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The aim of this review was to update evidence for benefit of convalescent plasma transfusion (CPT) in patients with coronavirus disease 2019 (COVID-19). Databases were searched for randomized controlled trials (RCT) comparing CPT plus standard treatment versus standard treatment only in adults with COVID-19. Primary outcome measures were mortality and need for invasive mechanical ventilation (IMV). Twenty-Six RCT involving 19,816 patients were included in meta-analysis for mortality. Quantitative synthesis showed no statistically significant benefit of adding CPT to standard treatment (RR = 0.97, 95% CI = 0.92 to 1.02) with unimportant heterogeneity (Q(25) = 26.48, p = .38, I.sup.2 = 0.00%). Trim-and-fill-adjusted effect size was unimportantly changed and level of evidence was graded as high. Trial sequential analysis (TSA) indicated information size was adequate and CPT was futile. Seventeen trials involving 16,083 patients were included in meta-analysis for need of IMV. There was no statistically significant effect of CPT (RR = 1.02, 95% CI = 0.95 to 1.10) with unimportant heterogeneity (Q(16) = 9.43, p = .89, I.sup.2 = 3.30%). Trim-and-fill-adjusted effect size was trivially changed and level of evidence was graded as high. TSA showed information size was adequate and indicated futility of CPT. It is concluded with high level of certainty that CPT added to standard treatment of COVID-19 is not associated with reduced mortality or need of IMV compared with standard treatment alone. In view of these findings, further trials on efficacy of CPT in COVID-19 patients are probably not needed., Author(s): Sameh M. Hakim [sup.1], Ghosoun M. A. Chikhouni [sup.1], Mona A. Ammar [sup.1], Akram M. Amer [sup.1] Author Affiliations: (1) grid.7269.a, 0000 0004 0621 1570, Department of Anesthesiology, Intensive [...]

Byline: Mona. Ammar, Wael. Abdelmoneim, Waleed. Abdalla Background and Aims: Cerebral oedema and increased intracranial pressure are associated with poor neurological outcomes in traumatic brain injury (TBI). This study aimed [...]

Background and aims: Hemodynamic instability during postreperfusion syndrome remains the most significant concern for transplantation teams. Various strategies have been investigated in an attempt to reduce the occurrence of postreperfusion in liver transplantation, including the use of mannitol as a scavenger of free radicals and inflammatory mediators. The study examined mannitol intraoperative antioxidant effect on reperfusion hemodynamic events during living donor liver transplantation (LDLT). Methodology: This prospective randomized controlled trial divided 60 participants with endstage liver disease into two groups of 30 participants each. The mannitol group was administered 1 g/kg of mannitol (20%) in a 500-mL labeled bottle (solution A); the control group received the same amount of normal saline (0.9%) in a 500-mL labeled bottle (solution B). The primary outcome was mean arterial pressure (MAP) postreperfusion. Secondary outcomes were recorded after reperfusion: cardiac output (COP), systemic vascular resistance (SVR), the amount of vasopressor administered, central venous pressure (CVP), and urine output (UOP). This study received ethics committee approval (R 42/2022) and was registered at clinicaltrials. gov (NCT05277623). Results: The MAP parameters were significantly lower in the control group, with MAP<60 mm Hg in 93.3% of the control group versus 40% of the mannitol group (p 0.001). There was a statistically significant difference regarding SVR (p 0.001). Norepinephrine levels were lower for the mannitol group compared with controls (p = 0.003). As regards COP, CVP, and UOP there was no statistically significant difference between the two groups. Conclusion: Mannitol attenuates the postreperfusion syndrome during LDLT. [ABSTRACT FROM AUTHOR]

Objectives: Evaluation of diaphragmatic function by bedside ultrasound provides information on the degree of disability and the response to treatment intervention in respiratory failure patients with associated respiratory muscle fatigue. This study aimed to assess the impact of high and low-dose L-carnitine supplementation on diaphragmatic muscle function. Methods: This was a prospective, randomized, controlled clinical trial (trial registration number NCT05322447), for which approval was obtained from our institutional ethics committee (R80/2021). Participating patients were randomly assigned to two groups of 30 patients each. In the low-dose group, L-carnitine was administered at a dose of 6 g/day. The high-dose group received an intravenous infusion of 18 g/day of L-carnitine. On days 0, 3, and 7, diaphragmatic function was assessed by ultrasound, and serum levels of L-carnitine were measured. Results: Both diaphragmatic excursion (DE) and diaphragmatic thickening fraction (DTf) measurements were positively correlated with serum L-carnitine levels (+r = 0.58 and +r = 0.61, respectively; p< 0.001). High-dose L-carnitine independently influenced the DE only, both in an unadjusted model (p = 0.04) and after adjustment for age and sex (p = 0.02). However, it had no significant effect on DTf, either before (p = 0.25) or after (p = 0.17) adjustment. Conclusion: Serum levels of L-carnitine are positively correlated with the two measures of diaphragmatic function (DE and DTf). Moreover, high-dose L-carnitine supplementation had rapid and significant positive effects on DE. This improvement indirectly enhanced patient outcomes and resulted in shorter stays in the Intensive Care Unit and hospital. [ABSTRACT FROM AUTHOR]

Maladera modesta (Coleoptera: Scarabaeidae) infesting many plants and has become a serious pest since 2016 on citrus and strawberry crops, The adults feed on the leaves, buds and flowers of several plants The C-shaped larvae (white grubs) feed on roots The study was conducted as a part of a comprehensive baseline survey and population density of M. modesta infesting medicinal, aromatically and ornamental plants in a different region (Rawdat Al-Nil Park, Al-Firdaws Compound for the Armed Force, International Park and Nubaria) and studied the of M. modesta at (Giza and Beheira) during two successive seasons. The results indicated that the twenty-four plants are more infected by M. modesta. The population density recorded that, the general weekly mean number of M. modesta was more abundant at Beheira Governorate than recoded at Giza Governorate throughout two successive seasons 2021 and 2022. The statistical analysis of the total mean number of M. modesta showed a significant difference at <0.0001 for two different locations. At Giza Governorate showed that the adults recorded its highest levels of infestation in the months (June, October, September, July, Augusta, May, April, November and March) However, the months of January, February and December, insect population was absent. At Beheira Governorate, showed that the adults recorded their highest levels of infestation in the months of (June, Augusta, July, September, April, May, October and March), and the months of January, February, November and December, insect population was absent. [ABSTRACT FROM AUTHOR]

Byline: Mona. Ammar, Amr. Abdou Background and Aims: The proportion of patients undergoing living donor liver transplantation is high especially in countries without or with limited cadaver organ sharing programs. [...]

This was a Prospective, observational study conducted on 60 patients with Total Knee Replacement (TKR); to characterize the collapsibility index of the IVC as a potential screening tool to identify patients who are candidate for hypotensive events after tourniquet release in TKR in an otherwise hemodynamically stable population. We found that; the mean age of all patients was (57 ± 5.6) years. Regarding gender of the patients, (58.3%) of patients were females; while (41.7%) were males. Regarding basic clinical data; the mean BMI of all patients was (25.7 ± 2.5); with (60%) of patients had DM, and (56.7%) had HTN. Regarding ASA class, (3.3%) had class I, (73.3%) had class II, and (23.3%) had class III. Regarding Baseline hemodynamic data; the average MAP was (104.6 ± 6) mmHg, the average RR was (10.5 ± 1.3) breath/min, and the average HR was (74.75 ± 7) beat/min. Regarding Data before tourniquet release; the average MAP was (102.3 ± 7.5) mmHg, the average RR was (10.7 ± 1.2) breath/min, and the average HR was (75.3 ± 6.5) beat/min, with average IVC-CIof(48.46 7.7). Regarding Data 15-m after tourniquet release; the average MAP was (93.1 ± 9.3) mmHg, the average RR was (10.7 ± 1.4) breath/min, and the average HR was (76.45 ± 6.6) beat/min, with aver-age IVC-CI of (51 ± 8.4). Regarding final outcome, (11.7%) of patients suffered Hypotension (PTRH). The 60 TKR patients were classified according to outcomes into 2 independent groups: group A IVCCI >55,5% (12 patients) and group B IVCCI <55,5% (48 patients). Regarding comparative study between the 2 groups as regards demographic data; no statistically significant differences were found except for ASA physical status of patients where group A had patients in ASA I class and most of its patients are ASA II while group B had no patients in ASA I class and a quarter of its patients were ASA III. Regarding comparative study between the 2 groups as regards hemodynamic and ultrasonographic data; no statistically different results were noted between groups in baseline readings. Results recorded before tourniquet release showed that IVC during inspiration reading was statistically lower while IVC collapsibility index was statistically higher in Group A when compared with group B . Results recorded 15 min after tourniquet release showed that IVC during inspiration reading was statistically lower while IVC collapsibility index was statistically higher in Group A when compared with group B, the IVC-CI before tourniquet release was not correlated with percent reduction in systolic blood pressure after tourniquet release in both groups with high (Group A) or low IVC-CI (Group B). Comparing patients who developed hypotension versus patients who did not, the 60 TKR patients were classified into hypotensive (7 patients) and normotensive (53 patients) groups. No statistically significant differences were found between hypotensive versus normotensive patients concerning demographic data and data recorded before tourniquet release. Baseline data showed significantly higher respiratory rate in hypotensive patients. Data recorded 15 min after tourniquet release showed statistically lower SBP, DBP and MAP, significantly higher HR and significantly lower IVC during inspiration and expiration in patients who developed hypotension. We studied different factors that may be included before tourniquet release that may predict the degree of PTRH by using ROC-curve analysis. IVC-CI before tourniquet release and BMI failed to be predictive factors for the occurrence of PTRH, while respiratory and heart rates before tourniquet release significantly predict the occurrence of PTRH. Performing multiple regression analysis using forward method showed that the increase in RR had an independent effect on increasing the probability of PTRH occurrence; with significant statistical difference (p < 0.039). Conclusion: IVC-CI before tourniquet release is not a predictor for PTRH in patients undergoing TKR under spinal anesthesia. [ABSTRACT FROM AUTHOR]

Background: Nutrition is an integral part of health maintenance. The liver is the largest and most important metabolic organ, playing a pivotal role in integrating several biochemical pathways of carbohydrate, fat, protein, and vitamin metabolism. Malnutrition is a common complication of end- stage liver disease (ESLD). Progressive deterioration of nutritional status has been associated with poor outcome in cirrhotic patients. Liver transplantation (LT) revolutionized the management of liver disease. Nutritional therapy is an integral part of liver transplant care. Objective: To identity the efficacy of different dietary nutritional supplements as zinc, vit D and immunonutrients (glutamine, omega 3, arginine and ribonucleic acid) for recipient at early post operative course. Material and Methods: In this systematic review and meta-analysis we enrolled a total of 7 studies for assessing the clinical outcomes of ICU patients underwent liver transplantation surgery and supplied with dietary supplements during early postoperative period. The studies also assessed the laboratory assessment of patients postoperatively during ICU admission period. Results: Regarding postoperative dietary supplementations with HMB, we found significant difference for appendicular skeletal muscle mass (ASMI) regarding the baseline and the postoperative ASMI in the intervention group with HMB. But we did not report significant difference regarding the baseline and the postoperative Fat-free mass index (FFMI) in both intervention and control group with HMB. Also we did not find significant difference between base line and postoperative in both groups for Mid-arm muscle-circumference (MAMC), Fat mass index (FMI), 6-minute walk test (6MWT), and Handgrip (HG). Data Sources: Medline databases (PubMed, Medscape, ScienceDirect. EMF-Portal) and all materials available in the Internet till 2021. Conclusion: BCAA as dietary supplementation showing a significant favorable effect regarding the baseline and the postoperative BTR levels, also for BCAA levels, Tyrosine levels, prealbumin levels, retinol binding protein and PTINR levels in both intervention and control groups. For HMB, we found significant difference for appendicular skeletal muscle mass (ASMI) regarding the baseline and the postoperative ASMI in the intervention group with HMB. But we did not report significant difference regarding the baseline and the postoperative Fat-free mass index (FFMI) in both intervention and control group with HMB. [ABSTRACT FROM AUTHOR]

Background and Aims: Starting antibiotic therapy at the proper time is the cornerstone of the management of ventilator-associated pneumonia (VAP). However, using antibiotics for a long duration of therapy in intensive care leads to increased bacterial resistance, financial burden and adverse drug reactions. We hypothesised that lung ultrasound may have a role in guiding antibiotic discontinuation in patients with VAP that will help to reduce the antibiotic duration and decrease the resistance. Methods: This was a prospective blinded cohort study from October 2020 to September 2021 in which 62 VAP patients were recruited. Antibiotics were started, procalcitonin (PCT) level and clinical pulmonary infection score were estimated and lung ultrasound (US) was performed on day 1 and repeated on day 7. On day 7, discontinuation of antibiotics was recommended if the PCT level was <0.25 μg/L. A lung reaeration score was recorded. Results: Based on the PCT levels, antibiotics were discontinued in 40 patients. The computed tomography findings of VAP had improved in all. The ultrasound reaeration score showed a highly significant negative correlation with the PCT on day 7 (-0.718, P < 0.001). A cut-off of 5 for the US score showed a sensitivity of 92.5%, specificity of 95.5%, positive predictive value of 97.4% and negative predictive value of 87.5% in detecting a low PCT score on day 7. Conclusion: Lung US is a non-invasive and safe method that can be used to guide antibiotic therapy in VAP. [ABSTRACT FROM AUTHOR]

Background:Caudal analgesia is a safe technique that can be performed under fluoroscopy in lumbosacral spine surgeries. Studies have raised evidence supporting the use of epidural dexamethasone in such surgeries. Adding second adjuvant like dexmedetomidine or hyaluronidase to dexamethazone has not been investigated before. Methods: Sixty patients scheduled for lumbosacral spine surgery were randomized and allocated in 3 groups. All patients received 30ml of caudal mixture after insertion of caudal catheter. Group A received 0.125% bupivacaine with 8 mg dexamethasone. Group B received 50 µg dexmedetomidine in addition to the mixture given to group A. Group C received 1500 IU hyaluronidase in addition to the mixture given to group A. Results: Mean time to the first analgesic dose in group B was 589.5 min and in group C was 565.5 min, which is longer than mean time in group A (492 min), p = 0.021. Number of patients who needed intraoperative top-up doses of fentanyl was 5 (25%) in group B and 10 (50%) in group C versus 13 (65%) in group A, p = 0.038. Total pethidine dose in 24 hours was 50.75 ± 10 mg in group B and 55.25 ± 8 mg in group C versus 64.25 ± 22 mg in group A, p = 0.021. Post hoc analysis and pairwise comparisons were conducted to determine which intervention groups had significant differences. Conclusion: Dexmedetomidine and hyaluronidase addition to caudal bupivacaine and dexamethasone increased duration of analgesia after lumbosacral spine surgery, but dexmedetomidine was superior to hyaluronidase. [ABSTRACT FROM AUTHOR]

Copyright of Egyptian Journal of Agricultural Research is the property of Egyptian National Agricultural Library (ENAL) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Experiment was carried out for two successive seasons (2016 and 2017) at EL-Sharkia governorate. In both seasons tomato; plant "alsa" variety were cultivated to obtain different levels of infestation by Tuta abso/uta of tomato crop were sprayed periodically with King chem 5.7% WG (Emamectin benzoate). Results showed simple correlation "r" values obtained were strong significantly negative indicating a strong negative relationship between the density of infestation ( Tuta absoluta) and the corresponding crop yield of tomato produced. The simultaneous effect of some tomato pests ( Tuta absoluta, Bemisia tabaci and Tetranychus urticae) infestation on the crop yield indicated that the three factors were responsible for 73% and 93% of variability in the average weight of crop yield in 2016 - 2017 respectively. This study aims to the determination of economic infestation threshold level and economic injury level of Tuta absoluta to be used as a tool for controlling Tuta absoluta under Field conditions. Data indicated that (General Equilibrium Position (G.E.P.)) between 55 to 61 larvae / 20 leaves, Economic Threshold Level (E.T.L)] between 57 to 72 larvae I 20 leaves, [Economic Injury Level ( E.I.L)], 78 to 103 larvae / 20 leaves at this level of infestation control measures must be applied. [ABSTRACT FROM AUTHOR]

Background: Thoracolumbar interfascial plane (TLIP) block involves injection of local anesthetics between multifidus and longissimus muscles at the 3rd lumbar vertebral level assuming that it can block the dorsal rami of thoracolumbar nerves. Objective: The objective of this study was to evaluate the analgesic effects gained after performing TLIP block (analogous to the transversus abdominis plane [TAP] block, but intended for the back) in patients undergoing lumbar discectomy. Methodology: This was a prospective, randomized, double-blinded, controlled clinical trial. Computer-generated randomization numbers were used to allocate patients into two groups. A total of 102 patients scheduled for lumbar discectomy were considered eligible, of these 70 patients were randomly included in the analysis: 35 patients (control group) received the standard general anesthetic technique and 35 patients (TLIP group) received TLIP block with 20 ml mixture of 0.25% bupivacaine and 1% lidocaine on each side. The primary outcome was to compare the two groups with regard to pain scores, whereas the secondary outcomes included the time to first analgesic (TFA), 24-h morphine consumption, and side effects associated with morphine such as nausea, vomiting, and sedation. Results: TLIP group compared with the control group showed a significant reduction in the postoperative Visual Analog Scale for pain score both on rest and movement, with no statistically significant difference at 24 h during movement. TFA was significantly shorter in the control group compared to the TLIP group (82.00 ± 69.01 vs. 442.7 ± 126.47 min, P < 0.001). TLIP group had lower cumulative morphine consumption than control group of statistically significant difference (9.7 ± 6.38 vs. 25.88 ± 5.17 mg, P < 0.001). TLIP block group compared with the control group showed a significant reduction of nausea and a lower incidence of sedation. Conclusion: TLIP block is an effective and safe method for postoperative analgesia after lumbar discectomy. [ABSTRACT FROM AUTHOR]

Background: Traumatic brain injury (TBI) correlated with increased sympathetic activity on the expense of parasympathetic system due to loss of cortical control after brain injury. Manifestations of sympathetic storm include tachycardia, hypertension, tachypnea, and hyperthermia. The neuroprotective effects via reducing cerebral metabolism and lowering O2 and glucose consumption are the targets early after trauma. Beta-blockers reduce sympathetic activity. Objectives: We suppose that using propranolol blunts the sympathetic storming phenomenon as it is a nonselective β inhibitor and has a lipophilic property to steadily penetrate blood--brain barrier. Patients and Methods: Sixty patients allocated randomly into two groups, each consisting of 30 patients. Group A started propranolol and Group B received placebo within first 24 h. Primary outcome was catecholamine levels on day 7, and the secondary outcomes were physiological measures (heart rate [HR], respiratory rate [RR], mean arterial blood pressure [MABP], temperature, random blood sugar, and follow-up Glasgow coma score [GCS] and sedation score). Results: Analysis of outcomes demonstrated that Group A tended to have lower catecholamine levels in comparison to Group B in day 7 (norepinephrine 206.87 ± 44.44 vs. 529.33 ± 42.99 pg/ml, P = <0.001), epinephrine level (69.00 ± 8.66 vs. 190.73 ± 16.48 pg/ml, P < 0.001), and dopamine level (32.90 ± 4.57 vs. 78.00 ± 3.48 pg/ml P < 0.001). GCS of the patients in Group A improved and was statistically significant compared to Group B in day 7 (13 vs. 10 , P = 0.006), with percent change interquartile range (20.0 vs. 8.33, P = 0.006). Regarding hemodynamic parameters between the two groups MABP, HR, RR, and temperature, there was no statistically significant difference on day 1, while on day 7, there is high statistical significance and significant percent change (P < 0.001). Conclusion: Early usage of propranolol after TBI controls hemodynamics and blood sugar with decreased catecholamine levels correlated with the improvement of GCS. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Plant Protection & Pathology is the property of Egyptian National Agricultural Library (ENAL) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Plant Protection & Pathology is the property of Egyptian National Agricultural Library (ENAL) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background The concept of brain death is still not acceptable nor implemented in Egypt. Donor safety in liver transplantation is on the top of our priorities. Purpose The purpose of this study is to evaluate the effectiveness of using IJV distensibility as a reliable method for intraoperative assessment of fluid responsiveness. Methods A prospective observational study was conducted in Ain Shams university specialized hospitals. 40 donor candidates for right lobe hepatectomy for living donor liver transplantation were enrolled. During period of hypovolemia (T0) left IJV scanned and measured. After a given fluid bolus in the form of ringer acetate 5 ml/kg. ultrasonic and hemodynamic measurements were reassessed 10 min (T 10) after the fluid resuscitation. Results Highly significant changes in MABP, HR, and CVP (p < 0.01) were detected after fluid resuscitation, regarding the IJV distensibility it showed a highly significant reduction from baseline (T0) to post-resuscitation expansion (P = 0.0001). Baseline (T0) measurements showed no significant correlation between IJV distensibility and hemodynamic parameters (P ≥ 0.05). Post-resuscitation values (T10) showed no significance correlation between HR and IJV distensibility (P = 0.772). On the other side it showed a highly significance negative correlation between MABP, CVP and IJV distensibility (r = −0.390, P = 0.013) and (r = −0.332 ∗ , p = 0.036) respectively. The correlation between the percentages of change of IJV distensibility and hemodynamic parameters showed highly significant negative correlation between IJV distensibility and MABP (r = −0.359, P = 0.023) also with CVP (r = −0.464, P = 0.017). No difference was found regarding the HR (P = 0.336). Conclusion Organ transplantation centers with experience, CVP monitoring may not be necessary in highly selective patient population. IJV distensibility, a non-invasive and safe method can be used to guide fluid replacement in healthy donor. [ABSTRACT FROM AUTHOR]

The present study was conducted during 2014, 2105 and 2016 early summer seasons for potato (kara, variety) was performed under the field conditions, the experimental field was selected at a private farms at Shepa elnakaria village, Zagazig district and new Salhia, Hosinia district, Sharkia governorate. The present study aimed to study the impact of type soils (clay and sandy soil) on population density of P. operculella larvae infesting potato plants cultivated during 2014, 2015 and 2016 early summer seasons, evaluation infestation % to potato tubers and the effect of some climatic change on population density under field conditions. The statistical analysis of the total mean number of P. operculella larvae showed significant differentiation. The results show that the population density of P. operculella larvae was higher on sandy soil (518 individuals / 120 leaves) than the clay soil (332 individual / 120 leaves), These results revealed significant positive effects of maximum and minimum temperature and DP on population density of P. operculella during the first season 2014 in clay soil and sand soil. The combined effect (E.V) of these ecological factors on P. operculella showed that these factors were responsible as a group for 84 %, 15% and 35 % effects on the population density of P. operculella throughout seasons (2014, 2015 and 2016) in clay and sandy soil, also, these factors were responsible as a group for 72 %, 64% and 26 % effects on the population density. [ABSTRACT FROM AUTHOR]

Background: Ventilator-associated pneumonia (VAP) due to multidrug-resistant organisms (MDROs) is associated with a significant mortality in the Intensive Care Unit (ICU). The aim of this study was to compare the efficacy and safety of extended infusion of meropenem and nebulized amikacin on VAP caused by Gram-negative MDRO versus intravenous (IV) meropenem and amikacin alone. Methodology: A randomized nonblinded controlled trial was performed on ninety patients with VAP. Patients were randomized into three equal groups: Group I received IV amikacin 20 mg/kg/24 h and meropenem 2 g over 30 min/8 h. Group II received the same as Group I in addition to nebulized amikacin 25 mg/kg/day every 8 h. Group III received IV amikacin 20 mg/kg/24 h, nebulized amikacin 25 mg/kg/day every 8 h, and meropenem 2 g diluted in 240 ml normal saline over 3 h/8 h. The primary outcome was the clinical outcome of VAP. Secondary outcomes were microbiological outcome, VAP-related mortality, duration of MV, ICU stay, and nephrotoxicity. Results: Group II and Group III compared to Group I showed higher incidence of clinical cure (53.33% in Group II and 66.67% in Group III vs. 26.67% in Group I, P = 0.007). Group II compared to Group I showed significant reduction in ventilator days (5.32 ± 1.86 vs. 7.3 ± 2.1 days, respectively, P < 0.001) and reduction in ICU days (11.87 ± 2.6 vs. 15.3 ± 3.1 days, respectively, P < 0.001). Group III compared to Group II showed significant reduction in ventilator days (4.22 ± 1.32 vs. 5.32 ± 1.86, respectively, P = 0.011) and highly significant reduction in ICU days (9.21 ± 1.17 vs. 11.87 ± 2.6, respectively, P < 0.001). All groups were comparable as regards nephrotoxicity or mortality. Conclusions: Adding nebulized amikacin to systemic antibiotics in patients with VAP caused by Gram-negative MDRO may offer efficacy benefits, and the use of extended infusions of meropenem could improve the clinical outcomes in critically ill populations. [ABSTRACT FROM AUTHOR]

Experiments were conducted in the experimental Research Station, Qaha, Qalubiya Governorate on the autumn of 2015 and 2016.The current study aimed to evaluation the number, duration generation and efficiency of abamectin against Bemisia tabaci (Genn.), Liriomyza. trifolii (Burg.), and Tetranychus urticae (Koch) infesting green bean (Phaseolus vulgaris) under field condition and residue determination of abamectin in green leaves and green pods. During the 2015 season, the whitefly, B. tabaci recorded two generations, but in the 2016 season, they were three generations. In ad dation, the leaf miner, L. trifoliiwas recorded three generations during two seasons 2015 and 2106. In casered spider, T. urticae gave three generations in the 2015 season but in the second season gave only two generations. Especially, efficiency of Abamectin the results revealed that the highest percentage of reduction of Whitefly, B. tabaci after 10 days (64.64%) and the lowest reduction percentage (22.32%) after 21 day. L. trifolii, the highest percentage of reduction was after 21 days (28.64%) and the lowest percentage of reduction (18.17%) after 1 day. In case of T. urticae, the obtained data indicated that the highest percentage of reduction of Spider mite after 3 days was (44.04%) while after 21 days was the lowest percentage of reduction (10.33%).Studying of the Abamectin residues on and in green leaves, unwashed green pods, washed green pods and boiling green pods recorded 7.98 ppm, 4.2ppm, 0.5 ppm and not detectable after two hours from spraying, washing processing cause dissipation 88.09%loss from washed pods but in case boiling processing removed each Abamectin residues. The half-life measured in centuries Abamectin green beans leaves and unwashed green bean pods recorded 22.73 and 17.4 hours, respectively. The interval Preharvest (PHI) of Abamectin on the green beans pods for 17 day. [ABSTRACT FROM AUTHOR]

Copyright of Egyptian Journal of Agricultural Research is the property of Egyptian National Agricultural Library (ENAL) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction Although it is considered safe, spinal anesthesia has many side effects, including hypotension, and bradycardia. Increased activity of chemoreceptors (Bezold–Jarisch reflex) may play a role in this. The release of serotonin has been suggested as a possible trigger for Bezold–Jarisch reflex. Granisetron, a selective 5-HT3 receptor antagonist, may play a role in preventing hypotension and bradycardia. Aim The aim of this study was to assess the effects of granisetron on hypotension, bradycardia, shivering, nausea, and vomiting after spinal anesthesia in patients undergoing elective lower-abdominal surgeries. Patients and methods This study was designed as a randomized, double-blind, placebo-controlled trial. Fifty-four American Society of Anesthesiologists I–III patients, ages 25–55 years, scheduled for elective lower-abdominal surgeries under spinal anesthesia were included in this prospective study and were divided into two equal groups. Group G received 1 mg intravenous granisetron diluted in 0.9% normal saline to a total volume of 5 ml, and group C received 5 ml normal saline 5 min before undergoing spinal anesthesia. The mean arterial blood pressure, the heart rate, nausea, vomiting, and shivering were assessed. Results The reduction in mean arterial blood pressure and heart rate was significantly lower in group G compared with group C. Regarding the incidence of complications, hypotension, bradycardia, nausea, and shivering were significantly lower in group G compared with group C. No significant difference was observed with regard to the incidence of vomiting. Conclusion In lower-abdominal surgery, intravenously 1 mg granisetron before subarachnoid block decreased the incidence of hypotension and bradycardia significantly, besides being effective for the prevention of nausea, vomiting, and shivering. [ABSTRACT FROM AUTHOR]

Field trial was conducted during two successive seasons on 2015 and 2016 at greenhouse experimental area, Dokki, Giza Governorate. This study aims to evaluating the efficiency of different colors mulch and some environmental factors on reduction of population density to the main sapsucking pests infesting cucumber and yield. The trial were used five colors mulch to covering soil, i. e., red, green, blue, white, yellow and Control treatment without mulch. The results revealed that there are significant differences between using colors mulch with population densities of some pests the whitefly, Bemisia tabaci (Genn.), the thrips, Frankliniella intonsa(Trybom) and the spider mite, Tetranychus urticae (Koch). The tested mulch colors could be arranged according to population density of pests into six ecosystems. The red and white colors was the most potent treatments in low population pests in cucumber plants followed by blue, control, yellow and green which was the highest mean number of infestation in both seasons. Maximum and Minimum temperature were showed insignificant positive effect in first season but Minimum temperature was showed significant positive on B. tabaci (egg and nymph) during second season. Maximum and Minimum temperature were showed insignificant positive effect with F. intonsa and T. urticae (egg and immature) at the both seasons. The relative humidity had insignificant negative effect on B. tabaci, F. intonsa and T. urticae at the both seasons. The soil temperature had insignificant negative effect on B. tabaci, F. intonsa and T. urticae at the both seasons. The combined effect (E.V) of these ecological factors on B. tabaci (egg and nymph), F. intonsa and T. urticae (egg and immature) showed that these factors were responsible as a group for 94 %, 79 %, 83, 89, 98, 87, 99, 99, 93, 95 effects on the population dynamics of pests throughout both seasons, respectively. Especially infestation pests - Yield relationship, the mulch colors affect 75% and 82% in yield weight both seasons. Recommendation: the paper recommendation by cover soil surface with red and white mulch to reduce population of whitefly, thrips and red mite and increase yield. [ABSTRACT FROM AUTHOR]

Effect of different intercropping systems of sweet basil (Ocimum basilicum) plants and spraying with sweet basil oils on population of Green bean (Phaseolus vulgaris) L. pests (Bemisia tabaci (Genn.), Liriomyza trifolii (Burg.) and Tetrenchys urticae (Koch)) under three agricultural ecosystems namely; plastic greenhouse, scaffold net greenhouse and open field, an experiment was carried out inside greenhouse experimental area at Dokki, Giza Governorate during 2012. According to interaction between of intercropping system and agricultural ecosystems on the level infestation with certain green bean pests, it is clear that, plastic greenhouse harboured the highest number of pests infesting green bean plants while the open field had the lowest number of pests whereas, the scaffold net greenhouse was intermediate as a result to spraying with basil oil is the best method to reduction the number of pests attacking green bean irrespective of intercropping with basil plants or cultivating under plastic or scaffold net greenhouse. [ABSTRACT FROM AUTHOR]

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Background: Septic shock is one of the most common causes of admission to the intensive care unit in the world and one of the most common causes of death among intensive care patients. Since the definition of sepsis and septic shock and many studies have been designed to understand everything about sepsis regarding mechanism, pathophysiology, complications, diagnosis, management and all other aspects. Objective: To find the association between neutrophil to lymphocyte count ratio and the mortality from septic shock patients. The work aims also to determine if this ratio can be used as a prognostic marker of septic shock patients and to compare this ratio with other sepsis markers as C-reactive protein (CRP) and procalcitonin. Patients and Methods: This study was conducted prospectively in critical care unit in Ain Shams Hospital, a university-affiliated, tertiary referral center in Cairo, Egypt. Study subjects included 125 patients between January 2018 to January 2019. The ethics committee of our institution approved the study protocol, and written informed consent was obtained from each patient’s family. Results: In our study, the neutrophils count was significantly increased in survived patients compared with early and late mortality patients in day 1 while lymphocytes count was lower in survived patient than early and late mortality patients and the NLCR in our study was higher in survived patients than early and late mortality patients. In day 4, our results revealed significant increase in neutrophils count in patients of late mortality compared with its count in survived patients, while lymphocytes didn’t show any significant difference compared with its count in survived patients with significant increase in NLCR in patients of late mortality compared with those of survived patients in day 4. Both CRP and procalcitonin are increased in patients of early and late mortality groups compared with its value in survived patients in day 1 and 4. Conclusion: This study demonstrates a real relationship between the NLCR and the risk of death in septic shock patients. Septic shock patients at risk of early death presented a low NLCR at admission, although late death was associated with an increased NLCR during the first 5 days. Early and late death should be distinguished because they may involve different underlying mechanisms, and the NLCR might be considered as a discriminant indicator of early or late death. In addition, our findings provide more insight into biology. The circulating neutrophil and lymphocyte trends observed in this study offer an interesting mechanistic viewpoint. We observed that circulating lymphocytes and the NLCR behave in opposite ways in earlyand late death patients, supporting the hypothesis that divergent mechanisms could be involved in these two groups. [ABSTRACT FROM AUTHOR]

Background: Satisfactory analgesia is of great importance in the labor. The clinical efficacy and side effects of remifentanil in the management of labor pain had been evaluated. Dexmedetomidine (DMET) demonstrates an antinociceptive effect in visceral pain conditions. Aims of the study were to assess whether the combination of DMET with remifentanil would produce a synergistic effect that results in lower analgesic requirements. Furthermore, whether this combination would have less maternal and neonatal adverse effects. Patients and Methods: Sixty American Society of Anesthesiologists physical status I-II pregnant women had been enrolled into this study. All were full term (37- 40 weeks' gestation), singleton fetus with cephalic presentation in the first stage of spontaneous labor. They were divided into two groups group (I) Patient-controlled IV remifentanil analgesia (bolus dose 0.25 μg/kg, lockout interval 2 min) increased by 0.25 μg/kg to a maximum bolus dose 1 μg/kg in addition to a loading dose of DMET 1 μg/kg over 20 min, followed by infusion at 0.5 μg/kg/h group (II) Patient-controlled IV remifentanil analgesia (PCA) (bolus dose 0.25 μg/kg, lockout interval 2 min) increased by 0.25 μg/kg to a maximum bolus dose 1 μg/kg in addition to a the same volume of normal saline as a loading dose, followed by a continuous saline infusion. Visual analog scale score, maternal, and fetal complications and patients' satisfaction were recorded. Results: Patients receiving a combination of PCA remifentanil and DMET had a lower pain score compared with remifentanil alone in the second stage of labor (P = 0.001). The Total consumption of remifentanil was reduced by 53.3% in group I. There was an increased incidence of maternal complications and a lower patient satisfaction score in group II. Conclusion: DMET has an opioid sparing effect; a combination of DMET and remifentanil produces a synergistic effect that results in lower analgesic requirements and less maternal and neonatal adverse events. [ABSTRACT FROM AUTHOR]

Background: The use of opioid-free analgesic technique have the propensity to decrease and even avoid many of these side effects and lead to early oral intake, early ambulation, earlier hospital discharge, and lesser readmission rates to the hospital in the post-operative period. Aim of the Work: to compare the effect of opioid-free using Dexmedetomidine and opioid-based using Fentanyl on hemodynamics (inducing deliberate hypotension and providing a better surgical field exposure), post-operative pain intensity and the incidence of side effects in patients scheduled for rhinoplasty surgeries. Patients and Methods: This study included Fifty adult patients undergoing rhinoplasty surgery. Patients were randomly divided into two equal groups. Group D received Dexmedetomidine and Group F received Fentanyl. Patients are ASA physical status I, age group ranged from 18 to 45 years. Results: The study revealed a statistically significant decrease mean of group D compared to group F according to intraoperative mean arterial blood pressure. statistically significant decrease mean of group D compared to group F according to intraoperative heart rate (beat/min). Conclusion: We found that dexmedetomidine is better than fentanyl for patients who undergo rhinoplasty surgeries to achieve controlled hypotension, decrease dosages of postoperative analgesics, prolong the duration of postoperative analgesia and decrease postoperative nausea and vomiting. [ABSTRACT FROM AUTHOR]

Background & Objective: Ultrasound-guided 4-in-1 block has been suggested as a good alternative to various other nerve blocks to control pain after total knee replacement (TKR) surgery. We compared the three regional techniques; 4-in-1 block, femoral nerve block (FNB) and adductor canal block (ACB) following TKR regarding pain scores, opioid consumption, quadriceps muscle strength and early ambulation. Methodology: We enrolled 93 patients and divided them into three equal groups of 31 each. Patients received either 4-in-1 block (Group A), FNB (Group B) or ACB (Group C) under ultrasound guidance. Outcome measures included assessment of VAS scores at 2, 4, 8, 12, 16, and 24 h). Nalbuphine consumption was calculated in the first 24 h. We also evaluated quadriceps muscle strength and early ambulation using straight leg raising (SLR) test at 12 and 24 h, and timed up-and-go (TUG) test at 24 h postoperatively. Results: Patients received 4-in-1 block showed lower pain scores and lower nalbuphine consumption compared to FNB or ACB. Also, the SLR test values at 12h were higher (p-value<0.001), and TUG test values were lower (pvalue0.005) in 4-in-1 block and ACB groups compared to FNB group. Conclusion: The results of our study conclude that 4-in-1 block was found to be superior in pain control after TKR surgeries compared to FNB or ACB alone. It also facilitates early ambulation as it preserves quadriceps muscle strength. [ABSTRACT FROM AUTHOR]

Introduction: The aim of this review was to determine current evidence for the effect of therapeutic hypothermia (TH) on survival and neurological outcome in adults suffering cardiac arrest (CA)., Evidence Aquisition: We searched the Cochrane Controlled Trials Register, MEDLINE, EMBASE and NLM databases from 2000 to 2017 using the following terms: hypothermia, cooling, therapeutic, cardiac arrest, resuscitation, cardiopulmonary, CPR. Studies were eligible if they compared TH versus normothermic management in adult humans sustaining CA. Randomized controlled trials (RCT), pilot studies and observational trials were included., Evidence Synthesis: Ten studies involving 3259 patients were included in meta-analysis. Pooling all eligible studies showed a favorable effect for TH on survival and neurological recovery. However, sensitivity analysis for RCTs showed no benefit on either outcome, while observational trials showed benefit for neurological recovery with just marginally significant benefit regarding survival. Studies including patients with shockable rhythms demonstrated benefit for both outcome measures, while those including patients with any rhythms demonstrated benefit for neurological recovery but not for survival. TH did not benefit patients with non-shockable rhythms. Trials using external cooling favored TH regarding survival and neurological outcome but those using systemic cooling with or without external cooling did not show such benefit. When the overall incidence of complications was pooled, there was a statistically significant shift in odds ratio favoring normothermic management over TH., Conclusions: Evidence from RCTs suggests TH does not improve survival or neurological outcome, while observational trials favor TH over normothermia. TH may be attended with higher risk for complications.