Autonomous vehicles (AVs) are rapidly emerging in United States cities, leaving urban and regional planning institutions unsure how to plan and develop policies. This paper analyzes how regional transportation plans (RTPs) developed by metropolitan planning organizations (MPOs) are approaching the risks and opportunities presented by AVs. Among 52 MPOs, a majority only mention key issues and emphasize high levels of uncertainty. Twelve MPOs develop policies on infrastructure, safety, partnerships, data-sharing, and multimodal transportation. Despite a positive trend, many recently adopted RTPs do not incorporate AVs. To plan for uncertain mobility futures, MPOs must develop more flexible approaches to long-term infrastructure investment. [ABSTRACT FROM AUTHOR]