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170 results on '"Appelbaum, Evan"'

1. Protein Biomarkers of Adverse Clinical Features and Events in Sarcomeric Hypertrophic Cardiomyopathy

Author

Tahir, Usman A., Kolm, Paul, Kwong, Raymond Y., Desai, Milind Y., Dolman, Sarahfaye F., Deng, Shuliang, Appelbaum, Evan, Desvigne-Nickens, Patrice, DiMarco, John P., Tiwari, Gaurav, Friedrich, Matthias G., Zelaya-Portillo, Julissa H., Jerosch-Herold, Michael, Kim, Dong-Yun, Maron, Martin S., Piechnik, Stefan K., Schulz-Menger, Jeanette, Watkins, Hugh, Weintraub, William S., Neubauer, Stefan, Kramer, Christopher M., Jarolim, Petr, Gerszten, Robert E., and Ho, Carolyn Y.

Published
2024
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2. 3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry

Author

Heydari, Bobak, Satriano, Alessandro, Jerosch-Herold, Michael, Kolm, Paul, Kim, Dong-Yun, Cheng, Kathleen, Choi, Yuna L., Antiochos, Panagiotis, White, James A., Mahmod, Masliza, Chan, Kenneth, Raman, Betty, Desai, Milind Y., Ho, Carolyn Y., Dolman, Sarahfaye F., Desvigne-Nickens, Patrice, Maron, Martin S., Friedrich, Matthias G., Schulz-Menger, Jeanette, Piechnik, Stefan K., Appelbaum, Evan, Weintraub, William S., Neubauer, Stefan, Kramer, Christopher M., and Kwong, Raymond Y.

Published
2023
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3. Predictors of Major Atrial Fibrillation Endpoints in the National Heart, Lung, and Blood Institute HCMR

Author

Kramer, Christopher M., DiMarco, John P., Kolm, Paul, Ho, Carolyn Y., Desai, Milind Y., Kwong, Raymond Y., Dolman, Sarahfaye F., Desvigne-Nickens, Patrice, Geller, Nancy, Kim, Dong-Yun, Maron, Martin S., Appelbaum, Evan, Jerosch-Herold, Michael, Friedrich, Matthias G., Schulz-Menger, Jeanette, Piechnik, Stefan K., Mahmod, Masliza, Jacoby, Daniel, White, James, Chiribiri, Amedeo, Helms, Adam, Choudhury, Lubna, Michels, Michelle, Bradlow, William, Salerno, Michael, Dawson, Dana K., Weinsaft, Jonathan W., Berry, Colin, Nagueh, Sherif F., Buccarelli-Ducci, Chiara, Owens, Anjali, Casadei, Barbara, Watkins, Hugh, Weintraub, William S., and Neubauer, Stefan

Published
2021
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4. Distinct Subgroups in Hypertrophic Cardiomyopathy in the NHLBI HCM Registry

Author

Mahmod, Masliza, Jacoby, Daniel, White, James, Chiribiri, Amedeo, Helms, Adam, Choudhury, Lubna, Michels, Michelle, Bradlow, William, Salerno, Michael, Heitner, Stephen, Prasad, Sanjay, Mohiddin, Saidi, Swoboda, Peter, Mahrholdt, Heiko, Bucciarelli-Ducci, Chiara, Weinsaft, Jonathan, Kim, Han, McCann, Gerry, van Rossum, Albert, Williamson, Eric, Flett, Andrew, Dawson, Dana, Mongeon, F. Pierre, Olivotto, Iacopo, Crean, Andrew, Owens, Anjali, Anderson, Lisa, Biagini, Elena, Newby, David, Berry, Colin, Kim, Bette, Larose, Eric, Abraham, Theodore, Sherrid, Mark, Nagueh, Sherif, Rimoldi, Ornella, Elstein, Eleanor, Autore, Camillo, Neubauer, Stefan, Kolm, Paul, Ho, Carolyn Y., Kwong, Raymond Y., Desai, Milind Y., Dolman, Sarahfaye F., Appelbaum, Evan, Desvigne-Nickens, Patrice, DiMarco, John P., Friedrich, Matthias G., Geller, Nancy, Harper, Andrew R., Jarolim, Petr, Jerosch-Herold, Michael, Kim, Dong-Yun, Maron, Martin S., Schulz-Menger, Jeanette, Piechnik, Stefan K., Thomson, Kate, Zhang, Cheng, Watkins, Hugh, Weintraub, William S., and Kramer, Christopher M.

Published
2019
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5. Significance of Late Gadolinium Enhancement at Right Ventricular Attachment to Ventricular Septum in Patients With Hypertrophic Cardiomyopathy

Author

Chan, Raymond H., Maron, Barry J., Olivotto, Iacopo, Assenza, Gabriele E., Haas, Tammy S., Lesser, John R., Gruner, Christiane, Crean, Andrew M., Rakowski, Harry, Rowin, Ethan, Udelson, James, Lombardi, Massimo, Tomberli, Benedetta, Spirito, Paolo, Formisano, Francesco, Marra, Martina P., Biagini, Elena, Autore, Camillo, Manning, Warren J., Appelbaum, Evan, Roberts, William C., Basso, Cristina, and Maron, Martin S.

Published
2015
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8. Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (β-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy

Author

Weissler-Snir, Adaya, Hindieh, Waseem, Gruner, Christiane, Fourey, Dana, Appelbaum, Evan, Rowin, Ethan, Care, Melanie, Lesser, John R., Haas, Tammy S., Udelson, James E., Manning, Warren J., Olivotto, Iacopo, Tomberli, Benedetta, Maron, Barry J., Maron, Martin S., Crean, Andrew M., Rakowski, Harry, and Chan, Raymond H.

Published
2017
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12. Hypertrophic Cardiomyopathy Registry: The rationale and design of an international, observational study of hypertrophic cardiomyopathy

Author

Kramer, Christopher M., Appelbaum, Evan, Desai, Milind Y., Desvigne-Nickens, Patrice, DiMarco, John P., Friedrich, Matthias G., Geller, Nancy, Heckler, Sarahfaye, Ho, Carolyn Y., Jerosch-Herold, Michael, Ivey, Elizabeth A., Keleti, Julianna, Kim, Dong-Yun, Kolm, Paul, Kwong, Raymond Y., Maron, Martin S., Schulz-Menger, Jeanette, Piechnik, Stefan, Watkins, Hugh, Weintraub, William S., Wu, Pan, and Neubauer, Stefan

Published
2015
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18. Significance of left ventricular apical–basal muscle bundle identified by cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Author

Gruner, Christiane, Chan, Raymond H., Crean, Andrew, Rakowski, Harry, Rowin, Ethan J., Care, Melanie, Deva, Djeven, Williams, Lynne, Appelbaum, Evan, Gibson, C. Michael, Lesser, John R., Haas, Tammy S., Udelson, James E., Manning, Warren J., Siminovitch, Katherine, Ralph-Edwards, Anthony C., Rastegar, Hassan, Maron, Barry J., and Maron, Martin S.

Published
2014
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20. Skin-derived microorgan autotransplantation as a novel approach for therapeutic angiogenesis

Author

Voisine, Pierre, Rosinberg, Audrey, Wykrzykowska, Joanna J., Shamis, Yulia, Wu, Gui Fu, Appelbaum, Evan, Li, Jian, Sellke, Frank W., Pinto, Duane, Gibson, C. Michael, Mitrani, Eduardo, and Laham, Roger J.

Subjects
Neovascularization -- Research, Myocardial ischemia -- Research, Hematopoietic growth factors -- Research, Cardiovascular research, Biological sciences
Abstract

Despite promising preclinical results, transient single-factor-based therapeutic angiogenesis has shown no definitive benefits in clinical trials. The use of skin-derived microorgans (SMOs), capable of sustained expression of angiogenic factors and sustained viability with their cellular and extracellular elements, constitutes an attractive alternative. We sought to evaluate the efficacy of SMO implantation in a porcine model of chronic myocardial ischemia. Eighteen pigs underwent placement of an ameroid constrictor on the proximal circumflex artery. Three weeks later, split-thickness skin biopsies were harvested and pigs were randomized to lateral wall implantation of either 8 or 16 SMOs or blank injections. The procedure was safe and resulted in no adverse events. Three weeks after treatment, SMO implantation resulted in significant improvement of lateral wall perfusion during pacing, assessed by isotope-labeled microspheres [post- vs. pretreatment ratios of lateral/anterior wall blood flow were 1.31 [+ or -] 0.09 (SMOs) and 1.04 [+ or -] 0.06 (controls); P = 0.03]. No significant difference in angiographic scores was observed. Microvascular relaxation in response to VEGF was impaired in the ischemic territory of the control group but returned to normal after SMO implantation, indicating restoration of endothelial function. Molecular studies showed significant increases in VEGF and CD31 expression in the ischemic area of treated animals. Morphometric analysis showed increased neovascularization with SMO treatment. Autotransplantation of SMOs constitutes a novel approach for safe and effective therapeutic angiogenesis with improvement in perfusion, normalization of microvascular reactivity, and increased expression of VEGF and CD31. growth factors; myocardial ischemia

Published
2008

22. Characterization of subacute and convalescent fibrotic burden in the remote myocardium after acute infarction provides strong and incremental prediction of changes in left and right functions and final infarct size, incremental to knowledge of the subacute infarct size

Author

Mandry Damien, Appelbaum Evan, Heydari Bobby, Abdullah Shuaib, Francis Sanjeev, Lumish Heidi S, Ghoshhajra Brian B, Hoffmann Udo, Gewirtz Henry, Blankstein Ron, Chen Yucheng, Feng Jiazuo H, Kienle Karl-Philipp, van der Geest Rob J, Antman Elliott, Jerosch-Herold Michael, and Kwong Raymond

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2012
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37. Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease: The PRIMO Randomized Controlled Trial

Author

Thadhani, Ravi, Appelbaum, Evan, Pritchett, Yili, Chang, Yuchiao, Wenger, Julia, Tamez, Hector, Bhan, Ishir, Agarwal, Rajiv, Zoccali, Carmine, Wanner, Christoph, Lloyd-Jones, Donald, Cannata, Jorge, Thompson, B. Taylor, Andress, Dennis, Zhang, Wuyan, Packham, David, Singh, Bhupinder, Zehnder, Daniel, Shah, Amil, Pachika, Ajay, Manning, Warren J., and Solomon, Scott D.

Published
2012
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41. Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease

Author

Tamez, Hector, Zoccali, Carmine, Packham, David, Wenger, Julia, Bhan, Ishir, Appelbaum, Evan, Pritchett, Yili, Chang, Yuchiao, Agarwal, Rajiv, Wanner, Christoph, Lloyd-Jones, Donald, Cannata, Jorge, Thompson, Taylor B., Andress, Dennis, Zhang, Wuyan, Singh, Bhupinder, Zehnder, Daniel, Pachika, Ajay, Manning, Warren J., Shah, Amil, Solomon, Scott D., and Thadhani, Ravi

Published
2012
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42. Contributors

Author

Akçakaya, Mehmet, Alpendurada, Francisco, Appelbaum, Evan, Arai, Andrew, Auger, Dominique, Balaban, Robert S., Bax, Jeroen J., Bellenger, Nicholas G., Bluemke, David A., Botnar, René M., Butler, Craig Ronald, Caravan, Peter, Celeng, Csilla, Chuang, Michael L., de Roos, Albert, Delgado, Victoria, Dharmakumar, Rohan, Dweck, Marc R., Farzaneh-Far, Afshin, Fayad, Zahi A., Firmin, David, Fogel, Mark A., Frank, Herbert, Friedrich, Matthias G., Gale, Eric M., Geva, Tal, Grizzard, John D., Halliday, Brian P., Hansen, Michael, Hauser, Thomas H., Hong, Susie N., Huelnhagen, Till, Hundley, W. Gregory, Ibrahim, El-Sayed H., Ipek, Esra Gucuk, Jerosch-Herold, Michael, Judd, Robert M., Keegan, Jennifer, Kellman, Peter, Khan, Muhammad Shahzeb, Khosa, Faisal, Khurshid, Kiran, Kilner, Philip J., Kim, Daniel H., Kim, Raymond J., Kim, W. Yong, Kramer, Christopher M., Krieger, Eric V., Kwong, Raymond Y., Leb, Jay S., Lederman, Robert, Leiner, Tim, Li, Debiao, Lopez, David, Maceira, Alicia M., Mahrholdt, Heiko, Makowski, Marcus R., Manning, Warren J., Marcu, Constantin B., Maron, Martin S., Mohiaddin, Raad H., Moon, James C., Motwani, Manish, Nakamori, Shiro, Nazarian, Saman, Nensa, Felix, Neubauer, Stefan, Nezafat, Reza, Nienaber, Christoph A., Niendorf, Thoralf, Partington, Sara L., Paterson, Ian, Paul, Katharina, Pennell, Dudley J., Peshock, Ronald M., Peters, Dana C., Planken, R. Nils, Plein, Sven, Powell, Andrew J., Prasad, Sanjay, Prieto, Claudia, Pushparajah, Kuberan, Rashid, Imran, Razavi, Reza S., Rehwald, Wolfgang G., Robson, Philip M., Rodgers, Christopher T., Rogers, Toby, Rowin, Ethan J., Rudd, James H.F., Sakuma, Hajime, Salerno, Michael, Schlosser, Thomas, Schwitter, Juerg, Sechtem, Udo P., Stacey, R. Brandon, Stuber, Matthias, Sykora, Teresa, Tayal, Upasana, te Riele, Anneline S.J.M., Treibel, Thomas A., Tsaftaris, Sotirios A., Valente, Anne Marie, van den Bosch, Harrie, van der Bijl, Pieter, van Rossum, Albert C., Wendell, David C., Westenberg, Jos J.M., Westwood, Mark A., Wilke, Norbert, Winter, Lukas, and Yang, Hsin-Jung

Published
2019
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43. Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes.

Author

Adalsteinsdottir, Berglind, Palsson, Runolfur, Desnick, Robert J., Gardarsdottir, Marianna, Teekakirikul, Polakit, Maron, Martin, Appelbaum, Evan, Neisius, Ulf, Maron, Barry J., Burke, Michael A., Chen, Brenden, Pagant, Silvere, Madsen, Christoffer V., Danielsen, Ragnar, Arngrimsson, Reynir, Feldt-Rasmussen, Ulla, Seidman, Jonathan G., Seidman, Christine E., and Gunnarsson, Gunnar Th.

Abstract

Background--The screening of Icelandic patients clinically diagnosed with hypertrophic cardiomyopathy resulted in identification of 8 individuals from 2 families with X-linked Fabry disease (FD) caused by GLA (α-galactosidase A gene) mutations encoding p.D322E (family A) or p.I232T (family B). Methods and Results--Familial screening of at-risk relatives identified mutations in 16 family A members (8 men and 8 heterozygotes) and 25 family B members (10 men and 15 heterozygotes). Clinical assessments, α-galactosidase A (α-GalA) activities, glycosphingolipid substrate levels, and in vitro mutation expression were used to categorize p.D322E as a classic FD mutation and p.I232T as a later-onset FD mutation. In vitro expression revealed that p.D322E and p.I232T had α-GalA activities of 1.4% and 14.9% of the mean wild-type activity, respectively. Family A men had markedly decreased α-GalA activity and childhood-onset classic manifestations, except for angiokeratoma and cornea verticillata. Family B men had residual α-GalA activity and developed FD manifestations in adulthood. Despite these differences, all family A and family B men >30 years of age had left ventricular hypertrophy, which was mainly asymmetrical, and had similar late gadolinium enhancement patterns. Ischemic stroke and severe white matter lesions were more frequent among family A men, but neither family A nor family B men had overt renal disease. Family A and family B heterozygotes had less severe or no clinical manifestations. Conclusions--Men with classic or later-onset FD caused by GLA missense mutations developed prominent and similar cardiovascular disease at similar ages, despite markedly different α-GalA activities. [ABSTRACT FROM AUTHOR]

Published
2017
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44. Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction: The OMEGA-REMODEL Randomized Clinical Trial.

Author

Heydari, Bobak, Abdullah, Shuaib, Pottala, James V., Shah, Ravi, Abbasi, Siddique, Mandry, Damien, Francis, Sanjeev A., Lumish, Heidi, Ghoshhajra, Brian B., Hoffmann, Udo, Appelbaum, Evan, Jiazhuo H. Feng, Blankstein, Ron, Steigner, Michael, McConnell, Joseph P., Harris, William, Antman, Elliott M., Jerosch-Herold, Michael, Kwong, Raymond Y., and Feng, Jiazhuo H

Published
2016
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47. DOES FOCAL LATE GADOLINIUM ENHANCEMENT AT THE RIGHT VENTRICULAR INSERTION POINTS MATTER IN RISK STRATIFICATION FOR SUDDEN DEATH IN HYPERTROPHIC CARDIOMYOPATHY?

Author

Chan, Raymond H., Maron, Barry, Olivotto, Iacopo, Assenza, Gabriele, Lesser, John, Haas, Tammy, Gruner, Christiane, Creane, Andrew, Rakowski, Harry, Udelson, James, Rowin, Ethan, Tomberli, Benedetta, Spirito, Paolo, Formisano, Francesco, Biagini, Elena, Rapezzi, Claudio, Nicola De Cecco, Carlo, Autore, Camillo, Cook, Earl, Hong, Susie, Gibson, C. Michael, Manning, Warren, Appelbaum, Evan, and Maron, Martin

Published
2013
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50. Intermediate-Signal-Intensity Late Gadolinium Enhancement Predicts Ventricular Tachyarrhythmias in Patients With Hypertrophic Cardiomyopathy.

Author

Appelbaum, Evan, Maron, Barry J., Adabag, Selcuk, Hauser, Thomas H., Lesser, John R., Haas, Tammy S., Riley, Anne B., Harrigan, Caitlin J., Delling, Francesca N., Udelson, James E., Gibson, C. Michael, Manning, Warren J., and Maron, Martin S.

Subjects
GADOLINIUM, MAGNETIC resonance imaging, ELECTROCARDIOGRAPHY, HYPERTROPHIC cardiomyopathy, ARRHYTHMIA
Abstract

The article presents a study on the relationship of intermediate late gadolinium enhancement-signal intensity (LGE-SI) to several important demographic and clinical variables. The researchers used contrast-enhanced cardiovascular magnetic resonance (CMR) and 24-hour ambulatory Holter electrocardiogram (ECG) to assess hypertrophic cardiomyopathy (HCM) patients eligible for magnetic resonance imaging. They found that hyperenhancement may be a marker for an unstable electric substrate.

Published
2012
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