Search

Your search keyword '"Weissman, Irving L."' showing total 1,393 results
Start Over Author "Weissman, Irving L." Language english
1,393 results on '"Weissman, Irving L."'

102. Something in the Eye of the Beholder

Author

Blau, Helen, Brazelton, Tim, Keshet, Gilmor, Rossi, Fabio, Castro, Raymond F., Jackson, Kathyjo A., Goodell, Margaret A., Robertson, Claudia S., Liu, Hao, Shine, H. David, Wagers, Amy J., Sherwood, Richard I., Christensen, Julie L., and Weissman, Irving L.

Published
2002

103. Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

Author

Gholamin, Sharareh, Mitra, Siddhartha S., Feroze, Abdullah H., Liu, Jie, Kahn, Suzana A., Zhang, Michael, Esparza, Rogelio, Richard, Chase, Ramaswamy, Vijay, Remke, Marc, Volkmer, Anne K., Willingham, Stephen, Ponnuswami, Anitha, McCarty, Aaron, Lovelace, Patricia, Storm, Theresa A., Schubert, Simone, Hutter, Gregor, Narayanan, Cyndhavi, Chu, Pauline, Raabe, Eric H., Harsh, Griffith, IV, Taylor, Michael D., Monje, Michelle, Cho, Yoon-Jae, Majeti, Ravi, Volkmer, Jens P., Fisher, Paul G., Grant, Gerald, Steinberg, Gary K., Vogel, Hannes, Edwards, Michael, Weissman, Irving L., and Cheshier, Samuel H.

Published
2017
Full Text
View/download PDF

104. Pharmacological rescue of diabetic skeletal stem cell niches

Author

Tevlin, Ruth, Seo, Eun Young, Marecic, Owen, McArdle, Adrian, Tong, Xinming, Zimdahl, Bryan, Malkovskiy, Andrey, Sinha, Rahul, Gulati, Gunsagar, Li, Xiyan, Wearda, Taylor, Morganti, Rachel, Lopez, Michael, Ransom, Ryan C., Duldulao, Christopher R., Rodrigues, Melanie, Nguyen, Allison, Januszyk, Michael, Maan, Zeshaan, Paik, Kevin, Yapa, Kshemendra-Senarath, Rajadas, Jayakumar, Wan, Derrick C., Gurtner, Geoffrey C., Snyder, Michael, Beachy, Philip A., Yang, Fan, Goodman, Stuart B., Weissman, Irving L., Chan, Charles K. F., and Longaker, Michael T.

Published
2017
Full Text
View/download PDF

111. Multiple Forms of Neural Cell Death in the Cyclical Brain Degeneration of A Colonial Chordate.

Author

Anselmi, Chiara, Caicci, Federico, Bocci, Tommaso, Guidetti, Matteo, Priori, Alberto, Giusti, Veronica, Levy, Tom, Raveh, Tal, Voskoboynik, Ayelet, Weissman, Irving L., and Manni, Lucia

Subjects
BRAIN degeneration, CELL death, BRAIN death, COLONIAL animals (Marine invertebrates), LIFE history theory, HOMOLOGY (Biology), SCRAPIE
Abstract

Human neuronal loss occurs through different cellular mechanisms, mainly studied in vitro. Here, we characterized neuronal death in B. schlosseri, a marine colonial tunicate that shares substantial genomic homology with mammals and has a life history in which controlled neurodegeneration happens simultaneously in the brains of adult zooids during a cyclical phase named takeover. Using an ultrastructural and transcriptomic approach, we described neuronal death forms in adult zooids before and during the takeover phase while comparing adult zooids in takeover with their buds where brains are refining their structure. At takeover, we found in neurons clear morphologic signs of apoptosis (i.e., chromatin condensation, lobed nuclei), necrosis (swollen cytoplasm) and autophagy (autophagosomes, autolysosomes and degradative multilamellar bodies). These results were confirmed by transcriptomic analyses that highlighted the specific genes involved in these cell death pathways. Moreover, the presence of tubulovesicular structures in the brain medulla alongside the over-expression of prion disease genes in late cycle suggested a cell-to-cell, prion-like propagation recalling the conformational disorders typical of some human neurodegenerative diseases. We suggest that improved understanding of how neuronal alterations are regulated in the repeated degeneration–regeneration program of B. schlosseri may yield mechanistic insights relevant to the study of human neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

112. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Author

Weiskopf, Kipp, Jahchan, Nadine S., Schnorr, Peter J., Cristea, Sandra, Ring, Aaron M., Maute, Roy L., Volkmer, Anne K., Volkmer, Jens-Peter, Liu, Jie, Lim, Jing Shan, Yang, Dian, Seitz, Garrett, Nguyen, Thuyen, Wu, Di, Jude, Kevin, Guerston, Heather, Barkal, Amira, Trapani, Francesca, George, Julie, Poirier, John T., Gardner, Eric E., Miles, Linde A., de Stanchina, Elisa, Lofgren, Shane M., Vogel, Hannes, Winslow, Monte M., Dive, Caroline, Thomas, Roman K., Rudin, Charles M., van de Rijn, Matt, Majeti, Ravindra, Garcia, K. Christopher, Weissman, Irving L., and Sage, Julien

Subjects
Lung cancer, Small cell -- Care and treatment, Immunotherapy -- Patient outcomes, Macrophages -- Physiological aspects -- Health aspects, Health care industry
Abstract

Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited treatment options. CD47 Is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alpha (SIRPα), which serves as an inhibitory receptor on macrophages. Here, we found that CD47 is highly expressed on the surface of human SCLC cells; therefore, we investigated CD47-blocking immunotherapies as a potential approach for SCLC treatment. Disruption of the interaction of CD47 with SIRPα using anti-CD47 antibodies induced macrophage-mediated phagocytosis of human SCLC patient cells in culture. In a murine model, administration of CD47-blocking antibodies or targeted inactivation of the Cd47 gene markedly inhibited SCLC tumor growth. Furthermore, using comprehensive antibody arrays, we identified several possible therapeutic targets on the surface of SCLC cells. Antibodies to these targets, including CD56/neural cell adhesion molecule (NCAM), promoted phagocytosis in human SCLC cell lines that was enhanced when combined with CD47-blocking therapies. In light of recent clinical trials for CD47-blocking therapies in cancer treatment, these findings identify disruption of the CD47/SIRPα axis as a potential immunotherapeutic strategy for SCLC. This approach could enable personalized immunotherapeutic regimens in patients with SCLC and other cancers., Introduction Small-cell lung cancer (SCLC), which originates from neuroendocrine cells of the lung (1, 2), is one of the most lethal subtypes of cancer. Each year, more than 25,000 patients [...]

Published
2016
Full Text
View/download PDF

113. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

Author

Chen, James Y., Miyanishi, Masanori, Wang, Sean K., Yamazaki, Satoshi, Sinha, Rahul, Kao, Kevin S., Sahoo, Jun Seita Debashis, Nakauchi, Hiromitsu, and Weissman, Irving L.

Subjects
Hematopoietic stem cells -- Health aspects, Cell interaction -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Haematopoietic stem cells (HSCs) are arguably the most extensively characterized tissue stem cells. Since the identification of HSCs by prospective isolation (1), complex multi-parameter flow cytometric isolation of phenotypic subsets [...]

Published
2016

115. 2021 Hoeg Lecture: Defining The Role Of Efferocytosis In Cardiovascular Disease – A Focus On The CD47 Axis

Author

Jarr, Kai-Uwe, Kojima, Yoko, Weissman, Irving L., and Leeper, Nicholas J.

Subjects
Phagocytosis, Cardiovascular Diseases, Macrophages, Awards and Prizes, Humans, Apoptosis, CD47 Antigen, Article, Plaque, Atherosclerotic
Abstract

A key feature of atherogenesis is the accumulation of diseased and dying cells within the lesional necrotic core. While the burden of intraplaque apoptotic cells may be driven in part by an increase in programmed cell death, mounting evidence suggests that their presence may primarily be dictated by a defect in programmed cell removal, or efferocytosis. In this brief review, we will summarize the evidence suggesting that inflammation-dependent changes within the plaque render target cells inedible and reduce the appetite of lesional phagocytes. We will present the genetic causation studies, which indicate these phenomena promote lesion expansion and plaque vulnerability, and the interventional data which suggest that these processes can be reversed. Particular emphasis is provided related to the antiphagocytic CD47 (cluster of differentiation 47) do not eat me axis, which has emerged as a novel antiatherosclerotic translational target that is predicted to provide benefit independent of traditional cardiovascular risk factors.

Published
2022

116. Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells

Author

Chan, Charles K. F., Lindau, Paul, Jiang, Wen, Chen, James Y., Zhang, Lillian F., Chen, Ching-Cheng, Seita, Jun, Sahoo, Debashis, Kim, Jae-Beom, Lee, Andrew, Park, Sujin, Nag, Divya, Gong, Yongquan, Kulkarni, Subhash, Luppen, Cynthia A., Theologis, Alexander A., Wan, Derrick C., DeBoer, Anthony, Seo, Eun Young, Vincent-Tompkins, Justin D., Loh, Kyle, Walmsley, Graham G., Kraft, Daniel L., Wu, Joseph C., Longaker, Michael T., and Weissman, Irving L.

Published
2013

117. Identification of a Colonial Chordate Histocompatibility Gene

Author

Voskoboynik, Ayelet, Newman, Aaron M., Corey, Daniel M., Sahoo, Debashis, Pushkarev, Dmitry, Neff, Norma F., Passarelli, Benedetto, Koh, Winston, Ishizuka, Katherine J., Palmeri, Karla J., Dimov, Ivan K., Keasar, Chen, Fan, H. Christina, Mantalas, Gary L., Sinha, Rahul, Penland, Lolita, Quake, Stephen R., and Weissman, Irving L.

Published
2013
Full Text
View/download PDF

128. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Author

Willingham, Stephen B., Volkmer, Jens-Peter, Gentles, Andrew J., Sahoo, Debashis, Dalerba, Piero, Mitra, Siddhartha S., Wang, Jian, Contreras-Trujillo, Humberto, Martin, Robin, Cohen, Justin D., Lovelace, Patricia, Scheeren, Ferenc A., Chao, Mark P., Weiskopf, Kipp, Tang, Chad, Volkmer, Anne Kathrin, Naik, Tejaswitha J., Storm, Theresa A., Mosley, Adriane R., Edris, Badreddin, Schmid, Seraina M., Sun, Chris K., Chua, Mei-Sze, Murillo, Oihana, Rajendran, Pradeep, Cha, Adriel C., Chin, Robert K., Kim, Dongkyoon, Adorno, Maddalena, Raveh, Tal, Tseng, Diane, Jaiswal, Siddhartha, Enger, Per Øyvind, Steinberg, Gary K., Li, Gordon, So, Samuel K., Majeti, Ravindra, Harsh, Griffith R., van de Rijn, Matt, Teng, Nelson N. H., Sunwoo, John B., Alizadeh, Ash A., Clarke, Michael F., and Weissman, Irving L.

Published
2012

129. Three differentiation states risk-stratify bladder cancer into distinct subtypes

Author

Volkmer, Jens-Peter, Sahoo, Debashis, Chin, Robert K., Ho, Philip Levy, Tang, Chad, Kurtova, Antonina V., Willingham, Stephen B., Pazhanisamy, Senthil K., Contreras-Trujillo, Humberto, Storm, Theresa A., Lotan, Yair, Beck, Andrew H., Chung, Benjamin I., Alizadeh, Ash A., Godoy, Guilherme, Lerner, Seth P., van de Rijn, Matt, Shortliffe, Linda D., Weissman, Irving L., and Chan, Keith S.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results