89 results on '"Bayona M"'
Search Results
2. Correction to: A lead isotope database for copper mineralization along the Guadalquivir River Valley and surrounding areas
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Sáez, R., Nocete, F., Gil Ibarguchi, J. I., Rodríguez-Bayona, M., Inacio, N., Quispe, D., Rodríguez, J., and Zalduegui, J. F. Santos
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- 2021
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Catalog
3. An exploration of older adults' constructions of their experiences of sexuality
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Garcia-Bayona, M. E.va
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155.3 - Published
- 1998
4. Comparative prevalence of sensitization to common animal, plant and mould allergens in subjects with asthma, or atopic dermatitis and/or allergic rhinitis living in a tropical environment
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Montealegre, F., Meyer, B., Chardon, D., Vargas, W., Zavala, D., Hart, B., and Bayona, M.
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- 2004
5. The dynamics of interactions between Plasmodium and the mosquito: a study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti
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Alavi, Y., Arai, M., Mendoza, J., Tufet-Bayona, M., Sinha, R., Fowler, K., Billker, O., Franke-Fayard, B., Janse, C.J., Waters, A., and Sinden, R.E.
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- 2003
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6. The S & T potential of Mexico and Hungary
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Jiménez, J., Hunya, P., Bayona, M., and Halász, A.
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- 1988
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7. Screening of pharmaceuticals and personal care products in Danish small-scale domestic sewage treatment systems
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Matamoros, V., Carlos A Arias, Hans Brix, and Bayona, M.
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- 2008
8. Corrigendum to “The dynamics of interactions between Plasmodium and the mosquito: a study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti” [International Journal for Parasitology 33 (2003) 933–943]
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Alavi, Y, Arai, M, Mendoza, J, Tufet-Bayona, M, Sinha, R, Fowler, K, Billker, O, Franke-Fayard, B, Janse, C.J, Waters, A, and Sinden, R.E
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- 2004
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9. Blood characterization using UV/vis spectroscopy.
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Mattley, Yvette D., Mitrani-Gold, F., Orton, S., Bacon, Christina P., Leparc, German F., Bayona, M., Potter, Robert L., and Garcia-Rubio, Luis H.
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- 1995
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10. Gender and ethnic differences in survival in a cohort of HIV positive clients.
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Bright PE, Arnett DK, Blair C, and Bayona M
- Abstract
Objectives: The purpose of this study was to examine gender and ethnic differences in survival of persons receiving treatment for HIV infection to determine if differences existed, and if they did, to assess the possibility of explaining these differences by examining other factors, such as age, disease severity when beginning treatment, alcohol, illicit drugs, tobacco, educational level, living arrangements, antiretroviral treatment, PCP prophylaxis, sexually transmitted diseases, mode of transmission and opportunistic infections. Design: A retrospective cohort study of all clients receiving treatment at an HIV only clinic from its opening in early 1988 until the end of May 1993. Statistical methods used to examine the data included incidence density ratios, Kaplan-Meier survival curves, Breslow (generalized Wilcoxon) tests of equality of survival curves and Cox proportional hazards models both with and without time dependent covariates. Results: In the cohort (37% African American, 7% Hispanic American and 25% female), 220 deaths occurred during 1223 person years of follow-up. Compared to European American males, the following incidence density ratios were observed: European American females: 0.50, Hispanic American females: 0.70, Hispanic American males: 0.96, African American females: 1.28 and African American males: 2.38. The differences were noted above for gender/ethnicity groups were significant at the p < 0.0001 level. After adjusting for disease stage (as measured by laboratory testing of CD4 positive T-lymphocytes), educational level, and age, no differences in survival by gender or ethnicity remained. Disease stage and educational level had the greatest prognostic significance. Conclusions: European Americans entered treatment at a much earlier disease stage (as measured by CD4 positive T-lymphocyte counts) and had higher educational levels (a surrogate for socioeconomic status) than African Americans. These factors may explain the longer survival in European Americans as compared to African Americans in this cohort. [ABSTRACT FROM AUTHOR] more...
- Published
- 1996
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11. Morphological Studies of Potato Starch Modified by Grafting Using Mn3+ as Initiator and by Saponification.
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Rodehed, C., Rånby, B., de la Bayona, M., and Mehrotra, R.
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- 1985
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12. High rates of autoimmune, intestinal and endocrine disorders among women with endometriosis in Puerto Rico
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Fourquet, J.A., Abac, S., Laboy, J., Bayona, M., and Flores, I.
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- 2008
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13. The role of the α-1-protease inhibitor in Puerto Rican high frequency ED asthmatics: A pilot study
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Montealegre, F.J., Bayona, M., Delgado, A., Vargas, W., Chardon, D., and Zavala, D.
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- 2005
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14. The association of DNA Repair with breast cancer risk in women. A comparative observational study
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Matta Jaime, Echenique Miguel, Negron Esperanza, Morales Luisa, Vargas Wanda, Gaetan Felipe Sánchez, Lizardi Eduardo Ramírez, Torres Aníbal, Rosado Jose Ortiz, Bolaños Guillermo, Cruz Juan González, Laboy Joaquín, Barnes Ricardo, Medina Santos Santiago, Romero Ángel, Martinez Rosendo, Dutil Julie, Suarez Erick, Alvarez-Garriga Carolina, and Bayona Manuel more...
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Breast cancer ,DNA repair capacity ,Association ,Risk ,Biomarker ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological study in a Hispanic community. Methods We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously. Results Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (p < 0.0001). Conclusions Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness. more...
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- 2012
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15. High blood pressure in school children: prevalence and risk factors
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Rivers Patrick A, Bayona Manuel, Menchaca John, Bae Sejong, Egbuchunam Christie U, Urrutia-Rojas Ximena, and Singh Karan P
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Pediatrics ,RJ1-570 - Abstract
Abstract Background The purpose of this study was to determine the prevalence of high blood pressure (HBP) and associated risk factors in school children 8 to 13 years of age. Methods Elementary school children (n = 1,066) were examined. Associations between HBP, body mass index (BMI), gender, ethnicity, and acanthosis nigricans (AN) were investigated using a school based cross-sectional study. Blood pressure was measured and the 95th percentile was used to determine HBP. Comparisons between children with and without HBP were utilized. The crude and multiple logistic regression adjusted odds ratios were used as measures of association. Results Females, Hispanics, overweight children, and children with AN had an increased likelihood of HBP. Overweight children (BMI ≥ 85th percentile) and those with AN were at least twice as likely to present with HBP after controlling for confounding factors. Conclusion Twenty one percent of school children had HBP, especially the prevalence was higher among the overweight and Hispanic group. The association identified here can be used as independent markers for increased likelihood of HBP in children. more...
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- 2006
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16. Using GIS technology to identify areas of tuberculosis transmission and incidence
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Jost Kenneth C, Dunbar Denise, Oppong Joseph, Quitugua Teresa N, Bayona Manuel, Moonan Patrick K, Burgess Gerry, Singh Karan P, and Weis Stephen E
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Currently in the U.S. it is recommended that tuberculosis screening and treatment programs be targeted at high-risk populations. While a strategy of targeted testing and treatment of persons most likely to develop tuberculosis is attractive, it is uncertain how best to accomplish this goal. In this study we seek to identify geographical areas where on-going tuberculosis transmission is occurring by linking Geographic Information Systems (GIS) technology with molecular surveillance. Methods This cross-sectional analysis was performed on data collected on persons newly diagnosed with culture positive tuberculosis at the Tarrant County Health Department (TCHD) between January 1, 1993 and December 31, 2000. Clinical isolates were molecularly characterized using IS6110-based RFLP analysis and spoligotyping methods to identify patients infected with the same strain. Residential addresses at the time of diagnosis of tuberculosis were geocoded and mapped according to strain characterization. Generalized estimating equations (GEE) analysis models were used to identify risk factors involved in clustering. Results Evaluation of the spatial distribution of cases within zip-code boundaries identified distinct areas of geographical distribution of same strain disease. We identified these geographical areas as having increased likelihood of on-going transmission. Based on this evidence we plan to perform geographically based screening and treatment programs. Conclusion Using GIS analysis combined with molecular epidemiological surveillance may be an effective method for identifying instances of local transmission. These methods can be used to enhance targeted screening and control efforts, with the goal of interruption of disease transmission and ultimately incidence reduction. more...
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- 2004
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17. Content-based image nesting.
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Puigardeu, Sergio, Martinez, Angel, and Bayona, M. Isabel Borrell
- Abstract
The article discusses an image printing process called content-based image nesting. Cited are the relevant features in inkjet printing which are image quality (IQ) and usability. An automatic printmode selection algorithm is applied after the images are classified based on their content in such a way that simple content images can be printed with a high throughput printmode while maintaining an acceptable IQ level, and complex content images are printed with a low throughput printmode. more...
- Published
- 2009
18. A comparison of the impact of anti-IL5/5r therapies in allergic versus non-allergic patients with severe eosinophilic asthma in a real-life setting.
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Navarro-Cascales T, Colque-Bayona M, Fernandez-Concha I, Laorden D, Quirce S, and Domínguez-Ortega J
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- Humans, Male, Female, Retrospective Studies, Middle Aged, Adult, Interleukin-5 antagonists & inhibitors, Interleukin-5 immunology, Receptors, Interleukin-5 antagonists & inhibitors, Receptors, Interleukin-5 immunology, Severity of Illness Index, Respiratory Function Tests, Aged, Treatment Outcome, Hypersensitivity drug therapy, Asthma drug therapy, Asthma immunology, Antibodies, Monoclonal, Humanized therapeutic use, Antibodies, Monoclonal, Humanized administration & dosage, Anti-Asthmatic Agents therapeutic use, Anti-Asthmatic Agents administration & dosage
- Abstract
Objective: This study aimed to compare the clinical characteristics and treatment outcomes of allergic patients (AP) and non-allergic patients (NAP) with severe eosinophilic asthma (SEA) treated with anti-IL5/IL5R biologic agents (mepolizumab, benralizumab, or reslizumab) over one year. Sub-analyses assessed treatment response variations between AP and NAP based on the biological used and compared outcomes among AP with and without fungal allergy., Methods: Observational retrospective analysis. Clinical characteristics, laboratory findings, pulmonary function tests, Asthma Control Test (ACT) scores, oral corticosteroid (OCS) usage, and exacerbation frequency were assessed at the initiation of biological treatment and after one year., Results: Sixty-five patients with SEA were included, 41 AP and 24 NAP. 55.4% were treated with mepolizumab, 33.8% with benralizumab, and 10.8% with reslizumab. Before anti-IL5/5R treatment, AP had worse baseline outcomes but there were no differences in pulmonary function. Mean annual exacerbation rate and percentage of patients requiring OCS and dose of prednisone were higher in AP than NAP. AP had significantly higher total IgE values. After one year of treatment, more AP discontinued OCS than NAP ( p = 0.025). Both experienced a significant reduction in exacerbation frequency ( p = 0.001) and improved respiratory function. 70.7% of AP and 60% of NAP improved ACT ≥3 points. There was no significant difference between AP and NAP using mepolizumab ( p = 0.145) or benralizumab ( p = 0.174) in reducing OCS., Conclusions: Anti-IL5/IL5R reduced the need for OCS and improved asthma control, regardless of allergic status. Fungal allergy led to lower ACT scores and higher exacerbations than other allergens; both groups improved with anti-IL5/ILR. more...
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- 2025
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19. Sensitization to Quercus ilex Pollen Is Clinically Relevant in Patients With Seasonal Pollen Allergy.
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Lluch-Bernal M, Pedrosa M, Domínguez-Ortega J, Colque-Bayona M, Correa-Borit J, Phillips-Anglés E, Gómez-Traseira C, Quirce S, and Rodríguez-Pérez R
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- 2024
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20. Global influence of dupilumab on Quality of Life in a severe asthma patient with T2 multimorbidities: a case report on atopic dermatitis, chronic rhinosinusitis with nasal polyposis, and eosinophilic esophagitis.
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Colque-Bayona M, Hernández-Cano N, Tomás-Pérez M, Caballero T, Quirce S, and Domínguez-Ortega J
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- Humans, Chronic Disease, Male, Interleukin-13 antagonists & inhibitors, Interleukin-13 immunology, Multimorbidity, Interleukin-4 antagonists & inhibitors, Interleukin-4 immunology, Adult, Female, Rhinosinusitis, Antibodies, Monoclonal, Humanized therapeutic use, Quality of Life, Sinusitis drug therapy, Sinusitis complications, Nasal Polyps drug therapy, Nasal Polyps complications, Nasal Polyps immunology, Asthma drug therapy, Dermatitis, Atopic drug therapy, Dermatitis, Atopic complications, Rhinitis drug therapy, Eosinophilic Esophagitis drug therapy
- Abstract
Introduction: Interleukin (IL)-4 and IL-13 are considered key drivers of type 2 inflammatory diseases. Dupilumab is a fully human monoclonal antibody that blocks the shared receptor component for IL-4 and IL-13, thus inhibiting signaling of both cytokines., Case Study: We report a case of a patient with uncontrolled severe asthma and other T2 inflammatory diseases (atopic dermatitis, chronic rhinosinusitis with nasal polyposis and eosinophilic esophagitis) treated with dupilumab., Results: After one year of treatment, dupilumab improved asthma control together with lung function parameters and airway inflammation. Additionally, a positive impact on quality of life (QoL), evaluated by validated questionnaires, across all the diseases was observed., Conclusion: In this case report, a positive and objectively measurable of global improvement on QoL across all four T2 comorbidities was observed after treatment with dupilumab, demonstrating the important role of IL-4 and IL-13 and the existence of a unifying pathological mechanism in T2 diseases. more...
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- 2024
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21. Facilitating the development of urgently required combination vaccines.
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Hausdorff WP, Madhi SA, Kang G, Kaboré L, Tufet Bayona M, and Giersing BK
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- Humans, Vaccine Development, Health Policy, Vaccines, Combined
- Abstract
The essence of a vaccine lies in its ability to elicit a set of immune responses specifically directed at a particular pathogen. Accordingly, vaccines were historically designed, developed, registered, recommended, procured, and administered as monopathogen formulations. Nonetheless, the control and elimination of an astonishing number of diseases was realised only after several once-separate vaccines were provided as combinations. Unfortunately, the current superabundance of recommended and pipeline vaccines is now at odds with the number of acceptable vaccine administrations and feasible health-care visits for vaccine recipients and health-care providers. Yet, few new combinations are in development because, in addition to the scientific and manufacturing hurdles intrinsic to coformulation, developers face a gauntlet of regulatory, policy, and commercialisation obstacles in a milieu still largely designed for monopathogen vaccines. We argue here that national policy makers and public health agencies should prospectively identify and advocate for the development of new multipathogen combination vaccines, and suggest ways to accelerate the regulatory pathways to licensure of combinations and other concrete, innovative steps to mitigate current obstacles., Competing Interests: Declaration of interests WPH reports receiving a travel grant from GSK. SAM reports receiving funds from the Bill & Melinda Gates Foundation, GSK, Pfizer, Minervax, Novavax, Merck, Providence, Gritstone, and Immunity Bio. All other authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.) more...
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- 2024
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22. Telemedicine for Screening and Follow-Up of Glaucoma: A Descriptive Study.
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Lozano AC, Serrano A, Salazar D, Rincón JV, and Pardo Bayona M
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- Humans, Female, Male, Middle Aged, Retrospective Studies, Colombia, Aged, Adult, SARS-CoV-2, Referral and Consultation statistics & numerical data, Referral and Consultation organization & administration, Mass Screening organization & administration, Mass Screening methods, Aged, 80 and over, COVID-19 epidemiology, Telemedicine organization & administration, Glaucoma diagnosis, Glaucoma therapy
- Abstract
Introduction: Glaucoma is a leading cause of irreversible blindness. It is a prevalent disease worldwide, affecting ∼70 million people and expected to reach up to 112 million by 2040. Purpose: The aim of this study is to describe the implementation and initial experience of a telemedicine program to monitor glaucoma and glaucoma suspect patients in a large, integrated health care system during the COVID-19 pandemic. Methods: A retrospective chart review of established glaucoma or glaucoma suspect patients who participated in a telemedicine evaluation at the ophthalmic center of a large, Colombian health care system between June 2020 and April 2023 was conducted. Clinical and sociodemographic variables were analyzed. Generated clinical orders for additional testing, surgical procedures, follow-ups, and referrals, as well as changes in medical treatment, were evaluated. Results: A total of 11,034 telemedicine consults were included. The mean ± standard deviation age of this group was 63 ± 17.2 years and 67% were female. Of the patients who attended teleconsults, 49% were glaucoma suspects and 38.5% were followed with a diagnosis of open-angle glaucoma. After the consult, 25% of patients were referred to a glaucoma specialist, 40% had additional testing ordered, and 8% had a surgical procedure ordered, mainly laser iridotomy (409 cases). Almost a third of patients returned for subsequent telemedicine visits after the initial encounter. Despite some technical difficulties, 99.8% of patients attended and completed their scheduled telemedicine appointments. Conclusions: A telemedicine program aimed to monitor established glaucoma patients can be successfully implemented. Established patients within an integrated health care system have high adherence to the virtual model. Further research by health care institutions and government agencies will be key to expand coverage to additional populations. Clinical Trial Registration Number: CEIFUS 1026-24. more...
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- 2024
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23. The Full Value of Vaccine Assessments Concept-Current Opportunities and Recommendations.
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White RG, Menzies NA, Portnoy A, Clark RA, Toscano CM, Weller C, Tufet Bayona M, Silal SP, Karron RA, Lee JS, Excler JL, Lauer JA, Giersing B, Lambach P, Hutubessy R, and Jit M
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For vaccine development and adoption decisions, the 'Full Value of Vaccine Assessment' (FVVA) framework has been proposed by the WHO to expand the range of evidence available to support the prioritization of candidate vaccines for investment and eventual uptake by low- and middle-income countries. Recent applications of the FVVA framework have already shown benefits. Building on the success of these applications, we see important new opportunities to maximize the future utility of FVVAs to country and global stakeholders and provide a proof-of-concept for analyses in other areas of disease control and prevention. These opportunities include the following: (1) FVVA producers should aim to create evidence that explicitly meets the needs of multiple key FVVA consumers, (2) the WHO and other key stakeholders should develop standardized methodologies for FVVAs, as well as guidance for how different stakeholders can explicitly reflect their values within the FVVA framework, and (3) the WHO should convene experts to further develop and prioritize the research agenda for outcomes and benefits relevant to the FVVA and elucidate methodological approaches and opportunities for standardization not only for less well-established benefits, but also for any relevant research gaps. We encourage FVVA stakeholders to engage with these opportunities. more...
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- 2024
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24. Letter to the editor analysing a study about diabetes mellitus.
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Ursúa EU, Aldea A, Bayona M, and Oliván PM
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- Humans, Diabetes Mellitus, Type 2, Diabetes Mellitus
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- 2024
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25. Anti-IL5/5R in the treatment of chronic eosinophilic pneumonia and severe asthma.
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Colque-Bayona M, Laorden D, Romero D, Quirce S, and Domínguez-Ortega J
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- 2024
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26. Climate and health strategies must take vaccination into account.
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Jadeja N, Omumbo J, Adelekan I, Rees H, Bonfoh B, Kariuki T, and Tufet Bayona M
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- Vaccination, Climate
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- 2023
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27. Vaccine Value Profiles.
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Giersing B, Karron R, Tufet-Bayona M, Trotter C, Lambach P, and Jit M
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- Vaccines, Cost-Benefit Analysis
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- 2023
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28. Cat and dog specific immunotherapy impact on quality of life and self-reported satisfaction in a real-world setting.
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Colque-Bayona M, Dominguez-Ortega J, and Tomás-Pérez M
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- 2023
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29. Challenges and opportunities in developing a Shigella-containing combination vaccine for children in low- and middle-income countries: Report of an expert convening.
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Riddle MS, Louis Bourgeois A, Clifford A, Jeon S, Giersing BK, Jit M, Tufet Bayona M, Ovitt J, and Hausdorff WP
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- Infant, Child, Humans, Developing Countries, Diarrhea prevention & control, Vaccines, Combined, Shigella Vaccines, Dysentery, Bacillary, Escherichia coli Infections prevention & control, Enterotoxigenic Escherichia coli, Shigella
- Abstract
The gram-negative bacterium Shigella is an enteric pathogen responsible for significant morbidity and mortality due primarily to severe diarrhea and dysentery, mainly among children younger than five years of age living in low- and middle-income countries (LMICs). Long considered a priority target for vaccine development, recent scientific advances have led to a number of promising Shigella vaccine candidates now entering advanced stages of clinical testing. Yet, there is no guarantee that even a highly efficacious Shigella vaccine will be recommended, prioritized, purchased, and widely adopted-especially if it requires additional doses in the immunization schedule and/or visits within the immunization program. This uncertainty is due to a variety of factors, including continuing declines in Shigella-specific and overall diarrheal disease mortality rates, the increasing complexity and cost of infant immunization programs in LMICs, and the recent availability of other high-priority vaccines. Since combining a Shigella vaccine with an existing infant vaccine would conceivably increase its attractiveness, there is a need to systematically consider the challenges determining the public health value, clinical development, manufacturing, licensure, policy recommendations, and financing for a Shigella-containing combination vaccine. The international non-governmental health organization PATH convened an independent panel of 34 subject matter experts across academic, industry, philanthropic, and global health sectors to discuss hypothetical combinations of a notional parenteral Shigella vaccine with three existing vaccines in order to begin exploring the challenges associated with their development. The resulting insights and recommendations from this meeting contribute to PATH's broader effort to evaluate the public health value of potential Shigella vaccines. They may also help guide future combination vaccine development efforts more broadly., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mark S. Riddle reports financial support was provided by PATH. Mark S. Riddle reports a relationship with LimmaTech Biologics AG that includes: consulting or advisory. Jared Ovitt reports financial support was provided by PATH., (Copyright © 2023.) more...
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- 2023
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30. A living mapping review for COVID-19 funded research projects: one year update.
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Norton A, Bucher A, Antonio E, Advani N, Johnston C, Grund H, Mburu S, Clegg E, Gollish M, Sahota S, Jabin N, Scott L, Boily-Larouche G, Lay AM, Carson G, and Tufet Bayona M
- Abstract
Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There is however a need for greater coordination, with limited resources and the shifting global nature of the pandemic resulting in a proliferation of research projects underpowered and unable to achieve their aims. Methods: The UK Collaborative on Development Research (UKCDR) and Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), two funder coordination groups have collaborated to develop a live database of funded research projects across the world relating to COVID-19. Drawing data continually from their members and further global funding bodies, as of 15
th July 2021 the database contains 12,419 projects, funded by 255 funders, taking place across 149 countries representing an investment of at least $4.9 billion. To our knowledge it is one of the most comprehensive databases. The database is aligned to the World Health Organisation and GloPID-R Global Research Roadmap: 2019 Novel Coronavirus. It is being used by the WHO, governments and multi-lateral policy makers, research funders and researchers. This living mapping review aims to supplement the database by providing an open accessible and frequently updated resource summarising the characteristics of the COVID-19 funded research portfolio. Both descriptive and thematic analysis will be presented and updated frequently to aid interpretation of the global COVID-19 funded research portfolio. Results: In this version five analysis we provide an updated detailed descriptive analysis of the database (three months after version four) and focus our thematic analysis on research gaps, research areas in need of coordination, study populations and research locations (with a focus on resource-limited countries). Conclusions: As the global funding response to COVID-19 plateaus, this living mapping review helps both funders and researchers to prioritise resources to areas where there is continued unmet research need., Competing Interests: Competing interests: GB-L and AML are both employed by the Canadian Institutes of Health Research funder and undertook this work as a contribution to GloPID-R’s work. The other authors declare no competing interests., (Copyright: © 2022 Norton A et al.) more...- Published
- 2022
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31. A living mapping review for COVID-19 funded research projects: nine-month update.
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Norton A, Bucher A, Antonio E, Advani N, Grund H, Mburu S, Clegg E, Gollish M, Jabin N, Scott L, Boily-Larouche G, Lay AM, Carson G, and Tufet Bayona M
- Abstract
Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There is however a need for greater coordination, with limited resources and the shifting global nature of the pandemic resulting in a proliferation of research projects underpowered and unable to achieve their aims., Methods: The UK Collaborative on Development Research (UKCDR) and Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), two funder coordination groups have collaborated to develop a live database of funded research projects across the world relating to COVID-19. Drawing data continually from their members and further global funding bodies, as of 15th April 2021 the database contains 10,608 projects, funded by 201 funders, taking place across 142 countries representing an investment of at least $4.7 billion. To our knowledge it is one of the most comprehensive databases. The database is aligned to the World Health Organisation and GloPID-R Global Research Roadmap: 2019 Novel Coronavirus. It is being used by the WHO, governments and multi-lateral policy makers, research funders and researchers. This living mapping review aims to supplement the database by providing an open accessible and frequently updated resource summarising the characteristics of the COVID-19 funded research portfolio. Both descriptive and thematic analysis will be presented and updated frequently to aid interpretation of the global COVID-19 funded research portfolio., Results: In this version four analysis we provide an updated detailed descriptive analysis of the database (three months after version three) and focus our thematic analysis on research gaps, research areas in need of coordination, study populations and research locations (with a focus on resource-limited countries)., Conclusions: As the global funding response to COVID-19 plateaus, this living mapping review helps both funders and researchers to prioritise resources to areas where there is continued unmet research need., Competing Interests: Competing interests: GB-L and AML are both employed by the Canadian Institutes of Health Research funder and undertook this work as a contribution to GloPID-R’s work. The other authors declare no competing interests., (Copyright: © 2021 Norton A et al.) more...
- Published
- 2021
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32. A living mapping review for COVID-19 funded research projects: six-month update.
- Author
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Norton A, Bucher A, Antonio E, Advani N, Grund H, Mburu S, Clegg E, Gollish M, Jabin N, Scott L, Boily-Larouche G, Lay AM, Carson G, and Tufet Bayona M
- Abstract
Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There is however a need for greater coordination, with limited resources and the shifting global nature of the pandemic resulting in a proliferation of research projects underpowered and unable to achieve their aims. Methods: The UK Collaborative on Development Research (UKCDR) and Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), two funder coordination groups have collaborated to develop a live database of funded research projects across the world relating to COVID-19. Drawing data continually from their members and further global funding bodies, as of 15
th January 2021 the database contains 7,778 projects, funded by 101 funders, taking place across 136 countries representing an investment of at least $3.8 billion. To our knowledge it is one of the most comprehensive databases. The database is aligned to the World Health Organisation (WHO) Global Research Roadmap: 2019 Novel Coronavirus. It is being used by the WHO, governments and multi-lateral policy makers, research funders and researchers. This living mapping review aims to supplement the database by providing an open accessible and frequently updated resource summarising the characteristics of the COVID-19 funded research portfolio. Both descriptive and thematic analysis will be presented and updated frequently to aid interpretation of the global COVID-19 funded research portfolio. Results: In this version three analysis we provide an updated detailed descriptive analysis of the database (three months after version two) and focus our thematic analysis on research gaps, research areas in need of coordination, study populations and research locations (with a focus on resource-limited countries). Conclusions: As the global funding response to COVID-19 plateaus, this living mapping review helps both funders and researchers to prioritise resources to areas where there is continued unmet research need., Competing Interests: Competing interests: GB-L and AML are both employed by the Canadian Institutes of Health Research funder and undertook this work as a contribution to GloPID-R’s work. The other authors declare no competing interests., (Copyright: © 2021 Norton A et al.) more...- Published
- 2021
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33. A living mapping review for COVID-19 funded research projects: three-month update.
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Norton A, Bucher A, Antonio E, Advani N, Grund H, Mburu S, Clegg E, Scott L, Boily-Larouche G, Lay AM, Carson G, and Tufet Bayona M
- Abstract
Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There is however a need for greater coordination, with limited resources and the shifting global nature of the pandemic resulting in a proliferation of research projects underpowered and unable to achieve their aims. Methods: The UK Collaborative on Development Research (UKCDR) and Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), two funder coordination groups have collaborated to develop a live database of funded research projects across the world relating to COVID-19. Drawing data continually from their members and further global funding bodies, as of 15
th October 2020 the database contains 5,084 projects, funded by 71 funders, taking place across 134 countries representing an investment of at least $1.7 billion. To our knowledge it is one of the most comprehensive databases, covering a wide breadth of research disciplines. The database is aligned to the World Health Organisation (WHO) Global Research Roadmap: 2019 Novel Coronavirus. It is being used by the WHO, governments and multi-lateral policy makers, research funders and researchers. This living mapping review aims to supplement the database by providing an open accessible and frequently updated resource summarising the characteristics of the COVID-19 funded research portfolio. Both descriptive and thematic analysis will be presented and updated frequently to aid interpretation of the global COVID-19 funded research portfolio. Results: In this three-month update analysis we provide an updated detailed descriptive analysis of the database and focus our thematic analysis on research gaps, research areas in need of coordination, study populations and research locations (with a focus on resource-limited countries). Conclusions: This living mapping review will help both funders and researchers to prioritise resources to underfunded areas where there is greatest research need and facilitate further strategic collaboration., Competing Interests: Competing interests: GB-L and AML are both employed by the Canadian Institutes of Health Research funder and undertook this work as a contribution to GloPID-R’s work. The other authors declare no competing interests., (Copyright: © 2020 Norton A et al.) more...- Published
- 2020
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34. Funding and COVID-19 research priorities - are the research needs for Africa being met?
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Antonio E, Alobo M, Tufet Bayona M, Marsh K, and Norton A
- Abstract
Background : Emerging data from Africa indicates remarkably low numbers of reported COVID-19 deaths despite high levels of disease transmission. However, evolution of these trends as the pandemic progresses remains unknown. More certain are the devastating long-term impacts of the pandemic on health and development evident globally. Research tailored to the unique needs of African countries is crucial. UKCDR and GloPID-R have launched a tracker of funded COVID-19 projects mapped to the WHO research priorities and research priorities of Africa and less-resourced countries and published a baseline analysis of a living systematic review (LSR) of these projects. Methods : In-depth analyses of the baseline LSR for COVID-19 funded research projects in Africa (as of 15th July 2020) to determine the funding landscape and alignment of the projects to research priorities of relevance to Africa. Results : The limited COVID-19 related research across Africa appears to be supported mainly by international funding, especially from Europe, although with notably limited funding from United States-based funders. At the time of this analysis no research projects funded by an African-based funder were identified in the tracker although there are several active funding calls geared at research in Africa and there may be funding data that has not been made publicly available. Many projects mapped to the WHO research priorities and five particular gaps in research funding were identified, namely: investigating the role of children in COVID-19 transmission; effective modes of community engagement; health systems research; communication of uncertainties surrounding mother-to-child transmission of COVID-19; and identifying ways to promote international cooperation. Capacity strengthening was identified as a dominant theme in funded research project plans. Conclusions : We found significantly lower funding investments in COVID-19 research in Africa compared to high-income countries, seven months into the pandemic, indicating a paucity of research targeting the research priorities of relevance to Africa., Competing Interests: No competing interests were disclosed., (Copyright: © 2020 Antonio E et al.) more...
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- 2020
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35. Baseline results of a living systematic review for COVID-19 funded research projects.
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Norton A, Bucher A, Antonio E, Advani N, Grund H, Mburu S, Clegg E, Boily-Larouche G, Lay AM, Carson G, and Tufet Bayona M
- Abstract
Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid research and collaboration. There is however a need for greater coordination, with limited resources and the shifting global nature of the pandemic resulting in a proliferation of research projects underpowered and unable to achieve their aims. Methods: The UK Collaborative on Development Research (UKCDR) and Global Research Collaboration for Infectious Disease Preparedness (GloPID-R), two funder coordination groups have collaborated to develop a live database of funded research projects across the world relating to COVID-19. Drawing data continually from their members and further global funding bodies, as of 15
th July 2020 the database contains 1,858 projects, funded by 25 funders, taking place across 102 countries. To our knowledge it is one of the most comprehensive databases, covering a wide breadth of research disciplines. The database is aligned to the World Health Organisation (WHO) Global Research Roadmap: 2019 Novel Coronavirus. It is being used by the WHO, governments and multi-lateral policy makers, research funders and researchers. This living systematic review aims to supplement the database by providing an open accessible and frequently updated resource summarising the characteristics of the COVID-19 funded research portfolio. Both descriptive and thematic analysis will be presented and updated frequently to aid interpretation of the global COVID-19 funded research portfolio. Results: In this baseline analysis we provide the first detailed descriptive analysis of the database and focus our thematic analysis on research gaps, study populations and research locations (with a focus on resource-limited countries). Conclusions: This living systematic review will help both funders and researchers to prioritise resources to underfunded areas where there is greatest research need and facilitate further strategic collaboration., Competing Interests: Competing interests: GB-L and AML are both employed by the Canadian Institutes of Health Research funder and undertook this work as a contribution to GloPID-R’s work. The other authors declare no competing interests., (Copyright: © 2020 Norton A et al.) more...- Published
- 2020
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36. Use of the six core surgical indicators from the Lancet Commission on Global Surgery in Colombia: a situational analysis.
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Hanna JS, Herrera-Almario GE, Pinilla-Roncancio M, Tulloch D, Valencia SA, Sabatino ME, Hamilton C, Rehman SU, Mendoza AK, Gómez Bernal LC, Salas MFM, Navarro MAP, Nemoyer R, Scott M, Pardo-Bayona M, Rubiano AM, Ramirez MV, Londoño D, Dario-Gonzalez I, Gracias V, and Peck GL more...
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- Colombia, Humans, Societies, Medical, Quality Indicators, Health Care, Surgical Procedures, Operative standards
- Abstract
Background: Surgical, anaesthetic, and obstetric (SAO) health-care system strengthening is needed to address the emergency and essential surgical care that approximately 5 billion individuals lack globally. To our knowledge, a complete, non-modelled national situational analysis based on the Lancet Commission on Global Surgery surgical indicators has not been done. We aimed to undertake a complete situation analysis of SAO system preparedness, service delivery, and financial risk protection using the core surgical indicators proposed by the Commission in Colombia, an upper-middle-income country., Methods: Data to inform the six core surgical system indicators were abstracted from the Colombian national health information system and the most recent national health survey done in 2007. Geographical access to a Bellwether hospital (defined as a hospital capable of providing essential and emergency surgery) within 2 h was assessed by determining 2 h drive time boundaries around Bellwether facilities and the population within and outside these boundaries. Physical 2 h access to a Bellwether was determined by the presence of a motor vehicle suitable for individual transportation. The Department Administrativo Nacional de Estadística population projection for 2016 and 2018 was used to calculate the SAO provider density. Total operative volume was calculated for 2016 and expressed nationally per 100 000 population. The total number of postoperative deaths that occurred within 30 days of a procedure was divided by the total operative volume to calculate the all-cause, non-risk-adjusted postoperative mortality. The proportion of the population subject to impoverishing costs was calculated by subtracting the baseline number of impoverished individuals from those who fell below the poverty line once out-of-pocket payments were accounted for. Individuals who incurred out-of-pocket payments that were more than 10% of their annual household income were considered to have experienced catastrophic expenditure. Using GIS mapping, SAO system preparedness, service delivery, and cost protection were also contextualised by socioeconomic status., Findings: In 2016, at least 7·1 million people (15·1% of the population) in Colombia did not have geographical access to SAO services within a 2 h driving distance. SAO provider density falls short of the Commission's minimum target of 20 providers per 100 000 population, at an estimated density of 13·7 essential SAO health-care providers per 100 000 population in 2018. Lower socioeconomic status of a municipality, as indicated by proportion of people enrolled in the subsidised insurance regime, was associated with a smaller proportion of the population in the municipality being within 2 h of a Bellwether facility, and the most socioeconomically disadvantaged municipalities often had no SAO providers. Furthermore, Colombian providers appear to be working at or beyond capacity, doing 2690-3090 procedures per 100 000 population annually, but they have maintained a relatively low median postoperative mortality of 0·74% (IQR 0·48-0·84). Finally, out-of-pocket expenses for indirect health-care costs were a key barrier to accessing surgical care, prompting 3·1 million (6·4% of the population) individuals to become impoverished and 9·5 million (19·4% of the population) individuals to incur catastrophic expenditures in 2007., Interpretation: We did a non-modelled, indicator-based situation analysis of the Colombian SAO system, finding that it has not yet met, but is working towards achieving, the targets set by the Lancet Commission on Global Surgery. The observed interdependence of these indicators and correlation with socioeconomic status are consistent with well recognised factors and outcomes of social, health, and health-care inequity. The internal consistency observed in Colombia's situation analysis validates the use of the indicators and has now informed development of an early national SAO plan in Colombia, to set a data-informed stage for implementation and evaluation of timely, safe, and affordable SAO health care, within the National Public Health Decennial Plan, which is due in 2022., Funding: Zoll Medical., (Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.) more...
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- 2020
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37. External funding to strengthen capacity for research in low-income and middle-income countries: exigence, excellence and equity.
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Maher D, Aseffa A, Kay S, and Tufet Bayona M
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- Humans, Capacity Building, Developing Countries, Research economics, Research organization & administration, Research Support as Topic
- Abstract
Competing Interests: Competing interests: None declared.
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- 2020
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38. Occurrence and molecular characterization of Giardia duodenalis in child population from Colombia.
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Avendaño C, Ramo A, Vergara-Castiblanco C, Bayona M, Velasco-Benitez CA, Sánchez-Acedo C, and Quílez J
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- Adolescent, Child, Child, Preschool, Colombia epidemiology, Feces parasitology, Female, Giardia lamblia genetics, Giardiasis parasitology, Humans, Infant, Male, Prevalence, Schools, Young Adult, Community-Acquired Infections epidemiology, Cross Infection epidemiology, Giardia lamblia isolation & purification, Giardiasis epidemiology, Rural Population statistics & numerical data, Urban Population statistics & numerical data
- Abstract
Giardia duodenalis is one of the most prevalent human intestinal parasite, with children living in developing countries being particularly at risk of infection. The occurrence and molecular diversity of G. duodenalis was investigated in stools specimens from 307 individuals aged one to nineteen years in Colombia. Samples were collected in three educational establishments (n: 163) and two hospital laboratories (n: 144) from urban and rural areas. Feces were concentrated using a biphasic sedimentation method and wet mounts of the sediment were examined by light microscopy. G. duodenalis assemblages and sub-assemblages were determined on positive samples by PCR of the triose phosphate isomerase (tpi), β-giardin (bg) and small-subunit (ssu) rRNA genes. G. duodenalis infection was detected by microscopy in 23 individuals (7.5%). The protozoan was more prevalent among specimens collected in educational establishments (11.6%) than in those obtained from hospital laboratories (2.8%). Infection was most common in individuals from urban areas and children aged 1-5 years. No significant association between diarrhea and infection could be demonstrated. Twenty Giardia-positive samples were successfully allocated to assemblage B (n: 11), sub-assemblage AII (n: 7), and assemblage A (n: 2). Results indicate the potential for transmission of G. duodenalis infection in children attending educational establishments and individuals from urban areas, where transmission seems to be primarily anthroponotic., (Copyright © 2019 Elsevier B.V. All rights reserved.) more...
- Published
- 2019
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39. Stress During Development of Experimental Endometriosis Influences Nerve Growth and Disease Progression.
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Cuevas M, Cruz ML, Ramirez AE, Flores I, Thompson KJ, Bayona M, Vernon MW, and Appleyard CB
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- Animals, Disease Models, Animal, Disease Progression, Endometriosis pathology, Female, Nerve Tissue Proteins, Phosphorylation, Rats, Rats, Sprague-Dawley, Receptors, Growth Factor, Stress, Psychological pathology, Endometriosis metabolism, Nerve Growth Factor metabolism, Neurogenesis physiology, Receptor, trkA metabolism, Receptors, Nerve Growth Factor metabolism, Stress, Physiological physiology, Stress, Psychological metabolism
- Abstract
Purpose: We have previously shown that stress prior to induction worsens clinical presentation and inflammatory parameters in a rat model of endometriosis. This study was designed to examine whether stress during the development of endometriosis can affect the growth of endometriotic implants through nerve growth and immune alterations., Methods: Endometriosis was surgically induced in female Sprague-Dawley rats by suturing uterine horn implants onto the small intestine mesentery. Two weeks later, one group of rats (endo-stress) was subjected to a 10-day swim stress protocol. Controls had no stress (endo-no stress) or sutures only and stress (sham-stress). On day 60, all rats were killed and examined for the presence of endometriotic vesicles. The size of each vesicle was measured. The uterus and colon were removed and assessed for damage, cell infiltration, and expression of nerve growth factor (NGF), its receptors (p75 and Tropomyosin receptor kinase A (Trk-A)/pTrk-A), and calcitonin gene-related peptide, a sensory fiber marker. A differential analysis of peritoneal fluid white blood cell count was performed., Results: Stress significantly increased endometriotic vesicle size but not colonic damage and increased infiltration of mast cells. Significantly increased expression of NGF and its receptors was found in the uterus of animals with endometriosis receiving stress., Conclusions: Stress stimulates the development of ectopic endometrial vesicles in an animal model of endometriosis and increases inflammatory cell recruitment to the peritoneum. In addition, stress promotes nerve fiber growth in the uterus. more...
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- 2018
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40. Measurement Properties of Patient-Reported Outcome Measures Used in Patients Undergoing Total Hip Arthroplasty: A Systematic Review.
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Gagnier JJ, Huang H, Mullins M, Marinac-Dabić D, Ghambaryan A, Eloff B, Mirza F, and Bayona M
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- Humans, Psychometrics, Arthroplasty, Replacement, Hip, Patient Reported Outcome Measures
- Abstract
Background: Many patient-reported outcome measures (PROMs) have been developed to evaluate patient conditions before and after total hip arthroplasty. Also, many studies have been conducted to evaluate and compare the qualities of these instruments. Previously published reports suggest that most of these studies have poor methodology. Recently, 2 sets of criteria were developed for guiding and assessing the methodological and psychometric quality of these PROMs. We reviewed PROMs for total hip arthroplasty patients and appraised the methodological quality and psychometric evidence of evaluations of each identified instrument., Methods: Databases including PubMed, MEDLINE, Embase, CINAHL, the Cochrane Library, and others were searched for English-language articles published on or before April 14, 2017, using search terms related to outcome instrument, the condition or procedure of interest (hip arthroplasty), and psychometric properties. The methodological quality of the studies and the evidence of the psychometric properties were summarized and appraised using the COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) checklist and the psychometric evidence criteria. Overall psychometric ratings were derived by combining the 2 criteria., Results: Seventy-three studies investigating 26 instruments were included. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Oxford Hip Score, Harris hip score, and the Hip disability and Osteoarthritis Outcome Score (HOOS) were the most frequently assessed instruments. The WOMAC had 5 properties with positive evidence and was the highest-quality instrument overall, followed by the HOOS and the European Health Interview Survey (EUROHIS)-Quality of Life 8-item index., Conclusions: Despite a large number of included studies, many had low COSMIN ratings. We recommend additional rigorous studies to explore the psychometric properties of these instruments. Furthermore, the development of a core outcome set for total hip arthroplasty clinical trials is needed. more...
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- 2018
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41. Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion.
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Ruiz A, Ruiz L, Colón-Caraballo M, Torres-Collazo BJ, Monteiro JB, Bayona M, Fazleabas AT, and Flores I
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- Anti-HIV Agents pharmacology, Benzylamines, Cell Culture Techniques, Cell Movement, Cell Proliferation, Chemokine CXCL12 genetics, Chemokine CXCL12 metabolism, Cyclams, Endometriosis pathology, Endometrium cytology, Female, Heterocyclic Compounds pharmacology, Humans, Receptors, CXCR4 genetics, Tissue Culture Techniques, Chemokine CXCL12 pharmacology, Endometriosis metabolism, Endometrium metabolism, Gene Expression Regulation drug effects, Immunohistochemistry, Receptors, CXCR4 metabolism
- Abstract
High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, reported to be elevated in human endometriosis lesions and in the rat model of endometriosis. Activation of the CXCR4-CXCL12 axis increases cell proliferation, migration, and invasion of cancer cells. To obtain insights into the CXCR4 expression profile in lesions and endometrium, as well as functionality of the CXCR4-CXCL12 axis in endometriosis, we analyzed the expression of CXCR4 in tissues on a human tissue array and studied CXCL12-mediated activation of proliferation, invasion, and migration in vitro. We observed differences in levels of nuclear CXCR4 expression among lesion types, being higher in ovarian lesions. Endometriotic cell lines (12Z) showed higher levels of CXCR4, proliferative and migratory potential, and AKT phosphorylation/kinase activity compared to untreated control cells (endometrial epithelial cells). CXCL12 and endometriotic stromal cell-enriched media increased proliferation of non-endometriotic epithelial cells. CXCL12 caused a significant increase in 12Z cell invasion but had no effect on migration; AMD3100, a CXCR4-specific inhibitor, significantly increased invasion of 12Z cells but decreased their migration. However, treatment with CXCL12 plus AMD3100 significantly decreased invasion and migration of 12Z cells. In conclusion, the CXCR4-CXCL12 axis is functional in endometriosis cells, but the expression of CXCR4 varies among lesions. CXCL12 promoted proliferation, migration, and invasion of endometriotic cells, while inducing AKT phosphorylation and activity, but pharmacologically blocking this axis in the absence of the ligand induced their invasiveness., (© The Author(s) 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) more...
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- 2018
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42. A Systematic Review of Measurement Properties of Patient-Reported Outcome Measures Used in Patients Undergoing Total Knee Arthroplasty.
- Author
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Gagnier JJ, Mullins M, Huang H, Marinac-Dabic D, Ghambaryan A, Eloff B, Mirza F, and Bayona M
- Subjects
- Checklist, Female, Health Status, Humans, Male, Osteoarthritis, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires, Arthroplasty, Replacement, Knee, Patient Reported Outcome Measures, Psychometrics
- Abstract
Background: While clinical research on total knee arthroplasty (TKA) outcomes is prevalent in the literature, studies often have poor methodological and reporting quality. A high-quality patient-reported outcome instrument is reliable, valid, and responsive. Many studies evaluate these properties, but none have done so with a systematic and accepted method. The objectives of this study were to identify patient-reported outcome measures (PROMs) for TKA, and to critically appraise, compare, and summarize their psychometric properties using accepted methods., Methods: MEDLINE, EMBASE, SCOPUS, Web of Science, PsycINFO, and SPORTDiscus were systematically searched for articles with the following inclusion criteria: publication before December 2014, English language, non-generic PRO, and evaluation in the TKA population. Methodological quality and evidence of psychometric properties were assessed with the COnsensus-based standards for the selection of health Status Measurement INstruments (COSMIN) checklist and criteria for psychometric evidence proposed by the COSMIN group and Terwee et al., Results: One-hundred fifteen studies on 32 PROMs were included in this review. Only the Work, Osteoarthritis or joint-Replacement Questionnaire, the Oxford Knee Score, and the Western Ontario and McMaster Universities Arthritis Index had 4 or more properties with positive evidence., Conclusion: Most TKA PROMs have limited evidence for their psychometric properties. Although not all the properties were studied, the Work, Osteoarthritis or joint-Replacement Questionnaire, with the highest overall ratings, could be a useful PROM for evaluating patients undergoing TKA. The methods and reporting of this literature can improve by following accepted guidelines., (Published by Elsevier Inc.) more...
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- 2017
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43. Characteristics of women with endometriosis from the USA and Puerto Rico.
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Fourquet J, Sinaii N, Stratton P, Khayel F, Alvarez-Garriga C, Bayona M, Ballweg ML, and Flores I
- Abstract
Purpose: To describe lifetime differences in clinical characteristics of women with endometriosis between the USA and Puerto Rico., Methods: A descriptive study using self-administered demographic and clinical questionnaires was undertaken. Women with self-reported surgically diagnosed endometriosis who completed questionnaires from the Endometriosis Association (EA), Wisconsin, USA (n = 4358) and the Endometriosis Research Program (ERP) in Puerto Rico (n = 878), were included in this study. We compared demographic, gynecological and clinical history, frequency of endometriosis-associated symptoms and co-morbidities., Results: Although both groups have similar symptomatology, EA respondents had significantly higher rates of chronic pelvic pain and incapacitating pain than ERP participants. EA respondents were significantly more likely to report a history of problems getting pregnant, heavy bleeding, and hysterectomy than ERP respondents. Miscarriages were more frequently reported by the ERP group. Co-morbidities such as allergies, chronic fatigue syndrome, and fibromyalgia were more prevalent in EA respondents, whereas asthma was significantly more frequent in participants from ERP., Conclusions: Overall, women with endometriosis from the USA and Puerto Rico reported high rates of pain and infertility and a similar spectrum of symptoms. Those from the EA reported longer time to diagnosis, and diagnostic delays than those from the ERP, which may explain the observed increased in rates of endometriosis-related symptoms and co-morbidities in EA as compared to ERP. more...
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- 2015
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44. Stress management affects outcomes in the pathophysiology of an endometriosis model.
- Author
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Appleyard CB, Cruz ML, Hernández S, Thompson KJ, Bayona M, and Flores I
- Subjects
- Adaptation, Psychological, Animals, Behavior, Animal, Colon pathology, Colon physiopathology, Corticosterone metabolism, Defecation, Disease Models, Animal, Endometriosis complications, Endometriosis metabolism, Endometriosis pathology, Endometriosis psychology, Endometrium metabolism, Endometrium pathology, Female, Gastrointestinal Motility, Maze Learning, Neutrophil Infiltration, Rats, Sprague-Dawley, Stress, Psychological metabolism, Stress, Psychological physiopathology, Stress, Psychological psychology, Time Factors, Endometriosis physiopathology, Endometrium physiopathology, Stress, Psychological complications, Uterine Contraction
- Abstract
We have previously shown detrimental effects of stress in an animal model of endometriosis. We now investigated whether the ability to control stress can affect disease parameters. Endometriosis was surgically induced in female Sprague-Dawley rats before exposing animals to a controllable (submerged platform) or uncontrollable (no platform) swim stress protocol. Corticosterone levels and fecal pellet numbers were measured as an indicator of stress. Uncontrollable stress increased the number and size of the endometriotic cysts. Rats receiving uncontrollable stress had higher anxiety than those exposed to controllable stress or no stress and higher corticosterone levels. Uncontrollable stressed rats had more colonic damage and uterine cell infiltration compared to no stress, while controllable stress rats showed less of an effect. Uncontrollable stress also increased both colonic and uterine motility. In summary, the level of stress controllability appears to modulate the behavior and pathophysiology of endometriosis and offers evidence for evaluating therapeutic interventions., (© The Author(s) 2014.) more...
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- 2015
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45. Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity.
- Author
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Guerrero-Preston R, Hadar T, Ostrow KL, Soudry E, Echenique M, Ili-Gangas C, Pérez G, Perez J, Brebi-Mieville P, Deschamps J, Morales L, Bayona M, Sidransky D, and Matta J
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Case-Control Studies, Epigenesis, Genetic, Female, Humans, Middle Aged, Myelin and Lymphocyte-Associated Proteolipid Proteins genetics, Nerve Growth Factors genetics, Promoter Regions, Genetic, Tacrolimus Binding Proteins genetics, Breast Neoplasms blood, Breast Neoplasms genetics, DNA Methylation, DNA Repair, Kinesins genetics
- Abstract
Methylation alterations of CpG islands, CpG island shores and first exons are key events in the formation and progression of human cancer, and an increasing number of differentially methylated regions and genes have been identified in breast cancer. Recent studies of the breast cancer methylome using deep sequencing and microarray platforms are providing a novel insight on the different roles aberrant methylation plays in molecular subtypes of breast cancer. Accumulating evidence from a subset of studies suggests that promoter methylation of tumor-suppressor genes associated with breast cancer can be quantified in circulating DNA. However, there is a paucity of studies that examine the combined presence of genetic and epigenetic alterations associated with breast cancer using blood-based assays. Dysregulation of DNA repair capacity (DRC) is a genetic risk factor for breast cancer that has been measured in lymphocytes. We isolated plasma DNA from 340 participants in a breast cancer case control project to study promoter methylation levels of five genes previously shown to be associated with breast cancer in frozen tissue and in cell line DNA: MAL, KIF1A, FKBP4, VGF and OGDHL. Methylation of at least one gene was found in 49% of the cases compared to 20% of the controls. Three of the four genes had receiver characteristic operator curve values of ≥ 0.50: MAL (0.64), KIF1A (0.51) and OGDHL (0.53). KIF1A promoter methylation was associated with breast cancer and inversely associated with DRC. This is the first evidence of a significant association between genetic and epigenetic alterations in breast cancer using blood-based tests. The potential diagnostic utility of these biomarkers and their relevance for breast cancer risk prediction should be examined in larger cohorts. more...
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- 2014
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46. Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk.
- Author
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Matta JL, Flores I, Morales LM, Monteiro J, Alvarez-Garriga C, and Bayona M
- Abstract
Introduction: Breast cancer (BC) and endometriosis are important reproductive health diseases for women. Although endometriosis is not a malignant condition, some of its characteristics mimic that of a malignancy. Endometriosis is associated with increased risk of certain cancers; however, whether it alters BC risk is unclear. This study evaluates the association of endometriosis and BC and explores whether DNA repair capacity (DRC) plays a role in such a relationship., Materials and Methods: A case-control study of 991 women (385 with BC and 606 controls, all recruited over 5 years) was undertaken in Puerto Rico. Eighty participants with self-reported surgically diagnosed endometriosis were identified, 20 of whom also had a diagnosis of BC. Data from a structured questionnaire and DRC measurements were assessed to determine the association between BC, DRC, and endometriosis., Results: Participants with BC cases were 50% less likely to have history of endometriosis (OR = 0.5 95%CI: 0.3, 0.9, p = 0.038) than women without BC controls. Findings that did not reach statistical significance included the following: women with history of endometriosis had a slightly higher DRC level than those without it; BC cases and history of endometriosis were less likely to have had endometriosis diagnosis before age 38 as compared to controls with endometriosis., Discussion: Here we report an inverse association between endometriosis and BC, the former possibly conferring a protective effect on the latter. Although the mechanisms involved are unknown they may include protection provided by higher DRC and or hormonal treatments for endometriosis. A larger sample of endometriosis cases is necessary to confirm these results and answer the question of whether a higher DRC capacity may contribute to this potential protection, and to identify other factors at play. more...
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- 2013
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47. Factors associated with breast cancer in Puerto Rican women.
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Morales L, Alvarez-Garriga C, Matta J, Ortiz C, Vergne Y, Vargas W, Acosta H, Ramírez J, Perez-Mayoral J, and Bayona M
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, DNA Repair physiology, Female, Humans, Middle Aged, Odds Ratio, Pregnancy, Puerto Rico epidemiology, Risk Factors, Socioeconomic Factors, Breast Neoplasms epidemiology
- Abstract
Background: Breast cancer (BC) is the most common cancer afflicting Puerto Rican women and accounts for more cancer-related deaths in this population than any other cancer., Methods: Demographic, anthropometric, family history, and lifestyle data, as well as DNA repair capacity (DRC), were compared in 465 BC cases and 661 controls. Crude and multiple logistic regression-derived adjusted odds ratios were used as indicators of the associations between BC and the variables under study., Results: A low DRC level, aging (>61years), family history of BC, and low education level had statistically significant associations with increased BC risk. Endometriosis, full-term pregnancy at an earlier age, higher parity, hysterectomy before age 50, multivitamin and calcium intake, and longer duration of breastfeeding significantly decreased BC risk., Conclusions: This study discusses the major risk factors for BC in Puerto Rico (PR). Because many of these findings represent modifiable risk factors, they can translate into public health initiatives to lower BC risk. In addition, the possibility of using DRC as a simple screening tool for BC risk is explored., (Copyright © 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.) more...
- Published
- 2013
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48. THE CONSUMPTION OF RED PUPUNHA (BACTRIS GASIPAES KUNTH) INCREASES HDL CHOLESTEROL AND REDUCES WEIGHT GAIN OF LACTATING AND POST-LACTATING WISTAR RATS.
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Carvalho RP, Lemos JR, de Aquino Sales RS, Martins MG, Nascimento CH, Bayona M, Marcon JL, and Monteiro JB
- Abstract
Introduction: The lactating and post-lactating periods are marked by large metabolic change. Production of milk is 60% lipid dependent. We reported in a recent scientific meeting that Red pupunha palm tree fruit increases HDL cholesterol in lactating rats. This study evaluated if consumption of Red Pupunha by adult female rats has a beneficial impact on the lipid metabolism of lacting and post-lacting adult rats., Objective: Evaluate if consumption of red pupunha has a beneficial effect in the lipid metabolism of lacting and post-lacting adult Wistar rats., Research Methods: Four groups including two for control; (1) control adult lactating rats, (2) control adults post-lactating rats; and two experimental groups; (3) pupunha adults lactating rats and (4) pupunha adult post-lactating rats were evaluated and compared regarding: weight gain, food consumption, plasma total protein, glucose, total lipid, triglycerides, total cholesterol and HDL-cholesterol levels. The mean difference and its 95% confidence intervals were used for group comparisons. Group comparisons were evaluated by using analysis of variance (one-way ANOVA). The statistical significance of the pairwise differences among groups was assessed by using the two-sided Tukey test., Results: There were no important differences in food consumption, plasma glucose, total lipids and triglycerides among groups. The red pupunha lactating group gain less weight showing lower body mass index (BMI) than controls (p < 0.05). Total cholesterol was lower in red pupunha lactating than in controls but not in the red pupunha post-lactating group as compared to controls. Triglycerides were lower in the post-lactating red pupunha group as compared to the control group (p = 0.039) but not for the lactating groups. Red pupunha lactating and post-lactating groups had higher HDL-cholesterol than their corresponding control groups (p ≤ 0.01)., Conclusion: Original findings include the beneficial effect of red pupunha in post-lactating rats increasing the HDL-cholesterol and lowering the BMI. Red pupunha was confirmed to increase HDL-cholesterol in lactating rats. These results suggest that red pupunha is a healthy fruit to be consumed during lactating and post-lactating periods as it is related to better lipid profile and less body weight gain. more...
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- 2013
49. Breast Cancer and DNA Repair Capacity: Association With Use of Multivitamin and Calcium Supplements.
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Vergne Y, Matta J, Morales L, Vargas W, Alvarez-Garriga C, and Bayona M
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Context: Breast cancer (BC) is the most common cancer in women, with over 1 million new cases diagnosed every year worldwide. Over recent decades, considerable interest has emerged regarding whether vitamins and/or other supplements can lower the risk of BC. However, previous epidemiologic studies that investigated the association between intake of multivitamin and supplements of single vitamins and minerals and BC risk have reported conflicting results. Whether vitamins can actually reduce BC risk is still controversial., Objective: This study examined whether multivitamin and calcium use was associated with BC incidence and DNA repair capacity (DRC)., Design: The research team designed an observational, case-control study., Setting: All work was performed at the Ponce School of Medicine and Health Sciences under the direct supervision of principal investigator Dr Jaime Matta., Participants: Participants were 836 women recruited primarily from the private practices of oncologists, gynecologists, and surgeons in Puerto Rico., Interventions: A total of 312 individuals in the breast cancer (BC) group and 524 individuals in the control group were compared for their multivitamin and calcium intake, DRC levels, and other covariates., Outcome Measures: Odds ratios (OR), adjusted using both crude analysis and multiple logistic regression, were used as measures of association between BC and DRC and other selected variables., Results: The BC group had 30% reduced odds of taking multivitamins and calcium as compared to controls: (1) OR = 0.7 (95% CI, 0.4-1.0; P = .073) for multivitamins and (2) OR = 0.7 (95% CI, 0.4-1.2; P = .167) for calcium. Women with low DRC had 50% lower odds of taking calcium and 30% lower odds of currently taking vitamins OR = 0.5 (95% CI, 0.4-0.7; P = .001) for calcium and (2) OR = 0.7 (95% CI, 0.5-0.9.1; P = .047) for vitamins., Conclusions: Although this study is a case-control study in which the risk of BC could not be assessed, results suggest that vitamin supplementation could be an independent protective factor for BC. Calcium intake appears to affect DRC in a positive way, because it was associated with a high DRC level, which in turn is associated with low odds for BC. more...
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- 2013
50. Differential expression of DNA repair genes in Hispanic women with breast cancer.
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Matta J, Morales L, Dutil J, Bayona M, Alvarez C, and Suarez E
- Abstract
Previous studies have found a link between a low DNA repair capacity (DRC) level and increased risk for breast cancer (BC). A recent study by Matta et al. 2012 showed that women with BC have an average reduction of 60% in DRC compared to controls ( P < 0.001). Using the same group of Hispanic women, we selected a subgroup of cases (n=35) and controls (n=2) who donated their tumors and normal tissue for performing molecular studies in order to 1) compare the expression of DNA repair genes in breast tissue between BC cases and controls without this disease, 2) assess the correlation between gene expression and DRC levels, 3) examine whether DRC levels are associated with tumor DNA repair gene expression profiling when women were stratified according to their hormone receptor status. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. Gene expression levels were measured in tumors by means of DNA microarray analysis. Twenty-one DNA repair genes were found to be differentially and significantly expressed in women with BC. Those candidate genes were CHEK2, EME1 (MMS4L), ERCC3 (XPB), FANCM, H2AFX (H2AX), HMGB1, HUS1, MBD4, NEIL3, PCNA, RAD1, RAD23B, RAD51, RAD54B, RDM1 (RAD52B), SHFM1 (DSS1), TP1, UBE2N ( UBC13 ) and XRCC5 (Ku80) . Most DNA repair genes (n=18 or 82%) were overexpressed, ranging from 3.76-fold ( RDM1 ) to 1.47-fold ( XRCC5 ). Only 4 genes (18%) were underexpressed, ranging from 62% ( SAPCD1 ) to 25% ( RAD23B ). Statistically significant positive correlations between DRC level and gene expression were found for the RAD51, FANCB and FANCA genes. We discuss the clinical and translational significance of these findings. Our results support the usefulness of studying DNA repair as a measure of BC risk. This study also provides a list of candidate DNA repair genes that might be associated with dysregulation of DNA repair in breast cancer. more...
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- 2013
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