16 results on '"Alsahafi, Rashed"'
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2. Novel rechargeable nano-calcium phosphate and nano-calcium fluoride resin cements
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AlSahafi, Rashed, Mitwalli, Heba, Alhussein, Abdullah, Balhaddad, Abdulrahman A., Alquria, Theeb A, Melo, Mary Anne S., Lynch, Christopher D., Oates, Thomas W., Zhang, Ke, Xu, Hockin.H.K., and Weir, Michael D.
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- 2022
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3. Novel rechargeable nanostructured calcium phosphate crown cement with long-term ion release and antibacterial activity to suppress saliva microcosm biofilms
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AlSahafi, Rashed, Mitwalli, Heba, Alhussein, Abdullah, Melo, Mary Anne S., Martinho, Frederico, Lynch, Christopher D., Oates, Thomas W., Xu, Hockin H.K., and Weir, Michael D.
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- 2022
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4. Novel Nano Calcium Fluoride Remineralizing and Antibacterial Dental Composites
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Mitwalli, Heba, AlSahafi, Rashed, Albeshir, Ebtehal G., Dai, Quan, Sun, Jirun, Oates, Thomas W., Melo, Mary Anne S., Xu, Hockin H.K., and Weir, Michael D.
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- 2021
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5. Magnetic‐based photosensitizer to improve the efficiency of antimicrobial photodynamic therapy against mature dental caries‐related biofilms.
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Balhaddad, Abdulrahman A., Mokeem, Lamia, Alsahafi, Rashed, Weir, Michael D., Xu, Hockin H. K., and Melo, Mary Anne S.
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PHOTOSENSITIZERS ,BIOFILMS ,STREPTOCOCCUS mutans ,DENTAL caries ,MAGNETIC fields ,NANOTECHNOLOGY - Abstract
Antimicrobial photodynamic therapy (aPDT) shows promise in eliminating oral pathogens without inducing microbial resistance. Yet, it faces limited biofilm penetration by the photosensitizer, which hinders its efficacy against mature, thick biofilms. This study assesses the effectiveness of the MagTBO (magnetic nanoparticles and toluidine‐blue ortho) nanoplatform against mature Streptococcus mutans biofilms associated with dental caries. The study employs constant‐depth film fermenter (CDFF) models, known as "artificial mouth," to replicate caries processes and allow biofilm growth over teeth. This method enables the evaluation of biofilm‐induced mineral loss under cariogenic challenge over 5 and 10 days. The study shows that MagTBO improves aPDT's effectiveness against highly mature and complex biofilms over 5 and 10 days. However, the biofilm reduction unaffected the mineral content in the underlying dentin. This presents a promising approach for clinical aPDT protocols. However, it is crucial to acknowledge that these findings are based on in vitro studies and may necessitate further clinical confirmation. In summary, our data indicate that magnetic‐based photosensitizers enhance the modulation of pathogenic oral biofilms by aPDT, offering potential advancements in clinical aPDT protocols. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Novel Remineralizing and Antibiofilm Low-Shrinkage-Stress Nanocomposites to Inhibit Salivary Biofilms and Protect Tooth Structures.
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Alhussein, Abdullah, Alsahafi, Rashed, Alfaifi, Areej, Alenizy, Mohammad, Ba-Armah, Ibrahim, Schneider, Abraham, Jabra-Rizk, Mary-Ann, Masri, Radi, Garcia Fay, Guadalupe, Oates, Thomas W., Sun, Jirun, Weir, Michael D., and Xu, Hockin H. K.
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CALCIUM fluoride , *BIOFILMS , *NANOCOMPOSITE materials , *DENTAL materials , *CALCIUM phosphate , *LACTIC acid - Abstract
Recurrent caries remain a persistent concern, often linked to microleakage and a lack of bioactivity in contemporary dental composites. Our study aims to address this issue by developing a low-shrinkage-stress nanocomposite with antibiofilm and remineralization capabilities, thus countering the progression of recurrent caries. In the present study, we formulated low-shrinkage-stress nanocomposites by combining triethylene glycol divinylbenzyl ether and urethane dimethacrylate, incorporating dimethylaminododecyl methacrylate (DMADDM), along with nanoparticles of calcium fluoride (nCaF2) and nanoparticles of amorphous calcium phosphate (NACP). The biofilm viability, biofilm metabolic activity, lactic acid production, and ion release were evaluated. The novel formulations containing 3% DMADDM exhibited a potent antibiofilm activity, exhibiting a 4-log reduction in the human salivary biofilm CFUs compared to controls (p < 0.001). Additionally, significant reductions were observed in biofilm biomass and lactic acid (p < 0.05). By integrating both 10% NACP and 10% nCaF2 into one formulation, efficient ion release was achieved, yielding concentrations of 3.02 ± 0.21 mmol/L for Ca, 0.5 ± 0.05 mmol/L for P, and 0.37 ± 0.01 mmol/L for F ions. The innovative mixture of DMADDM, NACP, and nCaF2 displayed strong antibiofilm effects on salivary biofilm while concomitantly releasing a significant amount of remineralizing ions. This nanocomposite is a promising dental material with antibiofilm and remineralization capacities, with the potential to reduce polymerization-related microleakage and recurrent caries. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Novel Bioactive Nanocomposites Containing Calcium Fluoride and Calcium Phosphate with Antibacterial and Low-Shrinkage-Stress Capabilities to Inhibit Dental Caries.
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Alhussein, Abdullah, Alsahafi, Rashed, Balhaddad, Abdulrahman A., Mokeem, Lamia, Schneider, Abraham, Jabra-Rizk, Mary-Ann, Masri, Radi, Hack, Gary D., Oates, Thomas W., Sun, Jirun, Weir, Michael D., and Xu, Hockin H. K.
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CALCIUM fluoride , *CALCIUM phosphate , *DENTAL caries , *NANOCOMPOSITE materials , *DENTAL pulp , *DENTAL fillings , *LACTIC acid , *METHACRYLATES - Abstract
Objectives: Composites are commonly used for tooth restorations, but recurrent caries often lead to restoration failures due to polymerization shrinkage-stress-induced marginal leakage. The aims of this research were to: (1) develop novel low-shrinkage-stress (L.S.S.) nanocomposites containing dimethylaminododecyl methacrylate (DMADDM) with nanoparticles of calcium fluoride (nCaF2) or amorphous calcium phosphate (NACP) for remineralization; (2) investigate antibacterial and cytocompatibility properties. Methods: Nanocomposites were made by mixing triethylene glycol divinylbenzyl ether with urethane dimethacrylate containing 3% DMADDM, 20% nCaF2, and 20% NACP. Flexural strength, elastic modulus, antibacterial properties against Streptococcus mutans biofilms, and cytotoxicity against human gingival fibroblasts and dental pulp stem cells were tested. Results: Nanocomposites with DMADDM and nCaF2 or NACP had flexural strengths matching commercial composite control without bioactivity. The new nanocomposite provided potent antibacterial properties, reducing biofilm CFU by 6 logs, and reducing lactic acid synthesis and metabolic function of biofilms by 90%, compared to controls (p < 0.05). The new nanocomposites produced excellent cell viability matching commercial control (p > 0.05). Conclusions: Bioactive L.S.S. antibacterial nanocomposites with nCaF2 and NACP had excellent bioactivity without compromising mechanical and cytocompatible properties. The new nanocomposites are promising for a wide range of dental restorations by improving marginal integrity by reducing shrinkage stress, defending tooth structures, and minimizing cariogenic biofilms. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer.
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Alhussein, Abdullah, Alsahafi, Rashed, Wang, Xiaohong, Mitwalli, Heba, Filemban, Hanan, Hack, Gary D., Oates, Thomas W., Sun, Jirun, Weir, Michael D., and Xu, Hockin H. K.
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DENTAL materials ,DENTAL resins ,MONOMERS ,STREPTOCOCCUS mutans ,FLEXURAL strength ,METHACRYLATES ,FLUORIDES - Abstract
Objectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent to combat recurrent caries. Methods: Triethylene glycol divinylbenzyl ether and urethane dimethacrylate were used to reduce shrinkage stress. DMADDM was incorporated at different mass fractions (0%, 1.5%, 3%, and 5%). Flexural strength, elastic modulus, degree of conversion, polymerization stress, and antimicrobial activity were assessed. Results: The composite with 5% DMADDM demonstrated higher flexural strength than the commercial group (p < 0.05). The addition of DMADDM in BisGMA-TEGDMA resin and LSS resin achieved clinically acceptable degrees of conversion. However, LSS composites exhibited much lower polymerization shrinkage stress than BisGMA-TEGDMA composite groups (p < 0.05). The addition of 3% and 5% DMADDM showed a 6-log reduction in Streptococcus mutans (S. mutans) biofilm CFUs compared to commercial control (p < 0.001). Biofilm biomass and lactic acid were also substantially decreased via DMADDM (p < 0.05). Conclusions: The novel LSS dental composite containing 3% DMADDM demonstrated potent antibacterial action against S. mutans biofilms and much lower polymerization shrinkage-stress, while maintaining excellent mechanical characteristics. The new composite is promising for dental applications to prevent secondary caries and increase restoration longevity. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Novel antibacterial low-shrinkage-stress resin-based cement.
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AlSahafi, Rashed, Wang, Xiaohong, Mitwalli, Heba, Alhussein, Abdullah, Balhaddad, Abdulrahman A., Melo, Mary Anne S., Oates, Thomas W., Sun, Jirun, Xu, H.K., and Weir, Michael D.
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CEMENT , *DENTAL crowns , *DENTAL fillings , *STREPTOCOCCUS mutans , *LACTIC acid - Abstract
A low-shrinkage-stress resin-based cement with antibacterial properties could be beneficial to create a cement with lower stress at the tooth-restoration interface, which could help to enhance the longevity of the fixed dental restoration by reducing microleakage and recurrent caries. To date, there has been no report on the development of a low-shrinkage-stress and bio-interactive cement. Therefore, the objectives of this study were to develop a novel low-shrinkage-stress resin-based cement containing dimethylaminohexadecyl methacrylate (DMAHDM) and investigate the mechanical and antibacterial properties for the first time. The monomers urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) were combined and denoted as UV resin. Three cements were fabricated: (1) UV+ 0%DMAHDM (experimental control); (2) UV+ 3%DMAHDM, (3) UV+ %5DMAHDM. RelyX Ultimate cement was used as commercial control. Mechanical properties and Streptococcus mutans (S. mutans) biofilms growth on cement were evaluated. The novel bio-interactive cement demonstrated excellent antibacterial and mechanical properties. Compared to commercial and experimental controls, adding DMAHDM into the UV cement significantly reduced colony forming unit (CFU) counts by approximately 7 orders of magnitude, metabolic activities from 0.29 ± 0.03 A 540 /cm2 to 0.01 ± 0.01 A 540 /cm2, and lactic acid production from 22.3 ± 0.74 mmol/L to 1.2 ± 0.27 mmol/L (n = 6) (p < 0.05). The low-shrinkage-stress cement demonstrated a high degree of conversion of around 70 %, while reducing the shrinkage stress by approximately 60%, compared to a commercial control (p < 0.05). The new antibacterial low-shrinkage-stress resin-based cement provides strong antibacterial action and maintains excellent mechanical properties with reduced polymerization shrinkage stress. A low-shrinkage-stress resin-based cement containing DMAHDM was developed with potent antibacterial effects and promising mechanical properties. This cement may potentially enhance the longevity of fixed dental restoration such as a dental crown, inlay, onlay, and veneers through its excellent mechanical properties, low shrinkage stress, and strong antibacterial properties. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Low-Shrinkage Resin Matrices in Restorative Dentistry-Narrative Review.
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Albeshir, Ebtehal G., Alsahafi, Rashed, Albluwi, Reem, Balhaddad, Abdulrahman A., Mitwalli, Heba, Oates, Thomas W., Hack, Gary D., Sun, Jirun, Weir, Michael D., and Xu, Hockin H. K.
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PRACTICE of dentistry , *PREVENTIVE dentistry , *DENTAL materials , *POLYMERIZATION , *BIOFILMS - Abstract
Dimethacrylate-based resin composites restorations have become widely-used intraoral materials in daily dental practice. The increasing use of composites has greatly enhanced modern preventive and conservative dentistry. They have many superior features, especially esthetic properties, bondability, and elimination of mercury and galvanic currents. However, polymeric materials are highly susceptible to polymerization shrinkage and stresses that lead to microleakage, biofilm formation, secondary caries, and restoration loss. Several techniques have been investigated to minimize the side effects of these shrinkage stresses. The primary approach is through fabrications and modification of the resin matrices. Therefore, this review article focuses on the methods for testing the shrinkage, as well as formulations of resinous matrices available to reduce polymerization shrinkage and its associated stress. Furthermore, this article reviews recent cutting-edge developments on bioactive low-shrinkage-stress nanocomposites to effectively inhibit the growth and activities of cariogenic pathogens and enhance the remineralization process. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Novel rechargeable calcium fluoride dental nanocomposites.
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Mitwalli, Heba, AlSahafi, Rashed, Alhussein, Abdullah, Oates, Thomas W., Melo, Mary Anne S., Xu, Hockin H.K., and Weir, Michael D.
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CALCIUM fluoride , *NANOCOMPOSITE materials , *FLEXURAL strength , *ELASTIC modulus , *CALCIUM ions - Abstract
• Resin formulations had a significant effect on ion recharging/re-releasing efficacy. • BT-nCaF 2 had the best combination of mechanical properties and ion recharge/re-release. • Rechargeable nCaF 2 composites had significant recharging potential of F and Ca ions. • After 6 recharge cycles, composites continued F and Ca ions re-release for 42 days. Composite restorations with calcium fluoride nanoparticles (nCaF 2) can remineralize tooth structure through F and Ca ion release. However, the persistence of ion release is limited. The objectives for this study were to achieve long-term remineralization by developing a rechargeable nCaF 2 nanocomposite and investigating the F and Ca recharge and re-release capabilities. Three nCaF 2 nanocomposites were formulated: (1) BT-nCaF 2 :Bisphenol A glycidyl dimethacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA); (2) PE-nCaF 2 :Pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA); (3) BTM-nCaF 2 :BisGMA, TEGDMA, and Bis[2-(methacryloyloxy)ethyl] phosphate (Bis-MEP). All formulations contained 15% nCaF 2 and 55% glass particles. Initial flexural strength and elastic modulus, F and Ca ion release, recharge and re-release were tested and compared to three commercial fluoride-containing materials. BT and BTM nCaF 2 composites were 3–4 times stronger and had elastic modulus 2 times that of resin-modified glass ionomer controls. PE-nCaF 2 had comparable strength to RMGIs. All nCaF 2 composites had significant F and Ca ion release and ion rechargeability. In F and Ca recharging cycles, PE-nCaF 2 had the highest ion recharging capability among nCaF 2 groups, followed by BT-nCaF 2 and BTM-nCaF 2 (p < 0.05). For all recharge cycles, ion release maintained similar levels, demonstrating long-term ion release was possible. Furthermore, after the final recharge cycle, nCaF 2 nanocomposites provided continuous ion release for 42 days without further recharge. Novel nCaF 2 rechargeable nanocomposites exhibited significant F and Ca ion release over multiple recharge cycles, demonstrating continuous long-term ion release. These nanocomposites are promising restorations with lasting remineralization potential. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Metal Oxide Nanoparticles and Nanotubes: Ultrasmall Nanostructures to Engineer Antibacterial and Improved Dental Adhesives and Composites.
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Balhaddad, Abdulrahman A., Garcia, Isadora M., Mokeem, Lamia, Alsahafi, Rashed, Collares, Fabrício Mezzomo, and Sampaio de Melo, Mary Anne
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METAL nanoparticles ,DENTAL adhesives ,DENTAL materials ,METALLIC oxides ,NANOTUBES ,NANOSTRUCTURES ,OPERATIVE dentistry - Abstract
Advances in nanotechnology have unlocked exclusive and relevant capabilities that are being applied to develop new dental restorative materials. Metal oxide nanoparticles and nanotubes perform functions relevant to a range of dental purposes beyond the traditional role of filler reinforcement--they can release ions from their inorganic compounds damaging oral pathogens, deliver calcium phosphate compounds, provide contrast during imaging, protect dental tissues during a bacterial acid attack, and improve the mineral content of the bonding interface. These capabilities make metal oxide nanoparticles and nanotubes useful for dental adhesives and composites, as these materials are the most used restorative materials in daily dental practice for tooth restorations. Secondary caries and material fractures have been recognized as the most common routes for the failure of composite restorations and bonding interface in the clinical setting. This review covers the significant capabilities of metal oxide nanoparticles and nanotubes incorporated into dental adhesives and composites, focusing on the novel benefits of antibacterial properties and how they relate to their translational applications in restorative dentistry. We pay close attention to how the development of contemporary antibacterial dental materials requires extensive interdisciplinary collaboration to accomplish particular and complex biological tasks to tackle secondary caries. We complement our discussion of dental adhesives and composites containing metal oxide nanoparticles and nanotubes with considerations needed for clinical application. We anticipate that readers will gain a complete picture of the expansive possibilities of using metal oxide nanoparticles and nanotubes to develop new dental materials and inspire further interdisciplinary development in this area. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials.
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Mitwalli, Heba, Alsahafi, Rashed, Balhaddad, Abdulrahman A., Weir, Michael D., Xu, Hockin H. K., and Anne S. Melo, Mary
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DENTAL materials , *DENTAL adhesives , *BACTERIAL adhesion , *POLYMER structure , *ROOT canal treatment , *BACTERIAL growth - Abstract
Polymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored fillings, sealing root canal systems, and many other dental restorative applications. However, polymeric materials are highly susceptible to bacterial attachment and colonization, leading to dental diseases. Many approaches have been investigated to minimize the formation of biofilms over polymeric restorative materials and at the tooth/material interfaces. Among them, contact-killing compounds have shown promising results to inhibit dental biofilms. Contact-killing compounds can be immobilized within the polymer structure, delivering a long-lasting effect with no leaching or release, thus providing advantages compared to release-based materials. This review discusses cutting-edge research on the development of contact-killing compounds in dental restorative materials to target oral pathogens. Contact-killing compounds in resin composite restorations, dental adhesives, root canal sealers, denture-based materials, and crown cements have all demonstrated promising antibacterial properties. Contact-killing restorative materials have been found to effectively inhibit the growth and activities of several oral pathogens related to dental caries, periodontal diseases, endodontic, and fungal infections. Further laboratory optimization and clinical trials using translational models are needed to confirm the clinical applicability of this new generation of contact-killing dental restorative materials. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles.
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AlSahafi, Rashed, Balhaddad, Abdulrahman A., Mitwalli, Heba, Ibrahim, Maria Salem, Melo, Mary Anne S., Oates, Thomas W., Xu, Hockin H.K., and Weir, Michael D.
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DENTAL cements , *CALCIUM phosphate , *DENTAL glass ionomer cements , *CEMENT , *MONOMERS , *DENTAL fillings , *DENTAL caries , *BACTERIAL diseases - Abstract
Oral biofilm accumulation at the tooth–restoration interface often leads to recurrent dental caries and restoration failure. The objectives of this study were to: (1) develop a novel bioactive crown cement containing dimethylaminohexadecyl methacrylate (DMAHDM) and nano-sized amorphous calcium phosphate (NACP), and (2) investigate the mechanical properties, anti-biofilm activity, and calcium (Ca2+) and phosphate (PO43−) ion release of the crown cement for the first time. The cement matrix consisted of pyromellitic glycerol dimethacrylate and ethoxylated bisphenol-A dimethacrylate monomers and was denoted PEHB resin matrix. The following cements were tested: (1) RelyX luting cement (commercial control); (2) 55% PEHB + 45% glass fillers (experimental control); (3) 55% PEHB + 20% glass + 25% NACP + 0% DMAHDM; (4) 52% PEHB + 20% glass + 25% NACP + 3% DMAHDM; (5) 51% PEHB + 20% glass + 25% NACP + 4% DMAHDM; (6) 50% PEHB + 20% glass + 25% NACP + 5% DMAHDM. Mechanical properties and ion release were measured. Streptococcusmutans (S. mutans) biofilms were grown on cements, and colony-forming units (CFUs) and other biofilm properties were measured. The novel bioactive cement demonstrated strong antibacterial properties and high levels of Ca2+ and PO43− ion release to remineralize tooth lesions. Adding NACP and DMAHDM into the cement did not adversely affect the mechanical properties and dentin bonding strength. In conclusion, the novel NACP + DMAHDM crown cement has excellent potential for restoration cementation to inhibit caries by suppressing oral biofilm growth and increasing remineralization via Ca2+ and PO43− ions. The NACP + DMAHDM composition may have wide applicability to other biomaterials to promote hard-tissue formation and combat bacterial infection. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
15. Novel CaF2 Nanocomposites with Antibacterial Function and Fluoride and Calcium Ion Release to Inhibit Oral Biofilm and Protect Teeth.
- Author
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Mitwalli, Heba, Balhaddad, Abdulrahman A., AlSahafi, Rashed, Oates, Thomas W., Melo, Mary Anne S., Xu, Hockin H. K., and Weir, Michael D.
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CALCIUM fluoride ,NANOCOMPOSITE materials ,CALCIUM ions ,DENTAL glass ionomer cements ,NANOPARTICLES ,LACTIC acid ,TEETH - Abstract
(1) Background: The objective of this study was to develop a novel dental nanocomposite containing dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC), and nanoparticles of calcium fluoride (nCaF
2 ) for preventing recurrent caries via antibacterial, protein repellent and fluoride releasing capabilities. (2) Methods: Composites were made by adding 3% MPC, 3% DMAHDM and 15% nCaF2 into bisphenol A glycidyl dimethacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) (denoted BT). Calcium and fluoride ion releases were evaluated. Biofilms of human saliva were assessed. (3) Results: nCaF2 +DMAHDM+MPC composite had the lowest biofilm colony forming units (CFU) and the greatest ion release; however, its mechanical properties were lower than commercial control composite (p < 0.05). nCaF2 +DMAHDM composite had similarly potent biofilm reduction, with mechanical properties matching commercial control composite (p > 0.05). Fluoride and calcium ion releases from nCaF2 +DMAHDM were much more than commercial composite. Biofilm CFU on composite was reduced by 4 logs (n = 9, p < 0.05). Biofilm metabolic activity and lactic acid were also substantially reduced by nCaF2 +DMAHDM, compared to commercial control composite (p < 0.05). (4) Conclusions: The novel nanocomposite nCaF2 +DMAHDM achieved strong antibacterial and ion release capabilities, without compromising the mechanical properties. This bioactive nanocomposite is promising to reduce biofilm acid production, inhibit recurrent caries, and increase restoration longevity. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
16. Novel CaF 2 Nanocomposites with Antibacterial Function and Fluoride and Calcium Ion Release to Inhibit Oral Biofilm and Protect Teeth.
- Author
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Mitwalli H, Balhaddad AA, AlSahafi R, Oates TW, Melo MAS, Xu HHK, and Weir MD
- Abstract
(1) Background: The objective of this study was to develop a novel dental nanocomposite containing dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC), and nanoparticles of calcium fluoride (nCaF
2 ) for preventing recurrent caries via antibacterial, protein repellent and fluoride releasing capabilities. (2) Methods: Composites were made by adding 3% MPC, 3% DMAHDM and 15% nCaF2 into bisphenol A glycidyl dimethacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) (denoted BT). Calcium and fluoride ion releases were evaluated. Biofilms of human saliva were assessed. (3) Results: nCaF2 +DMAHDM+MPC composite had the lowest biofilm colony forming units (CFU) and the greatest ion release; however, its mechanical properties were lower than commercial control composite ( p < 0.05). nCaF2 +DMAHDM composite had similarly potent biofilm reduction, with mechanical properties matching commercial control composite ( p > 0.05). Fluoride and calcium ion releases from nCaF2 +DMAHDM were much more than commercial composite. Biofilm CFU on composite was reduced by 4 logs ( n = 9, p < 0.05). Biofilm metabolic activity and lactic acid were also substantially reduced by nCaF2 +DMAHDM, compared to commercial control composite ( p < 0.05). (4) Conclusions: The novel nanocomposite nCaF2 +DMAHDM achieved strong antibacterial and ion release capabilities, without compromising the mechanical properties. This bioactive nanocomposite is promising to reduce biofilm acid production, inhibit recurrent caries, and increase restoration longevity.- Published
- 2020
- Full Text
- View/download PDF
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