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This study presents the publications output of the four most productive Indian academic institutions in the mainstream scientific literature for the eight-year-period 2000-2007. This paper discusses the distribution of publications by institution, type of publication, pattern of co-authorship, and citations. The results show that among the four universities, the authors of Delhi University contributed the highest number of articles, followed by Banaras Hindu University. There is also an increasing trend of collaborative research among Indian authors as well as more frequent collaboration with international authors. Biochemistry and molecular biology is one of the most prolific research areas in these four Indian universities. The average rate of references per item is 28 and the citations received per item are 3.56. [ABSTRACT FROM AUTHOR]