Search

Circuit breakers for residential branch circuits must trip at or below 135% of rated current. A breaker that fails that requirement is defective. Samples of two brands, purchased from retail sources, are tested for that basic calibration. Both brands were tested 4 years ago. Previous samples of one brand were 50% defective, and new samples manufactured in 2021 are 28% defective. The second brand, previously defect-free, is again defect-free. The test results, past and present, imply that some manufacturers are calibrating breakers to trip too close to the allowable upper current limit, and are checking calibration by testing at higher current. The standard calibration test at 200% of rated current is shown to be incapable of indicating whether or not a breaker will trip properly, as required by the applicable standard, at 135% of rated current. A third brand tested came on the market recently. Its thermal-magnetic breakers trip correctly, but the brand's hydraulic-magnetic breakers are erratic, with 38% of the samples malfunctioning. The malfunctions are attributed to thermal distortion that causes mechanical binding of the triggering mechanism. Some breaker brands with a high defect rate have been in the distribution chain for many years and are permanently installed in homes. The increased risk of fire and injury for the occupants of these dwellings is significant. The long-standing history of this problem and the fire safety consequences are discussed.

The experimental results are presented for minimum trip current as a function of temperature for residential circuit breakers. These are often installed in enclosures that are exposed to seasonal temperature extremes. The trip current of these thermally actuated breakers is inversely related to temperature. The relationship is shown to be linear and it varies as much as 2:1 between brands. The trip current at extremely high and low temperatures can be estimated. At low outside ambient temperature the worst case 15 A breakers will not trip at 25 A, which would be the current load of two 1500 W portable heaters plugged into the same 15 A circuit. The diminished overcurrent protection at low temperature may be a factor that contributes to the elevated incidence of residential electrical fires during winter months.

AbstractBackgroundWe present a comprehensive transcriptome analysis of the fungus Ascosphaera apis, an economically important pathogen of the Western honey bee (Apis mellifera) that causes chalkbrood disease. Our goals were to further annotate the A. apis reference genome and to identify genes that are candidates for being differentially expressed during host infection versus axenic culture.ResultsWe compared A. apis transcriptome sequence from mycelia grown on liquid or solid media with that dissected from host-infected tissue. 454 pyrosequencing provided 252 Mb of filtered sequence reads from both culture types that were assembled into 10,087 contigs. Transcript contigs, protein sequences from multiple fungal species, and ab initio gene predictions were included as evidence sources in the Maker gene prediction pipeline, resulting in 6,992 consensus gene models. A phylogeny based on 12 of these protein-coding loci further supported the taxonomic placement of Ascosphaera as sister to the core Onygenales. Several common protein domains were less abundant in A. apis compared with related ascomycete genomes, particularly cytochrome p450 and protein kinase domains. A novel gene family was identified that has expanded in some ascomycete lineages, but not others. We manually annotated genes with homologs in other fungal genomes that have known relevance to fungal virulence and life history. Functional categories of interest included genes involved in mating-type specification, intracellular signal transduction, and stress response. Computational and manual annotations have been made publicly available on the Bee Pests and Pathogens website.ConclusionsThis comprehensive transcriptome analysis substantially enhances our understanding of the A. apis genome and its expression during infection of honey bee larvae. It also provides resources for future molecular studies of chalkbrood disease and ultimately improved disease management.

Test results presented in this paper demonstrate that some brands of residential molded case circuit breakers do not operate properly within the limits specified by the applicable standard. The samples tested are both used, from homes, and new, purchased at retail sources. The minimum trip current is determined for each breaker. The test procedure encompasses the basic overload trip requirements of the applicable standard. Breakers that do not open the circuit at or below 135% of rated current fail to meet the requirements of the standard. Test results vary substantially from brand to brand. The best brands are essentially failure free. The failure rate of the worst-case brands is in the order of 50% for both used breakers from homes and new breakers recently purchased. Some samples, primarily multi-pole breakers, do not open the circuit at any level of applied current. Failure of a circuit breaker in a home to operate properly when required poses an increased risk of fire and injury.

Disneyland is work disguised as play; school disguised as vacation. While Walt Disney's curriculum deploys across all of its products, it literally engulfs the approximately 50 million "guests" who visit the Disney Parks each year. Drawing on Sarah Ahmed's phenomenological reading of orientation in Queer phenomenology, this article investigates the ways in which Disney's didacticism is made material through practices and procedures designed to orient the park's visitors, to ensure that those visitors always know where they are and who they are, as a means of educating "good" citizens. The argument focuses not on Disneyland's narrative curriculum but on its corporeal one: visitors are enticed to make affective investments, to construct or reconstruct their identities to comply with the Disney version of the ideal American worker and consumer, as the park attempts to reorient those who resist those roles. (Contains 21 notes.)

Pollinators, including honey bees, are responsible for the successful reproduction of more than 87% of flowering plant species: they are thus vital to ecosystem health and agricultural services world-wide. To investigate honey bee exposure to pesticides, 168 pollen samples and 142 wax comb samples were collected from colonies within six stationary apiaries in six U.S. states. These samples were analyzed for evidence of pesticides. Samples were taken bi-weekly when each colony was active. Each apiary included thirty colonies, of which five randomly chosen colonies in each apiary were sampled for pollen. The pollen samples were separately pooled by apiary. There were a total of 714 detections in the collected pollen and 1008 detections in collected wax. A total of 91 different compounds were detected: of these, 79 different pesticides and metabolites were observed in the pollen and 56 were observed in the wax. In all years, insecticides were detected more frequently than were fungicides or herbicides: one third of the detected pesticides were found only in pollen. The mean (standard deviation (SD)) number of detections per pooled pollen sample varied by location from 1.1 (1.1) to 8.7 (2.1). Ten different modes of action were found across all four years and nine additional modes of action occurred in only one year. If synergy in toxicological response is a function of simultaneous occurrence of multiple distinct modes of action, then a high frequency of potential synergies was found in pollen and wax-comb samples. Because only pooled pollen samples were obtained from each apiary, and these from only five colonies per apiary per year, more data are needed to adequately evaluate the differences in pesticide exposure risk to honey bees among colonies in the same apiary and by year and location.

Chronic bee paralysis virus (CBPV) is an important viral disease of adult bees which induces significant losses in honey bee colonies. Despite comprehensive research, only limited data is available from experimental infection for this virus. In the present study winter worker bees were experimentally infected in three different experiments. Bees were first inoculated per os (p/o) or per cuticle (p/c) with CBPV field strain M92/2010 in order to evaluate the virus replication in individual bees. In addition, potential synergistic effects of co-infection with CBPV and Nosema ceranae (N. ceranae) on bees were investigated. In total 558 individual bees were inoculated in small cages and data were analyzed using quantitative real time RT-PCR (RT-qPCR). Our results revealed successful replication of CBPV after p/o inoculation, while it was less effective when bees were inoculated p/c. Dead bees harbored about 1,000 times higher copy numbers of the virus than live bees. Co-infection of workers with CBPV and N. ceranae using either method of virus inoculation (p/c or p/o) showed increased replication ability for CBPV. In the third experiment the effect of inoculation on bee mortality was evaluated. The highest level of bee mortality was observed in a group of bees inoculated with CBPV p/o, followed by a group of workers simultaneously inoculated with CBPV and N. ceranae p/o, followed by the group inoculated with CBPV p/c and the group with only N. ceranae p/o. The experimental infection with CBPV showed important differences after p/o or p/c inoculation in winter bees, while simultaneous infection with CBPV and N. ceranae suggesting a synergistic effect after inoculation.

We investigated the effect of the parasitic mite Varroa destructor on the immunological and nutritional condition of honey bees, Apis mellifera, from the perspective of the individual bee and the colony. Pupae, newly-emerged adults and foraging adults were sampled from honey bee colonies at one site in S. Texas, USA. Varroa‑infested bees displayed elevated titer of Deformed Wing Virus (DWV), suggestive of depressed capacity to limit viral replication. Expression of genes coding three anti-microbial peptides (defensin1, abaecin, hymenoptaecin) was either not significantly different between Varroa-infested and uninfested bees or was significantly elevated in Varroa-infested bees, varying with sampling date and bee developmental age. The effect of Varroa on nutritional indices of the bees was complex, with protein, triglyceride, glycogen and sugar levels strongly influenced by life-stage of the bee and individual colony. Protein content was depressed and free amino acid content elevated in Varroa-infested pupae, suggesting that protein synthesis, and consequently growth, may be limited in these insects. No simple relationship between the values of nutritional and immune-related indices was observed, and colony-scale effects were indicated by the reduced weight of pupae in colonies with high Varroa abundance, irrespective of whether the individual pupa bore Varroa.

Taking Euroscepticism that mainly concentrates on the tension between European integration and the preservation of cultural diversity and national identity as a point of departure, this contribution serves as a normative observation of the Lisbon Treaties' competences and procedures in relation to the statement that the EU will respect cultural diversity and national identity. The question is whether the Lisbon Treaties are giving in to Euroscepticism by respecting and protecting diversity or whether the statements are only a window-dressing formality which, in reality, is not effectuated by the Union. When one looks at some Union developments and initiatives over the last few years, the EU's eventual ideal of becoming a more centralised political entity becomes clear. If, when looking at the new provisions in the Lisbon Treaties, this ideal is taken into account, the Treaties seem to reflect this progressive approach. Overall, it seems that 'Lisbon' has indeed considered the Eurosceptic arguments concerning a lack of democratic control and the tension concerning diversity and national identity. Nonetheless, the general signal expressed by the innovations seems to be that progressive integration by increased effectiveness is more important than the satisfaction of the Member States' wishes with regard to respect for cultural diversity and national identity. It may well be that this effectiveness results in a counter-effect: an intensification of Euroscepticism that may negatively reflect on the Union's progressive integration.

Describes a multifaceted administrator leadership workshop that relies on case studies, role playing, and peer coaching exercises to enhance leadership skills. Administrators work collaboratively with staff members to analyze problems, prioritize needs, make decisions, and facilitate these three processes by using a repertoire of group dynamic skills. (MLH)

Describes documents developed for school business officials' self-assessment of seven major skill sets in "Professional Standards," published by the Association of School Business Officials in 2001. Documents are available from Professional Development section of Association's Web site at www.asbointl.org. (PKP)

The pathophysiology of COVID-19 includes immune-mediated hyperinflammation, which could potentially lead to respiratory failure and death. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is among cytokines that contribute to the inflammatory processes. Lenzilumab, a GM-CSF neutralising monoclonal antibody, was investigated in the LIVE-AIR trial to assess its efficacy and safety in treating COVID-19 beyond available treatments. In LIVE-AIR, a phase 3, randomised, double-blind, placebo-controlled trial, hospitalised adult patients with COVID-19 pneumonia not requiring invasive mechanical ventilation were recruited from 29 sites in the USA and Brazil and were randomly assigned (1:1) to receive three intravenous doses of lenzilumab (600 mg per dose) or placebo delivered 8 h apart. All patients received standard supportive care, including the use of remdesivir and corticosteroids. Patients were stratified at randomisation by age and disease severity. The primary endpoint was survival without invasive mechanical ventilation to day 28 in the modified intention-to-treat population (mITT), comprising all randomised participants who received at least one dose of study drug under the documented supervision of the principal investigator or sub-investigator. Adverse events were assessed in all patients who received at least one dose of study drug. This trial is registered with ClinicalTrials.gov , NCT04351152 , and is completed. Patients were enrolled from May 5, 2020, until Jan 27, 2021. 528 patients were screened, of whom 520 were randomly assigned and included in the intention-to-treat population. 479 of these patients (n=236, lenzilumab; n=243, placebo) were included in the mITT analysis for the primary outcome. Baseline demographics were similar between groups. 311 (65%) participants were males, mean age was 61 (SD 14) years at baseline, and median C-reactive protein concentration was 79 (IQR 41–137) mg/L. Steroids were administered to 449 (94%) patients and remdesivir to 347 (72%) patients; 331 (69%) patients received both treatments. Survival without invasive mechanical ventilation to day 28 was achieved in 198 (84%; 95% CI 79–89) participants in the lenzilumab group and in 190 (78%; 72–83) patients in the placebo group, and the likelihood of survival was greater with lenzilumab than placebo (hazard ratio 1·54; 95% CI 1·02–2·32; p=0·040). 68 (27%) of 255 patients in the lenzilumab group and 84 (33%) of 257 patients in the placebo group experienced at least one adverse event that was at least grade 3 in severity based on CTCAE criteria. The most common treatment-emergent adverse events of grade 3 or higher were related to respiratory disorders (26%) and cardiac disorders (6%) and none led to death. Lenzilumab significantly improved survival without invasive mechanical ventilation in hospitalised patients with COVID-19, with a safety profile similar to that of placebo. The added value of lenzilumab beyond other immunomodulators used to treat COVID-19 alongside steroids remains unknown. Humanigen. [ABSTRACT FROM AUTHOR]

A Bedford, Massachusetts, middle school lived through a series of critical incidents while moving into site-based management. Flaps developed over minute-taking responsibilities in faculty meetings and a student exchange arrangement with an inner-city middle school. A "pyramiding" process to close the communication gap helped maintain mutual trust. (MLH)

Abstract Background We present a comprehensive transcriptome analysis of the fungus Ascosphaera apis, an economically important pathogen of the Western honey bee (Apis mellifera) that causes chalkbrood disease. Our goals were to further annotate the A. apis reference genome and to identify genes that are candidates for being differentially expressed during host infection versus axenic culture. Results We compared A. apis transcriptome sequence from mycelia grown on liquid or solid media with that dissected from host-infected tissue. 454 pyrosequencing provided 252 Mb of filtered sequence reads from both culture types that were assembled into 10,087 contigs. Transcript contigs, protein sequences from multiple fungal species, and ab initio gene predictions were included as evidence sources in the Maker gene prediction pipeline, resulting in 6,992 consensus gene models. A phylogeny based on 12 of these protein-coding loci further supported the taxonomic placement of Ascosphaera as sister to the core Onygenales. Several common protein domains were less abundant in A. apis compared with related ascomycete genomes, particularly cytochrome p450 and protein kinase domains. A novel gene family was identified that has expanded in some ascomycete lineages, but not others. We manually annotated genes with homologs in other fungal genomes that have known relevance to fungal virulence and life history. Functional categories of interest included genes involved in mating-type specification, intracellular signal transduction, and stress response. Computational and manual annotations have been made publicly available on the Bee Pests and Pathogens website. Conclusions This comprehensive transcriptome analysis substantially enhances our understanding of the A. apis genome and its expression during infection of honey bee larvae. It also provides resources for future molecular studies of chalkbrood disease and ultimately improved disease management.

Abstract Background Diseases and other stress factors working synergistically weaken honey bee health and may play a major role in the losses of bee populations in recent years. Among a large number of bee diseases, chalkbrood has been on the rise. We present here the experimental identification of honey bee genes that are differentially expressed in response to infection of honey bee larvae with the chalkbrood fungus, Ascosphaera apis. Results We used cDNA-AFLP ®Technology to profile transcripts in infected and uninfected bee larvae. From 64 primer combinations, over 7,400 transcriptionally-derived fragments were obtained A total of 98 reproducible polymorphic cDNA-AFLP fragments were excised and sequenced, followed by quantitative real-time RT-PCR (qRT-PCR) analysis of these and additional samples. We have identified a number of differentially-regulated transcripts that are implicated in general mechanisms of stress adaptation, including energy metabolism and protein transport. One of the most interesting differentially-regulated transcripts is for a chitinase-like enzyme that may be linked to anti-fungal activities in the honey bee larvae, similarly to gut and fat-body specific chitinases found in mosquitoes and the red flour beetle. Surprisingly, we did not find many components of the well-characterized NF-κB intracellular signaling pathways to be differentially-regulated using the cDNA-AFLP approach. Therefore, utilizing qRT-PCR, we probed some of the immune related genes to determine whether the lack of up-regulation of their transcripts in our analysis can be attributed to lack of immune activation or to limitations of the cDNA-AFLP approach. Conclusions Using a combination of cDNA-AFLP and qRT-PCR analyses, we were able to determine several key transcriptional events that constitute the overall effort in the honey bee larvae to fight natural fungal infection. Honey bee transcripts identified in this study are involved in critical functions related to transcriptional regulation, apoptotic degradation of ubiquitinated proteins, nutritional regulation, and RNA processing. We found that immune regulation of the anti-fungal responses in honey bee involves highly coordinated activation of both NF-κB signaling pathways, leading to production of anti-microbial peptides. Significantly, activation of immune responses in the infected bee larvae was associated with down-regulation of major storage proteins, leading to depletion of nutritional resources.

The Adventures of Sir Galahad premiered as America's atomic narrative shifted from global cooperation to nuclear superiority. This Arthurian Western marked the beginning of Hollywood's Cold War engagement with the Arthurian legend, participating in the nation's nuclear discussion as it offered its audience a therapeutic narrative to ameliorate their atomic anxiety. (SA). [ABSTRACT FROM AUTHOR]

Ernest Cline's Ready Player One (2011) is a Grail tale for the Twitter-PS4-Wii generation masquerading as a postmodern techno-bildungsroman. [ABSTRACT FROM AUTHOR]

William Byron Forbush founded The Queens of Avalon in 1894 as a parallel organization to his Knights of the Round Table, to construct courtly ladies worthy of his chivalric knights. This essay examines the group's interpretation of Arthurian legend, founding principles, rituals and material culture in the context of Forbush's own anxieties about 'modern' girls and larger early-twentieth-century discussions of the 'girl problem.' For Forbush, the Queens of Avalon was the perfect 'antidote' to this problem as it returned girls to an idealized medieval past to teach them to perform their 'role in modern chivalry': inspiring and refining knights. [ABSTRACT FROM AUTHOR]

Summary: Objective: To investigate whether early changes in biochemical markers of bone (NTX-I) and cartilage (CTX-II [C-terminal crosslinking telopeptide of type II collagen]) degradation are associated with radiological progression in patients with knee osteoarthritis (OA) receiving risedronate. Design: Two thousand four hundred and eighty three patients with medial compartment knee OA were randomized in two 24-month studies in North America (NA) and European Union (EU). Studies evaluated risedronate 5mg/day, 35mg/week (EU), 50mg/week (NA), and 15mg/day (NA and EU), compared to placebo in reducing signs and symptoms and in slowing radiographic progression. One thousand eight hundred and eighty five patients from the pooled EU and NA studies with available NTX-I/CTX-II at both baseline and 6 months and radiographs at baseline and at 24 months were analyzed. Results: Risedronate produced a dose-dependent reduction of NTX-I and CTX-II observed at 6 months which continued up to 24 months. Patients who had CTX-II levels returned to low levels (<150ng/mmol creatinine) at 6 months had a lower risk of radiographic progression at 24 months than patients whose CTX-II levels were increased both at baseline and 6 months [odds-ratio (95% confidence interval): 0.57 (0.39–0.85) after adjustment for demographics and joint space width]. The lowest risk of progression was observed in patients who had low CTX-II levels both at baseline and at 6 months [odds-ratio 0.36 (0.21–0.63)]. No significant association between NTX-I levels and radiological progression was observed. Conclusion: CTX-II decreased with risedronate in patients with knee OA and levels reached after 6 months were associated with radiological progression at 24 months. Monitoring a marker of cartilage degradation 6 months after initiating treatment may be instructive in identifying patients with low progression. [Copyright &y& Elsevier]

This article focuses on the study of Celtic literature and culture as done by Matthew Arnold. He emerged as a major spokesmen and champion of Celtic literature and culture, using his influence to establish a Chair of Celtic Studies at Oxford. Arnold's philologically based Celtic Studies, both appropriated the Celtic past and, by removing the culture from its political and historical context, denied it a political future. The author informs that from the time of Sir John Rhys, the first professor to inhabit the Chair of Celtic at Oxford to the present, the native scholars of Celtic Studies have used philology for their own counter-colonial ends.

The article provides remarks given at Columbia Law School on October 19, 2002 for the luncheon to honor the 75th anniversary of women at Columbia. There is reference to the importance of the admission of a few women to the school in 1927. The speakers discussed their feelings about assuming positions of power in the field of law. Speaker Barbara Aronstein Black spoke about her role as a professor at Yale Law School and how she served as dean in 1985 at Columbia. She stresses her devotion to Columbia as an institution of higher learning and intellectual enrichment. Notes are made about speeches of women such as justices Ruth Ginsburg and Mary Robinson.

Cell lines were established from spleen and heart tissues of a juvenile white sturgeon Acipenser transmontanus and designated WSS-2 and WSH-1, respectively. Isoenzyme analyses of both lines confirmed their host of origin. Both lines were hypotetraploid and possessed micro- and macrochromosomes. The modal chromosome number for the WSS-2 line was 219; the WSH-1 line had a bimodal distribution with modes of 237 and 243. The effects of temperature on growth and susceptibility to selected viral pathogens were examined for the WSS-2 line. Cell replication occurred at 15-30°C, optimum temperature was 25°C. Cell survival was observed after 11 d at 10°C but not at 35°C. The WSS-2line was refractory to infections with channel catfish virus (CCV) and infectious pancreatic necrosis virus (IPNV) but susceptible to infectious hematopoietic necrosis virus (IHNV) and white sturgeon iridovirus (WSIV). The need for cell lines from the host of origin in studies of viral pathogens of fish was demonstrated by the ability of the WSS-2 line to support replication of WSIV. [ABSTRACT FROM AUTHOR]

Understanding the nanoscale chemical speciation of heterogeneous systems in their native environment is critical for several disciplines such as life and environmental sciences, biogeochemistry, and materials science. Synchrotron-based X-ray spectromicroscopy tools are widely used to understand the chemistry and morphology of complex material systems owing to their high penetration depth and sensitivity. The multidimensional (4D+) structure of spectromicroscopy data poses visualization and data-reduction challenges. This paper reports the strategies for the visualization and analysis of spectromicroscopy data. We created a new graphical user interface and data analysis platform named XMIDAS (X-ray multimodal image data analysis software) to visualize spectromicroscopy data from both image and spectrum representations. The interactive data analysis toolkit combined conventional analysis methods with well-established machine learning classification algorithms (e.g. nonnegative matrix factorization) for data reduction. The data visualization and analysis methodologies were then defined and optimized using a model particle aggregate with known chemical composition. Nanoprobe-based X-ray fluorescence (nano-XRF) and X-ray absorption near edge structure (nano-XANES) spectromicroscopy techniques were used to probe elemental and chemical state information of the aggregate sample. We illustrated the complete chemical speciation methodology of the model particle by using XMIDAS. Next, we demonstrated the application of this approach in detecting and characterizing nanoparticles associated with alveolar macrophages. Our multimodal approach combining nano-XRF, nano-XANES, and differential phase-contrast imaging efficiently visualizes the chemistry of localized nanostructure with the morphology. We believe that the optimized data-reduction strategies and tool development will facilitate the analysis of complex biological and environmental samples using X-ray spectromicroscopy techniques., (© The Author(s) 2022. Published by Oxford University Press.)

The speciation, oxidation states, and relative abundance of iron (Fe) phases in PM 2.5 samples from two locations in urban Los Angeles were investigated using a combination of bulk and spatially resolved, element-specific spectroscopy and microscopy methods. Synchrotron X-ray absorption spectroscopy (XAS) of bulk samples in situ (i.e., without extraction or digestion) was used to quantify the relative fractions of major Fe phases, which were corroborated by spatially resolved spectro-microscopy measurements. Ferrihydrite (amorphous Fe(III)-hydroxide) comprised the largest Fe fraction (34-52%), with hematite (α-Fe 2 O 3 ; 13-23%) and magnetite (Fe 3 O 4 ; 10-24%) identified as major crystalline oxide components. An Fe-bearing phyllosilicate fraction (16-23%) was fit best with a reference spectrum of a natural illite/smectite mineral, and metallic Fe(0) was a relatively small (2-6%) but easily identified component. Sizes, morphologies, oxidation state, and trace element compositions of Fe-bearing PM from electron microscopy, electron energy loss spectroscopy (EELS), and scanning transmission X-ray microscopy (STXM) revealed variable and heterogeneous mixtures of Fe species and phases, often associated with carbonaceous material with evidence of surface oxidation. Ferrihydrite (or related Fe(III) hydroxide phases) was ubiquitous in PM samples. It forms as an oxidation or surface alteration product of crystalline Fe phases, and also occurs as coatings or nanoparticles dispersed with other phases as a result of environmental dissolution and re-precipitation reactions. The prevalence of ferrihydrite (and adsorbed Fe(III) has likely been underestimated in studies of ambient PM because it is non-crystalline, non-magnetic, more soluble than crystalline phases, and found in complex mixtures. Review of potential sources of different particle types suggests that the majority of Fe-bearing PM from these urban sites originates from anthropogenic activities, primarily abrasion products from vehicle braking systems and engine emissions from combustion and/or wear. These variable mixtures have a high probability for electron transfer reactions between Fe, redox-active metals such as copper, and reactive carbon species such as quinones. Our findings suggest the need to assess biological responses of specific Fe-bearing phases both individually and in combination to unravel mechanisms of adverse health effects of particulate Fe., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.