965 results on '"Bergman, Richard N."'
Search Results
2. Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
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Williamson, Alice, Norris, Dougall M., Yin, Xianyong, Broadaway, K. Alaine, Moxley, Anne H., Vadlamudi, Swarooparani, Wilson, Emma P., Jackson, Anne U., Ahuja, Vasudha, Andersen, Mette K., Arzumanyan, Zorayr, Bonnycastle, Lori L., Bornstein, Stefan R., Bretschneider, Maxi P., Buchanan, Thomas A., Chang, Yi-Cheng, Chuang, Lee-Ming, Chung, Ren-Hua, Clausen, Tine D., Damm, Peter, Delgado, Graciela E., de Mello, Vanessa D., Dupuis, Josée, Dwivedi, Om P., Erdos, Michael R., Silva, Lilian Fernandes, Frayling, Timothy M., Gieger, Christian, Goodarzi, Mark O., Guo, Xiuqing, Gustafsson, Stefan, Hakaste, Liisa, Hammar, Ulf, Hatem, Gad, Herrmann, Sandra, Højlund, Kurt, Horn, Katrin, Hsueh, Willa A., Hung, Yi-Jen, Hwu, Chii-Min, Jonsson, Anna, Kårhus, Line L., Kleber, Marcus E., Kovacs, Peter, Lakka, Timo A., Lauzon, Marie, Lee, I-Te, Lindgren, Cecilia M., Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Luan, Jian’an, Aly, Dina Mansour, Mathiesen, Elisabeth, Moissl, Angela P., Morris, Andrew P., Narisu, Narisu, Perakakis, Nikolaos, Peters, Annette, Prasad, Rashmi B., Rodionov, Roman N., Roll, Kathryn, Rundsten, Carsten F., Sarnowski, Chloé, Savonen, Kai, Scholz, Markus, Sharma, Sapna, Stinson, Sara E., Suleman, Sufyan, Tan, Jingyi, Taylor, Kent D., Uusitupa, Matti, Vistisen, Dorte, Witte, Daniel R., Walther, Romy, Wu, Peitao, Xiang, Anny H., Zethelius, Björn, Ahlqvist, Emma, Bergman, Richard N., Chen, Yii-Der Ida, Collins, Francis S., Fall, Tove, Florez, Jose C., Fritsche, Andreas, Grallert, Harald, Groop, Leif, Hansen, Torben, Koistinen, Heikki A., Komulainen, Pirjo, Laakso, Markku, Lind, Lars, Loeffler, Markus, März, Winfried, Meigs, James B., Raffel, Leslie J., Rauramaa, Rainer, Rotter, Jerome I., Schwarz, Peter E. H., Stumvoll, Michael, Sundström, Johan, Tönjes, Anke, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Wagner, Robert, Barroso, Inês, Walker, Mark, Grarup, Niels, Boehnke, Michael, Wareham, Nicholas J., Mohlke, Karen L., Wheeler, Eleanor, O’Rahilly, Stephen, Fazakerley, Daniel J., and Langenberg, Claudia
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- 2023
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3. Methods for estimating insulin resistance from untargeted metabolomics data
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Hsu, Fang-Chi, Palmer, Nicholette D., Chen, Shyh-Huei, Ng, Maggie C. Y., Goodarzi, Mark O., Rotter, Jerome I., Wagenknecht, Lynne E., Bancks, Michael P., Bergman, Richard N., and Bowden, Donald W.
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- 2023
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4. Measures of glucose homeostasis during and after duodenal exclusion using a duodenal-jejunal bypass liner in a normoglycemic, nonobese canine model
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Paszkiewicz, Rebecca L., Burch, Miguel A., Asare Bediako, Isaac, Mkrtchyan, Hasmik, Piccinini, Francesca, Ader, Marilyn, Bresee, Catherine, and Bergman, Richard N.
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- 2022
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5. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
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Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa, Stafford, Jeanette M., Pourcain, Beate St, Timpson, Nicholas J., Salo, Perttu, Shin, So-Youn, Amin, Najaf, Smith, Albert V., Li, Guo, Verweij, Niek, Goel, Anuj, Ford, Ian, Johnson, Paul C. D., Johnson, Toby, Kapur, Karen, Thorleifsson, Gudmar, Strawbridge, Rona J., Rasmussen-Torvik, Laura J., Esko, Tõnu, Mihailov, Evelin, Fall, Tove, Fraser, Ross M., Mahajan, Anubha, Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E., Silbernagel, Günther, Meyer, Julia, Müller-Nurasyid, Martina, Ganna, Andrea, Sarin, Antti-Pekka, Yengo, Loic, Shungin, Dmitry, Luan, Jian’an, Horikoshi, Momoko, An, Ping, Sanna, Serena, Boettcher, Yvonne, Rayner, N. William, Nolte, Ilja M., Zemunik, Tatijana, Iperen, Erik van, Kovacs, Peter, Hastie, Nicholas D., Wild, Sarah H., McLachlan, Stela, Campbell, Susan, Polasek, Ozren, Carlson, Olga, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Dimitriou, Maria, Hicks, Andrew A., Rauramaa, Rainer, Bandinelli, Stefania, Thorand, Barbara, Liu, Yongmei, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Hingorani, Aroon, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J., Groves, Christopher J., Herder, Christian, Koistinen, Heikki A., Kinnunen, Leena, Faire, Ulf de, Bakker, Stephan J. L., Uusitupa, Matti, Palmer, Colin N. A., Jukema, J. Wouter, Sattar, Naveed, Pouta, Anneli, Snieder, Harold, Boerwinkle, Eric, Pankow, James S., Magnusson, Patrik K., Krus, Ulrika, Scapoli, Chiara, de Geus, Eco J. C. N., Blüher, Matthias, Wolffenbuttel, Bruce H. R., Province, Michael A., Abecasis, Goncalo R., Meigs, James B., Hovingh, G. Kees, Lindström, Jaana, Wilson, James F., Wright, Alan F., Dedoussis, George V., Bornstein, Stefan R., Schwarz, Peter E. H., Tönjes, Anke, Winkelmann, Bernhard R., Boehm, Bernhard O., März, Winfried, Metspalu, Andres, Price, Jackie F., Deloukas, Panos, Körner, Antje, Lakka, Timo A., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Bergman, Richard N., Tuomilehto, Jaakko, Wareham, Nicholas J., Langenberg, Claudia, Männistö, Satu, Franks, Paul W., Hayward, Caroline, Vitart, Veronique, Kaprio, Jaakko, Visvikis-Siest, Sophie, Balkau, Beverley, Altshuler, David, Rudan, Igor, Stumvoll, Michael, Campbell, Harry, van Duijn, Cornelia M., Gieger, Christian, Illig, Thomas, Ferrucci, Luigi, Pedersen, Nancy L., Pramstaller, Peter P., Boehnke, Michael, Frayling, Timothy M., Shuldiner, Alan R., Peyser, Patricia A., Kardia, Sharon L. R., Palmer, Lyle J., Penninx, Brenda W., Meneton, Pierre, Harris, Tamara B., Navis, Gerjan, Harst, Pim van der, Smith, George Davey, Forouhi, Nita G., Loos, Ruth J. F., Salomaa, Veikko, Soranzo, Nicole, Boomsma, Dorret I., Groop, Leif, Tuomi, Tiinamaija, Hofman, Albert, Munroe, Patricia B., Gudnason, Vilmundur, Siscovick, David S., Watkins, Hugh, Lecoeur, Cecile, Vollenweider, Peter, Franco-Cereceda, Anders, Eriksson, Per, Jarvelin, Marjo-Riitta, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Karpe, Fredrik, Dermitzakis, Emmanouil T., Lindgren, Cecilia M., McCarthy, Mark I., Froguel, Philippe, Kaakinen, Marika A., Lyssenko, Valeriya, Watanabe, Richard M., Ingelsson, Erik, Florez, Jose C., Dupuis, Josée, Barroso, Inês, Morris, Andrew P., and Prokopenko, Inga
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- 2021
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6. Novel aspects of the role of the liver in carbohydrate metabolism
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Bergman, Richard N., Piccinini, Francesca, Kabir, Morvarid, and Ader, Marilyn
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- 2019
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7. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
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O'Mara, Alana E., Johnson, James W., Linderman, Joyce D., Brychta, Robert J., McGehee, Suzanne, Fletcher, Laura A., Fink, Yael A., Kapuria, Devika, Cassimatis, Thomas M., Kelsey, Nathan, Cero, Cheryl, Sater, Zahraa Abdul, Piccinini, Francesca, Baskin, Alison S., Leitner, Brooks P., Cai, Hongyi, Millo, Corina M., Dieckmann, William, Walter, Mary, Javitt, Norman B., Rotman, Yaron, Walter, Peter J., Ader, Marilyn, Bergman, Richard N., Herscovitch, Peter, Chen, Kong Y., and Cypess, Aaron M.
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United States. National Institute of Diabetes and Digestive and Kidney Diseases ,Obesity -- Care and treatment ,Mirabegron -- Physiological aspects ,Glucose -- Physiological aspects ,Blood glucose tests -- Physiological aspects ,Glucose metabolism -- Physiological aspects ,Bile acids -- Physiological aspects ,Adipose tissue -- Physiological aspects ,Insulin -- Physiological aspects ,Blood cholesterol -- Physiological aspects ,Metabolites -- Physiological aspects ,Glucose tolerance test -- Physiological aspects ,Diabetes therapy -- Physiological aspects ,Body weight -- Physiological aspects ,Cholesterol ,Hormones ,Biological markers ,Positron emission tomography ,Diseases ,Kidney diseases ,Research funding ,Urinary incontinence ,Health care industry - Abstract
BACKGROUND. Mirabegron is a [beta]3-adrenergic receptor ([beta]3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that [beta]3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity. METHODS. We treated 14 healthy women of diverse ethnicities (27.5 [+ or -] 1.1 years of age, BMI of 25.4 [+ or -] 1.2 kg/[m.sup.2]) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [[sup.18]F]-2-fluoro -D-2-deoxy-D-glucose ([sup.18]F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test. RESULTS. Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion. CONCLUSION. These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of [beta]3-AR agonists as a treatment for metabolic disease. TRIAL REGISTRATION. Clinicaltrials.gov NCT03049462. FUNDING. This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014)., Introduction The rising rates of obesity are a global health epidemic. In the US alone, by 2030 it is predicted that 86% of adults will be overweight or obese (1). [...]
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- 2020
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8. Defining cutoffs to diagnose obesity using the relative fat mass (RFM): Association with mortality in NHANES 1999–2014
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Woolcott, Orison O. and Bergman, Richard N.
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- 2020
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9. Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs
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Brouwer, Annelies, Asare Bediako, Isaac, Paszkiewicz, Rebecca L., Kolka, Cathryn M., Bergman, Richard N., and Broussard, Josiane L.
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- 2020
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10. Exaggerated glucagon responses to hypoglycemia in women with polycystic ovary syndrome
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Sam, Susan, Vellanki, Priyathama, Yalamanchi, Sudha K., Bergman, Richard N., and Dunaif, Andrea
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- 2017
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11. Relative Fat Mass as an estimator of whole-body fat percentage among children and adolescents: A cross-sectional study using NHANES
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Woolcott, Orison O. and Bergman, Richard N.
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- 2019
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12. Type 2 Diabetes: Evidence for Linkage on Chromosome 20 in 716 Finnish Affected Sib Pairs
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Ghosh, Soumitra, Watanabe, Richard M., Hauser, Elizabeth R., Valle, Timo, Magnuson, Victoria L., Erdos, Michael R., Langefeld, Carl D., Balow,, James, Ally, Delphine S., Kohtamaki, Kimmo, Chines, Peter, Birznieks, Gunther, Kaleta, Hong-Shi, Musick, Anjene, Te, Catherine, Tannenbaum, Joyce, Eldridge, William, Shapiro, Shane, Martin, Colin, Witt, Alyson, So, Alistair, Chang, Jennie, Shurtleff, Ben, Porter, Rachel, Kudelko, Kristina, Unni, Arun, Segal, Leonid, Sharaf, Ravi, Blaschak-Harvan, Jillian, Eriksson, Johan, Tenkula, Tuula, Vidgren, Gabriele, Ehnholm, Christian, Tuomilehto-Wolf, Eva, Hagopian, William, Buchanan, Thomas A., Tuomilehto, Jaakko, Bergman, Richard N., Collins, Francis S., and Boehnke, Michael
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- 1999
13. Mechanisms of improved glucose handling after metabolic surgery: the big 6
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Paszkiewicz, Rebecca L. and Bergman, Richard N.
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- 2016
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14. Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin‐resistant canine model.
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Kabir, Morvarid, Bergman, Richard N., Porter, Jay, Stefanovski, Darko, Paszkiewicz, Rebecca L., Piccinini, Francesca, Woolcott, Orison O., Yang, HsiuChiung, Gopaul, V. Sashi, Stiles, Linsey, and Kolka, Cathryn M.
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ADIPOSE tissues ,SODIUM-glucose cotransporter 2 inhibitors ,WEIGHT gain ,FREE fatty acids ,DAPAGLIFLOZIN - Abstract
Objective: Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) promote urinary glucose excretion, induce weight loss, and reduce fat accumulation. The effects of the SGLT2i dapagliflozin (DAPA) on subcutaneous (SC) and visceral (VIS) adipose tissue function remain unclear. The objective of this study is to evaluate SC and VIS adipose tissue function in an insulin‐resistant canine model. Methods: A total of 12 dogs were fed a high‐fat diet (HFD) for 6 weeks and then were given a single low dose of streptozotocin (18.5 mg/kg) to induce insulin resistance. Animals were then randomized and exposed to DAPA (n = 6, 1.25 mg/kg) or placebo (n = 6) once per day for 6 weeks while remaining on the HFD. Results: DAPA prevented further weight gain induced by the HFD and normalized fat mass. DAPA reduced fasting glucose and increased free fatty acids, adiponectin, and β‐hydroxybutyrate. DAPA reduced adipocyte diameter and cell distribution. Furthermore, DAPA increased genes associated with beiging, lipolysis, and adiponectin secretion and the expression of the adiponectin receptor ADR2, in SC and VIS adipose tissue. DAPA increased AMP‐activated protein kinase activity and maximal mitochondrial respiratory function, especially in the SC depot. Furthermore, DAPA reduced cytokines and ceramide synthesis enzymes in SC and VIS depots. Conclusions: For the first time, to our knowledge, we identify mechanisms by which DAPA enhances adipose tissue function in regulating energy homeostasis in an insulin‐resistant canine model. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle
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Kolka, Cathryn M., Castro, Ana Valeria B., Kirkman, Erlinda L., and Bergman, Richard N.
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- 2015
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16. The genetic architecture of type 2 diabetes
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Fuchsberger, Christian, Flannick, Jason, Teslovich, Tanya M., Mahajan, Anubha, Agarwala, Vineeta, Gaulton, Kyle J., Ma, Clement, Fontanillas, Pierre, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R. B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N. William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn, Pearson, Richard D., Kumar, Ashish, Müller-Nurasyid, Martina, Grarup, Niels, Stringham, Heather M., Gamazon, Eric R., Lee, Jaehoon, Chen, Yuhui, Scott, Robert A., Below, Jennifer E., Chen, Peng, Huang, Jinyan, Go, Min Jin, Stitzel, Michael L., Pasko, Dorota, Parker, Stephen C. J., Varga, Tibor V., Green, Todd, Beer, Nicola L., Day-Williams, Aaron G., Ferreira, Teresa, Fingerlin, Tasha, Horikoshi, Momoko, Hu, Cheng, Huh, Iksoo, Ikram, Mohammad Kamran, Kim, Bong-Jo, Kim, Yongkang, Kim, Young Jin, Kwon, Min-Seok, Lee, Juyoung, Lee, Selyeong, Lin, Keng-Han, Maxwell, Taylor J., Nagai, Yoshihiko, Wang, Xu, Welch, Ryan P., Yoon, Joon, Zhang, Weihua, Barzilai, Nir, Voight, Benjamin F., Han, Bok-Ghee, Jenkinson, Christopher P., Kuulasmaa, Teemu, Kuusisto, Johanna, Manning, Alisa, Ng, Maggie C. Y., Palmer, Nicholette D., Balkau, Beverley, Stančáková, Alena, Abboud, Hanna E., Boeing, Heiner, Giedraitis, Vilmantas, Prabhakaran, Dorairaj, Gottesman, Omri, Scott, James, Carey, Jason, Kwan, Phoenix, Grant, George, Smith, Joshua D., Neale, Benjamin M., Purcell, Shaun, Butterworth, Adam S., Howson, Joanna M. M., Lee, Heung Man, Lu, Yingchang, Kwak, Soo-Heon, Zhao, Wei, Danesh, John, Lam, Vincent K. L., Park, Kyong Soo, Saleheen, Danish, So, Wing Yee, Tam, Claudia H. T., Afzal, Uzma, Aguilar, David, Arya, Rector, Aung, Tin, Chan, Edmund, Navarro, Carmen, Cheng, Ching-Yu, Palli, Domenico, Correa, Adolfo, Curran, Joanne E., Rybin, Denis, Farook, Vidya S., Fowler, Sharon P., Freedman, Barry I., Griswold, Michael, Hale, Daniel Esten, Hicks, Pamela J., Khor, Chiea-Chuen, Kumar, Satish, Lehne, Benjamin, Thuillier, Dorothée, Lim, Wei Yen, Liu, Jianjun, van der Schouw, Yvonne T., Loh, Marie, Musani, Solomon K., Puppala, Sobha, Scott, William R., Yengo, Loïc, Tan, Sian-Tsung, Taylor Jr., Herman A., Thameem, Farook, Wilson, Gregory, Wong, Tien Yin, Njølstad, Pål Rasmus, Levy, Jonathan C., Mangino, Massimo, Bonnycastle, Lori L., Schwarzmayr, Thomas, Fadista, João, Surdulescu, Gabriela L., Herder, Christian, Groves, Christopher J., Wieland, Thomas, Bork-Jensen, Jette, Brandslund, Ivan, Christensen, Cramer, Koistinen, Heikki A., Doney, Alex S. F., Kinnunen, Leena, Esko, Tõnu, Farmer, Andrew J., Hakaste, Liisa, Hodgkiss, Dylan, Kravic, Jasmina, Lyssenko, Valeriya, Hollensted, Mette, Jørgensen, Marit E., Jørgensen, Torben, Ladenvall, Claes, Justesen, Johanne Marie, Käräjämäki, Annemari, Kriebel, Jennifer, Rathmann, Wolfgang, Lannfelt, Lars, Lauritzen, Torsten, Narisu, Narisu, Linneberg, Allan, Melander, Olle, Milani, Lili, Neville, Matt, Orho-Melander, Marju, Qi, Lu, Qi, Qibin, Roden, Michael, Rolandsson, Olov, Swift, Amy, Rosengren, Anders H., Stirrups, Kathleen, Wood, Andrew R., Mihailov, Evelin, Blancher, Christine, Carneiro, Mauricio O., Maguire, Jared, Poplin, Ryan, Shakir, Khalid, Fennell, Timothy, DePristo, Mark, Hrabé de Angelis, Martin, Deloukas, Panos, Gjesing, Anette P., Jun, Goo, Nilsson, Peter, Murphy, Jacquelyn, Onofrio, Robert, Thorand, Barbara, Hansen, Torben, Meisinger, Christa, Hu, Frank B., Isomaa, Bo, Karpe, Fredrik, Liang, Liming, Peters, Annette, Huth, Cornelia, O’Rahilly, Stephen P., Palmer, Colin N. A., Pedersen, Oluf, Rauramaa, Rainer, Tuomilehto, Jaakko, Salomaa, Veikko, Watanabe, Richard M., Syvänen, Ann-Christine, Bergman, Richard N., Bharadwaj, Dwaipayan, Bottinger, Erwin P., Cho, Yoon Shin, Chandak, Giriraj R., Chan, Juliana C. N., Chia, Kee Seng, Daly, Mark J., Ebrahim, Shah B., Langenberg, Claudia, Elliott, Paul, Jablonski, Kathleen A., Lehman, Donna M., Jia, Weiping, Ma, Ronald C. W., Pollin, Toni I., Sandhu, Manjinder, Tandon, Nikhil, Froguel, Philippe, Barroso, Inês, Teo, Yik Ying, Zeggini, Eleftheria, Loos, Ruth J. F., Small, Kerrin S., Ried, Janina S., DeFronzo, Ralph A., Grallert, Harald, Glaser, Benjamin, Metspalu, Andres, Wareham, Nicholas J., Walker, Mark, Banks, Eric, Gieger, Christian, Ingelsson, Erik, Im, Hae Kyung, Illig, Thomas, Franks, Paul W., Buck, Gemma, Trakalo, Joseph, Buck, David, Prokopenko, Inga, Mägi, Reedik, Lind, Lars, Farjoun, Yossi, Owen, Katharine R., Gloyn, Anna L., Strauch, Konstantin, Tuomi, Tiinamaija, Kooner, Jaspal Singh, Lee, Jong-Young, Park, Taesung, Donnelly, Peter, Morris, Andrew D., Hattersley, Andrew T., Bowden, Donald W., Collins, Francis S., Atzmon, Gil, Chambers, John C., Spector, Timothy D., Laakso, Markku, Strom, Tim M., Bell, Graeme I., Blangero, John, Duggirala, Ravindranath, Tai, E. Shyong, McVean, Gilean, Hanis, Craig L., Wilson, James G., Seielstad, Mark, Frayling, Timothy M., Meigs, James B., Cox, Nancy J., Sladek, Rob, Lander, Eric S., Gabriel, Stacey, Burtt, Noël P., Mohlke, Karen L., Meitinger, Thomas, Groop, Leif, Abecasis, Goncalo, Florez, Jose C., Scott, Laura J., Morris, Andrew P., Kang, Hyun Min, Boehnke, Michael, Altshuler, David, and McCarthy, Mark I.
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- 2016
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17. Relative fat mass (RFM) as a new estimator of whole-body fat percentage ─ A cross-sectional study in American adult individuals
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Woolcott, Orison O. and Bergman, Richard N.
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- 2018
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18. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents
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Scarlett, Jarrad M., Rojas, Jennifer M., Matsen, Miles E., Kaiyala, Karl J., Stefanovski, Darko, Bergman, Richard N., Nguyen, Hong T., Dorfman, Mauricio D., Lantier, Louise, Wasserman, David H., Mirzadeh, Zaman, Unterman, Terry G., Morton, Gregory J., and Schwartz, M ichael W.
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Type 2 diabetes -- Care and treatment -- Genetic aspects -- Development and progression ,Molecular targeted therapy -- Innovations ,Fibroblast growth factors -- Health aspects ,Biological sciences ,Health - Abstract
Type 2 diabetes (T2D) is among the most common and costly disorders worldwide (1). The goal of current medical management for T2D is to transiently ameliorate hyperglycemia through daily dosing of one or more antidiabetic drugs. Hypoglycemia and weight gain are common side effects of therapy, and sustained disease remission is not obtainable with nonsurgical approaches. On the basis of the potent glucose-lowering response elicited by activation of brain fibroblast growth factor (FGF) receptors (2-4), we explored the antidiabetic efficacy of centrally administered FGF1, which, unlike other FGF peptides, activates all FGF receptor subtypes (5). We report that a single intracerebroventricular injection of FGF1 at a dose one-tenth of that needed for antidiabetic efficacy following peripheral injection induces sustained diabetes remission in both mouse and rat models of T2D. This antidiabetic effect is not secondary to weight loss, does not increase the risk of hypoglycemia, and involves a novel and incompletely understood mechanism for increasing glucose clearance from the bloodstream. We conclude that the brain has an inherent potential to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for achieving this goal., Growing evidence points to the brain as a potential target for the treatment of T2D (6,7). In rodent models of T2D, hyperglycemia can be ameliorated transiently by either systemic or [...]
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- 2016
19. Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity
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Broussard, Josiane L., Nelson, Michael D., Kolka, Cathryn M., Bediako, Isaac Asare, Paszkiewicz, Rebecca L., Smith, Laura, Szczepaniak, Edward W., Stefanovski, Darko, Szczepaniak, Lidia S., and Bergman, Richard N.
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- 2016
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20. Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs
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Broussard, Josiane L., Kolka, Cathryn M., Castro, Ana V. B., Asare Bediako, Isaac, Paszkiewicz, Rebecca L., Szczepaniak, Edward W., Szczepaniak, Lidia S., Knutson, Kristen L., Kim, Stella P., and Bergman, Richard N.
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- 2015
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21. Insulin enhances glucose-stimulated insulin secretion in healthy humans
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Bouche, Clara, Lopez, Ximena, Fleischman, Amy, Cypess, Aaron M., O'Shea, Sheila, Stefanovski, Darko, Bergman, Richard N., Rogatsky, Eduard, Stein, Daniel T., Kahn, C. Ronald, Kulkarni, Rohit N., and Goldfine, Allison B.
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- 2010
22. A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
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Scott, Laura J., Mohlke, Karen L., Bonnycastle, Lori L., Willer, Cristen J., Li, Yun, Duren, William L., Erdos, Michael R., Stringham, Heather M., Chines, Peter S., Jackson, Anne U., Prokunina-Olsson, Ludmila, Ding, Chia-Jen, Switt, Amy J., Narisu, Narisu, Hu, Tianle, Pruim, Randall, Xiao, Rui, Li, Xiao-Yi, Conneely, Karen N., Riebow, Nancy L., Sprau, Andrew G., Tong, Maurine, White, Peggy P., Hetrick, Kurt N., Barnhart, Michael W., Bark, Craig W., Goldstein, Janet L., Watkins, Lee, Xiang, Fang, Saramies, Jouko, Buchanan, Thomas A., Watanabe, Richard M., Valle, Timo T., Kinnunen, Leena, Abecasis, Gonçalo R., Pugh, Elizabeth W., Doheny, Kimberly F., Bergman, Richard N., Tuomilehto, Jaakko, Collins, Francis S., and Boehnke, Michael
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- 2007
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23. Subsets of Finns with High HDL to Total Cholesterol Ratio Show Evidence for Linkage to Type 2 Diabetes on Chromosome 6q
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Shtir, Corina, Nagakawa, I. Sharon, Duren, William L., Conneely, Karen N., Scott, Laura J., Silander, Kaisa, Valle, Timo T., Tuomilehto, Jaakko, Buchanan, Thomas A., Bergman, Richard N., Collins, Francis S., Boehnke, Michael, and Watanabe, Richard M.
- Published
- 2007
24. Utility of a Surrogate Measure of Insulin Resistance in American Indians: The Strong Heart Study
- Author
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Resnick, Helaine E., Bergman, Richard N., Henderson, Jeffrey A., Nez-Henderson, Patricia, and Howard, Barbara V.
- Published
- 2002
25. Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
- Author
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Palmer, Nicholette D., Goodarzi, Mark O., Langefeld, Carl D., Wang, Nan, Guo, Xiuqing, Taylor, Kent D., Fingerlin, Tasha E., Norris, Jill M., Buchanan, Thomas A., Xiang, Anny H., Haritunians, Talin, Ziegler, Julie T., Williams, Adrienne H., Stefanovski, Darko, Cui, Jinrui, Mackay, Adrienne W., Henkin, Leora F., Bergman, Richard N., Gao, Xiaoyi, Gauderman, James, Varma, Rohit, Hanis, Craig L., Cox, Nancy J., Highland, Heather M., Below, Jennifer E., Williams, Amy L., Burtt, Noel P., Aguilar-Salinas, Carlos A., Huerta-Chagoya, Alicia, Gonzalez-Villalpando, Clicerio, Orozco, Lorena, Haiman, Christopher A., Tsai, Michael Y., Johnson, W. Craig, Yao, Jie, Rasmussen-Torvik, Laura, Pankow, James, Snively, Beverly, Jackson, Rebecca D., Liu, Simin, Nadler, Jerry L., Kandeel, Fouad, Chen, Yii-Der I., Bowden, Donald W., Rich, Stephen S., Raffel, Leslie J., Rotter, Jerome I., Watanabe, Richard M., and Wagenknecht, Lynne E.
- Published
- 2015
- Full Text
- View/download PDF
26. Glucose Homeostasis During Short-term and Prolonged Exposure to High Altitudes
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Woolcott, Orison O., Ader, Marilyn, and Bergman, Richard N.
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- 2015
27. Metabolomic Profile Associated With Insulin Resistance and Conversion to Diabetes in the Insulin Resistance Atherosclerosis Study
- Author
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Palmer, Nicholette D., Stevens, Robert D., Antinozzi, Peter A., Anderson, Andrea, Bergman, Richard N., Wagenknecht, Lynne E., Newgard, Christopher B., and Bowden, Donald W.
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- 2015
28. Genetic studies of body mass index yield new insights for obesity biology
- Author
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Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jianʼan, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E., de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Jörgen, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Quinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Sin Lo, Ken, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Vernon Smith, Albert, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, vanʼt Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Adrienne Cupples, L., Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Kees Hovingh, G., Humphries, Steve E., Hunt, Steven C., Hyppönen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Wouter Jukema, J., Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Carola Zillikens, M., Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stéphane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., OʼConnell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Abecasis, Gonçalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, André, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Inês, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., and Speliotes, Elizabeth K.
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- 2015
- Full Text
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29. New genetic loci link adipose and insulin biology to body fat distribution
- Author
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Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jianʼan, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., OʼConnell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, Adrienne L., Morris, Andrew P., Lindgren, Cecilia M., and Mohlke, Karen L
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- 2015
- Full Text
- View/download PDF
30. Familiality of Quantitative Metabolic Traits in Finnish Families with Non-Insulin-Dependent Diabetes mellitus
- Author
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Watanabe, Richard M., Valle, Timo, Hauser, Elizabeth R., Ghosh, Soumitra, Eriksson, Johan, Kohtamäki, Kimmo, Ehnholm, Christian, Tuomilehto, Jaakko, Collins, Francis S., Bergman, Richard N., and Boehnke, Michael
- Published
- 1999
31. Primacy of Liver Glucosensors in the Sympathetic Response to Progressive Hypoglycemia
- Author
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Donovan, Casey M., Hamilton-Wessler, Marianthe, Halter, Jeffrey B., and Bergman, Richard N.
- Published
- 1994
32. Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults1-3
- Author
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Chiu, Sally, Williams, Paul T., Dawson, Taylor, Bergman, Richard N., Stefanovski, Darko, Watkins, Steven M., and Krauss, Ronald M.
- Published
- 2014
- Full Text
- View/download PDF
33. The endothelium in diabetes: Its role in insulin access and diabetic complications
- Author
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Kolka, Cathryn M. and Bergman, Richard N.
- Published
- 2013
- Full Text
- View/download PDF
34. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- Author
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Scott, Robert A, Lagou, Vasiliki, Welch, Ryan P, Wheeler, Eleanor, Montasser, May E, Luan, Jian'an, Mägi, Reedik, Strawbridge, Rona J, Rehnberg, Emil, Gustafsson, Stefan, Kanoni, Stavroula, Rasmussen-Torvik, Laura J, Yengo, Loïc, Lecoeur, Cecile, Shungin, Dmitry, Sanna, Serena, Sidore, Carlo, Johnson, Paul C D, Jukema, J Wouter, Johnson, Toby, Mahajan, Anubha, Verweij, Niek, Thorleifsson, Gudmar, Hottenga, Jouke-Jan, Shah, Sonia, Smith, Albert V, Sennblad, Bengt, Gieger, Christian, Salo, Perttu, Perola, Markus, Timpson, Nicholas J, Evans, David M, Pourcain, Beate St, Wu, Ying, Andrews, Jeanette S, Hui, Jennie, Bielak, Lawrence F, Zhao, Wei, Horikoshi, Momoko, Navarro, Pau, Isaacs, Aaron, O'Connell, Jeffrey R, Stirrups, Kathleen, Vitart, Veronique, Hayward, Caroline, Esko, Tõnu, Mihailov, Evelin, Fraser, Ross M, Fall, Tove, Voight, Benjamin F, Raychaudhuri, Soumya, Chen, Han, Lindgren, Cecilia M, Morris, Andrew P, Rayner, Nigel W, Robertson, Neil, Rybin, Denis, Liu, Ching-Ti, Beckmann, Jacques S, Willems, Sara M, Chines, Peter S, Jackson, Anne U, Kang, Hyun Min, Stringham, Heather M, Song, Kijoung, Tanaka, Toshiko, Peden, John F, Goel, Anuj, Hicks, Andrew A, An, Ping, Müller-Nurasyid, Martina, Franco-Cereceda, Anders, Folkersen, Lasse, Marullo, Letizia, Jansen, Hanneke, Oldehinkel, Albertine J, Bruinenberg, Marcel, Pankow, James S, North, Kari E, Forouhi, Nita G, Loos, Ruth J F, Edkins, Sarah, Varga, Tibor V, Hallmans, Göran, Oksa, Heikki, Antonella, Mulas, Nagaraja, Ramaiah, Trompet, Stella, Ford, Ian, Bakker, Stephan J L, Kong, Augustine, Kumari, Meena, Gigante, Bruna, Herder, Christian, Munroe, Patricia B, Caulfield, Mark, Antti, Jula, Mangino, Massimo, Small, Kerrin, Miljkovic, Iva, Liu, Yongmei, Atalay, Mustafa, Kiess, Wieland, James, Alan L, Rivadeneira, Fernando, Uitterlinden, Andre G, Palmer, Colin N A, Doney, Alex S F, Willemsen, Gonneke, Smit, Johannes H, Campbell, Susan, Polasek, Ozren, Bonnycastle, Lori L, Hercberg, Serge, Dimitriou, Maria, Bolton, Jennifer L, Fowkes, Gerard R, Kovacs, Peter, Lindström, Jaana, Zemunik, Tatijana, Bandinelli, Stefania, Wild, Sarah H, Basart, Hanneke V, Rathmann, Wolfgang, Grallert, Harald, Maerz, Winfried, Kleber, Marcus E, Boehm, Bernhard O, Peters, Annette, Pramstaller, Peter P, Province, Michael A, Borecki, Ingrid B, Hastie, Nicholas D, Rudan, Igor, Campbell, Harry, Watkins, Hugh, Farrall, Martin, Stumvoll, Michael, Ferrucci, Luigi, Waterworth, Dawn M, Bergman, Richard N, Collins, Francis S, Tuomilehto, Jaakko, Watanabe, Richard M, de Geus, Eco J C, Penninx, Brenda W, Hofman, Albert, Oostra, Ben A, Psaty, Bruce M, Vollenweider, Peter, Wilson, James F, Wright, Alan F, Hovingh, G Kees, Metspalu, Andres, Uusitupa, Matti, Magnusson, Patrik K E, Kyvik, Kirsten O, Kaprio, Jaakko, Price, Jackie F, Dedoussis, George V, Deloukas, Panos, Meneton, Pierre, Lind, Lars, Boehnke, Michael, Shuldiner, Alan R, van Duijn, Cornelia M, Morris, Andrew D, Toenjes, Anke, Peyser, Patricia A, Beilby, John P, Körner, Antje, Kuusisto, Johanna, Laakso, Markku, Bornstein, Stefan R, Schwarz, Peter E H, Lakka, Timo A, Rauramaa, Rainer, Adair, Linda S, Smith, George Davey, Spector, Tim D, Illig, Thomas, de Faire, Ulf, Hamsten, Anders, Gudnason, Vilmundur, Kivimaki, Mika, Hingorani, Aroon, Keinanen-Kiukaanniemi, Sirkka M, Saaristo, Timo E, Boomsma, Dorret I, Stefansson, Kari, van der Harst, Pim, Dupuis, Josée, Pedersen, Nancy L, Sattar, Naveed, Harris, Tamara B, Cucca, Francesco, Ripatti, Samuli, Salomaa, Veikko, Mohlke, Karen L, Balkau, Beverley, Froguel, Philippe, Pouta, Anneli, Jarvelin, Marjo-Riitta, Wareham, Nicholas J, Bouatia-Naji, Nabila, McCarthy, Mark I, Franks, Paul W, Meigs, James B, Teslovich, Tanya M, Florez, Jose C, Langenberg, Claudia, Ingelsson, Erik, Prokopenko, Inga, and Barroso, Inês
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- 2012
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35. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
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Manning, Alisa K, Hivert, Marie-France, Scott, Robert A, Grimsby, Jonna L, Bouatia-Naji, Nabila, Chen, Han, Rybin, Denis, Liu, Ching-Ti, Bielak, Lawrence F, Prokopenko, Inga, Amin, Najaf, Barnes, Daniel, Cadby, Gemma, Hottenga, Jouke-Jan, Ingelsson, Erik, Jackson, Anne U, Johnson, Toby, Kanoni, Stavroula, Ladenvall, Claes, Lagou, Vasiliki, Lahti, Jari, Lecoeur, Cecile, Liu, Yongmei, Martinez-Larrad, Maria Teresa, Montasser, May E, Navarro, Pau, Perry, John R B, Rasmussen-Torvik, Laura J, Salo, Perttu, Sattar, Naveed, Shungin, Dmitry, Strawbridge, Rona J, Tanaka, Toshiko, van Duijn, Cornelia M, An, Ping, de Andrade, Mariza, Andrews, Jeanette S, Aspelund, Thor, Atalay, Mustafa, Aulchenko, Yurii, Balkau, Beverley, Bandinelli, Stefania, Beckmann, Jacques S, Beilby, John P, Bellis, Claire, Bergman, Richard N, Blangero, John, Boban, Mladen, Boehnke, Michael, Boerwinkle, Eric, Bonnycastle, Lori L, Boomsma, Dorret I, Borecki, Ingrid B, Böttcher, Yvonne, Bouchard, Claude, Brunner, Eric, Budimir, Danijela, Campbell, Harry, Carlson, Olga, Chines, Peter S, Clarke, Robert, Collins, Francis S, Corbatón-Anchuelo, Arturo, Couper, David, de Faire, Ulf, Dedoussis, George V, Deloukas, Panos, Dimitriou, Maria, Egan, Josephine M, Eiriksdottir, Gudny, Erdos, Michael R, Eriksson, Johan G, Eury, Elodie, Ferrucci, Luigi, Ford, Ian, Forouhi, Nita G, Fox, Caroline S, Franzosi, Maria Grazia, Franks, Paul W, Frayling, Timothy M, Froguel, Philippe, Galan, Pilar, de Geus, Eco, Gigante, Bruna, Glazer, Nicole L, Goel, Anuj, Groop, Leif, Gudnason, Vilmundur, Hallmans, Göran, Hamsten, Anders, Hansson, Ola, Harris, Tamara B, Hayward, Caroline, Heath, Simon, Hercberg, Serge, Hicks, Andrew A, Hingorani, Aroon, Hofman, Albert, Hui, Jennie, Hung, Joseph, Jarvelin, Marjo-Riitta, Jhun, Min A, Johnson, Paul C D, Jukema, J Wouter, Jula, Antti, Kao, W H, Kaprio, Jaakko, Kardia, Sharon L R, Keinanen-Kiukaanniemi, Sirkka, Kivimaki, Mika, Kolcic, Ivana, Kovacs, Peter, Kumari, Meena, Kuusisto, Johanna, Kyvik, Kirsten Ohm, Laakso, Markku, Lakka, Timo, Lannfelt, Lars, Lathrop, G Mark, Launer, Lenore J, Leander, Karin, Li, Guo, Lind, Lars, Lindstrom, Jaana, Lobbens, Stéphane, Loos, Ruth J F, Luan, Jian'an, Lyssenko, Valeriya, Mägi, Reedik, Magnusson, Patrik K E, Marmot, Michael, Meneton, Pierre, Mohlke, Karen L, Mooser, Vincent, Morken, Mario A, Miljkovic, Iva, Narisu, Narisu, O'Connell, Jeff, Ong, Ken K, Oostra, Ben A, Palmer, Lyle J, Palotie, Aarno, Pankow, James S, Peden, John F, Pedersen, Nancy L, Pehlic, Marina, Peltonen, Leena, Penninx, Brenda, Pericic, Marijana, Perola, Markus, Perusse, Louis, Peyser, Patricia A, Polasek, Ozren, Pramstaller, Peter P, Province, Michael A, Räikkönen, Katri, Rauramaa, Rainer, Rehnberg, Emil, Rice, Ken, Rotter, Jerome I, Rudan, Igor, Ruokonen, Aimo, Saaristo, Timo, Sabater-Lleal, Maria, Salomaa, Veikko, Savage, David B, Saxena, Richa, Schwarz, Peter, Seedorf, Udo, Sennblad, Bengt, Serrano-Rios, Manuel, Shuldiner, Alan R, Sijbrands, Eric J G, Siscovick, David S, Smit, Johannes H, Small, Kerrin S, Smith, Nicholas L, Smith, Albert Vernon, Stančáková, Alena, Stirrups, Kathleen, Stumvoll, Michael, Sun, Yan V, Swift, Amy J, Tönjes, Anke, Tuomilehto, Jaakko, Trompet, Stella, Uitterlinden, Andre G, Uusitupa, Matti, Vikström, Max, Vitart, Veronique, Vohl, Marie-Claude, Voight, Benjamin F, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Watkins, Hugh, Wheeler, Eleanor, Widen, Elisabeth, Wild, Sarah H, Willems, Sara M, Willemsen, Gonneke, Wilson, James F, Witteman, Jacqueline C M, Wright, Alan F, Yaghootkar, Hanieh, Zelenika, Diana, Zemunik, Tatijana, Zgaga, Lina, Wareham, Nicholas J, McCarthy, Mark I, Barroso, Ines, Watanabe, Richard M, Florez, Jose C, Dupuis, Josée, Meigs, James B, and Langenberg, Claudia
- Published
- 2012
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36. Ethnic heterogeneity in glucoregulatory function during treatment with atypical antipsychotics in patients with schizophrenia
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Ader, Marilyn, Garvey, W. Timothy, Phillips, Lawrence S., Nemeroff, Charles B., Gharabawi, Georges, Mahmoud, Ramy, Greenspan, Andrew, Berry, Sally A., Musselman, Dominique L., Morein, Jacqueline, Zhu, Young, Mao, Lian, and Bergman, Richard N.
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- 2008
- Full Text
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37. Pulsatile changes in free fatty acids augment hepatic glucose production and preserves peripheral glucose homeostasis
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Hsu, Isabel R., Zuniga, Edward, and Bergman, Richard N.
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Homeostasis -- Research ,Fatty acids -- Properties ,Nervous system, Sympathetic -- Properties ,Glucose -- Synthesis ,Glucose -- Research ,Biological sciences - Abstract
Recent studies in animal and human models have revealed that free fatty acid (FFA) release from adipose tissue is oscillatory. We have shown in our laboratory that these oscillations are controlled by the sympathetic nervous system (SNS). Although FFAs have been shown to directly stimulate glucose production [endogenous glucose production (EGP)] by the liver and to reduce peripheral glucose utilization, whether the specific pattern of FFA release affects glucose metabolism is unknown. The aim of this study was to examine the effects of pulsatile vs. constant infusion of FFA on glucose homeostasis in the canine model. Euglycemic clamps with basal insulin replacement (0.1 mU x [kg.sup.-1] x [min.sup.-1] insulin) were performed in dogs (n = 8) during infusion of saline (SAL) or the medium-chain fatty acid octanoate, which was given by either pulsatile infusion (PUL: 10 mmol over 2 rain every 10 min) or continuous infusion (C-INF: 1 mmol/min) designed to achieve equivalent total FFA mass. Endogenous lipolytic pulses were suppressed with the [[beta].sub.3]-specific adrenergic receptor antagonist bupranolol. PUL infusion elicited a pulsatile pattern of FFA in circulation with average maximum pulse height of 0.82 [+ or -] 0.04 mM, whereas C-INF FFA levels reached 0.47 [+ or -] 0.03 mM (fasting levels) and were maintained throughout. Glucose uptake was not affected by PUL; however, C-INF significantly reduced glucose uptake compared with both SAL and PUL. Steady-state EGP increased by >90% from basal steady state during PUL but did not change during either SAL or C-INF. Thus, pulsatile FFA infusion led to an increase in EGP while preserving glucose disposal. These data suggest that the pattern of FFA may have a role in regulation of glucose homeostasis, which may have consequences in the obese or insulin-resistant state where the SNS is known to be altered. octanoate; oscillations; lipolysis; sympathetic nervous system doi: 10.1152/ajpendo.00427.2009.
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- 2010
38. Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal
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Zhen, Dan, Ionut, Viorica, Mooradian, Vahe, Stefanovski, Darko, and Bergman, Richard N.
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Blood sugar monitoring -- Usage ,Blood sugar monitoring -- Health aspects ,Glucose metabolism -- Physiological aspects ,Glucose metabolism -- Research ,Liver -- Physiological aspects ,Liver -- Health aspects ,Liver -- Research ,Biological sciences - Abstract
The full impact of the liver, through both glucose production and uptake, on systemic glucose appearance cannot be readily studied in a classical glucose clamp because hepatic glucose metabolism is regulated not only by portal insulin and glucose levels but also portal glucose delivery (the portal signal). In the present study, we modified the classical glucose clamp by giving exogenous glucose through portal vein, the 'portal glucose infusion (PoG)-glucose clamp', to determine the net hepatic effect on postprandial systemic glucose supply along with the measurement of whole body glucose disposal. By comparing systemic rate of glucose appearance (Ra) with portal glucose infusion rate ([PoG.sub.inf]), we quantified 'net hepatic glucose addition (NHGA)' in the place of endogenous glucose production determined in a regular clamp. When PoG-glucose clamps (n = 6) were performed in dogs at basal insulinemia and hyperglycemia (~150 mg/dl, portal and systemic), we measured consistently higher Ra than [PoG.sub.inf] (4.2 [+ or -] 0.6 vs. 2.9 [+ or -] 0.6 mg * [kg.sup.-1] * [min.sup.-1] at steady state, P < 0.001) and thus positive NHGA at 1.3 [+ or -] 0.1 mg * [kg.sup.-1] * [min.sup.-1], identifying net hepatic addition of glucose to portal exogenous glucose. In contrast, when PoG-glucose clamps (n = 6) were performed at hyperinsulinemia (~250 pmol/l) and systemic euglycemia (portal hyperglycemia due to portal glucose infusion), we measured consistently lower [R.sub.a] than [PoG.sub.inf] (13.1 [+ or -] 2.4 vs. 14.3 [+ or -] 2.4 mg * [kg.sup.-1] * [min.sup.-1], P < 0.001), and therefore negative NHGA at - 1.1 [+ or -] 0.1 mg * [kg.sup.-1] * [min.sup.-l], identifying a switch of the liver from net production to net uptake of portal exogenous glucose. Steady-state whole body glucose disposal was 4.1 [+ or -] 0.5 and 13.0 [+ or -] 2.4 mg * [kg.sup.-1] * [min.sup.-1], respectively, determined as in a classical glucose clamp. We conclude that the PoG-glucose clamp, simulating postprandial glucose entry and metabolism, enables simultaneous assessment of the net hepatic effect on postprandial systemic glucose supply as well as whole body glucose disposal in various animal models (rodents, dogs, and pigs) with established portal vein catheterization. net hepatic glucose addition doi: 10.1152/ajpendo.00280.2009
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- 2010
39. Novel canine models of obese prediabetes and mild type 2 diabetes
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Ionut, Viorica, Liu, Huiwen, Mooradian, Vahe, Castro, Ana Valeria B., Kabir, Morvarid, Stefanovski, Darko, Zheng, Dan, Kirkman, Erlinda L., and Bergman, Richard N.
- Subjects
Obesity -- Complications and side effects ,Prediabetic state -- Risk factors ,Prediabetic state -- Development and progression ,Prediabetic state -- Models ,Animal models in research -- Usage ,Type 2 diabetes -- Risk factors ,Type 2 diabetes -- Development and progression ,Type 2 diabetes -- Models ,Biological sciences - Abstract
Am J Physiol Endocrinol Metab 298: E38-E48, 2010. First published October 20, 2009; doi:10.1152/ajpendo.00466.2009.--Human type 2 diabetes mellitus (T2DM) is often characterized by obesity-associated insulin resistance (IR) and [beta]-cell function deficiency. Development of relevant large animal models to study T2DM is important and timely, because most existing models have dramatic reductions in pancreatic function and no associated obesity and IR, features that resemble more T1DM than T2DM. Our goal was to create a canine model of T2DM in which obesity-associated IR occurs first, followed by moderate reduction in [beta]-cell function, leading to mild diabetes or impaired glucose tolerance. Lean dogs (n = 12) received a high-fat diet that increased visceral (52%, P < 0.001) and subcutaneous (130%, P < 0.001) fat and resulted in a 31% reduction in insulin sensitivity ([S.sub.1]) (5.8 [+ or -] 0.7 X [10.sup.-4] to 4.1 [+ or -] 0.5 x [10.sup.-4] [micro]U x [ml.sup.-1] x [min.sup.-1], P < 0.05). Animals then received a single low dose of streptozotocin (STZ; range 30-15 mg/kg). The decrease in [beta]-cell function was dose dependent and resulted in three diabetes models: 1) frank hyperglycemia (high STZ dose); 2) mild T2DM with normal or impaired fasting glucose (FG), 2-h glucose >200 mg/dl during OGTT and 77-93% [AIR.sub.g] reduction (intermediate dose); and 3) prediabetes with normal FG, normal 2-h glucose during OGTT and 17-74% [AIR.sub.g] reduction (low dose). Twelve weeks after STZ, animals without frank diabetes had 58% more body fat, decreased [beta]-cell function (17-93%), and 40% lower [S.sub.I]. We conclude that high-fat feeding and variable-dose STZ in dog result in stable models of obesity, insulin resistance, and 1) overt diabetes, 2) mild T2DM, or 3) impaired glucose tolerance. These models open new avenues for studying the mechanism of compensatory changes that occur in T2DM and for evaluating new therapeutic strategies to prevent progression or to treat overt diabetes. obesity; animal models; streptozotocin; insulin secretion
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- 2010
40. Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
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Dimas, Antigone S., Lagou, Vasiliki, Barker, Adam, Knowles, Joshua W., Mägi, Reedik, Hivert, Marie-France, Benazzo, Andrea, Rybin, Denis, Jackson, Anne U., Stringham, Heather M., Song, Ci, Fischer-Rosinsky, Antje, Boesgaard, Trine Welløv, Grarup, Niels, Abbasi, Fahim A., Assimes, Themistocles L., Hao, Ke, Yang, Xia, Lecoeur, Cécile, Barroso, Inês, Bonnycastle, Lori L., Böttcher, Yvonne, Bumpstead, Suzannah, Chines, Peter S., Erdos, Michael R., Graessler, Jurgen, Kovacs, Peter, Morken, Mario A., Narisu, Narisu, Payne, Felicity, Stancakova, Alena, Swift, Amy J., Tönjes, Anke, Bornstein, Stefan R., Cauchi, Stéphane, Froguel, Philippe, Meyre, David, Schwarz, Peter E.H., Häring, Hans-Ulrich, Smith, Ulf, Boehnke, Michael, Bergman, Richard N., Collins, Francis S., Mohlke, Karen L., Tuomilehto, Jaakko, Quertemous, Thomas, Lind, Lars, Hansen, Torben, Pedersen, Oluf, Walker, Mark, Pfeiffer, Andreas F.H., Spranger, Joachim, Stumvoll, Michael, Meigs, James B., Wareham, Nicholas J., Kuusisto, Johanna, Laakso, Markku, Langenberg, Claudia, Dupuis, Josée, Watanabe, Richard M., Florez, Jose C., Ingelsson, Erik, McCarthy, Mark I., and Prokopenko, Inga
- Published
- 2014
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41. Failure of Homeostatic Model Assessment of Insulin Resistance to Detect Marked Diet-Induced Insulin Resistance in Dogs
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Ader, Marilyn, Stefanovski, Darko, Richey, Joyce M., Kim, Stella P., Kolka, Cathryn M., Ionut, Viorica, Kabir, Morvarid, and Bergman, Richard N.
- Published
- 2014
- Full Text
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42. Essentiality of Portal Vein Receptors in Hypoglycemic Counterregulation: Direct Proof Via Denervation in Male Canines
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Ionut, Viorica, Castro, Ana Valeria B., Woolcott, Orison O., Stefanovski, Darko, Iyer, Malini S., Broussard, Josiane L., Mkrtchyan, Hasmik, Burch, Miguel, Elazary, Ram, Kirkman, Erlinda, and Bergman, Richard N.
- Published
- 2014
43. Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs
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Ader, Marilyn, Kolka, Cathryn M., and Bergman, Richard N.
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- 2020
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44. Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs
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Richey, Joyce M., Woolcott, Orison O., Stefanovski, Darko, Harrison, L. Nicole, Zheng, Dan, Lottati, Maya, Hsu, Isabel R., Kim, Stella P., Kabir, Morvarid, Catalano, Karyn J., Chiu, Jenny D., Ionut, Viorica, Kolka, Cathryn, Mooradian, Vahe, and Bergman, Richard N.
- Subjects
Adipose tissues -- Physiological aspects ,Adipose tissues -- Research ,Obesity -- Prevention ,Obesity -- Research ,Biological sciences - Abstract
We investigated whether rimonabant, a type 1 cannabinoid receptor antagonist, reduces visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in dogs maintained on a hypercaloric high-fat diet (HHFD). To determine whether energy expenditure contributed to body weight changes, we also calculated resting metabolic rate. Twenty male dogs received either rimonabant (1.25 mg x [kg.sup.-1] x [day.sup.-1], orally; n = 11) or placebo (n = 9) for 16 wk, concomitant with a HHFD. VAT, SAT, and nonfat tissue were measured by magnetic resonance imaging. Resting metabolic rate was assessed by indirect calorimetry. By week 16 of treatment, rimonabant dogs lost 2.5% of their body weight (P = 0.029), whereas in placebo dogs body weight increased by 6.2% (P < 0.001). Rimonabant reduced food intake (P = 0.027), concomitant with a reduction of SAT by 19.5% (P < 0.001). In contrast with the VAT increase with placebo (P < 0.01), VAT did not change with rimonabant. Nonfat tissue remained unchanged in both groups. Body weight loss was not associated with either resting metabolic rate ([r.sup.2] = 0.24; P = 0.154) or food intake ([r.sup.2] = 0.24; P = 0.166). In conclusion, rimonabant reduced body weight together with a reduction in abdominal fat, mainly because of SAT loss. Body weight changes were not associated with either resting metabolic rate or food intake. The findings provide evidence of a peripheral effect of rimonabant to reduce adiposity and body weight, possibly through a direct effect on adipose tissue. adipose tissue; body weight; energy expenditure; magnetic resonance; resting metabolic rate
- Published
- 2009
45. FGF19 action in the brain induces insulin-independent glucose lowering
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Morton, Gregory J., Matsen, Miles E., Bracy, Deanna P., Meek, Thomas H., Nguyen, Hong T., Stefanovski, Darko, Bergman, Richard N., Wasserman, David H., and Schwartz, Michael W.
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- 2013
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46. Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
- Author
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Yaghootkar, Hanieh, Lamina, Claudia, Scott, Robert A., Dastani, Zari, Hivert, Marie-France, Warren, Liling L., Stancáková, Alena, Buxbaum, Sarah G., Lyytikäinen, Leo-Pekka, Henneman, Peter, Wu, Ying, Cheung, Chloe Y.Y., Pankow, James S., Jackson, Anne U., Gustafsson, Stefan, Zhao, Jing Hua, Ballantyne, Christie M., Xie, Weijia, Bergman, Richard N., Boehnke, Michael, el Bouazzaoui, Fatiha, Collins, Francis S., Dunn, Sandra H., Dupuis, Josee, Forouhi, Nita G., Gillson, Christopher, Hattersley, Andrew T., Hong, Jaeyoung, Kähönen, Mika, Kuusisto, Johanna, Kedenko, Lyudmyla, Kronenberg, Florian, Doria, Alessandro, Assimes, Themistocles L., Ferrannini, Ele, Hansen, Torben, Hao, Ke, Häring, Hans, Knowles, Joshua W., Lindgren, Cecilia M., Nolan, John J., Paananen, Jussi, Pedersen, Oluf, Quertermous, Thomas, Smith, Ulf, Lehtimäki, Terho, Liu, Ching-Ti, Loos, Ruth J.F., McCarthy, Mark I., Morris, Andrew D., Vasan, Ramachandran S., Spector, Tim D., Teslovich, Tanya M., Tuomilehto, Jaakko, van Dijk, Ko Willems, Viikari, Jorma S., Zhu, Na, Langenberg, Claudia, Ingelsson, Erik, Semple, Robert K., Sinaiko, Alan R., Palmer, Colin N.A., Walker, Mark, Lam, Karen S.L., Paulweber, Bernhard, Mohlke, Karen L., van Duijn, Cornelia, Raitakari, Olli T., Bidulescu, Aurelian, Wareham, Nick J., Laakso, Markku, Waterworth, Dawn M., Lawlor, Debbie A., Meigs, James B., Richards, J. Brent, and Frayling, Timothy M.
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- 2013
- Full Text
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47. Evaluation of quantitative models of the effect of insulin on lipolysis and glucose disposal
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Periwal, Vipul, Chow, Carson C., Bergman, Richard N., Ricks, Madia, Vega, Gloria L., and Sumner, Anne E.
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Lipolysis -- Health aspects ,Insulin -- Health aspects ,Biological sciences - Abstract
The effects of insulin on the suppression of lipolysis are neither fully understood nor quantified. We examined a variety of mathematical models analogous to the minimal model of glucose disposal (MMG) to quantify the combined influence of insulin on lipolysis and glucose disposal during an insulin-modified frequently sampled intravenous glucose tolerance test. The tested models, which include two previously published ones, consisted of separate compartments for plasma free fatty acids (FFA), glucose, and insulin. They differed in the number of compartments and in the action of insulin to suppress lipolysis that decreased the plasma FFA level. In one category of models, a single insulin compartment acted on both glucose and FFA simultaneously. In a second category, there were two insulin compartments, each acting on FFA and glucose independently. For each of these two categories, we tested 11 variations of how insulin suppressed lipolysis. We also tested a model with an additional glucose compartment that acted on FFA. These 23 models were fit to the plasma FFA and glucose concentrations of I02 subjects individually. Using Bayesian model comparison methods, we selected the model that best balanced fit and minimized model complexity. In the best model, insulin suppressed lipolysis via a Hill function through a remote compartment that acted on both glucose and FFA simultaneously, and glucose dynamics obeyed the classic MMG. free fatty acids; insulin resistance; mathematical model
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- 2008
48. Exenatide can reduce glucose independent of islet hormones or gastric emptying
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Ionut, Viorica, Zheng, Dan, Stefanovski, Darko, and Bergman, Richard N.
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Glucose metabolism -- Evaluation ,Pancreas -- Physiological aspects ,Biological sciences - Abstract
Exenatide is a long-acting glucagon-like peptide-1 (GLP-1) mimetic used in the treatment of type 2 diabetes. There is increasing evidence that GLP-1 can influence glycemia not only via pancreatic (insulinotropic and glucagon suppression) and gastric-emptying effects, but also via an independent mechanism mediated by portal vein receptors. The aim of our study was to investigate whether exenatide has an islet-and gastric-independent glycemia-reducing effect, similar to GLP-1. First, we administered mixed meals, with or without exenatide (20 [micro]g sc) to dogs. Second, to determine whether exenatide-induced reduction in glycemia is independent of slower gastric emptying, in the same animals we infused glucose intraportally (to simulate meal test glucose appearance) with exenatide, exenatide + the intraportal GLP-1 receptor antagonist exendin-(9-39), or saline. Exenatide markedly decreased postprandial glucose: net 0- to 135-rain area under the curve = +526 [+ or -] 315 and -536 [+ or -] 197 mg*[dl.sup.-1]*[min.sup.-1] with saline and exenatide, respectively (P < 0.05). Importantly, the decrease in plasma glucose occurred without a corresponding increase in postprandial insulin but was accompanied by delayed gastric emptying and lower glucagon. Significantly lower glycemia was induced by intraportal glucose infusion with exenatide than with saline (92 [+ or -] 1 vs. 97 [+ or -] 1 mg/dl, P < 0.001) in the absence of hyperinsulinemia or glucagon suppression. The exenatide-induced lower glycemia was partly reversed by intraportal exendin-(9-39): 95 [+ or -] 3 and 92 [+ or -] 3 mg/dl with exenatide + antagonist and exenatide, respectively (P < 0.01). Our results suggest that, similar to GLP-1, exenatide lowers glycemia via a novel mechanism independent of islet hormones and slowing of gastric emptying. We hypothesize that receptors in the portal vein, via a neural mechanism, increase glucose clearance independent of islet hormones. glucagon-like peptide-1; insulin-independent; glucose regulation
- Published
- 2008
49. Obesity, insulin resistance, and the pathway to type 2 diabetes
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Bergman Richard N
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Medicine ,Science - Published
- 2012
- Full Text
- View/download PDF
50. Metabolic syndrome, hyperinsulinemia, and cancer
- Author
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Hsu, Isabel R, Kim, Stella P, Kabir, Morvarid, and Bergman, Richard N
- Published
- 2007
- Full Text
- View/download PDF
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