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Advancing Conversations is a line of interview books documenting conversations with artists, authors, philosophers, economists, scientists, and activists whose works are aimed at the future and at progress. The biogerontologist Aubrey de Grey, as the world's pre-eminent longevity advocate, is nothing if not future oriented. De Grey is the founder of the SENS Research Foundation, an organization developing medical interventions to repair the damage the body does to itself over time. Stated more directly, Aubrey de Grey and his organization aim to defeat aging. In 2005 a panel of scientists and doctors from MIT, Brigham and Women's Hospital in Boston, Microsoft, and the Venter Institute participated in a contest to judge whether de Grey's'Strategies for Engineered Negligible Senescence'were worthy of debate and verification or whether these ideas were wrong on their face. The panel found that de Grey's proposals for intervening in the aging process, while speculative, often'ran parallel to existing research'and were not'demonstrably wrong.'

“Ending Aging guides the reader through a maze of advances in molecular and cellular biology that could lead to anti-aging therapies.” —Dr. Judy Illes, NatureNearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.“The authors explore the nitty-gritty of how we age and posit an audacious blueprint for cheating the reaper.” —Janet Cromley, Los Angeles Times