1. CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension
- Author
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Modar Kassan, Khalid Matrougui, Philip J. Kadowitz, Mohamed Trebak, and Andrea Wecker
- Subjects
CD4-Positive T-Lymphocytes ,Endothelium ,Physiology ,Regulatory T cell ,Blood Pressure ,Inflammation ,T-Lymphocytes, Regulatory ,Article ,Immune tolerance ,Mice ,Immune system ,Immune Tolerance ,Internal Medicine ,medicine ,Homeostasis ,Animals ,Humans ,Vascular Diseases ,Endothelial dysfunction ,business.industry ,Microcirculation ,Interleukin-2 Receptor alpha Subunit ,FOXP3 ,Forkhead Transcription Factors ,Atherosclerosis ,medicine.disease ,Cardiovascular physiology ,medicine.anatomical_structure ,Immunology ,Hypertension ,Endothelium, Vascular ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.
- Published
- 2013