19 results on '"Acquarone N"'
Search Results
2. Experience of an information aid for newly diagnosed multiple sclerosis patients: a qualitative study on the SIMS-Trial
- Author
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Borreani, C, Giordano, A, Falautano, M, Lugaresi, A, Martinelli, V, Granella, F, Tortorella, C, Plasmati, I, Radaelli, M, Dalla Bella, E, Bianchi, E, Acquarone, N, Miccinesi, G, Solari, A, D' Alessandro, R, Pucci, E, Uccelli, Mm, Trojano, M, Heesen, C, Mancardi, Gl, Milanese, C, Calabrese, D, Ferrari, G, Mattarozzi, K, Confalonieri, P, Antozzi, C, Maggi, L, Mantegazza, R, Colombo, B, Esposito, F, Moiola, L, Rodegher, M, Immovilli, P, Farina, D, De Luca, G, Di Tommaso, V, Di Ioia, M, Travaglini, D, Pietrolongo, E, and Zimatore, G.
- Subjects
Adult ,Male ,Clinical Trials as Topic ,Multiple Sclerosis ,Time Factors ,Patient Education as Topic ,Patients ,Physicians ,Humans ,Female ,Middle Aged ,Original Research Papers ,Qualitative Research - Abstract
The SIMS-Trial (ISRCTN81072971) proved the effectiveness, in terms of patient's knowledge and care satisfaction, of an add-on information aid (personal interview with a physician using a navigable CD and take-home booklet) in 120 newly diagnosed patients with multiple sclerosis (MS) from five Italian centres.To scrutinize the experience of SIMS-Trial participants in order to gain better understanding of the effectiveness of the information aid and its components.We performed (i) nine individual semi-structured interviews with a purposeful sample of SIMS-Trial patients who received the information aid, (ii) focus group meeting (FGM) with the physicians who conducted the personal interview, and (iii) FGM with patients' caring neurologists.Patients' experience with the information aid was positive as it enhanced their understanding of their disease, being viewed as a guided tour of their medical condition. The physicians who conducted the personal interviews were also positive in their overall evaluation but noted an initial difficulty in using the CD. The caring neurologists had limited direct experience of the aid, and their views were confined to utility of the information aid in general. All participants considered the combination of personal interview, CD navigation and take-home booklet essential, but urged a more flexible scheduling of the personal interview. It also emerged that some content required revision and that the aid was unsuitable for patients with primary progressive MS.The results of the study further support the value of the aid and also provide important indications for improving it and refining indications for use.
- Published
- 2014
3. Specialty-related differences in the epidemiology, clinical profile, management and outcome of patients hospitalized for heart failure
- Author
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Bellotti P., Badano L., Acquarone N., Griffo R., Lo Pinto G., Maggioni A. P., Mattiauda C., Menardo G., Mombelloni P., Bellotti, P, Badano, L, Acquarone, N, Griffo, R, Lo Pinto, G, Maggioni, A, Mattiauda, C, Menardo, G, and Mombelloni, P
- Subjects
Adult ,Aged, 80 and over ,Heart Failure ,Male ,Cardiology ,Adrenergic beta-Antagonist ,Angiotensin-Converting Enzyme Inhibitor ,Cardiologist ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Middle Aged ,Internist ,Prospective Studie ,Treatment Outcome ,Echocardiography ,Electrocardiography, Ambulatory ,Internal Medicine ,Age Factor ,Female ,Practice Patterns, Physicians' ,Aged ,Human ,Quality of Health Care - Abstract
Aims: This study was designed to identify potential specialty-related differences in the epidemiology, clinical profile, management and outcome of patients hospitalized for congestive heart failure in departments of cardiology or internal medicine. Methods and Results: From 1 July to 31 December 1998, we prospectively recorded epidemiological and clinical data from patients with congestive heart failure consecutively admitted to 11 departments of cardiology and 12 departments of internal medicine in Liguria, a northern area of Italy. The overall study population included 749 patients; 22% were treated by cardiologists and 78% by internists (P
- Published
- 2001
4. Left ventricular and carotid structure in untreated, uncomplicated essential hypertension: Results from the Assessment Prognostic Risk Observational Survey (APROS)
- Author
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Cuspidi, C., Mancia, G., Ambrosioni, E., Pessina, A., Trimarco, B., Zanchetti, A., Acquarone, N., Lotti, G., Benemio, G., Ambrosio, G. B., Ambrosio, Giuseppe, Boscaro, M., Calcagnini, G., Manconi, R., Pola, P., Volpe, M., Campanini, M., Cappelletti, C., Cavatorta, A., Chiandussi, L., Circo, A., D'Addetta, G., De Cesaris, R., Degli Esposti, E., De Matteis, C., Ferrari, A., Giovannetti, R., Grasso, E., Russo, V., Lechi, A., Leonetti, G., Maiorano, G., Marchesi, E., Margaroli, P., Martines, C., Mezzetti, R., Mos, L., Nami, R., Pascal, G., Pasotti, C., Penzo, M., Pinna, G., Ragazzoni, R., Rappelli, A., Santucci, A., Scala, A., Stella, A., Stornello, M., Venco, A., Cuspidi, C, Mancia, G, Ambrosioni, E, Pessina, A, Trimarco, B, and Zanchetti, A
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,hypertension ,Physiology ,Heart Ventricles ,Concentric hypertrophy ,Blood Pressure ,Left ventricular hypertrophy ,Essential hypertension ,Internal medicine ,carotid arteries abnormalities, uncomplicated essential hypertension ,Internal Medicine ,medicine ,Humans ,Eccentric ,Mass index ,Prospective Studies ,cardiovascular diseases ,Risk factor ,Prospective cohort study ,carotid structure ,Ventricular Remodeling ,business.industry ,Medicine (all) ,Ultrasound ,Hypertrophy ,ultrasonography ,Middle Aged ,Prognosis ,medicine.disease ,Carotid structure ,Hypertension ,Ultrasonography ,Carotid Arteries ,Female ,Hypertrophy, Left Ventricular ,Tunica Intima ,Tunica Media ,Echocardiography ,Left Ventricular ,Pulse pressure ,Cardiology ,MED/09 - MEDICINA INTERNA ,Cardiology and Cardiovascular Medicine ,business - Abstract
The impact of hypertension on left ventricular (LV) and vascular structure and the relation of left ventricular hypertrophy (LVH) with vascular changes in untreated essential hypertensives has not been fully explored. This study investigated the prevalence of structural abnormalities of LV and carotid arteries and their determinants in a large population of untreated, uncomplicated essential hypertensive patients. The Assessment of Prognostic Risk Observational Survey was a multicentre (44 centres) prospective study including 1142 untreated hypertensives classified as low or medium cardiovascular risk on the basis of the routine diagnostic work-up recommended by the 1999 World Health Organization/International Society of Hypertension guidelines. All patients underwent ultrasound examinations of the heart and carotid arteries. LVH and carotid structural changes were diagnosed when: (1) LV mass index exceeded 125 g/m(2) in men and 110 g/m2 in women; (2) there was at least one plaque (focal thickening >41.3 mm) in any segment of either carotid artery or a diffuse common carotid intima media thickness (IMT) (average of IMT greater than or equal to0.8 mm) was present. Overall, 1074 patients (504 women, mean age 48.1+/-11.4 years) completed the study with ultrasonographic examinations of good technical quality. The prevalences of LVH and LV concentric remodelling in the total population were 26.8 and 10.7%, respectively. Eccentric hypertrophy was more prevalent than concentric hypertrophy (15.2 vs 11.6%). One or more carotid plaques or thickening were present in 27.4% of the patients. A stepwise increase in IM thickness occurred from the lowest values in patients with normal cardiac mass and geometry (0.68 mm) to intermediate in those with LV remodelling (0.76 mm) and eccentric LVH (0.81 mm) and to the highest level in patients with concentric LVH (0.87 mm). Patients with LV concentric remodelling and concentric LVH had a significantly greater relative carotid wall thickness than those with normal geometry and eccentric LVH (0.25 and 0.26 vs 0.18 and 0.19, respectively, P
- Published
- 2004
5. Communicating the diagnosis of multiple sclerosis -- a qualitative study.
- Author
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Solari, A., Acquarone, N., Pucci, E., Martinelli, V., Marrosu, M. G., Trojano, M., Borreani, C., and Uccelli, M. Messmer
- Subjects
- *
MULTIPLE sclerosis , *CHRONIC diseases , *FOCUS groups , *DECISION making , *PHYSICIAN-patient relations , *QUALITATIVE research - Abstract
Studies on communicating the diagnosis of multiple sclerosis (MS) are few, and all reveal communication and information deficits. We explored the personal experience of diagnosis communication of people with MS and health professionals, using a qualitative methodology. Data were obtained from two sets of focus group meetings (FGM) with people with MS (total 23; 16 females; age range: 23–70) and one FGMs with health professionals (four neurologists, three psychologists, two nurses). The methods of framework analysis were applied to meeting transcripts to identify key topics and categories. The experience of communicating/receiving an MS diagnosis was highly varied; all patients reported the moment as powerfully evocative and unforgettable. Very poor levels of support and information were sometimes given. Although diagnosis communication had improved in more recent experience, all felt it should be further improved with appropriate setting (privacy, no interruptions, sufficient time), information tailored to the individual, and continuity of care. Such improvements imply a more meaningful patient-neurologist relationship, and also structural and organisational changes. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
6. Specialty-related differences in the epidemiology, clinical profile, management and outcome of patients hospitalized for heart failure. The OSCUR study.
- Author
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Bellotti, P., Badano, L.P., Acquarone, N., Griffo, R., Lo Pinto, G., Maggioni, A.P., Mattiauda, C., Menardo, G., and Mombelloni, P.
- Abstract
Aims This study was designed to identify potential specialty-related differences in the epidemiology, clinical profile, management and outcome of patients hospitalized for congestive heart failure in departments of cardiology or internal medicine.Methods and Results From 1 July to 31 December 1998, we prospectively recorded epidemiological and clinical data from patients with congestive heart failure consecutively admitted to 11 departments of cardiology and 12 departments of internal medicine in Liguria, a northern area of Italy. The overall study population included 749 patients; 22% were treated by cardiologists and 78% by internists (P<0·0001). Patients managed by cardiologists were more likely to undergo echocardiography (92% vs 37%), Holter monitoring (25% vs 3%) and exercise stress testing (20% vs 0·5%) than those managed by internists (P=0·001). At discharge, patients treated by cardiologists were more likely to be prescribed beta-blockers (41% to 4%) and ACE inhibitors (100% to 74%) than those treated by internists (P<0·0001), and the latter medication at higher dosages by cardiologists than internists. In addition, patients followed by cardiologists were younger (70±9 to 79±1 years;P<0·0001), more likely to be male (61% to 50%;P=0·011) and to have coronary artery disease (57% to 45%;P<0·006) than those followed by internists. Conversely, patients followed by internists were more likely to have diabetes, chronic obstructive pulmonary disease, atrial fibrillation and renal failure (P<0·03). In the overall study population, 53 patients (7%) died during hospitalization. Patients treated by cardiologists had a mortality not significantly different from that of patients treated by internists (10% and 6%, respectively;P=0·067), although congestive heart failure was more severe on admission in patients treated by cardiologists.Conclusion Cardiologists follow published guidelines for congestive heart failure more strictly than internists, but treat a smaller number of patients who are younger, have more severe congestive heart failure and fewer co-morbidities than those managed by internists. [ABSTRACT FROM PUBLISHER]
- Published
- 2001
- Full Text
- View/download PDF
7. Successful Treatment of Mitomycin C-Associated Hemolytic Uremic Syndrome by Plasmapheresis.
- Author
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Garibotto, G., Acquarone, N., Saffioti, S., Deferrari, G., Villaggio, B., and Ferrario, F.
- Published
- 1989
- Full Text
- View/download PDF
8. GLYOXYLIC ACID IN ETHYLENE GLYCOL POISONING
- Author
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Garibotto, Giacomo and Acquarone, N.
- Published
- 1988
9. Postanaesthetic myoglobinuric renal failure: an isolated expression of malignant hyperthermia.
- Author
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Acquarone, N., Garibotto, G., Tegazzin, V., Sofia, A., and Gurreri, G.
- Published
- 1994
10. Hypernatremia Associated with Severe Rhabdomyolysis.
- Author
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Acquarone, N., Garibotto, G., Pontremoli, R., and Gurreri, G.
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- 1989
- Full Text
- View/download PDF
11. 872 Impact of diabetes on current in-hospital management of heart failure by cardiologists and internists. Data from the TEMISTOCLE study
- Author
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De Feo, S., Opasich, C., Acquarone, N., Ambrosio, G.B., Di Lenarda, A., Gonzini, L., Lavecchia, R., Scherillo, M., Cafiero, M., and Maggioni, A.P.
- Subjects
DIABETES ,HEART failure - Abstract
An abstract of the study "Impact of diabetes on current in-hospital management of heart failure by cardiologists and internists. Data from the TEMISTOCLE study," by S. De Feo et al. is presented.
- Published
- 2004
12. Current management of patients hospitalized for heart failure. The OSCUR (Outcome nello Scompenso Cardiaco in relazione all'Utilizzo delle Risorse) trial.
- Author
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Badano, L.P., Bellotti, P., Acquarone, N., Griffo, R., and Pinto, G. Lo
- Published
- 2000
- Full Text
- View/download PDF
13. Patients with chronic heart failure encountered in daily hospital practice are different from the “typical” patient enrolled in clinical trials.
- Author
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Badano, L.P., Bellotti, P., and Acquarone, N.
- Published
- 2000
- Full Text
- View/download PDF
14. Experience of an information aid for newly diagnosed multiple sclerosis patients: a qualitative study on the SIMS-Trial.
- Author
-
Borreani C, Giordano A, Falautano M, Lugaresi A, Martinelli V, Granella F, Tortorella C, Plasmati I, Radaelli M, Farina D, Dalla Bella E, Bianchi E, Acquarone N, Miccinesi G, and Solari A
- Subjects
- Adult, Clinical Trials as Topic, Female, Humans, Male, Middle Aged, Qualitative Research, Time Factors, Multiple Sclerosis therapy, Patient Education as Topic methods, Patients psychology, Physicians psychology
- Abstract
Background: The SIMS-Trial (ISRCTN81072971) proved the effectiveness, in terms of patient's knowledge and care satisfaction, of an add-on information aid (personal interview with a physician using a navigable CD and take-home booklet) in 120 newly diagnosed patients with multiple sclerosis (MS) from five Italian centres., Objective: To scrutinize the experience of SIMS-Trial participants in order to gain better understanding of the effectiveness of the information aid and its components., Design: We performed (i) nine individual semi-structured interviews with a purposeful sample of SIMS-Trial patients who received the information aid, (ii) focus group meeting (FGM) with the physicians who conducted the personal interview, and (iii) FGM with patients' caring neurologists., Results: Patients' experience with the information aid was positive as it enhanced their understanding of their disease, being viewed as a guided tour of their medical condition. The physicians who conducted the personal interviews were also positive in their overall evaluation but noted an initial difficulty in using the CD. The caring neurologists had limited direct experience of the aid, and their views were confined to utility of the information aid in general. All participants considered the combination of personal interview, CD navigation and take-home booklet essential, but urged a more flexible scheduling of the personal interview. It also emerged that some content required revision and that the aid was unsuitable for patients with primary progressive MS., Conclusions: The results of the study further support the value of the aid and also provide important indications for improving it and refining indications for use., (© 2011 John Wiley & Sons Ltd.)
- Published
- 2014
- Full Text
- View/download PDF
15. Pharmacologic therapy in patients with chronic heart failure and chronic kidney disease: a complex issue.
- Author
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Acquarone N, Castello C, Antonucci G, Lione S, and Bellotti P
- Subjects
- Cardiovascular Agents adverse effects, Chronic Disease, Heart Diseases complications, Heart Diseases physiopathology, Humans, Kidney Diseases drug therapy, Kidney Diseases physiopathology, Kidney Function Tests, Treatment Outcome, Cardiovascular Agents therapeutic use, Heart Diseases drug therapy, Kidney physiopathology, Kidney Diseases complications
- Abstract
Chronic kidney disease is common in patients with chronic heart failure and has important clinical implications. The coexistence of these two syndromes is associated with a higher risk of adverse outcome and increases the difficulties of heart failure treatment because of the complex interplay between renal dysfunction and pharmacologic therapy. The underrepresentation of patients with chronic kidney disease in most heart failure trials contributes to the suboptimal treatment of this high-risk population in clinical practice. In the present review, we briefly examine the pathophysiologic mechanisms connecting chronic kidney disease and chronic heart failure and discuss the therapeutic approach to patients affected by both conditions.
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- 2009
- Full Text
- View/download PDF
16. Current presentation and management of heart failure in cardiology and internal medicine hospital units: a tale of two worlds--the TEMISTOCLE study.
- Author
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Di Lenarda A, Scherillo M, Maggioni AP, Acquarone N, Ambrosio GB, Annicchiarico M, Bellis P, Bellotti P, De Maria R, Lavecchia R, Lucci D, Mathieu G, Opasich C, Porcu M, Tavazzi L, and Cafiero M
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Aged, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Coronary Care Units statistics & numerical data, Cross-Sectional Studies, Female, Follow-Up Studies, Heart Failure mortality, Hospital Mortality, Humans, Internal Medicine statistics & numerical data, Length of Stay statistics & numerical data, Male, Prospective Studies, Treatment Outcome, Heart Failure diagnosis, Heart Failure drug therapy
- Abstract
Background: The purpose pf the current article is to describe the clinical profile, use of resources, management and outcome in a population of real-world inpatients with heart failure., Methods and Results: With a prospective, cross-sectional survey on acute hospital admissions, we evaluated the overall and provider-related differences in patient characteristics, diagnostic work-up, treatment and inhospital outcome of 2127 patients with heart failure admitted to 167 cardiology departments and 250 internal medicine departments between February 14 and 25, 2000. Patients admitted to cardiology units were younger (56.3% >70 years vs 76.2%, P <.0001), had more severe symptoms (NYHA IV 35% vs 29%, P =.00014), and more often underwent evaluation of ventricular function (89.3% vs 54.8%, P <.0001) and coronary angiography (7.5% vs 0.9%, P <.0001) than those admitted to medical units. Moreover, they were more often prescribed beta-blockers (17.8% vs 8.7%, P <.0001). However, prescription of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers (78.7% vs 81.5%, P = not significant [NS]) and inhospital mortality (5.2% vs 5.9%, P = NS) were similar. A 6-month follow-up visit was performed in 56.4% of cases (68.2% of cardiology vs 49.4% of medicine patients, P <.0001); 6-month readmission (43.7% vs 45.4%, P = NS) and mortality (13.9% vs 16.7%, P = NS) rates were similar., Conclusions: Patients with heart failure admitted to cardiology and internal medicine units represent 2 clearly different populations. In both groups, diagnostic procedures and evidence-based treatments, such as beta-blockers, appeared to be underused, and there was a lack of structured follow-up, as well as a poor 6-month prognosis.
- Published
- 2003
- Full Text
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17. Glyoxylic acid in ethylene glycol poisoning.
- Author
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Garibotto G, Paoletti E, and Acquarone N
- Subjects
- Adult, Ethylene Glycols metabolism, Humans, Male, Suicide, Attempted, Ethylene Glycols poisoning, Glyoxylates blood
- Published
- 1988
- Full Text
- View/download PDF
18. Effects of metabolic alkalosis, metabolic acidosis and uraemia on whole-body intracellular pH in man.
- Author
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Tizianello A, De Ferrari G, Gurreri G, and Acquarone N
- Subjects
- Acid-Base Equilibrium drug effects, Acute Disease, Adolescent, Adult, Aged, Ammonium Chloride pharmacology, Bicarbonates pharmacology, Chronic Disease, Humans, Hydrogen-Ion Concentration, Middle Aged, Uremia, Acidosis metabolism, Alkalosis metabolism, Body Fluids physiology, Intracellular Fluid physiology
- Abstract
1. Whole-body intracellular pH (pHi) was measured by the 14C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute metabolic acidosis, twelve normal subjects with chronic acidosis and in fifteen patients with chronic renal insufficiency and acidosis. 2. The change in pHi per unit change in extracellular pH is significantly larger in acute metabolic alkalosis than in acute metabolic acidosis. In chronic metabolic acidosis, pHi decreased in proportion to the total amount of ammonium chloride administered; pHi was normal in patients with uraemic acidosis. 3. These observations confirm the role that tissue buffers play in the protection of the cellular environment in some forms of acidosis. When the acid load overwhelms tissue buffer capacity, pHi becomes a function of extracellular pH. 4. Cells seem more protected from acute acidosis than from acute alkalosis.
- Published
- 1977
- Full Text
- View/download PDF
19. Renal ammoniagenesis in an early stage of metabolic acidosis in man.
- Author
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Tizianello A, Deferrari G, Garibotto G, Robaudo C, Acquarone N, and Ghiggeri GM
- Subjects
- Acidosis physiopathology, Adult, Amino Acids metabolism, Bicarbonates blood, Diuresis, Glutamine metabolism, Glycine metabolism, Humans, Middle Aged, Ornithine metabolism, Time Factors, Acidosis urine, Ammonia urine, Kidney physiopathology
- Abstract
Total renal ammonia production and ammonia precursor utilization were evaluated in patients under normal acid-base balance and in patients with 24-h NH4Cl acidosis by measuring (a) ammonia excreted with urine and that added to renal venous blood, and (b) amino acid exchange across the kidney. In 24-h acidosis not only urinary ammonia excretion is increased, but also total ammonia production is augmented (P less than 0.005) in comparison with controls. By evaluating the individual role of acid-base parameters, urine pH and urine flow in influencing renal ammonia production, it was shown that the degree of acidosis and urine flow are likely major factors stimulating ammoniagenesis. Both urine pH and urine flow are determinant in the preferential shift of ammonia into urine. In 1-d acidosis, renal extraction of glutamine was not increased and the total ammonia produced/glutamine N extracted ratio was higher than in controls (P less than 0.005) and was inversely correlated with the log of arterial bicarbonate concentration (P less than 0.001). In the same condition, renal glycine and ornithine uptake took place; the more severe the acidosis, the greater was the renal extraction of these amino acids (P less than 0.001). These data indicate that at the early stages of metabolic acidosis, in spite of a brisk increase in ammonia production, the mechanisms responsible for the increased glutamine use, which are operative in chronic acidosis, are not activated and other ammonia precursors, besides glutamine, are probably used for ammonia production.
- Published
- 1982
- Full Text
- View/download PDF
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