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Background: Boron is an element commonly found in nature. The main boron source for organisms is through food and drinking water. In recent years, it is suggested that the “boron-rich diet” can affect human health positively. However, more detailed studies are needed. Objective: The aim of this study was to examine the effect of increased dietary boron intake on some biochemical parameters in humans. Material and methods: Thirteen healthy women consumed diets containing 10 mg more boron than their routine diet for one month. This boron intake was provided with the increase of boron-rich foods such as dried fruits, avocado, and nuts in the diet. Some biochemical and hematologic parameters were determined in blood, urine and saliva samples taken before and after a boron-rich diet. Results: Serum, salivary, and urine boron concentrations increased 1.3, 1.7, 6.0 fold, respectively. The most significant clinically change was found in the lipid profile. Serum total, LDL, VLDL cholesterol, and triglyceride levels decreased significantly. Body weight, body fat weight, and Body Mass Index also decreased. Significant changes in serum TSH and salivary buffering capacity were also found. Conclusion: Increasing the intake of boron through dietary means might contribute to beneficial effects on lipid metabolism, obesity, and thyroid metabolism; salivary boron may reflect serum boron; and boron may be used as a cariostatic agent in dentistry. An increased intake of other dietary factors such as fiber, potassium, iron, vitamin A, and vitamin E in the boron-rich foods might have been responsible of the effects described. To our knowledge, this study is the first clinical study in which dietary boron intake is increased via foods. © 2019 Elsevier GmbH SAG-C-YLP-070317-0092 This work was supported by the Marmara University Scientific Research Project Commission [grant number SAG-C-YLP-070317-0092 ].

Background: The oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. The present study was conducted to detect the presence of H.pylori within the dental biofilm and in saliva samples collected from children suffering from dyspepsia and children without any gastrointestinal complaints. Associations with gastric infection, halitosis, and some oral parameters were also evaluated. Methods: Seventy children (aged between 5-16) with dyspepsia were selected for the study group and control group composed of 30 healthy children without dyspepsia were also included in the study. After detailed oral and clinical examinations for oral parameters, saliva, and supragingival dental biofilm samples were collected for 16S rRNA and 23S rRNA genes detection by real-time polymerase chain reaction (RT-PCR). The presence of gastric H.pylori was evaluated in endoscopic biopsy specimens histopathologically. Halitosis was evaluated by benzoyl-DL-arginine-naphthylamid (BANA) test. Salivary S.mutans and Lactobacilli sp. counts were also carried out by commercial kits. Results: H.pylori was histopathologically detected amongst 83% of the children with the dyspeptic condition. The detection rate of this bacteria in dental biofilm and saliva samples and halitosis were found relatively higher in the dyspeptic children rather than the control group (p0.05). In the gastric H.pylori positive group with dyspepsia, DMFT/S and dmft/s numbers and plaque indices were found higher than the control group (p0.05). Comparing to those with negative for both genes, in children whose dental biofilm and saliva samples were positive for both 16S rRNA and 23S rRNA genes, significantly higher results for halitosis, and DMFS numbers and significantly lower results for dmfs numbers and pH values were found (p

Based on the observation that sports teams rely on colored jerseys to define group membership, we examined how grouping by similarity affected observers’ abilities to track a “ball” target passed between 20 colored circle “players” divided into two color “teams” of 10 players or five color teams of four players each. Observers were more accurate and exerted less effort (indexed by pupil diameter) when their task was to count the number of times any player gained possession of the ball versus when they had to count only the possessions by a given color team, especially when counting the possessions of one team when players were grouped into fewer teams of more individual members each. Overall, results confirm previous reports of costs for segregating a larger set into smaller sub-sets and suggest that grouping by similarity facilitates processing at the set level.

Treatment for dental avulsion cases is early or late replantation of the traumatized teeth. Prognosis of the replanted tooth depends on the level of periodontal injury. Adipose tissue stem cells (ATSCs) were reported to improve periodontal ligament tissue (PDL) regeneration. Fibrin sealant (FS) contains thrombin and fibrinogen to form an adhesive fibrin clot routinely used in surgical procedures. Here, we aimed to investigate the effects of ATSCs + FS treatment on healing of PDL after tooth replantation in a rat model. After 60 min of extraction, maxillary central incisor teeth were replanted with ATSCs + FS. Two months later, the rats were sacrificed and hemimaxilla blocks were dissected out for histological analysis. The results showed that there was a significant improvement in histological findings of ATSCs + FS treated group compared to only FS treated and non-treated groups corresponding to reduced inflammatory resorption and increased new PDL formation. Furthermore, the ankylosis levels were lowered after ATSCs + FS treatment. Singular use of FS improved PDL healing moderately. Our results indicated that ATSCs + FS treatment improves PDL healing after tooth replantation suggesting a new therapeutic potential in the treatment of dental avulsion cases. © 2016, The Author(s).

Introduction: Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder characterized by immune dysregulation because of a mutation in cathepsin c gene, resulting in hyperkeratosis of the palms, soles, elbows, and knees combined with premature loss of the primary and permanent dentitions. Periodontal tissue abnormalities in PLS patients were reported previously. However, less is known about dental pulp tissue derived cells of PLS patients. This study aimed to show stem cell potential of PLS dental pulp stem cells (DPSCs) and provide new evidence regarding the pathophysiology of the disease. Methods: DPSCs were characterized by using flow cytometry and immunocytochemistry. They were also induced to differentiate into adipogenic, osteogenic, chondrogenic, odontogenic, and myogenic cells. Results: The results revealed that PLS DPSCs are stained positive for mesenchymal stem cells surface markers CD29, CD73, CD90, CD105, and CD166. PLS DPSCs were able to differentiate into adipogenic, osteogenic, chondrogenic, and odontogenic cell types properly. PLS DPSCs expressed embryonic stem cell markers Oct4, Sox2, cMYc, and Klf4 and showed similar proliferation rate compared with DPSCs isolated from healthy young controls. Interestingly, it was found that unlike the healthy DPSCs, PLS DPSCs are not able to form myotubes with correct morphology. Conclusions: These data are being reported for the first time; therefore, they might provide new insights to the pathology of the disease. Our results suggest that the PLS DPSCs might be an autologous stem cell source for PLS patients for cellular therapy of alveolar bone defects and other dental tissue abnormalities observed in PLS. © 2013 American Association of Endodontists.

Aim: The aim of this study was to investigate carbonic anhydrase (CA) VI exon 2 genetic polymorphism and its possible association with low caries experience in healthy young adults. Patients and Methods: Healthy young adults with caries or who where caries-free were recruited and unstimulated whole saliva and blood samples were taken. The number of decayed, missing and filled teeth (DMFT) and oral hygiene parameters were examined. Single nucleotide polymorphism (SNP) of CA VI gene exon 2 was determined by PCR and DNA sequencing. Salivary CA activity, buffering capacity and pH were also determined. Results: Two SNPs (dbSNP: 142460367 and 142460368), which are responsible for amino acid changes, were found. The frequencies of these SNPs were not significantly different between the caries-free group and the group with caries. There was no correlation between these SNPs and the salivary parameters. Conclusion: Two SNPs found in young Turkish adults have no correlation with low caries prevalance.

Aim. The aim of this study was to investigate the influence of anxiety and type of dental injection, a plastic syringe or an electronic computerized device, on the pain perceived by children. Design. Two dental injectors, a computerized device (Wand®, Milestone Scientific, Livingston, NJ, USA) and a traditional plastic syringe, were compared. Forty-one children, aged 9-13 years, who had registered for treatment in Marmara University, Istanbul, Turkey, were included in the study. Both anxious and non-anxious children were included in the study group. The Children's Fear Survey Schedule-Dental Subscale, Facial Image Scale, Spielberger's State Anxiety Index for Children, and heart rates were used to determine the anxiety levels. Participants were assigned to interventions by using random allocation. The first appointment was designed as an introductive familiarization session and injections were administered in the second and third sessions, with one or the other injector. The visual analogue scale was used for pain measurement after injections. Results. No significant differences in injection pain scores were observed between the Wand and traditional plastic injector. Higher levels of pre-injection anxiety were found to be related to more severe pain reports by the children. Conclusions. Anxiety plays an important role in the pain reaction of children, and was found to be more determinative in pain perception than the injection devices preferred. © 2007 BSPD, IAPD and Blackwell Publishing Ltd.

Ab initio DFT calculations were performed on GenSem nanoclusters (n=2, 3, 5, 6, 12; m=6-9, 14, 16, 30) that represent the local structure of GeSe2 glass and on some defect' GenSem clusters that are thought to be related to the inhomogeneity of the structure at the nanoscale. The optimal geometries, total energies and their derivatives as well as the electronic properties of GenSem nanoclusters were calculated using traditional DFT method. In addition, the TD-DFT method has been applied to calculate the electronic band gaps of the clusters. The calculated physico-chemical properties of GenSem nanoclusters and their couplings with the local-and medium-range order structure formations in GeSe2 glass are analysed and discussed.

Akyuz, Sevim/0000-0003-3313-6927 WOS: A1994MW67900001 The FT-IR and Raman spectra of eight new Hofmann-type complexes of 3- and 4-methylpyridine, ML(2)Ni(CN)(4) (M = Mn, Fe, Co or Zn; L = 3- or 4-methylpyridine) are reported. The structure consists of corrugated polymeric layers of [M-Ni(CN)(4)](infinity) with methylpyridine molecules bound directly to the metal (M). For a given ligand (3-Mepy or 4-Mepy) the effects of metal-ligand bond formation on the ligand modes are examined and the metal sensitivity sequence of the ligand frequencies is found to be Mn < Fe < Co < Zn. The metal-ligand bond strengths of the methyl derivatives of pyridine in which the substituents are in different positions have also been compared and are found to increase in the order 3-Mepy < 4-Mepy for a given transition metal. The effective magnetic moments of the complexes are given.