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186 results on '"Behrends, Uta"'

1. Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome

Author

Haunhorst, Simon, Dudziak, Diana, Scheibenbogen, Carmen, Seifert, Martina, Sotzny, Franziska, Finke, Carsten, Behrends, Uta, Aden, Konrad, Schreiber, Stefan, Brockmann, Dirk, Burggraf, Paul, Bloch, Wilhelm, Ellert, Claudia, Ramoji, Anuradha, Popp, Juergen, Reuken, Philipp, Walter, Martin, Stallmach, Andreas, and Puta, Christian

Published
2024
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5. Pediatric and adult patients with ME/CFS following COVID-19: A structured approach to diagnosis using the Munich Berlin Symptom Questionnaire (MBSQ)

Author

Peo, Laura-Carlotta, Wiehler, Katharina, Paulick, Johannes, Gerrer, Katrin, Leone, Ariane, Viereck, Anja, Haegele, Matthias, Stojanov, Silvia, Warlitz, Cordula, Augustin, Silvia, Alberer, Martin, Hattesohl, Daniel B. R., Froehlich, Laura, Scheibenbogen, Carmen, Jason, Leonard A., Mihatsch, Lorenz L., Pricoco, Rafael, and Behrends, Uta

Published
2024
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6. Comparing SARS-CoV-2 variants among children and adolescents in Germany: relative risk of COVID-19-related hospitalization, ICU admission and mortality

Author

Jank, Marietta, Oechsle, Anna-Lisa, Armann, Jakob, Behrends, Uta, Berner, Reinhard, Chao, Cho-Ming, Diffloth, Natalie, Doenhardt, Maren, Hansen, Gesine, Hufnagel, Markus, Lander, Fabian, Liese, Johannes G., Muntau, Ania C., Niehues, Tim, von Both, Ulrich, Verjans, Eva, Weil, Katharina, von Kries, Rüdiger, and Schroten, Horst

Published
2023
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7. Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival

Author

Vallée, Tanja C., Glasmacher, Jannik S., Buchner, Hannes, Arkwright, Peter D., Behrends, Uta, Bondarenko, Anastasia, Browning, Michael J., Buchbinder, David, Cattoni, Alessandro, Chernyshova, Liudmyla, Ciznar, Peter, Cole, Theresa, Czogała, Wojciech, Dueckers, Gregor, Edgar, John David M., Erbey, Fatih, Fasth, Anders, Ferrua, Francesca, Formankova, Renata, Gambineri, Eleonora, Gennery, Andrew R., Goldman, Frederick D., Gonzalez-Granado, Luis I., Heilmann, Carsten, Heiskanen-Kosma, Tarja, Juntti, Hanna, Kainulainen, Leena, Kanegane, Hirokazu, Karaca, Neslihan E., Kilic, Sara S., Klein, Christoph, Kołtan, Sylwia, Kondratenko, Irina, Meyts, Isabelle, Nasrullayeva, Gulnara M., Notarangelo, Lucia D., Pasic, Srdjan, Pellier, Isabelle, Pignata, Claudio, Misbah, Siraj, Schulz, Ansgar, Segundo, Gesmar R., Shcherbina, Anna, Slatter, Mary, Sokolic, Robert, Soler-Palacin, Pere, Stepensky, Polina, van Montfrans, Joris M., Ryhänen, Samppa, Wolska-Kuśnierz, Beata, Ziegler, John B., Zhao, Xiaodong, Aiuti, Alessandro, Ochs, Hans D., and Albert, Michael H.

Published
2024
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8. Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

Author

Levin, Michael, Coin, Lachlan, Gormley, Stuart, Hamilton, Shea, Hoggart, Clive, Kaforou, Myrsini, Sancho-Shimizu, Vanessa, Wright, Victoria, Abdulla, Amina, Agapow, Paul, Bartlett, Maeve, Eleftherohorinou, Hariklia, Galassini, Rachel, Inwald, David, Mashbat, Meg, Menikou, Stephanie, Mustafa, Sobia, Nadel, Simon, Rahman, Rahmeen, Shailes, Hannah, Thakker, Clare, Bokhandi, S., Power, Sue, Barham, Heather, Pathan, N., Ridout, Jenna, White, Deborah, Thurston, Sarah, Faust, S., Patel, S., McCorkell, Jenni, Davies, P., Crate, Lindsey, Navarra, Helen, Carter, Stephanie, Ramaiah, R., Patel, Rekha, Tuffrey, Catherine, Gribbin, Andrew, McCready, Sharon, Peters, Mark, Hardy, Katie, Standing, Fran, O'Neill, Lauren, Abelake, Eugenia, Deep, Akash, Nsirim, Eniola, Pollard, Andrew, Willis, Louise, Young, Zoe, Royad, C., White, Sonia, Fortune, Peter-Marc, Hudnott, Phil, Martinón-Torres, Federico, Salas, Antonio, Álvez González, Fernando, Barral-Arca, Ruth, Cebey-López, Miriam, Curras-Tuala, María José, García, Natalia, García Vicente, Luisa, Gómez-Carballa, Alberto, Gómez Rial, Jose, Grela Beiroa, Andrea, Justicia Grande, Antonio, Leboráns Iglesias, Pilar, Martínez Santos, Alba Elena, Martinón-Torres, Nazareth, Martinón Sánchez, José María, Morillo Gutiérrez, Beatriz, Mosquera Pérez, Belén, Obando Pacheco, Pablo, Pardo-Seco, Jacobo, Pischedda, Sara, Rivero-Calle, Irene, Rodríguez-Tenreiro, Carmen, Redondo-Collazo, Lorenzo, Salas Ellacuriaga, Antonio, Fernández, Sonia Serén, del Sol Porto Silva, María, Vega, Ana, Vilanova Trillo, Lucía, Reyes, Susana Beatriz, Cruz León León, María, Navarro Mingorance, Álvaro, Gabaldó Barrio, Xavier, Oñate Vergara, Eider, Concha Torre, Andrés, Vivanco, Ana, Fernández, Reyes, Giménez Sánchez, Francisco, Sánchez Forte, Miguel, Rojo, Pablo, Contreras, J. Ruiz, Palacios, Alba, Epalza Ibarrondo, Cristina, Fernández Cooke, Elizabeth, Navarro, Marisa, Álvarez Álvarez, Cristina, José Lozano, María, Carreras, Eduardo, Brió Sanagustín, Sonia, Neth, Olaf, Martínez Padilla, Mª del Carmen, Prieto Tato, Luis Manuel, Guillén, Sara, Fernández Silveira, Laura, Moreno, David, de Groot, R., Tutu van Furth, A.M., van der Flier, M., Boeddha, N.P., Driessen, G.J.A., Emonts, M., Hazelzet, J.A., Kuijpers, T.W., Pajkrt, D., Sanders, E.A.M., van de Beek, D., van der Ende, A., Philipsen, H.L.A., Adeel, A.O.A., Breukels, M.A., Brinkman, D.M.C., de Korte, C.C.M.M., de Vries, E., de Waal, W.J., Dekkers, R., Dings-Lammertink, A., Doedens, R.A., Donker, A.E., Dousma, M., Faber, T.E., Gerrits, G.P.J.M., Gerver, J.A.M., Heidema, J., Homan-van der Veen, J., Jacobs, M.A.M., Jansen, N.J.G., Kawczynski, P., Klucovska, K., Kneyber, M.C.J., Koopman-Keemink, Y., Langenhorst, V.J., Leusink, J., Loza, B.F., Merth, I.T., Miedema, C.J., Neeleman, C., Noordzij, J.G., Obihara, C.C., van Overbeek- van Gils, A.L.T., Poortman, G.H., Potgieter, S.T., Potjewijd, J., Rosias, P.P.R., Sprong, T., ten Tussher, G.W., Thio, B.J., Tramper-Stranders, G.A., van Deuren, M., van der Meer, H., van Kuppevelt, A.J.M., van Wermeskerken, A.M., Verwijs, W.A., Wolfs, T.F.W., Schlapbach, Luregn J., Agyeman, Philipp, Aebi, Christoph, Giannoni, Eric, Stocker, Martin, Posfay-Barbe, Klara M., Heininger, Ulrich, Bernhard-Stirnemann, Sara, Niederer-Loher, Anita, Kahlert, Christian, Hasters, Paul, Relly, Christa, Baer, Walter, Berger, Christoph, Carrol, Enitan D., Paulus, Stéphane, Frederick, Hannah, Jennings, Rebecca, Johnston, Joanne, Kenwright, Rhian, Fink, Colin G, Pinnock, Elli, Emonts, Marieke, Agbeko, Rachel, Anderson, Suzanne, Secka, Fatou, Bojang, Kalifa, Sarr, Isatou, Kebbeh, Ngange, Sey, Gibbi, Saidykhan, Momodou, Cole, Fatoumata, Thomas, Gilleh, Antonio, Martin, Zenz, Werner, Kohlfürst, Daniela S., Binder, Alexander, Schweintzger, Nina A., Sagmeister, Manfred, Baumgart, Hinrich, Baumgartner, Markus, Behrends, Uta, Biebl, Ariane, Birnbacher, Robert, Blanke, Jan-Gerd, Boelke, Carsten, Breuling, Kai, Brunner, Jürgen, Buller, Maria, Dahlem, Peter, Dietrich, Beate, Eber, Ernst, Elias, Johannes, Emhofer, Josef, Etschmaier, Rosa, Farr, Sebastian, Girtler, Ylenia, Grigorow, Irina, Heimann, Konrad, Ihm, Ulrike, Jaros, Zdenek, Kalhoff, Hermann, Kaulfersch, Wilhelm, Kemen, Christoph, Klocker, Nina, Köster, Bernhard, Kohlmaier, Benno, Komini, Eleni, Kramer, Lydia, Neubert, Antje, Ortner, Daniel, Pescollderungg, Lydia, Pfurtscheller, Klaus, Reiter, Karl, Ristic, Goran, Rödl, Siegfried, Sellner, Andrea, Sonnleitner, Astrid, Sperl, Matthias, Stelzl, Wolfgang, Till, Holger, Trobisch, Andreas, Vierzig, Anne, Vogel, Ulrich, Weingarten, Christina, Welke, Stefanie, Wimmer, Andreas, Wintergerst, Uwe, Wüller, Daniel, Zaunschirm, Andrew, Ziuraite, Ieva, Žukovskaja, Veslava, Hibberd, Martin L., Davila, Sonia, Delany, Isabel, Schlapbach, Luregn J, Raman, Sainath, Sharp, Nathalie, Phillips, Natalie, Irwin, Adam, Balch, Ross, Harley, Amanda, Johnson, Kerry, Sever, Zoe, George, Shane, Grimwood, Keith, Snelling, Peter J, Chavan, Arjun, Kitcatt, Eleanor, Lawton, Luke, Hempenstall, Allison, Pilot, Pelista, Gibbons, Kristen S, Le Marsney, Renate, Blumenthal, Antje, Ganesamoorthy, Devika, Pardo, Carolyn, Kling, Jessica, McPherson, Stephen, MacDonald, Anna D, Bialasiewicz, Seweryn, Pham, Trang, Wilson, Clare, Sharp, Natalie, Kling, Jessica C, McPherson, Stephen J, Herberg, Jethro A, and Coin, Lachlan J M

Published
2024
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9. Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Author

Steiner, Sophie, Fehrer, Annick, Hoheisel, Friederike, Schoening, Simon, Aschenbrenner, Anna, Babel, Nina, Bellmann-Strobl, Judith, Finke, Carsten, Fluge, Øystein, Froehlich, Laura, Goebel, Andreas, Grande, Bettina, Haas, Johannes-Peter, Hohberger, Bettina, Jason, Leonard A., Komaroff, Anthony L., Lacerda, Eliana, Liebl, Max, Maier, Andrea, Mella, Olav, Nacul, Luis, Paul, Friedemann, Prusty, Bhupesh K., Puta, Christian, Riemekasten, Gabriela, Ries, Wolfgang, Rowe, Peter C., Sawitzki, Birgit, Shoenfeld, Yehuda, Schultze, Joachim L., Seifert, Martina, Sepúlveda, Nuno, Sotzny, Franziska, Stein, Elisa, Stingl, Michael, Ufer, Friederike, Veauthier, Christian, Westermeier, Francisco, Wirth, Klaus, Wolfarth, Bernd, Zalewski, Pawel, Behrends, Uta, and Scheibenbogen, Carmen

Published
2023
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12. Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021

Author

Sorg, Anna-Lisa, Bergfeld, Leon, Jank, Marietta, Corman, Victor, Semmler, Ilia, Goertz, Anna, Beyerlein, Andreas, Verjans, Eva, Wagner, Norbert, Von Bernuth, Horst, Lander, Fabian, Weil, Katharina, Hufnagel, Markus, Spiekerkoetter, Ute, Chao, Cho-Ming, Naehrlich, Lutz, Muntau, Ania Carolina, Schulze-Sturm, Ulf, Hansen, Gesine, Wetzke, Martin, Jung, Anna-Maria, Niehues, Tim, Fricke-Otto, Susanne, Von Both, Ulrich, Huebner, Johannes, Behrends, Uta, Liese, Johannes G., Schwerk, Christian, Drosten, Christian, Von Kries, Ruediger, and Schroten, Horst

Published
2022
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13. Author Correction: A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity

Author

Kedor, Claudia, Freitag, Helma, Meyer-Arndt, Lil, Wittke, Kirsten, Hanitsch, Leif G., Zoller, Thomas, Steinbeis, Fridolin, Haffke, Milan, Rudolf, Gordon, Heidecker, Bettina, Bobbert, Thomas, Spranger, Joachim, Volk, Hans-Dieter, Skurk, Carsten, Konietschke, Frank, Paul, Friedemann, Behrends, Uta, Bellmann-Strobl, Judith, and Scheibenbogen, Carmen

Published
2022
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14. A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity

Author

Kedor, Claudia, Freitag, Helma, Meyer-Arndt, Lil, Wittke, Kirsten, Hanitsch, Leif G., Zoller, Thomas, Steinbeis, Fridolin, Haffke, Milan, Rudolf, Gordon, Heidecker, Bettina, Bobbert, Thomas, Spranger, Joachim, Volk, Hans-Dieter, Skurk, Carsten, Konietschke, Frank, Paul, Friedemann, Behrends, Uta, Bellmann-Strobl, Judith, and Scheibenbogen, Carmen

Published
2022
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15. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations

Author

Boztug, Kaan, Brunner, Juergen, Demel, Ulrike F., Förster-Waldl, Elisabeth, Gasteiger, Lukas M., Göschl, Lisa, Kojić, Marina, Schroll, Andrea, Seidel, Markus G., Wintergerst, Uwe, Wisgrill, Lukas, Sharapova, Svetlana O., Goffard, Jean-Christophe, Kerre, Tessa, Meyts, Isabelle, Roosens, Fine, Smet, Julie, Haerynck, Filomeen, Eric, Zelimir Pavle, Milenova, Veneta, Gagro, Alenka, Richter, Darko, Chovancova, Zita, Hlavackova, Eva, Litzman, Jiri, Milota, Tomas, Sediva, Anna, Elaziz, Dalia Abd, Alkady, Radwa Salaheldin, El Sayed El Hawary, Rabab, Eldash, Alia S., Galal, Nermeen, Lotfy, Sohilla, Meshaal, Safa S., Reda, Shereen M., Sobh, Ali, Elmarsafy, Aisha, Seppänen, Mikko R.J., Brosselin, Pauline, Courteille, Virginie, De Vergnes, Nathalie, Kracker, Sven, Pergent, Martine, Randrianomenjanahary, Philippe, Ahrenstorf, Gerrit, Albert, Michael H., Ankermann, Tobias, Atschekzei, Faranaz, Baumann, Ulrich, Becker, Benjamin C., Behrends, Uta, Belohradsky, Bernd H., Biegner, Anika-Kerstin, Binder, Nadine, Bode, Sebastian F.N., Boesecke, Christoph, Boetticher, Benedikt, Borte, Michael, Borte, Stephan, Classen, Carl Friedrich, Dirks, Johannes, Dückers, Gregor, El-Helou, Sabine, Ernst, Diana, Fasshauer, Maria, Fecker, Gisela, Felgentreff, Kerstin, Foell, Dirk, Ghosh, Sujal, Girschick, Hermann J., Goldacker, Sigune, Graf, Norbert, Graf, Dagmar, Greil, Johann, Hanitsch, Leif Gunnar, Hauck, Fabian, Heeg, Maximilian, Heine, Sabine I., Henes, Joerg C., Hoenig, Manfred, Holzer, Ursula, Holzinger, Dirk, Horneff, Gerd, Hundsdoerfer, Patrick, Jablonka, Alexandra, Jakoby, Donate, Joean, Oana, Kaiser-Labusch, Petra, Klemann, Christian, Kobbe, Robin, Körholz, Julia, Kramm, Christof M., Krüger, Renate, Landwehr-Kenzel, Sybille, Lehmberg, Kai, Liese, Johannes G., Lippert, Conrad Ferdinand, Maccari, Maria Elena, Masjosthusmann, Katja, Meinhardt, Andrea, Metzler, Markus, Morbach, Henner, Müller, Ingo, Naumann-Bartsch, Nora, Neubert, Jennifer, Niehues, Tim, Peter, Hans-Hartmut, Rieber, Nikolaus, Ritterbusch, Henrike, Rockstroh, Jürgen Kurt, Roesler, Joachim, Schauer, Uwe, Scheible, Raphael, Schmalzing, Marc, Schmidt, Reinhold Ernst, Schneider, Dominik T., Schreiber, Stefan, Schuetz, Catharina, Schulz, Ansgar, Schulze-Koops, Hendrik, Schulze-Sturm, Ulf, Schuster, Volker, Schwaneck, Eva C., Schwarz, Klaus, Schwarze-Zander, Carolynne, Sirin, Mehtap, Skapenko, Alla, Sogkas, Georgios, Sparber-Sauer, Monika, Speckmann, Carsten, Steinmann, Sandra, Stiehler, Sophie, Tenbrock, Klaus, von Bernuth, Horst, Warnatz, Klaus, Wasmuth, Jan-Christian, Weiss, Michael, Witte, Torsten, Wittke, Kirsten, Wittkowski, Helmut, Zeuner, Rainald A., Farmaki, Evangelia, Hatzistilianou, Maria N., Kakkas, Ioannis, Kanariou, Maria G., Kapousouzi, Androniki, Liatsis, Emmanouil, Maggina, Paraskevi, Papadopoulou-Alataki, Efimia, Raptaki, Maria, Speletas, Matthaios, Tantou, Sofia, Goda, Vera, Kriván, Gergely, Marodi, Laszlo, Abolhassani, Hassan, Aghamohammadi, Asghar, Rezaei, Nima, Feighery, Conleth, Leahy, Timothy Ronan, Ryan, Paul, Batzir, Nurit Assia, Garty, Ben Zion, Tamary, Hannah, Aiuti, Alessandro, Amodio, Donato, Azzari, Chiara, Barzaghi, Federica, Baselli, Lucia A., Cancrini, Caterina, Carrabba, Maria, Cazzaniga, Marco, Cesaro, Simone, Chinello, Matteo, Danieli, Maria Giovanna, Dellepiane, Rosa Maria, Fabio, Giovanna, Gambineri, Eleonora, Lodi, Lorenzo, Lougaris, Vassilios, Marasco, Carolina, Martire, Baldassarre, Marzollo, Antonio, Milito, Cinzia, Moschese, Viviana, Pignata, Claudio, Plebani, Alessandro, Porta, Fulvio, Quinti, Isabella, Ricci, Silvia, Soresina, Annarosa, Tommasini, Alberto, Vacca, Angelo, Vanessa, Clementina, Blažienė, Audra, Sitkauskiene, Brigita, Gowin, Ewelina, Heropolitańska-Pliszka, Edyta, Pietrucha, Barbara, Szaflarska, Anna, Więsik-Szewczyk, Ewa, Wolska-Kuśnierz, Beata, Esteves, Isabel, Faria, Emilia, Marques, Laura Hora, Neves, João Farela, Silva, Susana L., Teixeira, Carla, Pereira da Silva, Sara, Capilna, Brindusa Ruxandra, Guseva, Marina N., Shcherbina, Anna, Bobcakova, Anna, Ciznar, Peter, Gabzdilova, Juliana, Jesenak, Milos, Kapustova, Lenka, Orosova, Jaroslava, Petrovicova, Otilia, Raffac, Stefan, Kopač, Peter, Allende, Luis M., Antolí, Arnau, Blanch, Gemma Rocamora, Carbone, Javier, Dieli-Crimi, Romina, Garcia-Prat, Marina, Gil-Herrera, Juana, Gonzalez-Granado, Luis Ignacio, Agulló, Pilar Llobet, Olbrich, Peter, Parra-Martínez, Alba, Paz-Artal, Estela, Pleguezuelo, Daniel E., Rodríguez, Nerea Salmón, Sánchez-Ramón, Silvia, Santos-Pérez, Juan Luis, Solanich, Xavier, Soler-Palacin, Pere, González-Amores, Miriam, Ekwall, Olov, Fasth, Anders, Bitzenhofer-Grüber, Michaela, Candotti, Fabio, Dimitriou, Florentia, Heininger, Ulrich, Holbro, Andreas, Jandus, Peter, Kolios, Antonios G.A., Marschall, Karin, Schmid, Jana Pachlopnik, Posfay-Barbe, Klara M., Prader, Seraina, Reichenbach, Janine, Steiner, Urs C., Trück, Johannes, Bredius, Robbert G., de Kruijf- Bazen, Suzanne, de Vries, Esther, Henriet, Stefanie S.V., Kuijpers, Taco W., Potjewijd, Judith, Rutgers, Abraham, Stol, Kim, van Aerde, Koen J., Van den Berg, J. Merlijn, van de Ven, Annick A.J.M., Montfrans, Jorisvan, Aydemir, Sezin, Baris, Safa, Dogu, Figen, Ikinciogullari, Aydan, Karakoc-Aydiner, Elif, Kilic, Sara S., Kiykim, Ayca, Kökçü Karadağ, Şefika İlknur, Kutukculer, Necil, Ocak, Suheyla, UNAL, Ekrem, Boyarchuk, Oksana, Hilfanova, Anna, Kostyuchenko, Larysa V., Alachkar, Hana, Arkwright, Peter D., Baxendale, Helen E., Bernatoniene, Jolanta, Coulter, Tanya I., Garcez, Tomaz, Goddard, Sarah, Gompels, Mark M., Grigoriadou, Sofia, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Ibberson, Lisa, Nademi, Zoreh, Noorani, Sadia, Parvin, Shahnaz, Steele, Cathal Laurence, Thomas, Moira, Waruiru, Catherine, Yong, Patrick F.K., Bourne, Helen, Thalhammer, Julian, Kindle, Gerhard, Nieters, Alexandra, Rusch, Stephan, Fischer, Alain, Grimbacher, Bodo, Edgar, David, Buckland, Matthew, Mahlaoui, Nizar, and Ehl, Stephan

Published
2021
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16. First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”

Author

Jakob, Carolin E. M., Borgmann, Stefan, Duygu, Fazilet, Behrends, Uta, Hower, Martin, Merle, Uta, Friedrichs, Anette, Tometten, Lukas, Hanses, Frank, Jung, Norma, Rieg, Siegbert, Wille, Kai, Grüner, Beate, Klinker, Hartwig, Gersbacher-Runge, Nicole, Hellwig, Kerstin, Eberwein, Lukas, Dolff, Sebastian, Rauschning, Dominic, von Bergwelt-Baildon, Michael, Lanznaster, Julia, Strauß, Richard, Trauth, Janina, de With, Katja, Ruethrich, Maria, Lueck, Catherina, Nattermann, Jacob, Tscharntke, Lene, Pilgram, Lisa, Fuhrmann, Sandra, Classen, Annika, Stecher, Melanie, Schons, Maximilian, Spinner, Christoph, and Vehreschild, Jörg Janne

Published
2021
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17. Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries

Author

Irwin, Adam, Akula, Akhila, Bamford, Alasdair, Chang, Amanda, da Silva, Andre, Whitelaw, Andrew, Dramowski, Angela, Vasudevan, Anil Kumar, Sharma, Anita, Justicia, Antonio, Chikkappa, Ashok, Slowinska-Jarzabek, Barbara, Rippberger, Bianca, Zhao, Changan, Tersigni, Chiara, Cheng, Chinglan, Harkensee, Christian, Jing, Chuamei, Zhu, Chunmei, Li, Chunyan, Tagliabue, Claudia, Epalza, Cristina, Jacqueline, Daglish, Tian, Daiyin, Jinka, Dasaratha, Gkentzi, Despoina, Dharmapalan, Dhanya, Benadof, Dona, Papadimitriou, Eleni, Iosifidis, Elias, Roilides, Emmanuel, Yarci, Erbu, Majda-Stanisławska, Ewa, Gowin, Ewelina, Chappell, Faye, Torres, Federico Martinon, Collett-White, Francis, Liu, Gang, Lu, Gen, Syrogiannopoulos, George, Pitsava, Georgia, Alvarez-Uria, Gerardo, Renk, Hana, Mahmood, Hana, Saxen, Harri, Finlayson, Heather, Green, Helen, Rabie, Helena, Kandraju, Hemasree, Zhang, Hong, Okokon, Ita, Cross, Jack, Herberg, Jethro, Li, Jianping, Zhang, Jiaosheng, Deng, Jikui, Liu, Jing, Qian, Jing, Yang, Jinhong, Sicińska, Joanna, Hübner, Johannes, Fukuoka, Kahoru, Yao, Kaihu, Cheung, Kaman, Ojeda, Karla, Kaffe, Katerina, Kreitmeyer, Katharina, Doerholt, Katja, Grimwood, Keith, Ledoare, Kirsty, Vazouras, Konstantinos, Shen, Kunling, Tang, Lanfang, Zhang, Lehai, Lin, Li, Ashkenazi-Hoffnung, Liat, Wu, Lijuan, Wang, Lijun, Teston, Lilian, Galli, Luisa, Speirs, Lynne, Tsolia, Maria, Hufnagel, Markus, Knuf, Markus, Duse, Marzia, Ding, Mingjie, Rozic, Mojca, Premru, Mueller, O'Connell, Natasha, Rieber, Nikolaus, Spyridis, Nikos, Tunga, Onkaraiah, Conejo, Pablo Rojo, McMaster, Paddy, Lumbiganon, Pagakrong, Pansa, Paola, D'Argenio, Patrizia, Moriarty, Paul, Nikolic, Petra, Wang, Ping, Paopongsawan, Pongsatorn, Cao, Qing, Deng, Qiulian, Laxminarayan, Ramanan, Kanithi, Ravishankar, Jimenez, Rodolfo, Cao, Sancheng, Singh, Sanjeev, Rees, Sarah, Praveen, Saroey, Kekomaki, Satu, Hackett, Scott, Ashkenazi, Shai, Chang, Si Min, Drysdale, Simon, Koning, Sonia, Subramanian, Sreeram, Murki, Srinivas, Vergnano, Stefania, Gandra, Sumanth, Esposito, Susanna, Anugulruengkitt, Suvaporn, Puthanakit, Thanyawee, Behrends, Uta, Papaevangelous, Vana, Jian, Victoria, Li, Wei, Zhao, Wei, Wang, Wei, Zhang, Wenshuang, Mu, Xiaoping, Dong, Xiaoyie, Jiang, Xiyuan, Chen, Xu, Wang, Yi, Zheng, Yuejie, Horikoshi, Yuho, Aboderin, Aaron, Olayinka, Adebola, Dedeic-Ljubovic, Amela, McCorry, Ann, Enimil, Anthony, Neubert, Antje, solano, antonio, Pignatari, Antonio, Poojary, Aruna, Kambaralieva, Baktygul, McCullagh, Bernadette, Carevi, Biljana, Van Herendael, Bruno, Gormley, Cairine, Carvajal, Camila, Ramírez, Carlos, Fitzgerald, David, Sabuda, Deana, Konopnicki, Deborah, Lacej, Denada, Pierard, Denis, Rios, Edgar, Marshall, Emily, Firre, Eric, van Elzakker, Erika, Shaqiri, Erjona, Darwish Elhajji, Feras, Gawrys, Gerard, Markovic, Goran, Kunsihima, Hiroyuki, Chen, Hui Hiong, Sviestina, Inese, Pristas, Irina, Hoxha, Iris, Korinteli, Irma, Mareković, Ivana, Soltani, Jafar, Labarca, Jaime, AlSalman, Jameela, Horvatic, Jasminka, Frimpong, Juliet Ampomah, Pagava, Karaman, Kei, Kasahara, Okinaka, Keiji, Iregbu, Kenneth, Ghazaryan, Lilit, Raka, Lul, Gessner-Wharton, Mallory, Aldeyab, Mamoon, Cooper, Mandelin, del Castillo, Marcelo, Hojman, Martin, Hudson, Melissa, Alshehri, Mohamed, Ling, Moi Lin, Greer, Nickie, Oduyebo, Oyinlola, Buijtels, Patricia, TEROL BARRERO, PEDRO, Zarb, Peter, Schelstraete, PEtra, Nwajiobi-Princewill, Princewill Ifeanyi Philip, Khanna, Priya, Quiros, Rodolfo, Simovic, Sanja, Thompson, Sarah, Chan, Si Min, Burokiene, Sigita, Rachina, Svetlana, Usonis, Vytautas, Cornistein, Wanda, Holemans, Xavier, Gu, Yoshiaki, Brothers, Adam, Hersh, Adam, Fernandez, Alfred, Tribble, Alison, Hurst, Amanda, Green, Andrea, Hammer, Benjamin, Lee, Betty P, Kuzmic, Brenik, Shapiro, Craig, Boge, Craig, Haslam, David, Berman, David, Naeem, Fouzia, Johnson, George, Schwenk, Hayden, Orr, Hillary, Maples, Holly, Olsen, Jared, Gerber, Jeffrey, Girotto, Jennifer, Zweiner, Jennifer, Goldman, Jennifer, Gillon, Jessica, Tansmore, Jessica, Manaloor, John, Courter, Joshua, Mongkolrattanothai, Kanokporn, Patel, Karisma, Merkel, Kathryn, Namtu, Katie, Flett, Kelly, Lee, Kelly, Nichols, Kristen, Klein, Kristin, Handy, Lori, Castagnini, Luis, Mazade, Marc, Heger, Margaret, Fernandez, Marisol, Chang, Michael, Crawford, Michelle, Nelson, Miranda, Bennett, Nicholas, Jaggi, Preeti, Hamdy, Rana, Banerjee, Ritu, Olivero, Rosemary, Patel, Sameer, Arnold, Sandra, Ogrin, Sara, Jones, Sarah, Parker, Sarah, Kubes, Sarah, Hymes, Saul, Weissman, Scott, Chan, Shannon, Henderson, Sheryl, Metjian, Talene, Hsia, Yingfen, Lee, Brian R, Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, and Sharland, Mike

Published
2019
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23. Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis

Author

Ammann, Sandra, Lehmberg, Kai, zur Stadt, Udo, Klemann, Christian, Bode, Sebastian F. N., Speckmann, Carsten, Janka, Gritta, Wustrau, Katharina, Rakhmanov, Mirzokhid, Fuchs, Ilka, Hennies, Hans C., Ehl, Stephan, Ahlmann, Martina, Ammann, Roland, Behrends, Uta, Beier, Rita, von Bernuth, Horst, Beutel, Karin, Burkhardt, Birgit, Cario, Gunnar, Classen, Carl-Friedrich, Dürken, Matthias, Ebinger, Martin, Greil, Johann, Groß-Wieltsch, Ute, Gruhn, Bernd, Holter, Wolfgang, Hundsdörfer, Patrick, Kühnle, Ingrid, Jorch, Norbert, Kolb, Reinhard, Kühl, Jörn-Sven, Maecker, Britta, Meisel, Roland, Minkov, Milen, Müller, Ingo, Niehuis, Tim, Pachlopnik-Schmid, Jana, Pekrun, Arnulf, Prokop, Aram, Rischewski, Johannes, Schmid, Irene, Schulz, Ansgar, Schlegel, Paul-Gerhardt, Schündeln, Michael, Seidel, Markus, Simon, Thorsten, Sörensen, Jan, Chada, Martin, Suttorp, Meinolf, Woessmann, Wilhelm, and the HLH study of the GPOH

Published
2017
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24. Prospective evaluation of health care services for children, adolescents and young adults with post-COVID-19 condition in Bavaria, Germany

Author

Rathgeb, Chiara, Pawellek, Maja, Behrends, Uta, Alberer, Martin, Kabesch, Michael, Gerling, Stephan, Apfelbacher, Christian, and Brandstetter, Susanne

Subjects
ddc: 610, Medicine and health
Abstract

Background and status of (inter)national research: Some children and adolescents suffer from late effects of SARS-CoV-2 infection despite frequently mild courses of the initial coronavirus disease (COVID-19). Post-viral symptoms beyond three months after the infection were defined as post-COVID condition/post-COVID [for full text, please go to the a.m. URL]

Published
2022

26. Evaluation of a Webinar to Increase Health Professionals' Knowledge about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Author

Froehlich, Laura, Niedrich, Jasmin, Hattesohl, Daniel B. R., Behrends, Uta, Kedor, Claudia, Haas, Johannes-Peter, Stingl, Michael, and Scheibenbogen, Carmen

Subjects
RESEARCH, PROFESSIONS, ANALYSIS of variance, CONFIDENCE intervals, ATTITUDES of medical personnel, T-test (Statistics), CRONBACH'S alpha, WEBINARS, DESCRIPTIVE statistics, CHI-squared test, QUESTIONNAIRES, RESEARCH funding, STATISTICAL correlation, DATA analysis software, CHRONIC fatigue syndrome, HUMAN beings
Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic illness and patients with ME/CFS are often medically underserved in Germany and other countries. One contributing factor is health professionals' lack of knowledge about epidemiology, diagnostic criteria, and treatment of ME/CFS. Opportunities are scarce for health professionals to receive continuing medical education on ME/CFS. The current research addressed this need for further education and investigated the gain of knowledge from a webinar for German-speaking health professionals. In two studies (total sample: N = 378), participants in the intervention condition completed a knowledge test twice (before and after webinar participation). Study 2 also included a waiting-list control condition with repeated response to the knowledge test without webinar participation between measurements. Results showed that at baseline, most participants had seen patients with ME/CFS, but confidence in diagnosing and treating ME/CFS was only moderate-to-low. In the intervention condition, but not in the control condition, knowledge about ME/CFS increased between the first and the second knowledge test. These results indicate that the webinar was successful in increasing health professionals' knowledge about ME/CFS. We concluded that webinars can be a cost-efficient and effective tool in providing health professionals with large-scale continuing medical education about ME/CFS. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Post‐COVID‐19 condition in the German working population: A cross‐sectional study of 200,000 registered stem cell donors.

Author

Bernas, Stefanie N., Baldauf, Henning, Real, Ruben, Sauter, Jürgen, Markert, Jan, Trost, Sarah, Tausche, Kristin, Behrends, Uta, Schmidt, Alexander H., and Schetelig, Johannes

Subjects
STEM cell donors, COVID-19 pandemic, CROSS-sectional method, BODY mass index
Abstract

Background: The SARS‐CoV‐2 pandemic has strained health systems worldwide, and infection numbers continue to rise. While previous data have already shown that many patients suffer from symptoms for months after an acute infection, data on risk factors and long‐term outcomes are incomplete, particularly for the working population. Objectives: We aimed to provide information on the prevalence of post‐COVID‐19 conditions in a subset of the German working‐age population (18–61 years old) and to analyze risk factors. Methods: We conducted an online survey with a health questionnaire among registered potential stem cell donors with or without a self‐reported history of polymerase chain reaction (PCR)‐confirmed SARS‐CoV‐2 infection. Logistic regression models were used to examine the risks of severity of acute infection, sex, age, body mass index, diabetes mellitus, and arterial hypertension medication on post‐COVID‐19 symptoms. Results: A total of 199,377 donors reported evaluable survey questionnaires—12,609 cases had a history of SARS‐CoV‐2 infection and 186,768 controls had none. Overall, cases reported physical, cognitive, and psychological complaints more frequently compared to controls. Increased rates of complaints persisted throughout 15 months postinfection, for example, 28.4%/19.3% of cases/controls reported fatigue (p <0.0001) and 9.5%/3.6% of cases/controls reported loss of concentration (p <0.0001). No significant differences were observed in the frequency of reported symptoms between 3 and 15 months postinfection. Multivariate analysis revealed a strong influence of the severity of the acute SARS‐CoV‐2 infection episode and age on the risk for post‐COVID‐19 conditions. Conclusion: We report the prevalence of post‐COVID‐19 conditions in mainly unvaccinated individuals with SARS‐CoV‐2 infections between February 2020 and August 2021. The severity of the acute course and age were major risk factors. Vaccinations may reduce the risk of post‐COVID‐19 conditions by reducing the risk of severe infections. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany

Author

Sorg, Anna-Lisa, Becht, Selina, Wetzke, Martin, Stojanov, Silvia, Behrends, Uta, Drosten, Christian, Schroten, Horst, von Kries, Rüdiger, Jank, Marietta, Armann, Jakob, von Both, Ulrich, Hufnagel, Markus, Lander, Fabian, Liese, Johannes G., Niehues, Tim, and Verjans, Eva

Subjects
Male, Fatigue Syndrome, Chronic, Adolescent, SARS-CoV-2, COVID-19, General Medicine, Cross-Sectional Studies, Post-Acute COVID-19 Syndrome, Seroepidemiologic Studies, Germany, Immunoglobulin G, Communicable Disease Control, Quality of Life, Humans, Female, Child, Pandemics
Abstract

JAMA network open 5(9), 1-10 (2022). doi:10.1001/jamanetworkopen.2022.33454, Published by American Medical Association, Chicago, Ill.

Published
2022
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31. Post-COVID Syndrome.

Author

Hallek, Michael, Adorjan, Kristina, Behrends, Uta, Ertl, Georg, Suttorp, Norbert, and Lehmann, Clara

Abstract

Background: As defined by the WHO, the term post-COVID syndrome (PCS) embraces a group of symptoms that can occur following the acute phase of a SARS-CoV-2 infection and as a consequence thereof. PCS is found mainly in adults, less frequently in children and adolescents. It can develop both in patients who initially had only mild symptoms or none at all and in those who had a severe course of coronavirus disease 2019 (COVID-19). Methods: The data presented here were derived from a systematic literature review. Results: PCS occurs in up to 15% of unvaccinated adults infected with SARS-CoV-2. The prevalence has decreased in the most recent phase of the pandemic and is lower after vaccination. The pathogenesis of PCS has not yet been fully elucidated. Virus- triggered inflammation, autoimmunity, endothelial damage (to blood vessels), and persistence of virus are thought to be causative. Owing to the broad viral tropism, different organs are involved and the symptoms vary. To date, there are hardly any evidence-based recommendations for definitive diagnosis of PCS or its treatment. Conclusion: The gaps in our knowledge mean that better documentation of the prevalence of PCS is necessary to compile the data on which early detection, diagnosis, and treatment can be based. To ensure the best possible care of patients with PCS, regional PCS centers and networks embracing existing structures from all healthcare system sectors and providers should be set up and structured diagnosis and treatment algorithms should be established. Given the sometimes serious consequences of PCS for those affected, it seems advisable to keep the number of SARS-CoV-2 infections low by protective measures tailored to the prevailing pandemic situation. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Swarm Learning for decentralized and confidential clinical machine learning

Author

Warnat-Herresthal, Stefanie, Schultze, Hartmut, Ktena, Sofia, Franzenburg, Sören, Frick, Julia-Stefanie, Gabernet, Gisela, Gagneur, Julien, Ganzenmueller, Tina, Gauder, Marie, Geißert, Janina, Goesmann, Alexander, Göpel, Siri, Grundhoff, Adam, Tran, Florian, Grundmann, Hajo, Hain, Torsten, Hanses, Frank, Hehr, Ute, Heimbach, André, Hoeper, Marius, Horn, Friedemann, Hübschmann, Daniel, Hummel, Michael, Iftner, Thomas, Bitzer, Michael, Iftner, Angelika, Illig, Thomas, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keppler, Oliver T, Klein, Christoph, Knop, Michael, Kohlbacher, Oliver, Ossowski, Stephan, Köhrer, Karl, Korbel, Jan, Kremsner, Peter G, Kühnert, Denise, Landthaler, Markus, Li, Yang, Ludwig, Kerstin U, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice C, Casadei, Nicolas, Mertes, Christian, Münchhoff, Maximilian, Nahnsen, Sven, Nöthen, Markus M., Ntoumi, Francine, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Pink, Isabell, Poetsch, Anna R, Herr, Christian, Protzer, Ulrike, Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Reiche, Kristin, Ripke, Stephan, da Rocha, Ulisses Nunes, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Petersheim, Daniel, Scheithauer, Simone, Schiffer, Philipp, Schmid-Burgk, Jonathan, Schneider, Wulf, Schulte, Eva-Christina, Sczyrba, Alexander, Sharaf, Mariam L, Singh, Yogesh, Sonnabend, Michael, Stegle, Oliver, Behrends, Uta, Stoye, Jens, Vehreschild, Janne, Velavan, Thirumalaisamy P, Vogel, Jörg, Volland, Sonja, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Winkler, Sylke, Kern, Fabian, Ziebuhr, John, Fehlmann, Tobias, Shastry, Krishnaprasad Lingadahalli, Schommers, Philipp, Lehmann, Clara, Augustin, Max, Rybniker, Jan, Altmüller, Janine, Mishra, Neha, Bernardes, Joana P, Krämer, Benjamin, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Manamohan, Sathyanarayanan, De Domenico, Elena, Siever, Christian, Kraut, Michael, Desai, Milind, Monnet, Bruno, Saridaki, Maria, Siegel, Charles Martin, Drews, Anna, Nuesch Germano, Melanie, Theis, Heidi, Mukherjee, Saikat, Heyckendorf, Jan, Schreiber, Stefan, Kim-Hellmuth, Sarah, Study, COVID-19 Aachen, Nattermann, Jacob, Skowasch, Dirk, Kurth, Ingo, Keller, Andreas, Bals, Robert, Nürnberg, Peter, Garg, Vishesh, Rieß, Olaf, Rosenstiel, Philip, Netea, Mihai G, Theis, Fabian, Mukherjee, Sach, Backes, Michael, Aschenbrenner, Anna C, Ulas, Thomas, Initiative, Deutsche COVID-19 Omics, Breteler, Monique, Sarveswara, Ravi, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Becker, Matthias, Cheran, Sorin, Woodacre, Michael S, Goh, Eng Lim, Schultze, Joachim L, Balfanz, Paul, Eggermann, Thomas, Boor, Peter, Händler, Kristian, Hausmann, Ralf, Kuhn, Hannah, Isfort, Susanne, Stingl, Julia Carolin, Schmalzing, Günther, Kuhl, Christiane K, Röhrig, Rainer, Marx, Gernot, Uhlig, Stefan, Dahl, Edgar, Pickkers, Peter, Müller-Wieland, Dirk, Dreher, Michael, Marx, Nikolaus, Angelov, Angel, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Blumert, Conny, Bonifacio, Ezio, Bork, Peer, Aziz, Ahmad, Boyke, Bunk, Blum, Helmut, Clavel, Thomas, Colome-Tatche, Maria, Cornberg, Markus, De La Rosa Velázquez, Inti Alberto, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, and Stem Cell Aging Leukemia and Lymphoma (SALL)

Subjects
Lung Diseases, Male, 0301 basic medicine, Cancer Research, Computer science, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Privacy laws of the United States, Datasets as Topic, computer.software_genre, Disease Outbreaks, 0302 clinical medicine, Software, diagnosis [Leukemia], pathology [Leukemia], Leukocytes, Computational models, Use case, Confidentiality, 030212 general & internal medicine, Precision Medicine, Edge computing, Leukemia, Multidisciplinary, Swarm behaviour, diagnosis [Lung Diseases], ddc, 3. Good health, diagnosis [Tuberculosis], Female, ddc:500, Clinical Decision-Making, Predictive medicine, methods [Clinical Decision-Making], pathology [Leukocytes], Machine learning, Article, 03 medical and health sciences, methods [Precision Medicine], Blockchain, Humans, Tuberculosis, trends [Machine Learning], business.industry, COVID-19, Diagnostic markers, diagnosis [COVID-19], epidemiology [COVID-19], Precision medicine, 030104 developmental biology, Cardiovascular and Metabolic Diseases, Viral infection, Artificial intelligence, business, computer
Abstract

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes3. However, there is an increasing divide between what is technically possible and what is allowed, because of privacy legislation4,5. Here, to facilitate the integration of any medical data from any data owner worldwide without violating privacy laws, we introduce Swarm Learning—a decentralized machine-learning approach that unites edge computing, blockchain-based peer-to-peer networking and coordination while maintaining confidentiality without the need for a central coordinator, thereby going beyond federated learning. To illustrate the feasibility of using Swarm Learning to develop disease classifiers using distributed data, we chose four use cases of heterogeneous diseases (COVID-19, tuberculosis, leukaemia and lung pathologies). With more than 16,400 blood transcriptomes derived from 127 clinical studies with non-uniform distributions of cases and controls and substantial study biases, as well as more than 95,000 chest X-ray images, we show that Swarm Learning classifiers outperform those developed at individual sites. In addition, Swarm Learning completely fulfils local confidentiality regulations by design. We believe that this approach will notably accelerate the introduction of precision medicine., Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Published
2021

33. Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity.

Author

Nückel, Julius, Planatscher, Elisa, Wiebe Mohr, Anne, Deichl, Karolin, Mijočević, Hrvoje, Feuerherd, Martin, Wolff, Lisa, Erber, Johanna, Schneider, Jochen, Quante, Michael, Winter, Christoph, Ruland, Jürgen, Hapfelmeier, Alexander, Hammerschmidt, Wolfgang, Moosmann, Andreas, Protzer, Ulrike, Behrends, Uta, and Mautner, Josef

Subjects
SARS-CoV-2, COVID-19, VIRAL antigens, IMMUNOGLOBULIN G
Abstract

Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARSCoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha-but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Causal attributions and perceived stigma for myalgic encephalomyelitis/chronic fatigue syndrome.

Author

Froehlich, Laura, Hattesohl, Daniel BR, Cotler, Joseph, Jason, Leonard A, Scheibenbogen, Carmen, and Behrends, Uta

Subjects
SELF diagnosis, PSYCHOSOMATIC disorders, FUNCTIONAL status, SOCIAL stigma, SATISFACTION, COMMUNITY support, ATTITUDES toward illness, PATIENTS' attitudes, ATTRIBUTION (Social psychology), CHRONIC fatigue syndrome
Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disease with the hallmark symptom of post-exertional malaise. Evidence for physiological causes is converging, however, currently no diagnostic test or biomarker is available. People with ME/CFS experience stigmatization, including the perception that the disease is psychosomatic. In a sample of 499 participants with self-diagnosed ME/CFS, we investigated perceived stigma as a pathway through which perceived others' causal attributions relate to lower satisfaction with social roles and activities and functional status. Higher perceived attributions by others to controllable and unstable causes predicted lower health-related and social outcomes via higher perceived stigma. [ABSTRACT FROM AUTHOR]

Published
2022
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35. European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) : Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe

Author

Nacul, Luis, Authier, François Jérôme, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid Bergliot, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta, Nielsen, Henrik, Grabowski, Patricia, Sekulic, Slobodan, Sepulveda, Nuno, Estévez-López, Fernando, Zalewski, Paweł, Pheby, Derek, Castro-Marrero, Jesús, Sakkas, Giorgos K., Capelli, Enrica, Brundsdlund, Ivan, Cullinan, John, Krumina, Angelika, Bergquist, Jonas, Murovska, Modra, Vermuelen, Ruud C. W., Lacerda, Eliana, Universitat Autònoma de Barcelona, Child and Adolescent Psychiatry / Psychology, Institut Català de la Salut, [Nacul L] London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London WC1E 7HT, UK. BC Women’s Hospital, Vancouver, BC V6H 3N1, Canada. [Authier FJ] Faculty of Medicine Créteil—Paris Est, 94010 Creteil, France. [Scheibenbogen C] Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. [Lorusso L] Neurology and Stroke Unit—Neuroscience Department—A.S.S.T.—Lecco, 23900 Merate, Italy. [Helland IB] National Advisory Unit on CFS/ME, Oslo University Hospital, Rikshospitalet OUS, 0372 Oslo, Norway. [Martin JA] Unitat de Fatiga Crònica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castro-Marrero J] Secció de Reumatologia, Unitat de Recerca en Síndrome de Fatiga Crònica / Encefalomielitis Miàlgica (SFC/EM), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Chronic Fatigue Syndrome, Medicine (General), diagnosis, Service provision, Encephalomyelitis, Care, Malalties - Presa de decisions, Health services, 0302 clinical medicine, Health care, Diagnosis, Other subheadings::/diagnosis [Other subheadings], 030212 general & internal medicine, health care economics and organizations, Fatigue Syndrome, Chronic, General Medicine, Psychological Phenomena::Mental Processes::Thinking::Decision Making::Consensus [PSYCHIATRY AND PSYCHOLOGY], ddc, Europe, Nervous System Diseases::Central Nervous System Diseases::Encephalomyelitis::Nervous System Diseases::Fatigue Syndrome, Chronic [DISEASES], localizaciones geográficas::Europa (continente) [DENOMINACIONES GEOGRÁFICAS], fenómenos psicológicos::procesos mentales::pensamiento::toma de decisión::consenso [PSIQUIATRÍA Y PSICOLOGÍA], Myalgic Encephalomyelitis, Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi, musculoskeletal diseases, medicine.medical_specialty, Opinion, Consensus, Otros calificadores::/diagnóstico [Otros calificadores], Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Geographic Locations::Europe [GEOGRAPHICALS], Síndrome de fatiga crònica - Diagnòstic - Europa, 03 medical and health sciences, R5-920, medicine, Chronic fatigue syndrome, Humans, care, health services, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::encefalomielitis::enfermedades del sistema nervioso::síndrome de fatiga crónica [ENFERMEDADES], business.industry, Network on, Expert consensus, Health Care Service and Management, Health Policy and Services and Health Economy, medicine.disease, Family medicine, Clinical diagnosis, business, Delivery of Health Care, 030217 neurology & neurosurgery
Abstract

Encefalomielitis miàlgica/síndrome de fatiga crònica; Cura; Diagnòstic Myalgic encephalomyelitis/chronic fatigue syndrome; Care; Diagnosis Encefalomielitis miálgica/síndrome de fatiga crónica; Cuidado; Diagnóstico Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation in Science and Technology (COST)—COST action 15111—from 2016 to 2020. The main goal of the Cost Action was to assess the existing knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report our findings and make recommendations for clinical diagnosis, health services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS. This research received no external funding. EUROMENE receives funding for networking activities from the COST programme (COST Action 15111), via the COST Association.

Published
2021

36. HCoV- and SARS-CoV-2 cross-reactive T cells in CVID patients

Author

Steiner, Sophie, Sotzny, Franziska, Bauer, Sandra, Na, Il-Kang, Schmueck-Henneresse, Michael, Corman, Victor M., Schwarz, Tatjana, Drosten, Christian, Wendering, Désirée J., Behrends, Uta, Volk, Hans-Dieter, Scheibenbogen, Carmen, and Hanitsch, Leif G.

Subjects
Adult, Male, Cancer Research, human endemic coronavirus OC-43 (HCoV-OC43), Coronaviridae, T-Lymphocytes, viruses, Immunology, Cross Reactions, Antibodies, Viral, Young Adult, Humans, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Aged, Original Research, primary immunodeficiency (PID), human endemic coronavirus 229E (HCoV-229E), virus diseases, Middle Aged, T cell response, Common Variable Immunodeficiency, common variable immunodeficiency disorder (CVID), Immunoglobulin G, Cytokines, coronavirus disease 2019 (COVID-19), Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

The inability of patients with CVID to mount specific antibody responses to pathogens has raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role for protective T cells in these patients. SARS-CoV-2 reactive T cells have been reported for SARS-CoV-2 unexposed healthy individuals. Until now, there is no data on T cell immunity to SARS-CoV-2 infection in CVID. This study aimed to evaluate reactive T cells to human endemic corona viruses (HCoV) and to study pre-existing SARS-CoV-2 reactive T cells in unexposed CVID patients. We evaluated SARS-CoV-2- and HCoV-229E and -OC43 reactive T cells in response to seven peptide pools, including spike and nucleocapsid (NCAP) proteins, in 11 unexposed CVID, 12 unexposed and 11 post COVID-19 healthy controls (HC). We further characterized reactive T cells by IFNγ, TNFα and IL-2 profiles. SARS-CoV-2 spike-reactive CD4+ T cells were detected in 7 of 11 unexposed CVID patients, albeit with fewer multifunctional (IFNγ/TNFα/IL-2) cells than unexposed HC. CVID patients had no SARS-CoV-2 NCAP reactive CD4+ T cells and less reactive CD8+ cells compared to unexposed HC. We observed a correlation between T cell reactivity against spike of SARS-CoV-2 and HCoVs in unexposed, but not post COVID-19 HC, suggesting cross-reactivity. T cell responses in post COVID-19 HC could be distinguished from unexposed HC by higher frequencies of triple-positive NCAP reactive CD4+ T cells. Taken together, SARS-CoV-2 reactive T cells are detectable in unexposed CVID patients albeit with lower recognition frequencies and polyfunctional potential. Frequencies of triple-functional reactive CD4+ cells might provide a marker to distinguish HCoV cross-reactive from SARS-CoV-2 specific T cell responses. Our data provides evidence, that anti-viral T cell immunity is not relevantly impaired in most CVID patients.

Published
2020

37. EUROPEAN ME NETWORK (EUROMENE) Expert Consensus on the Diagnosis, Service Provision and Care of People with ME/CFS in Europe

Author

Nacul, Luis, Authier, Jerome, Scheibenbogen, Carmen, Lorusso, Lorenzo, Helland, Ingrid, Martin, Jose Alegre, Sirbu, Carmen Adella, Mengshoel, Anne Marit, Polo, Olli, Behrends, Uta, Nielsen, Henrik, Grabowski, Patricia, Sekulic, Slobodan, Sepulveda, Nuno, Lopez, Fernando Esteves, Zalewsk, Pawel, Pheby, Derek, Castro-Marrero, Jesus, Sakkas, Giorgos, Bergquist, Jonas, Capelli, Enrica, Brandslund, Ivan, Cullinan, John, Krumina, Angelika, Murovska, Modra, Vermuelen, Ruud, and Lacerda, Eliana

Subjects
musculoskeletal diseases, allergology, clinical_neurology, health care economics and organizations
Abstract

Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation is Science and Technology (COST) (https://www.cost.eu/cost-actions/what-are-cost-actions/ ) - COST action 15111 - from 2016 to 2020. The main goal of the Cost Action was to assess the existing fragmented knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report on the recommendations for clinical diagnosis, heath services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS (https://www.cost.eu/actions/CA15111/#tabs|Name:overview).

Published
2020

38. Immunoinformatic Analysis Reveals Antigenic Heterogeneity of Epstein-Barr Virus Is Immune-Driven.

Author

Cirac, Ana, Poirey, Remy, Dieckmeyer, Michael, Witter, Klaus, Delecluse, Henri-Jacques, Behrends, Uta, and Mautner, Josef

Subjects
EPSTEIN-Barr virus, WHOLE genome sequencing, EPITOPES, IMMUNE recognition, AMINO acid sequence
Abstract

Whole genome sequencing of Epstein-Barr virus (EBV) isolates from around the world has uncovered pervasive strain heterogeneity, but the forces driving strain diversification and the impact on immune recognition remained largely unknown. Using a data mining approach, we analyzed more than 300 T-cell epitopes in 168 published EBV strains. Polymorphisms were detected in approximately 65% of all CD8+ and 80% of all CD4+ T-cell epitopes and these numbers further increased when epitope flanking regions were included. Polymorphisms in CD8+ T-cell epitopes often involved MHC anchor residues and resulted in changes of the amino acid subgroup, suggesting that only a limited number of conserved T-cell epitopes may represent generic target antigens against different viral strains. Although considered the prototypic EBV strain, the rather low degree of overlap with most other viral strains implied that B95.8 may not represent the ideal reference strain for T-cell epitopes. Instead, a combinatorial library of consensus epitopes may provide better targets for diagnostic and therapeutic purposes when the infecting strain is unknown. Polymorphisms were significantly enriched in epitope versus non-epitope protein sequences, implicating immune selection in driving strain diversification. Remarkably, CD4+ T-cell epitopes in EBNA2, EBNA-LP, and the EBNA3 family appeared to be under negative selection pressure, hinting towards a beneficial role of immune responses against these latency type III antigens in virus biology. These findings validate this immunoinformatics approach for providing novel insight into immune targets and the intricate relationship of host defense and virus evolution that may also pertain to other pathogens. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries

Author

Hsia, Yingfen, Lee, Brian R, Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, Sharland, Mike, Irwin, Adam, Akula, Akhila, Bamford, Alasdair, Chang, Amanda, da Silva, Andre, Whitelaw, Andrew, Dramowski, Angela, Vasudevan, Anil Kumar, Sharma, Anita, Justicia, Antonio, Chikkappa, Ashok, Slowinska-Jarzabek, Barbara, Rippberger, Bianca, Zhao, Changan, Tersigni, Chiara, Cheng, Chinglan, Harkensee, Christian, Jing, Chuamei, Zhu, Chunmei, Li, Chunyan, Tagliabue, Claudia, Epalza, Cristina, Jacqueline, Daglish, Tian, Daiyin, Jinka, Dasaratha, Gkentzi, Despoina, Dharmapalan, Dhanya, Benadof, Dona, Papadimitriou, Eleni, Iosifidis, Elias, Roilides, Emmanuel, Yarci, Erbu, Majda-Stanisławska, Ewa, Gowin, Ewelina, Chappell, Faye, Torres, Federico Martinon, Collett-White, Francis, Liu, Gang, Lu, Gen, Syrogiannopoulos, George, Pitsava, Georgia, Alvarez-Uria, Gerardo, Renk, Hana, Mahmood, Hana, Saxen, Harri, Finlayson, Heather, Green, Helen, Rabie, Helena, Kandraju, Hemasree, Zhang, Hong, Okokon, Ita, Cross, Jack, Herberg, Jethro, Li, Jianping, Zhang, Jiaosheng, Deng, Jikui, Liu, Jing, Qian, Jing, Yang, Jinhong, Sicińska, Joanna, Hübner, Johannes, Fukuoka, Kahoru, Yao, Kaihu, Cheung, Kaman, Ojeda, Karla, Kaffe, Katerina, Kreitmeyer, Katharina, Doerholt, Katja, Grimwood, Keith, Ledoare, Kirsty, Vazouras, Konstantinos, Shen, Kunling, Tang, Lanfang, Zhang, Lehai, Lin, Li, Ashkenazi-Hoffnung, Liat, Wu, Lijuan, Wang, Lijun, Teston, Lilian, Galli, Luisa, Speirs, Lynne, Tsolia, Maria, Hufnagel, Markus, Knuf, Markus, Duse, Marzia, Ding, Mingjie, Rozic, Mojca, Premru, Mueller, O'Connell, Natasha, Rieber, Nikolaus, Spyridis, Nikos, Tunga, Onkaraiah, Conejo, Pablo Rojo, McMaster, Paddy, Lumbiganon, Pagakrong, Pansa, Paola, D'Argenio, Patrizia, Moriarty, Paul, Nikolic, Petra, Wang, Ping, Paopongsawan, Pongsatorn, Cao, Qing, Deng, Qiulian, Laxminarayan, Ramanan, Kanithi, Ravishankar, Jimenez, Rodolfo, Cao, Sancheng, Singh, Sanjeev, Rees, Sarah, Praveen, Saroey, Kekomaki, Satu, Hackett, Scott, Ashkenazi, Shai, Chang, Si Min, Drysdale, Simon, Koning, Sonia, Subramanian, Sreeram, Murki, Srinivas, Vergnano, Stefania, Gandra, Sumanth, Esposito, Susanna, Anugulruengkitt, Suvaporn, Puthanakit, Thanyawee, Behrends, Uta, Papaevangelous, Vana, Jian, Victoria, Li, Wei, Zhao, Wei, Wang, Wei, Zhang, Wenshuang, Mu, Xiaoping, Dong, Xiaoyie, Jiang, Xiyuan, Chen, Xu, Wang, Yi, Zheng, Yuejie, Horikoshi, Yuho, Aboderin, Aaron, Olayinka, Adebola, Dedeic-Ljubovic, Amela, McCorry, Ann, Enimil, Anthony, Neubert, Antje, solano, antonio, Pignatari, Antonio, Poojary, Aruna, Kambaralieva, Baktygul, McCullagh, Bernadette, Carevi, Biljana, Van Herendael, Bruno, Gormley, Cairine, Carvajal, Camila, Ramírez, Carlos, Fitzgerald, David, Sabuda, Deana, Konopnicki, Deborah, Lacej, Denada, Pierard, Denis, Rios, Edgar, Marshall, Emily, Firre, Eric, van Elzakker, Erika, Shaqiri, Erjona, Darwish Elhajji, Feras, Gawrys, Gerard, Markovic, Goran, Kunsihima, Hiroyuki, Chen, Hui Hiong, Sviestina, Inese, Pristas, Irina, Hoxha, Iris, Korinteli, Irma, Mareković, Ivana, Soltani, Jafar, Labarca, Jaime, AlSalman, Jameela, Horvatic, Jasminka, Frimpong, Juliet Ampomah, Pagava, Karaman, Kei, Kasahara, Okinaka, Keiji, Iregbu, Kenneth, Ghazaryan, Lilit, Raka, Lul, Gessner-Wharton, Mallory, Aldeyab, Mamoon, Cooper, Mandelin, del Castillo, Marcelo, Hojman, Martin, Hudson, Melissa, Alshehri, Mohamed, Ling, Moi Lin, Greer, Nickie, Oduyebo, Oyinlola, Buijtels, Patricia, TEROL BARRERO, PEDRO, Zarb, Peter, Schelstraete, Petra, Nwajiobi-Princewill, Princewill Ifeanyi Philip, Khanna, Priya, Quiros, Rodolfo, Simovic, Sanja, Thompson, Sarah, Chan, Si Min, Burokiene, Sigita, Rachina, Svetlana, Usonis, Vytautas, Cornistein, Wanda, Holemans, Xavier, Gu, Yoshiaki, Brothers, Adam, Hersh, Adam, Fernandez, Alfred, Tribble, Alison, Hurst, Amanda, Green, Andrea, Hammer, Benjamin, Lee, Betty P, Kuzmic, Brenik, Shapiro, Craig, Boge, Craig, Haslam, David, Berman, David, Naeem, Fouzia, Johnson, George, Schwenk, Hayden, Orr, Hillary, Maples, Holly, Olsen, Jared, Gerber, Jeffrey, Girotto, Jennifer, Zweiner, Jennifer, Goldman, Jennifer, Gillon, Jessica, Tansmore, Jessica, Manaloor, John, Courter, Joshua, Mongkolrattanothai, Kanokporn, Patel, Karisma, Merkel, Kathryn, Namtu, Katie, Flett, Kelly, Lee, Kelly, Nichols, Kristen, Klein, Kristin, Handy, Lori, Castagnini, Luis, Mazade, Marc, Heger, Margaret, Fernandez, Marisol, Chang, Michael, Crawford, Michelle, Nelson, Miranda, Bennett, Nicholas, Jaggi, Preeti, Hamdy, Rana, Banerjee, Ritu, Olivero, Rosemary, Patel, Sameer, Arnold, Sandra, Ogrin, Sara, Jones, Sarah, Parker, Sarah, Kubes, Sarah, Hymes, Saul, Weissman, Scott, Chan, Shannon, Henderson, Sheryl, Metjian, Talene, GARPEC and Global-PPS networks, on behalf of the, GARPEC Network, Global-PPS Network, Children's Hospital, HUS Children and Adolescents, and Clinicum

Subjects
medicine.medical_specialty, Adolescent, medicine.drug_class, 030231 tropical medicine, Antibiotics, MEDLINE, Psychological intervention, CHILDREN, World Health Organization, Pediatrics, Essential medicines, 03 medical and health sciences, Antimicrobial Stewardship, 0302 clinical medicine, Antibiotic resistance, POINT PREVALENCE SURVEY, SURVEILLANCE, Medicine and Health Sciences, Medicine, Antimicrobial stewardship, Humans, 030212 general & internal medicine, Medical prescription, Child, Neonatal sepsis, business.industry, lcsh:Public aspects of medicine, STEWARDSHIP, Infant, Newborn, Infant, lcsh:RA1-1270, General Medicine, medicine.disease, 3142 Public health care science, environmental and occupational health, Drug Utilization, 3. Good health, Anti-Bacterial Agents, QUALITY INDICATORS, Family medicine, Child, Preschool, Health Care Surveys, Human medicine, business, Pharmacy Service, Hospital
Abstract

Summary: Background: Improving the quality of hospital antibiotic use is a major goal of WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed to present data on patterns of paediatric AWaRe antibiotic use that could be used for local and national stewardship interventions. Methods: 1-day point prevalence survey antibiotic prescription data were combined from two independent global networks: the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children and the Global Point Prevalence Survey on Antimicrobial Consumption and Resistance networks. We included hospital inpatients aged younger than 19 years receiving at least one antibiotic on the day of the survey. The WHO AWaRe classification was used to describe overall antibiotic use as assessed by the variation between use of Access, Watch, and Reserve antibiotics, for neonates and children and for the commonest clinical indications. Findings: Of the 23 572 patients included from 56 countries, 18 305 were children (77·7%) and 5267 were neonates (22·3%). Access antibiotic use in children ranged from 7·8% (China) to 61·2% (Slovenia) of all antibiotic prescriptions. The use of Watch antibiotics in children was highest in Iran (77·3%) and lowest in Finland (23·0%). In neonates, Access antibiotic use was highest in Singapore (100·0%) and lowest in China (24·2%). Reserve antibiotic use was low in all countries. Major differences in clinical syndrome-specific patterns of AWaRe antibiotic use in lower respiratory tract infection and neonatal sepsis were observed between WHO regions and countries. Interpretation: There is substantial global variation in the proportion of AWaRe antibiotics used in hospitalised neonates and children. The AWaRe classification could potentially be used as a simple traffic light metric of appropriate antibiotic use. Future efforts should focus on developing and evaluating paediatric antibiotic stewardship programmes on the basis of the AWaRe index. Funding: GARPEC was funded by the PENTA Foundation. GARPEC-China data collection was funded by the Sanming Project of Medicine in Shenzhen (SZSM2015120330). bioMérieux provided unrestricted funding support for the Global-PPS.

Published
2019

40. The Epstein-Barr virus induces the expression of the LPAM-1 integrin in B-cells in vitro and in vivo

Author

Delecluse, Susanne, Tsai, Ming-Han, Shumilov, Anatoliy, Bencun, Maja, Arrow, Sebastian, Beshirova, Aisha, Cottignies-Calamarte, Andréa, Lasitschka, Felix, Bulut, Olcay Cem, Münz, Christian, Zeier, Martin, Behrends, Uta, Delecluse, Henri-Jacques, and University of Zurich

Subjects
2403 Immunology, 1109 Insect Science, 2404 Microbiology, 2406 Virology, 570 Life sciences, biology, 610 Medicine & health, 10263 Institute of Experimental Immunology
Published
2019

41. Medical Care Situation of People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Germany.

Author

Froehlich, Laura, Hattesohl, Daniel B. R., Jason, Leonard A., Scheibenbogen, Carmen, Behrends, Uta, and Thoma, Manuel

Subjects
CHRONIC fatigue syndrome, MEDICAL care, BIOMARKERS, PATIENT satisfaction
Abstract

Background and Objective: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe illness with the hallmark symptom of Post-Exertional Malaise (PEM). Currently, no biomarkers or established diagnostic tests for ME/CFS exist. In Germany, it is estimated that over 300,000 people are affected by ME/CFS. Research from the United States and the UK shows that patients with ME/CFS are medically underserved, as they face barriers to medical care access and are dissatisfied with medical care. The first aim of the current research was to investigate whether patients with ME/CFS are medically underserved in Germany in terms of access to and satisfaction with medical care. Second, we aimed at providing a German-language version of the DePaul Symptom Questionnaire Short Form (DSQ-SF) as a tool for ME/CFS diagnostics and research in German-speaking countries. Materials and Methods: The current research conducted an online questionnaire study in Germany investigating the medical care situation of patients with ME/CFS. The questionnaire was completed by 499 participants who fulfilled the Canadian Consensus Criteria and reported PEM of 14 h or longer. Results: Participants frequently reported geographic and financial reasons for not using the available medical services. Furthermore, they reported low satisfaction with medical care by the physician they most frequently visited due to ME/CFS. The German version of the DSQ-SF showed good reliability, a one-factorial structure and construct validity, demonstrated by correlations with the SF-36 as a measure of functional status. Conclusions: Findings provide evidence that patients with ME/CFS in Germany are medically underserved. The German-language translation of the DSQ-SF provides a brief, reliable and valid instrument to assess ME/CFS symptoms to be used for research and clinical practice in German-speaking countries. Pathways to improve the medical care of patients with ME/CFS are discussed. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Needs for an Integration of Specific Data Sources and Items -- First Insights of a National Survey Within the German Center for Infection Research.

Author

JAKOB, Carolin E. M., STECHER, Melanie, FUHRMANN, Sandra, WINGEN-HEIMANN, Sebastian, HEINEN, Stephanie, ANTON, Gabriele, BEHNKE, Michael, BEHRENDS, Uta, BOEKER, Martin, CASTELL, Stefanie, DEMSKI, Hans, DIEFENBACH, Maximilian, FALGENHAUER, Jane C., FRITZENWANKER, Moritz, GASTMEIER, Petra, GERHARD, Markus, GLÖCKNER, Stephan, GOLUBOVIC, Mira, GUNSENHEIMER BARTMEYER, Barbara, and INGENERF, Josef

Abstract

State-subsidized programs develop medical data integration centers in Germany. To get infection disease (ID) researchers involved in the process of data sharing, common interests and minimum data requirements were prioritized. In 06/2019 we have initiated the German Infectious Disease Data Exchange (iDEx) project. We have developed and performed an online survey to determine prioritization of requests for data integration and exchange in ID research. The survey was designed with three sub-surveys, including a ranking of 15 data categories and 184 specific data items and a query of available 51 data collecting systems. A total of 84 researchers from 17 fields of ID research participated in the survey (predominant research fields: gastrointestinal infections n=11, healthcare-associated and antibiotic-resistant infections n=10, hepatitis n=10). 48 % (40/84) of participants had experience as medical doctor. The three top ranked data categories were microbiology and parasitology, experimental data, and medication (53%, 52%, and 47% of maximal points, respectively). The most relevant data items for these categories were bloodstream infections, availability of biomaterial, and medication (88%, 87%, and 94% of maximal points, respectively). The ranking of requests of data integration and exchange is diverse and depends on the chosen measure. However, there is need to promote discipline-related digitalization and data exchange. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Immune Thrombocytopenia in Two Unrelated Fanconi Anemia Patients â€' A Mere Coincidence?

Author

Karastaneva, Anna, Lanz, Sofia, Wawer, Angela, Behrends, Uta, Schindler, Detlev, Dietrich, Ralf, Burdach, Stefan, Urban, Christian, Benesch, Martin, and Seidel, Markus G.

Subjects
DNA repair defect, immune thrombocytopenia, hemic and lymphatic diseases, Fanconi anemia, FANCD2, Pediatrics, Perinatology and Child Health, Evans syndrome, Pediatrics, bone marrow failure syndrome, danazol, FANCA
Abstract

Thrombocytopenia and pancytopenia, occurring in patients with Fanconi anemia (FA), are interpreted either as progression to bone marrow failure or as developing myelodysplasia. On the other hand, immune thrombocytopenia (ITP) represents an acquired and often self-limiting benign hematologic disorder, associated with peripheral, immune-mediated, platelet destruction requiring different management modalities than those used in congenital bone marrow failure syndromes, including FA. Here, we describe the clinical course of two independent FA patients with atypical – namely immune – thrombocytopenia. While in one patient belonging to complementation group FA-A, the ITP started at 17 months of age and showed a chronically persisting course with severe purpura, responding well to intravenous immunoglobulins (IVIG) and later also danazol, a synthetic androgen, the other patient (of complementation group FA-D2) had a self-limiting course that resolved after one administration of IVIG. No cytogenetic aberrations or bone marrow abnormalities other than FA-typical mild dysplasia were detected. Our data show that acute and chronic ITP may occur in FA patients and impose individual diagnostic and therapeutic challenges in this rare congenital bone marrow failure/tumor predisposition syndrome. The management and a potential context of immune pathogenesis with the underlying marrow disorder are discussed.

Published
2015
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44. Immune thrombocytopenia in two unrelated Fanconi anemia patients - a mere coincidence?

Author

Karastaneva, Anna, Lanz, Sofia, Wawer, Angela, Behrends, Uta, Schindler, Detlev, Dietrich, Ralf, Burdach, Stefan, Urban, Christian, Benesch, Martin, and Seidel, Markus G.

Subjects
DNA repair defect, immune thrombocytopenia, Fanconi anemia, FANCD2, hemic and lymphatic diseases, Evans syndrome, ddc:610, Pediatrics, bone marrow failure syndrome, danazol, Original Research, FANCA
Abstract

Thrombocytopenia and pancytopenia, occurring in patients with Fanconi anemia (FA), are interpreted either as progression to bone marrow failure or as developing myelodysplasia. On the other hand, immune thrombocytopenia (ITP) represents an acquired and often self-limiting benign hematologic disorder, associated with peripheral, immune-mediated, platelet destruction requiring different management modalities than those used in congenital bone marrow failure syndromes, including FA. Here, we describe the clinical course of two independent FA patients with atypical - namely immune - thrombocytopenia. While in one patient belonging to complementation group FA-A, the ITP started at 17 months of age and showed a chronically persisting course with severe purpura, responding well to intravenous immunoglobulins (IVIG) and later also danazol, a synthetic androgen, the other patient (of complementation group FA-D2) had a self-limiting course that resolved after one administration of IVIG. No cytogenetic aberrations or bone marrow abnormalities other than FA-typical mild dysplasia were detected. Our data show that acute and chronic ITP may occur in FA patients and impose individual diagnostic and therapeutic challenges in this rare congenital bone marrow failure/tumor predisposition syndrome. The management and a potential context of immune pathogenesis with the underlying marrow disorder are discussed.

Published
2015

45. Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs.

Author

Delecluse, Susanne, Yu, Jiyang, Bernhardt, Katharina, Haar, Janina, Poirey, Remy, Tsai, Ming-Han, Kiblawi, Rama, Kopp-Schneider, Annette, Schnitzler, Paul, Zeier, Martin, Dreger, Peter, Wuchter, Patrick, Bulut, Olcay Cem, Behrends, Uta, and Delecluse, Henri-Jacques

Subjects
LYMPHOBLASTOID cell lines, EPSTEIN-Barr virus diseases, MONONUCLEOSIS, INFECTION, VIRUS diseases, LYMPHOPROLIFERATIVE disorders, HOST-virus relationships
Abstract

The Epstein-Barr virus (EBV) induces B-cell proliferation with high efficiency through expression of latent proteins and microRNAs. This process takes place in vivo soon after infection, presumably to expand the virus reservoir, but can also induce pathologies, e.g. an infectious mononucleosis (IM) syndrome after primary infection or a B-cell lymphoproliferation in immunosuppressed individuals. In this paper, we investigated the growth characteristics of EBV-infected B-cells isolated from transplant recipients or patients with IM. We found that these cells grew and withstood apoptosis at highly variable rates, suggesting that the expansion rate of the infected B-cells widely varies between individuals, thereby influencing the size of the B-cell reservoir and the ability to form tumors in infected individuals. All viruses investigated were type 1 and genetically close to western strains. EBV-infected B-cells expressed the transforming EBV latent genes and microRNAs (miRNAs) at variable levels. We found that the B-cell growth rates positively correlated with the BHRF1 miRNA levels. Comparative studies showed that infected B-cells derived from transplant recipients with iEBVL on average expressed higher levels of EBV miR-BHRF1 miRNAs and grew more rapidly than B-cells from IM patients, suggesting infection by more transforming viruses. Altogether, these findings suggest that EBV infection has a highly variable impact on the B-cell compartment that probably reflects the genetic diversity of both the virus and the host. It also demonstrates the unexpected finding that B-cells from different individuals can grow at different speed under the influence of the same virus infection. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation

Author

Mynarek, Martin, Schober, Tilmann, Behrends, Uta, and Maecker-Kolhoff, Britta

Subjects
surgical procedures, operative, Article Subject, hemic and lymphatic diseases
Abstract

Patients after solid organ transplantation (SOT) carry a substantially increased risk to develop malignant lymphomas. This is in part due to the immunosuppression required to maintain the function of the organ graft. Depending on the transplanted organ, up to 15% of pediatric transplant recipients acquire posttransplant lymphoproliferative disease (PTLD), and eventually 20% of those succumb to the disease. Early diagnosis of PTLD is often hampered by the unspecific symptoms and the difficult differential diagnosis, which includes atypical infections as well as graft rejection. Treatment of PTLD is limited by the high vulnerability towards antineoplastic chemotherapy in transplanted children. However, new treatment strategies and especially the introduction of the monoclonal anti-CD20 antibody rituximab have dramatically improved outcomes of PTLD. This review discusses risk factors for the development of PTLD in children, summarizes current approaches to therapy, and gives an outlook on developing new treatment modalities like targeted therapy with virus-specific T cells. Finally, monitoring strategies are evaluated.

Published
2013
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47. Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature

Author

Grunewald, Thomas G. P., von Luettichau, Irene, Weirich, Gregor, Wawer, Angela, Behrends, Uta, Prodinger, Peter M., Jundt, Gernot, Bielack, Stefan S., Gradinger, Reiner, and Burdach, Stefan

Subjects
Article Subject
Abstract

Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue sarcoma mostly occurring in extraosseous sites. SEF represents a clinically challenging entity especially because no standardized treatment regimens are available. Intraosseous localization is an additional challenge with respect to the therapeutical approach. We report on a 16-year-old patient with SEF of the right proximal tibia. The patient underwent standardized neoadjuvant chemotherapy analogous to the EURAMOS-1 protocol for the treatment of osteosarcoma followed by tumor resection and endoprosthetic reconstruction. Histopathological analysis of the resected tumor showed >90% vital tumor cells suggesting no response to chemotherapy. Therefore, therapy was reassigned to the CWS 2002 High-Risk protocol for the treatment of soft tissue sarcoma. To date (22 months after diagnosis), there is no evidence of relapse or metastasis. Our data suggest that SEF may be resistant to a chemotherapy regimen containing Cisplatin, Doxorubicin, and Methotrexate, which should be considered in planning treatment for patients with SEF.

Published
2010
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48. Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.

Author

Loebel, Madlen, Eckey, Maren, Sotzny, Franziska, Hahn, Elisabeth, Bauer, Sandra, Grabowski, Patricia, Zerweck, Johannes, Holenya, Pavlo, Hanitsch, Leif G., Wittke, Kirsten, Borchmann, Peter, Rüffer, Jens-Ulrich, Hiepe, Falk, Ruprecht, Klemens, Behrends, Uta, Meindl, Carola, Volk, Hans-Dieter, Reimer, Ulf, and Scheibenbogen, Carmen

Subjects
CHRONIC fatigue syndrome, EPSTEIN-Barr virus, IMMUNOSPECIFICITY, PROTEIN microarrays, MONONUCLEOSIS
Abstract

Background: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various autoimmune diseases. In a subset of patients with Chronic Fatigue Syndrome (CFS) disease starts with infectious mononucleosis as late primary EBV-infection, whereby altered levels of EBV-specific antibodies can be observed in another subset of patients. Methods: We performed a comprehensive mapping of the IgG response against EBV comparing 50 healthy controls with 92 CFS patients using a microarray platform. Patients with multiple sclerosis (MS), systemic lupus erythematosus (SLE) and cancer-related fatigue served as controls. 3054 overlapping peptides were synthesised as 15-mers from 14 different EBV proteins. Array data was validated by ELISA for selected peptides. Prevalence of EBV serotypes was determined by qPCR from throat washing samples. Results: EBV type 1 infections were found in patients and controls. EBV seroarray profiles between healthy controls and CFS were less divergent than that observed for MS or SLE. We found significantly enhanced IgG responses to several EBNA-6 peptides containing a repeat sequence in CFS patients compared to controls. EBNA-6 peptide IgG responses correlated well with EBNA-6 protein responses. The EBNA-6 repeat region showed sequence homologies to various human proteins. Conclusion: Patients with CFS had a quite similar EBV IgG antibody response pattern as healthy controls. Enhanced IgG reactivity against an EBNA-6 repeat sequence and against EBNA-6 protein is found in CFS patients. Homologous sequences of various human proteins with this EBNA-6 repeat sequence might be potential targets for antigenic mimicry. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring.

Author

Körber, Nina, Behrends, Uta, Hapfelmeier, Alexander, Protzer, Ulrike, and Bauer, Tanja

Subjects
*ENZYME-linked immunosorbent assay, *FIRE assay, *CYTOKINES, *EPSTEIN-Barr virus diseases, *CLINICAL trials monitoring, *EPSTEIN-Barr virus, *IMMUNOLOGY, *CLINICAL trials, *COMPARATIVE studies, *IMMUNOASSAY, *INTERFERONS, *INTERLEUKIN-2, *LIGHT, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *EVALUATION research, RESEARCH evaluation
Abstract

Background: The FluoroSpot assay, an advancement of the ELISpot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. This allows parallel detection of several cytokines secreted by immune cells upon antigen recognition. Easier standardization, higher sensitivity and reduced labour intensity render FluoroSpot assays an interesting alternative to flow-cytometry based assays for analysis of clinical samples. While the use of immunoassays to study immunological primary and secondary endpoints becomes increasingly attractive, assays used require pre-trial validation. Here we describe the assay validation (precision, specificity and linearity) of a FluoroSpot immunological endpoint assay detecting Interferon γ (IFNγ) and Interleukin 2 (IL2) for use in clinical trial immune monitoring.Methods: We validated an IFNγ/IL2 FluoroSpot assay to determine Epstein-Barr virus (EBV)-specific cellular immune responses (IFNγ, IL2 and double positive IFNγ + IL2 responses), using overlapping peptide pools corresponding to EBV-proteins BZLF1 and EBNA3A. Assay validation was performed using cryopreserved PBMC of 16 EBV-seropositive and 6 EBV-seronegative donors. Precision was assessed by (i) testing 16 donors using three replicates per assay (intra-assay precision/repeatability) (ii) using two plates in parallel (intermediate precision/plate-to-plate variability) and (iii) by performing the assays on three different days (inter-assay precision/reproducibility). In addition, we determined specificity, linearity and quantification limits of the assay. Further we tested precision across the two assay systems, IFNγ/IL2 FluoroSpot and the corresponding enzymatic single cytokine ELISpot.Results: The validation revealed: (1) a high intra-assay precision (coefficient of variation (CV) 9.96, 8.85 and 13.05 %), intermediate precision (CV 6.48, 10.20 and 12.97 %) and reproducibility (CV 20.81 %, 12,75 % and 12.07 %) depending on the analyte and antigen used; (2) a specificity of 100 %; (3) a linearity with R (2) values from 0.93 to 0.99 depending on the analyte. The testing of the precision across the two assay systems, adduced a concordance correlation coefficient p c  = 0.99 for IFNγ responses and p c  = 0.93 for IL2 responses, indicating a large agreement between both assay methods.Conclusions: The validated primary endpoint assay, an EBV peptide pool specific IFNγ/IL2 FluoroSpot assay was found to be suitable for the detection of EBV-specific immune responses subject to the requirement of standardized assay procedure and data analysis. [ABSTRACT FROM AUTHOR]

Published
2016
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50. Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing.

Author

Fiebiger, Benjamin M., Pfister, Heike, Behrends, Uta, and Mautner, Josef

Abstract

Peptides presented on major histocompatibility complex (MHC) class I molecules are generated via cytosolic proteolysis. However, the nature of the endogenous peptide precursors and the intracellular processing steps preceding protein degradation remain poorly defined. Here, we assessed whether ubiquitination is an essential signal for proteasomal cleavage of antigen substrates in human cells. Conversion into antigenic peptides occurred in the absence of any detectable N-terminal ubiquitination of the model antigens, and did not require the presence of any of the four types, nor a minimum number of ubiquitinatable amino acids within the antigen substrate. However, the knockdown of ubiquitin, expression of a lysine 48 (K48) ubiquitin mutant, or inhibition of proteasome-associated deubiquitinases significantly impaired antigen presentation. The results presented here are consistent with a model in which the binding of the antigen substrate by an adaptor protein leads to its K48-polyubiquitination and the subsequent delivery of the antigen cargo for degradation by the 26S proteasome. Altogether, these findings show an important but indirect role of K48-polyubiquitination in preproteasomal antigen sampling. [ABSTRACT FROM AUTHOR]

Published
2015
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