite pharmacology, Wound Healing drug effects, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Silver chemistry, Silver pharmacology, Hydrogels chemistry, Hydrogels pharmacology
- Abstract
Introduction: Graphene oxide (GO) nanoparticles have emerged as a compelling photothermal agent (PHTA) in the realm of photothermal antibacterial therapy, owing to their cost-effectiveness, facile synthesis, and remarkable photostability. Nevertheless, the therapeutic efficacy of GO nanoparticles is commonly hindered by their inherent drawback of low photothermal conversion efficiency (PCE)., Methods: Herein, we engineer the Ag/GO-GelMA platform by growing the Ag on the surface of GO and encapsulating the Ag/GO nanoparticles into the GelMA hydrogels., Results: The resulting Ag/GO-GelMA platform demonstrates a significantly enhanced PCE (47.6%), surpassing that of pure GO (11.8%) by more than fourfold. As expected, the Ag/GO-GelMA platform, which was designed to integrate the benefits of Ag/GO nanoparticles (high PCE) and hydrogel (slowly releasing Ag
+ to exert an inherent antibacterial effect), has been shown to exhibit exceptional antibacterial efficacy. Furthermore, transcriptome analyses demonstrated that the Ag/GO-GelMA platform could significantly down-regulate pathways linked to inflammation (the MAPK and PI3K-Akt pathways) and had the ability to promote cell migration., Discussion: Taken together, this study presents the design of a potent photothermal antibacterial platform (Ag/GO-GelMA) aimed at enhancing the healing of infectious wounds. The platform utilizes a handy method to enhance the PCE of GO, thereby making notable progress in the utilization of GO nano-PHTAs., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper., (© 2024 Sun et al.)- Published
- 2024
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