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Your search keyword '"ANTHONY DIPPLE"' showing total 3 results
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3 results on '"ANTHONY DIPPLE"'

1. Polycyclic Hydrocarbons and Carcinogenesis

Author

RONALD G. HARVEY, ANTHONY DIPPLE, SHEN K. YANG, MOHAMMAD MUSHTAQ, PEI-LU CHIU, RONALD G. HARVEY, ROLAND E. LEHR, SUBODH KUMAR, WAYNE LEVIN, ALEXANDER W. WOOD, RICHARD L. CHANG, ALLAN H. CONNEY, HARUHIKO YAGI, JANE M. SAYER, DONALD M. JERINA, STEPHEN S. HECHT, SHANTU AMIN, ASSIEH A. MELIKIAN, EDMOND J. LAVOIE, DIETRICH, Ronald G. Harvey, M. Joan Comstock

Published
1985

2. Distribution of DNA damage in chromatin and its relation to repair in human cells treated with 7-bromomethylbenz(a) anthracene

Author

Frederick B. Oleson, Bonnie L Mitchell, Anthony Dipple, and Michael W. Lieberman

Subjects
DNA clamp, DNA Repair, DNA damage, DNA repair, DNA, Neoplasm, Biology, Molecular biology, Chromatin, Cell Line, Hydrocarbons, Brominated, Kinetics, Neuroblastoma, Excinuclease, Genetics, Benz(a)Anthracenes, Humans, Micrococcal Nuclease, DNA mismatch repair, Replication protein A, Nucleotide excision repair
Abstract

We have examined the relationship between the distribution of DNA damage and repair in chromatin from confluent human fibroblasts treated with the carcinogen 7-bromomethylbenz (a) anthracene. Analysis of staphylococcal nuclease (SN)4 digestion kinetics and gel electrophoresis revealed that more total damage occurs in nucleosome core DNA (approximately 80-85% of chromatin DNA) than in SN sensitive DNA (APPROXIMATELY15-20%). Furthermore, over a 24 hr period, damage is removed at about the same rate from these two regions. In contrast, virtually all of the nucleotides incorporated during repair synthesis are initially SN sensitive even when measured at 12 hr after damage. With time many repair-incorporated nucleotides become SN resistant and coelectrophorese with nucleosome core DNA. To explain these data we propose a model whereby excision repair occurs in both linker and core DNA; however, in core DNA the repair process induces conformational changes resulting in temporarily increased SN sensitivity; subsequently, rearrangement occurs and results in the re-establishment of native or near-native nucleosome conformation and SN resistance.

Published
1979

3. Xenobiotic Metabolism: Nutritional Effects

Author

JOHN W. FINLEY, DANIEL E. SCHWASS, D. E. SCHWASS, J. W. FINLEY, SUSHMA PALMER, VICTOR HERBERT, J. DONALD DEBETHIZY, ROBIN S. GOLDSTEIN, DAVID KRITCHEVSKY, ELLIOT S. VESELL, WILLIAM A. PRYOR, M. RAHIMTULA, W. MARSHALL, B. GREGORY, P. J. O'BRIEN, RAYMOND J. SHAMBERGER, BANDARU S. REDDY, M. MARGARET KING, JUNJI TERAO, GEMMA BRUEGGEMANN, PAUL B. McCAY, ROBERT A. MAGARIAN, EDWARD L. WHEELER, LADELL CRAWFORD, DAVID L. BERRY, PAUL M. NEWBERNE, KENNETH K. CARROLL, C. ANITA, H. BIGGER, ANTHONY DIPPLE, JOHNNIE R. HAYES, C. JELLEFF CARR, CHING K. CHOW, MARSHALL W. ANDERSON, PETER I. ADRIAENSSENS, CATHERINE M. WHITE, Y. M. IOANNOU, ALAN G. E. WILSON, C. CHANNA REDDY, CRAIG E. THOMAS, RICHARD W. SCHOLZ, JOHN A. MILNER, JONATHAN YAVELOW, KENNETH A. BECK, MORTIMER LEVITZ, WALTER TROLL, WILLARD J. VISEK, STEVEN K. CLINTON, H. SHINOZUKA, A. J. DEMETRIS, S. L. KATYAL, M. I. R. PERERA, MALCOLM B. BAIRD, OLGA GREENGARD, JOHN W. FINLEY, DANIEL E. SCHWASS, D. E. SCHWASS, J. W. FINLEY, SUSHMA PALMER, VICTOR HERBERT, J. DONALD DEBETHIZY, ROBIN S. GOLDSTEIN, DAVID KRITCHEVSKY, ELLIOT S. VESELL, WILLIAM A. PRYOR, M. RAHIMTULA, W. MARSHALL, B. GREGORY, P. J. O'BRIEN, RAYMOND J. SHAMBERGER, BANDARU S. REDDY, M. MARGARET KING, JUNJI TERAO, GEMMA BRUEGGEMANN, PAUL B. McCAY, ROBERT A. MAGARIAN, EDWARD L. WHEELER, LADELL CRAWFORD, DAVID L. BERRY, PAUL M. NEWBERNE, KENNETH K. CARROLL, C. ANITA, H. BIGGER, ANTHONY DIPPLE, JOHNNIE R. HAYES, C. JELLEFF CARR, CHING K. CHOW, MARSHALL W. ANDERSON, PETER I. ADRIAENSSENS, CATHERINE M. WHITE, Y. M. IOANNOU, ALAN G. E. WILSON, C. CHANNA REDDY, CRAIG E. THOMAS, RICHARD W. SCHOLZ, JOHN A. MILNER, JONATHAN YAVELOW, KENNETH A. BECK, MORTIMER LEVITZ, WALTER TROLL, WILLARD J. VISEK, STEVEN K. CLINTON, H. SHINOZUKA, A. J. DEMETRIS, S. L. KATYAL, M. I. R. PERERA, MALCOLM B. BAIRD, and OLGA GREENGARD

Subjects
Xenobiotics--Metabolism--Nutritional aspects -
Published
1985

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