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2 results on '"Baaij, J.H.F. de"'

1. Comment to 'Recommendation on an updated standardization of serum magnesium reference ranges'

Author

Baaij, J.H.F. de, Bockenhauer, D., Claverie-Martin, F., Hoenderop, J.G.J., Hoorn, E.J., Houillier, P., Knoers, N.V.A.M., Konrad, M., Müller, D., Nijenhuis, T., Schlingmann, K.P., Vargas Poussou, R., and Internal Medicine

Subjects
Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nutrition and Dietetics, Medicine (miscellaneous)
Abstract

Contains fulltext : 283448.pdf (Publisher’s version ) (Closed access)

Published
2022
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2. Chloride-sensitive signaling turns the potassium switch on

Author

Hoorn, E.J., Baaij, J.H.F. de, and Internal Medicine

Subjects
Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Nephrology
Abstract

Item does not contain fulltext The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation. 01 november 2022

Published
2022

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